Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Amino Acid Complex With Calcium Ingredients & Drug Interactions

by Sundown Naturals

Amino Acid Complex With Calcium label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Amino Acid Complex With Calcium against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Amino Acid Complex With Calcium is a dietary supplement by Sundown Naturals with 2 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis prevention, dietary calcium deficiency, heartburn relief (calcium carbonate antacids).Based on those ingredients, 586 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Calcium, Whey Protein concentrate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Amino Acid Complex With Calcium by Sundown Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Amino Acid Complex With Calcium by Sundown Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Amino Acid Complex With Calcium by Sundown Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 19 active ingredients.
  • “Whey Protein concentrate” is listed as a grouped ingredient — the label gives one combined amount (200 mg) without saying how much of each component you get.

Amino Acid Complex With Calcium by Sundown Naturals contains 19 ingredient components, including amino acids (glycine, aspartic acid, tryptophan, methionine, arginine, leucine, serine, tyrosine, histidine, isoleucine, lysine, phenylalanine, threonine, valine, glutamic acid, alanine, proline, and cystine) plus calcium and whey protein concentrate. Amino acids are the building blocks your body uses to make proteins and carry out vital functions like making neurotransmitters and supporting muscle.

Calcium supports bone strength and plays a role in nerve and muscle function. The product also contains inactive ingredients including vegetable cellulose as a capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Amino acid and nutritional supplementation.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Cognitive function, Muscle recovery, Protein synthesis, Nutritional support.
  • The strongest evidence on file: Tyrosine is rated "Possibly Effective" for Cognitive function (Natural Medicines).
  • Also on file: Tyrosine is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Aspartic Acid is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.

The evidence for what this product can do varies widely by ingredient. Calcium is effective for kidney failure, heartburn and indigestion (dyspepsia), low blood calcium, high potassium, and is likely effective for osteoporosis.

For the amino acids, the data is mixed: glycine is possibly effective for schizophrenia; tyrosine is effective for phenylketonuria (PKU) and possibly effective for cognitive function and memory; lysine is possibly effective for cold sores; and phenylalanine is possibly effective for vitiligo. For most other uses listed — athletic performance, ADHD, fatigue, muscle strength, memory, and others — the evidence we hold is insufficient to rate these ingredients, meaning the data simply isn't there yet to say whether they work.

The evidence, ingredient by ingredient Calcium Whey Protein Glycine Aspartic Acid L-tryptophan Methionine Serine Tyrosine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 9 of the 12 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 12 of 12.
  • General safety write-ups exist for 12 of 12.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium is generally safe at recommended doses, though very high intakes are linked to theoretical concerns about kidney stones and, in some studies, a potential link to cardiovascular risk — stay within recommended amounts. Glycine is generally well tolerated but long-term safety data are limited; rare side effects include mild sedation, soft stools, nausea, and GI upset.

L-tryptophan is also generally well tolerated orally but has a history of a contaminated-product safety scare in the late 1980s; common side effects include drowsiness, diarrhea, nausea, and headache. Tyrosine is generally well tolerated but reported side effects include fatigue, headache, heartburn, and nausea.

Phenylalanine should not be used by people with phenylketonuria (PKU). Serine may cause gastrointestinal distress; at very high doses it can trigger seizures.

Lysine is generally well tolerated; common side effects are diarrhea and abdominal pain. Aspartic acid, tryptophan, serine, tyrosine, phenylalanine, and threonine all lack sufficient safety data in pregnancy and breastfeeding — talk with your doctor or pharmacist before using if you're pregnant or nursing.

Methionine, histidine, and others have limited long-term safety data at supplement doses.

