American Saffron & Slippery Elm Ingredients & Drug Interactions
by TerraVita
What is this page for?
First and foremost: checking American Saffron & Slippery Elm against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
American Saffron & Slippery Elm is a dietary supplement by TerraVita with 1 active ingredient. Its ingredients are commonly taken for heart and cholesterol support, skin moisturizing, menstrual cramps.Based on those ingredients, 2,068 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are American Saffron and Slippery Elm Glycerite Liquid Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against American Saffron & Slippery Elm by TerraVita
Ask about any prescription or over-the-counter medication and we check it for interactions with American Saffron & Slippery Elm by TerraVita — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of American Saffron & Slippery Elm by TerraVita
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This is a two-ingredient liquid blend: American Saffron (safflower) glycerite and Slippery Elm glycerite, both extracted and delivered in glycerin. These are the active ingredients — the glycerin itself is an inactive carrier.
You're getting a concentrated liquid extract of each plant's traditional components, meant to be taken orally.
Does it work?
Couldn't assess
The evidence for both safflower and slippery elm is insufficient in the data we hold. Safflower has been studied for unstable angina, coronary heart disease, diabetes, and diabetic kidney damage, but reliable evidence isn't there to rate it for any of those.
Slippery elm has been researched for constipation, cough, inflammatory bowel disease, cancer, and diarrhea — again, the evidence doesn't support a clear rating. If you're considering this product for a specific condition, your pharmacist can help you weigh what the broader research literature shows.
How safe is it?
Well-documented data
Safflower oil in food is generally well tolerated, but concentrated flower extracts and high-dose supplements have less safety data backing them. At least seven case reports link over-use of safflower oil to acute liver failure requiring transplant, though the exact doses that triggered these cases aren't clear.
Slippery elm is generally well tolerated for short-term use, though high-quality safety data are limited. Both ingredients carry cautions in pregnancy and breastfeeding — safflower may stimulate the uterus and has been traditionally used to bring on menstruation, so medicinal amounts are not advised in pregnancy; slippery elm lacks reliable safety data for pregnancy or breastfeeding.
Topically, slippery elm pollen and extracts can cause contact dermatitis and urticaria in sensitive people.
Meds to double-check
Moderate interaction found
Check before using if you take blood thinners (anticoagulants), warfarin, or diabetes medications — safflower carries Moderate interactions with all three. Additionally, slippery elm may slow absorption of any oral medications you're on.
Use the medication checker on this page with your full list before starting.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product is best considered with your pharmacist's input, especially if you take blood thinners, warfarin, or diabetes drugs. The safflower component has documented interactions with those medications, and slippery elm may interfere with how your body absorbs other oral drugs.
If you're pregnant, planning to breastfeed, or have liver concerns, talk with your pharmacist before adding it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about American Saffron & Slippery Elm, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for American Saffron & Slippery Elm by TerraVita, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| American Saffron and Slippery Elm Glycerite Liquid Extract | 0.13 mL | -- |
| American Saffron Glycerite Liquid Extract | 0 NP | -- |
| Slippery Elm Glycerite Liquid Extract | 0 NP | -- |
Other ingredients: Glycerin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Copyright 2018 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.
Formula
Glycerite liquid extract (1:5)
Formulation
Alcohol free No flavor
Suggested/Recommended/Usage/Directions
Suggested Use: Take 25-40 drops of extract in a small amount of warm water 3-4 times daily. Shake well before using.
Precautions
Keep away from children.
Do not use if safety seal around cap is broken or missing.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
American Saffron & Slippery Elm by TerraVita label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in American Saffron & Slippery Elm by TerraVita
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size25 Drop(s) Dosage formLiquid Servings per container227 Amounts shown are per serving.
American Saffron and Slippery Elm Glycerite Liquid Extract
Interacts with208 drugs
Safflower is a thistle-like plant used mainly for its seed oil (a common cooking oil) and its colorful flowers. Safflower oil is a reasonable source o...
