Interactions on record — worth a quick check against your medications. Based on 8 of 10 ingredients. Check your meds →
Dietary supplement

Animal Pump Pro Green Apple Flavor Ingredients & Drug Interactions

by Animal

Animal Pump Pro Green Apple Flavor label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Animal Pump Pro Green Apple Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Animal Pump Pro Green Apple Flavor is a dietary supplement by Animal with 10 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 465 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Huperzine A, Sodium, L-Citrulline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Animal Pump Pro Green Apple Flavor by Animal

Ask about any prescription or over-the-counter medication and we check it for interactions with Animal Pump Pro Green Apple Flavor by Animal — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Animal Pump Pro Green Apple Flavor by Animal

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 10 of its 10 active ingredients.
  • “Energy and Focus Matrix” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Pump and Cell Volumization Complex” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Electrolytes” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Animal Pump Pro contains 10 active ingredients. The sodium and potassium are electrolytes that support fluid balance and muscle function.

Creatine monohydrate is included to support muscle strength and athletic performance. L-Citrulline and L-Tyrosine are amino acids — citrulline supports blood flow and performance, while tyrosine supports cognitive function and memory.

Huperzine A is a plant-derived compound for cognitive support. Alpha-GPC (L-Alpha Glycerylphosphorylcholine) is a choline compound also aimed at cognitive and brain health.

Glycerol powder aids hydration and athletic performance. The product also contains Sea Salt, Inositol-stabilized Arginine Silicate, and an "Energy and Focus Matrix" blend — a group of component ingredients listed separately.

Inactive ingredients include silica, citric acid, malic acid, calcium silicate, flavoring agents, sweeteners, dyes, and dicalcium phosphate.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Athletic performance and muscle support.
  • We looked for evidence on: Athletic performance, Physical performance, Muscle cramps, Muscle strength, Muscle breakdown, Fatigue — and 4 related terms.
  • The strongest evidence on file: Glycerol is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Creatine is rated "Possibly Effective" for Athletic performance, Muscle strength.
  • Also on file: L-citrulline is rated "Possibly Effective" for Athletic performance.

Evidence for the active ingredients varies. Creatine monohydrate is possibly effective for muscle strength, athletic performance, and sarcopenia.

L-Citrulline is possibly effective for athletic performance. L-Tyrosine is effective for phenylketonuria (PKU) and possibly effective for cognitive function and memory.

Huperzine A is possibly effective for Alzheimer disease. Alpha-GPC is possibly effective for Alzheimer disease.

Glycerol is likely effective for constipation and possibly effective for athletic performance. Sodium and potassium are not rated for athletic or cognitive purposes in the data we hold.

We have no effectiveness ratings for Sea Salt or Inositol-stabilized Arginine Silicate.

The evidence, ingredient by ingredient Sodium Potassium Tyrosine Huperzine A Alpha-gpc Creatine L-citrulline Glycerol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients in this product are generally well tolerated at normal doses. Sodium is essential in small amounts, but the safety notes caution that too much is linked to high blood pressure and heart strain — avoid sodium supplements or very high intake without medical guidance.

Potassium from food is fine, but supplements can raise blood levels dangerously, especially in people with kidney disease. Creatine is generally well tolerated in healthy adults but may cause dehydration, diarrhea, muscle cramps, and water retention; those with kidney problems should be careful.

L-Citrulline and L-Tyrosine are generally well tolerated but may cause gastrointestinal discomfort or heartburn. Huperzine A is a pharmacologically active compound that can cause cholinergic side effects — blurred vision, constipation, diarrhea, dizziness, dry mouth, nausea, sweating, and vomiting — and requires medical guidance.

Alpha-GPC is generally well tolerated but has rarely been associated with dizziness, headache, insomnia, and stroke risk with long-term use (2+ months). Glycerol can cause bloating, diarrhea, nausea, vomiting, headache, and dizziness at large doses.