Side effects, ingredient by ingredient Calcium Whey Protein Glycine Aspartic Acid L-tryptophan Methionine Serine Tyrosine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 7 of the 12 matched ingredients can interact with medications — Lysine, L-tryptophan, Phenylalanine, Calcium, Tyrosine, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 586 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist or doctor before starting if you take CNS depressants or sedatives (due to L-tryptophan's Major interaction), serotonergic antidepressants (L-tryptophan Moderate interaction), levodopa for Parkinson's (phenylalanine and tyrosine Major interactions), NMDA antagonist medications (threonine Major interaction), HIV drugs like dolutegravir or elvitegravir, levothyroxine for thyroid, sotalol, diltiazem, baclofen, non-selective MAOIs, calcipotriene, or 5-HT4 agonists. If you receive intravenous ceftriaxone, notify your healthcare provider before taking any calcium supplement.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a broad amino acid and mineral blend — useful if you're specifically looking to supplement amino acids and calcium, and if your doctor or dietitian recommends it. Anyone taking prescription medications, especially antidepressants, sedatives, heart medicines, thyroid hormone, or HIV drugs, needs to check their exact medicines against the interactions listed here before starting.

Pregnant or breastfeeding? Talk to your pharmacist first — several ingredients lack sufficient safety data.

If you have PKU, avoid phenylalanine entirely.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 12 of 19 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Amino Acid Complex With Calcium, straight from the product label.

Brand Sundown Naturals
Barcode (UPC) 030768005481
Net contents 100 Tablet(s)
Market status On market
Date entered into DSLD Feb 23, 2012
DSLD ID 5790
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Amino Acid Complex With Calcium by Sundown Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
50
UPC/BARCODE
030768005481
IngredientAmount% DV
Glycine0 NP--
Aspartic Acid0 NP--
Tryptophan0 NP--
Calcium178 mg18%
Methionine0 NP--
Arginine0 NP--
Leucine0 NP--
Serine0 NP--
Tyrosine0 NP--
Histidine0 NP--
Isoleucine0 NP--
Lysine0 NP--
Phenylalanine0 NP--
Threonine0 NP--
Valine0 NP--
Glutamic Acid0 NP--
Alanine0 NP--
Proline0 NP--
Cystine0 NP--
Whey Protein concentrate200 mg--

Other ingredients: Vegetable Cellulose, Contains <2% of

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

DIRECTIONS: FOR ADULTS, TAKE TWO (2) TABLETS THREE TIMES PER DAY, PREFERABLY WITH MEALS. As a reminder, discuss the supplements and medications you take with your health care providers.

Precautions

KEEP OUT OF REACH OF CHILDREN.

WARNING: If you are pregnant, nursing or taking any medications or have any medical condition, consult your doctor before use.

Contains milk ingredients.

Discontinue use and consult your doctor if any adverse reactions occur.

TAMPER RESISTANT: DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.

Storage

STORE AT ROOM TEMPERATURE AND AVOID EXCESSIVE HEAT.

Brand IP Statement(s)

2012

General Statements

Aminos from Whey Protein

Smart Facts Sundown Naturals’ Amino Acid Complex supplies aminos from whey protein.

General

Prod. No. 45091 10G B45104 MAA

Formulation

VEGETARIAN FORMULA

No Artificial Color, Flavor or Sweetener, No Preservatives, No Sugar, No Starch, No Soy, No Gluten, No Wheat, No Yeast, No Fish.

Sodium Free.

Seals/Symbols

FREE OF Gluten & Wheat

GUARANTEED QUALITY LABORATORY TESTED

PLEASE RECYCLE

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Amino Acid Complex With Calcium by Sundown Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Amino Acid Complex With Calcium label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Amino Acid Complex With Calcium by Sundown Naturals

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container50 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Calcium

Interacts with
168 drugs
178 mg per serving Form: Dicalcium Phosphate

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Whey Protein concentrate

Interacts with
53 drugs
200 mg per serving

Whey protein is a high-quality, complete protein made from cow's milk that can help people meet protein needs and support muscle growth when combined...

Whey Protein concentrate monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, Contains <2% of. These complete the product’s ingredient list but are not active constituents.