American Saffron and Slippery Elm Glycerite Liquid Extract monograph & interactionsOther (inactive) ingredients: Glycerin. These complete the product’s ingredient list but are not active constituents.
American Saffron & Slippery Elm by TerraVita Drug Interactions
HelloPharmacist Interaction Report
American Saffron & Slippery Elm by TerraVita is a two-ingredient liquid extract that does interact with medications.
The safflower component carries Moderate risk with blood thinners (anticoagulants) and warfarin — high doses may increase bleeding risk, and one case report describes a patient on warfarin who developed bleeding and elevated INR after taking safflower extract. The same ingredient also has Moderate interactions with diabetes medications; some research suggests safflower oil can raise fasting blood sugar, which could work against your diabetes control.
Read the full breakdown — every affected drug type, severity by severity
Slippery elm presents a Moderate interaction with oral medications in general. Its mucilage content may slow how your body absorbs drugs taken by mouth, potentially lowering their blood levels and effectiveness.
Altogether, these interactions span 2,049 individual medications.
Before you start this product, run your specific medications through the checker on this page — especially if you take blood thinners, warfarin, or diabetes drugs. The safflower in this blend isn't one you want to add without checking first.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against American Saffron & Slippery Elm?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in American Saffron & Slippery Elm interact with 2,068 drugs. Click any drug to see the details.
1 of the 1 ingredient in American Saffron & Slippery Elm interact with drugs. Each result below shows which ingredient is responsible. American Saffron and Slippery Elm Glycerite Liquid Extract
"phentolamineOraVerse, Rogitine, Ryzumvi
How "phentolamine interacts with American Saffron & Slippery Elm — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + "phentolamine interaction6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with American Saffron & Slippery Elm — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + 6-mercaptopurine interactionAbacavirZiagen
How Abacavir interacts with American Saffron & Slippery Elm — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Abacavir interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with American Saffron & Slippery Elm — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with American Saffron & Slippery Elm — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with American Saffron & Slippery Elm — through 2 ingredients. Tap an ingredient for the detail:
American Saffron Glycerite Liquid ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full American Saffron Glycerite Liquid Extract + Abciximab interactionSlippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with American Saffron & Slippery Elm — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with American Saffron & Slippery Elm — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with American Saffron & Slippery Elm — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with American Saffron & Slippery Elm — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Abrocitinib interactionAmerican Saffron Glycerite Liquid ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full American Saffron Glycerite Liquid Extract + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with American Saffron & Slippery Elm — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Acalabrutinib interactionAcamprosateCampral
How Acamprosate interacts with American Saffron & Slippery Elm — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Acamprosate interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with American Saffron & Slippery Elm — through 2 ingredients. Tap an ingredient for the detail:
American Saffron Glycerite Liquid ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Read the full American Saffron Glycerite Liquid Extract + Acarbose interactionSlippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with American Saffron & Slippery Elm — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with American Saffron & Slippery Elm — through 2 ingredients. Tap an ingredient for the detail:
American Saffron Glycerite Liquid ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full American Saffron Glycerite Liquid Extract + Acenocoumarol interactionSlippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with American Saffron & Slippery Elm — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with American Saffron & Slippery Elm — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with American Saffron & Slippery Elm — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Acetaminophen, Aspirin interactionAmerican Saffron Glycerite Liquid ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full American Saffron Glycerite Liquid Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with American Saffron & Slippery Elm — through 2 ingredients. Tap an ingredient for the detail:
American Saffron Glycerite Liquid ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full American Saffron Glycerite Liquid Extract + Acetaminophen, Aspirin, Caffeine interactionSlippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with American Saffron & Slippery Elm — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with American Saffron & Slippery Elm — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with American Saffron & Slippery Elm — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with American Saffron & Slippery Elm — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with American Saffron & Slippery Elm — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with American Saffron & Slippery Elm — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with American Saffron & Slippery Elm — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with American Saffron & Slippery Elm — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with American Saffron & Slippery Elm — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with American Saffron & Slippery Elm — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with American Saffron & Slippery Elm — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Glycerite Liquid ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Glycerite Liquid Extract + Acetaminophen, Caffeine, Isometheptene interactionEach ingredient & the kinds of drugs it affects
For each ingredient in American Saffron & Slippery Elm with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
American Saffron and Slippery Elm Glycerite Liquid Extract
Anticoagulant/Antiplatelet Drugs
High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Small clinical studies show that taking safflower oil, approximately 55 grams daily for 2-3 weeks, decreases platelet aggregation. However, taking lower doses of safflower oil, such as 5 grams daily for 4 weeks, does not seem to affect platelet function. In one case report, a 74-year-old male stabilized on warfarin developed urinary tract bleeding and an elevated INR after taking a safflower extract 20 grams daily for 14 days.