Side effects, ingredient by ingredient Sodium Potassium Tyrosine Huperzine A Alpha-gpc Creatine L-citrulline Glycerol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 8 matched ingredients can interact with medications — Huperzine A, Potassium, Tyrosine, Alpha-gpc, L-citrulline, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium; Parkinson's medications.
  • For scale: 465 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before using this product if you take blood pressure medications (Moderate), diuretics that spare potassium (Moderate), ACE inhibitors or ARBs for blood pressure or heart disease (Moderate), lithium for bipolar disorder (Moderate), levodopa for Parkinson disease (Moderate), thyroid hormone replacement (Moderate), anticholinergic or cholinergic drugs (Moderate), or the scopolamine motion sickness patch (Minor). We held no interaction data for Sea Salt or Inositol-stabilized Arginine Silicate, so incomplete checking is necessary.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-ingredient sports supplement with active ingredients for muscle, blood flow, and cognitive support. If you take any blood pressure medication, a diuretic, lithium, levodopa, thyroid hormone, scopolamine, anticholinergic drugs, or cholinergic drugs, check your exact medications with the tool below before using it.

Those with kidney disease or high blood pressure should talk to their pharmacist before starting, given the sodium and potassium content.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Animal Pump Pro Green Apple Flavor, straight from the product label.

Brand Animal
Barcode (UPC) 039442042071
Net contents 14.8 Ounce(s); 420 Gram(s)
Market status On market
Date entered into DSLD Apr 22, 2021
DSLD ID 247506
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Animal Pump Pro Green Apple Flavor by Animal, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
21 Gram(s)
Maximum serving Sizes:
21 Gram(s)
Servings per container
20
UPC/BARCODE
039442042071
IngredientAmount% DV
Calories10 Calorie(s)--
Total Carbohydrates3 Gram(s)1%
Sodium160 mg7%
Potassium75 mg2%
Creatine Monohydrate5000 mg--
L-Citrulline4000 mg--
L-Tyrosine2000 mg--
Sea Salt400 mg--
Energy and Focus Matrix0 NP--
Inositol-stabilized Arginine Silicate1500 mg--
Huperzine A100 mcg--
Pump and Cell Volumization Complex0 NP--
Glycerol powder3000 mg--
L-Alpha Glycerylphosphorylcholine powder600 mg--
Electrolytes0 NP--

Other ingredients: Silica, Citric Acid, Malic Acid, Calcium Silicate, natural & artificial Green Apple flavor, Natural flavor, Dicalcium Phosphate, Sucralose, Acesulfame Potassium, FD&C Yellow #5, FD&C Blue #1

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Contains: Soy. Made in a GMP facility on equipment that processes milk, soy, egg, peanuts, tree nuts, fish, shellfish, and wheat.

Warning: Exercise good judgement and keep this out of reach from children.

California Residents: Warning: Reproductive Harm - www.P65Warnings.ca.gov.

Suggested/Recommended/Usage/Directions

Dosage: Mix two scoops of Animal Pump Pro with 16 oz. of your beverage of choice 15-20 minutes before training.

General Statements

This product is formulated with ingredients that absorb moisture which can lead to clumping of the powder. This is normal and the product is okay to consume.

Plant US #3001104580

Our Ironclad Guarantee: Animal is dedicated to being the best in the business, no two ways about it. If this product doesn't meet with your tough requirements for any reason, let us know. When it comes to standing behind our products, we don't mess around. That's the truth.

...Up the Volume

Who We Are In 1983, Animal was founded with the birth of Animal Pak, the venerable training "pack" that started it all. Born from the needs and desires of pro bodybuilders, Animal has grown prodigiously over the decades. Today, Animal has stood the test of time and been proven in the trenches day in and day out.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

EAC (Eirasiatic Union)

Storage

To keep is as fresh as possible, store this product in a cool, dry place, away from heat, moisture and sunlight. You know the drill.