Interaction report

Amino Acid Complex With Calcium by Sundown Naturals Drug Interactions

Want to check YOUR meds against Amino Acid Complex With Calcium?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
586Drugs
263 Major 305 Moderate 18 Minor

Ingredients driving the most interactions

Calcium 168
Whey Protein concentrate 53

Individual Drug Interactions

The ingredients in Amino Acid Complex With Calcium interact with 586 drugs. Click any drug to see the details.

2 of the 2 ingredients in Amino Acid Complex With Calcium interact with drugs. Each result below shows which ingredient is responsible. Calcium Whey Protein concentrate

Each ingredient & the kinds of drugs it affects

For each ingredient in Amino Acid Complex With Calcium with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions

Whey Protein concentrate4 drug types · 53 drugs

Levodopa

Theoretically, whey protein might decrease levodopa absorption.
Small clinical studies show that concomitant ingestion of protein or high doses of leucine or isoleucine (100 mg/kg) and levodopa can exacerbate tremor, rigidity, and the "on-off" syndrome in patients with Parkinson disease.

Likelihood Probable Evidence D
Bisphosphonates

Theoretically, whey protein might reduce the absorption of bisphosphonates.
Whey protein contains minerals such as calcium that bind bisphosphonates in the gut. Advise patients to take bisphosphonates at least 30 minutes before whey protein, but preferably at a different time of day.

Likelihood Probable Evidence D
Quinolone Antibiotics

Theoretically, whey protein might decrease quinolone absorption.
Whey protein contains minerals, such as calcium, that can bind to quinolones in the gut. To avoid this interaction, advise patients to take oral quinolones at least 2 hours before or 4-6 hours after whey protein.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, whey protein might decrease tetracycline absorption.
Whey protein contains minerals, such as calcium, that bind to tetracyclines in the gut. To avoid this interaction, advise patients to take oral tetracyclines at least 2 hours before or 4-6 hours after whey protein.

Likelihood Probable Evidence D
Whey Protein concentrate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Amino Acid Complex With Calcium, from the product label.

Sundown Naturals

See all Sundown Naturals products
Web Address
www.sundownnaturals.com
Pharmacist Counseling Corner

Amino Acid Complex With Calcium by Sundown Naturals: Common Questions

Does Amino Acid Complex With Calcium by Sundown Naturals interact with any medications?
Yes. Based on its ingredients, Amino Acid Complex With Calcium has a known interaction with 586 medications, including 263 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Amino Acid Complex With Calcium contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this interfere with my thyroid medicine?
Possibly. Calcium in this product can reduce how much levothyroxine (Synthroid) your body absorbs, making it less effective. If you take thyroid hormone, separate your dose from calcium by at least 4 hours — take one in the morning and one later in the day. Also, tyrosine (an amino acid in this product) theoretically adds to thyroid hormone effects, though the practical impact isn't clear. Check with your pharmacist.
Is this safe during pregnancy?
Not all of it. Calcium is safe at recommended amounts and is important in pregnancy. But several amino acids — tryptophan, aspartic acid, serine, tyrosine, phenylalanine, and threonine — have insufficient safety data or are rated possibly unsafe or unsafe in pregnancy. Talk with your doctor or pharmacist before taking this product if you're pregnant.
Can I take this if I'm breastfeeding?
It depends on the ingredient. Calcium is fine at recommended amounts while breastfeeding. But tryptophan, aspartic acid, serine, tyrosine, phenylalanine, and threonine lack sufficient safety data or are not recommended during breastfeeding. Check with your doctor or pharmacist before use.
What's tryptophan in here for, and why does it make me drowsy?
Tryptophan is an amino acid your body uses to make serotonin, a neurotransmitter linked to mood and sleep. Clinical research shows L-tryptophan can cause fatigue and drowsiness — that's a known side effect. If you're sensitive to that, start with a small dose or take it at bedtime. Do not combine it with sedatives or sleep aids, as the drowsiness can add up dangerously.
Does this have any fillers?
The product contains vegetable cellulose as an inactive ingredient — that's the material the capsule is made from. Beyond that, the label notes fewer than 2% other ingredients, which are typical binders and flow agents.
I take an HIV medicine — can I use this?
Not without checking first. Calcium in this product reduces blood levels of the HIV drugs dolutegravir and elvitegravir, and may reduce raltegravir. You'd need to take your HIV medicine several hours apart from this supplement — but check the exact timing with your pharmacist or doctor, since timing requirements vary by drug. Do not start this without their approval.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Amino Acid Complex With Calcium label
Go deeper