Antidiabetes Drugs
Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Some clinical research shows that taking safflower oil 10 grams daily for 3 weeks can increase fasting blood glucose in patients with type 2 diabetes. However, clinical research in patients with metabolic syndrome with or without impaired glucose tolerance shows that taking safflower oil 8 grams daily for 12 weeks reduces fasting glucose levels by around 8 mg/dL. Some clinical research also shows that taking safflower oil 8 grams daily for 16 weeks does not affect fasting glucose levels in patients with type 2 diabetes.
Warfarin
Theoretically, safflower oil might increase the risk of bleeding when taken with warfarin.
In one case report, a 74-year-old male stabilized on warfarin developed urinary tract bleeding and an elevated INR after taking a safflower extract 20 grams daily for 14 days.
Brand information
Manufacturer and brand details for American Saffron & Slippery Elm, from the product label.
TerraVita
See all TerraVita products- Name
- ZooScape LLC
- Phone Number
- 844-449-0444
- Web Address
- www.ZooScape.com
American Saffron & Slippery Elm by TerraVita: Common Questions
Does American Saffron & Slippery Elm by TerraVita interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm on warfarin or a blood thinner?
Will this affect my diabetes medication?
Could this slow down my other medications?
Is this safe during pregnancy?
What are these ingredients actually used for?
Is there any risk of liver problems from this?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if American Saffron & Slippery Elm is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind American Saffron & Slippery Elm’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Safflower
Interacts with 208 drugsSafflower is a thistle-like plant used mainly for its seed oil (a common cooking oil) and its colorful flowers. Safflower oil is a reasonable source of unsaturated fats, but strong proof tha...
Read the full Safflower monograph → Herb & supplement monographSlippery Elm
Interacts with 2,022 drugsSlippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated digestive tracts. Its mucilage can coat an...
Read the full Slippery Elm monograph →Sources & How We Checked
American Saffron & Slippery Elm's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 17 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Safflower 14 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Borkman M, Chisholm DJ, Furler SM, et al. Effects of fish oil supplementation on glucose and lipid metabolism in NIDDM. Diabetes 1989;38:1314-9.. PubMed
- Amato, P. and Quercia, R. A. A historical perspective and review of the safety of lipid emulsion in pregnancy. Nutr Clin Pract. 1991;6(5):189-192. PubMed
- Demke, D. M., Peters, G. R., Linet, O. I., Metzler, C. M., and Klott, K. A. Effects of a fish oil concentrate in patients with hypercholesterolemia. Atherosclerosis 1988;70(1-2):73-80. PubMed
- Kaji, K., Yoshida, S., Nagata, N., Yamashita, T., Mizukoshi, E., Honda, M., Kojima, Y., and Kaneko, S. An open-label study of administration of EH0202, a health-food additive, to patients with chronic hepatitis C. J Gastroenterol. 2004;39(9):873-878. PubMed
- Kwon, J. S., Snook, J. T., Wardlaw, G. M., and Hwang, D. H. Effects of diets high in saturated fatty acids, canola oil, or safflower oil on platelet function, thromboxane B2 formation, and fatty acid composition of platelet phospholipids. Am.J.Clin.Nutr. PubMed
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