FDA Statement of Identity

Dietary Supplement

Formulation

Animal Training Powder

The Non-Stim Pre-Workout Muscle Volumizing Stack

Formula

What Animal Pump Pro Is Up the volume with Animal Pump, the "core" non-stim pre-workout product for "pumps". For the bodybuilder, getting the pump is the name of the game, what it's all about. It's not just an addictive feeling. Your muscles don't just feel bigger. They are. A pump signals the start of oxygen and nutrient-rich blood flooding into the muscle, setting the table for new growth. So is your table set?

Nitrosigine Citrulline HydroMax Alpha GPC

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Animal Pump Pro Green Apple Flavor by Animal label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Animal Pump Pro Green Apple Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Animal Pump Pro Green Apple Flavor by Animal

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size21 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
160 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Potassium

Interacts with
62 drugs
75 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Energy and Focus Matrix

0 NP per serving

Pump and Cell Volumization Complex

0 NP per serving

Electrolytes

0 NP per serving
  • › Sea Salt

Other (inactive) ingredients: Silica, Citric Acid, Malic Acid, Calcium Silicate, Natural & artificial Green Apple flavor, Natural flavor, Dicalcium Phosphate, Sucralose, Acesulfame Potassium, FD&C Yellow #5, FD&C Blue #1. These complete the product’s ingredient list but are not active constituents.

Interaction report

Animal Pump Pro Green Apple Flavor by Animal Drug Interactions

Want to check YOUR meds against Animal Pump Pro Green Apple Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
465Drugs
465 Moderate

Ingredients driving the most interactions

Huperzine A 219
Sodium 205
L-Citrulline 178
Potassium 62
L-Tyrosine 21

Individual Drug Interactions

The ingredients in Animal Pump Pro Green Apple Flavor interact with 465 drugs. Click any drug to see the details.

6 of the 10 ingredients in Animal Pump Pro Green Apple Flavor interact with drugs. Each result below shows which ingredient is responsible. Huperzine A Sodium L-Citrulline Potassium L-Tyrosine L-Alpha Glycerylphosphorylcholine powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Animal Pump Pro Green Apple Flavor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Huperzine A2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Huperzine A has acetylcholinesterase (AChE) inhibiting effects. In animal models, huperzine A reversed cognitive deficits induced by scopolamine, an anticholinergic drug.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of huperzine A with cholinergic drugs might increase the effects and side effects of these medications.
Huperzine A can inhibit acetylcholinesterase (AChE) and might cause cumulative effects if used with cholinergic drugs.

Likelihood Possible Evidence B
Huperzine A full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

L-Citrulline2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions

L-Tyrosine2 drug types · 21 drugs

Levodopa

Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.

Likelihood Probable Evidence D
Thyroid Hormone

Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.

Likelihood Probable Evidence D
L-Tyrosine full monograph & interactions

L-Alpha Glycerylphosphorylcholine powder1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
L-Alpha Glycerylphosphorylcholine powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Animal Pump Pro Green Apple Flavor, from the product label.

Animal

See all Animal products
Name
Universal Nutrition
City
New Brunswick
State
New Jersey
ZipCode
08901
Phone Number
800-872-0101
Web Address
www.animalpak.com
Pharmacist Counseling Corner