The Full Monographs Behind Amino Acid Complex With Calcium’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Whey Protein

Interacts with 53 drugs

Whey protein is a high-quality, complete protein made from cow's milk that can help people meet protein needs and support muscle growth when combined with exercise. It is generally safe for...

Read the full Whey Protein monograph → Herb & supplement monograph

Glycine

Interacts with 1 drug

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...

Read the full Glycine monograph → Herb & supplement monograph

Aspartic Acid

Aspartic acid is a common amino acid your body makes on its own and gets from protein-rich foods, so a true deficiency is rare. D-aspartic acid is heavily marketed for boosting testosterone...

Read the full Aspartic Acid monograph → Herb & supplement monograph

L-tryptophan

Interacts with 394 drugs

L-tryptophan is an essential amino acid the body uses to make serotonin and melatonin, and people take it to support sleep and mood. The evidence for supplement use is limited and mixed, and...

Read the full L-tryptophan monograph → Herb & supplement monograph

Methionine

Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a normal diet, and supplements are generally no...

Read the full Methionine monograph → Herb & supplement monograph

Serine

Serine is an amino acid your body can make on its own and also gets from protein-rich foods, so most people do not need a supplement. L-serine has been studied for certain neurological condi...

Read the full Serine monograph → Herb & supplement monograph

Tyrosine

Interacts with 21 drugs

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performance during short-term stress, sleep loss,...

Read the full Tyrosine monograph → Herb & supplement monograph

Histidine

Histidine is an essential amino acid your body needs to build proteins and to make compounds like histamine and carnosine. Most people get enough from a normal diet, and good-quality researc...

Read the full Histidine monograph → Herb & supplement monograph

Lysine

Interacts with 1 drug

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but...

Read the full Lysine monograph → Herb & supplement monograph

Phenylalanine

Interacts with 16 drugs

Phenylalanine is an essential amino acid the body uses to make brain chemicals like dopamine and norepinephrine. Some people take it for mood, vitiligo, or pain, but the evidence is mostly l...

Read the full Phenylalanine monograph → Herb & supplement monograph

Threonine

Interacts with 3 drugs

Threonine is an essential amino acid your body needs but cannot make, so you must get it from food or supplements. Most people get plenty from a normal diet, and high-quality evidence for ta...

Read the full Threonine monograph → Herb & supplement monograph

Proline

Proline is a non-essential amino acid that your body can make on its own and that you also get from protein-rich foods. It is a key building block of collagen, but strong human evidence that...

Read the full Proline monograph →
Sources

Sources & How We Checked

Amino Acid Complex With Calcium's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 171 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycine 5 references
  1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
  2. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
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Aspartic Acid 1 reference
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L-tryptophan 18 references
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Methionine 12 references
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Serine 3 references
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Tyrosine 4 references
  1. Meyer JS, Welch KM, Deshmukh VD, et al. Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease. J Amer Geriat Soc 1977;25:289-98.
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Histidine 3 references
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Lysine 7 references
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Phenylalanine 23 references
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Threonine 4 references
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Proline 4 references
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See these in context on the Proline monograph →

Whey Protein 25 references
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See these in context on the Whey Protein monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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