Animal Pump Pro Green Apple Flavor by Animal: Common Questions

Does Animal Pump Pro Green Apple Flavor by Animal interact with any medications?
Yes. Based on its ingredients, Animal Pump Pro Green Apple Flavor has a known interaction with 465 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Animal Pump Pro Green Apple Flavor contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on blood pressure medication?
Not without checking first. The sodium in this product can reduce how well blood pressure drugs work, and the L-citrulline may lower blood pressure further, risking a dangerous drop. Use the interaction checker on this page with your exact medication, or ask your pharmacist.
Is this safe during pregnancy?
The facts don't provide clear safety data for most ingredients during pregnancy. Creatine, L-citrulline, L-tyrosine, huperzine A, and alpha-GPC all say to avoid or note insufficient data — talk to your doctor before using this product if you're pregnant or planning to become pregnant.
What does creatine do, and will it cause side effects?
Creatine supports muscle strength and athletic performance. Common side effects are dehydration, diarrhea, muscle cramps, and water retention. In rare cases, it's been linked to kidney or muscle problems, so those with kidney disease should check with a doctor first.
Does this product have a lot of sodium?
Yes — sodium is one of the 10 active ingredients. The safety notes advise against sodium supplements or high intake without medical advice, especially if you have high blood pressure or are on a salt-restricted diet. Ask your pharmacist about the exact amount per serving.
What is huperzine A, and is it safe?
Huperzine A is a plant-derived compound included for cognitive support. It's possibly effective for Alzheimer disease, but it's pharmacologically active — it can cause real side effects like blurred vision, dizziness, nausea, and cholinergic toxicity. It requires medical guidance and caution with regular use.
Can I take this while breastfeeding?
The facts show insufficient safety data for creatine, L-citrulline, L-tyrosine, huperzine A, alpha-GPC, and glycerol during breastfeeding. Talk to your doctor or lactation specialist before using this product if you're nursing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Animal Pump Pro Green Apple Flavor is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Animal Pump Pro Green Apple Flavor label
Go deeper

The Full Monographs Behind Animal Pump Pro Green Apple Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Tyrosine

Interacts with 21 drugs

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performance during short-term stress, sleep loss,...

Read the full Tyrosine monograph → Herb & supplement monograph

Huperzine A

Interacts with 219 drugs

Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription Alzheimer's drugs. Some small studies sug...

Read the full Huperzine A monograph → Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph → Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph → Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph → Herb & supplement monograph

Glycerol

Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well established as a laxative and a skin and eye moi...

Read the full Glycerol monograph →
Sources

Sources & How We Checked

Animal Pump Pro Green Apple Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 173 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
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Tyrosine 4 references
  1. Meyer JS, Welch KM, Deshmukh VD, et al. Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease. J Amer Geriat Soc 1977;25:289-98.
  2. DiPiro JT, Talbert RL, Yee GC, et al; eds. Pharmacotherapy: A pathophysiologic approach. 4th ed. Stamford, CT: Appleton & Lange, 1999.
  3. Wood DR, Reimherr FW, Wender PH. Amino acid precursors for the treatment of attention deficit disorder, residual type. Psychopharmacol Bull 1985;21:146-9.
  4. van Spronsen FJ, van Rijn M, Bekhof J. Phenylketonuria: tyrosine supplementation in phenylalanine-restricted diets. Am J Clin Nutr 2001;73:153-7. PubMed

See these in context on the Tyrosine monograph →

Huperzine A 13 references
  1. Skolnick AA. Old Chinese herbal medicine used for fever yields possible new Alzheimer Disease therapy. JAMA 1997;277:776. DOI
  2. Ye JW, Cai JX, Wang LM, Tang XC. Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment. J Pharmacol Exp Ther 1999;288:814-9.. DOI
  3. Wang T, Tang XC. Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine. Eur J Pharmacol 1998;349:137-42. PubMed
  4. Xu SS, Gao ZX, Weng Z, et al. Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease. Zhongguo Yao Li Xue Bao 1995;16:391-5.
  5. Zhang RW, Tang XC, Han YY, et al. [Drug evaluation of huperzine A in the treatment of senile memory disorders]. Chung Kuo Yao Li Hsueh Pao 1991;12:250-2.
  6. Xu SS, Cai ZY, Qu ZW, et al. Huperzine-A in capsules and tablets for treating patients with Alzheimer disease. Zhongguo Yao Li Xue Bao 1999;20:486-90.
  7. Felgenhauer N, Zilker T, Worek F, Eyer P. Intoxication with huperzine A, a potent anticholinesterase found in the fir club moss. J Toxicol Clin Toxicol 2000;38:803-8.. PubMed
  8. Zhang, Z., Wang, X., Chen, Q., Shu, L., Wang, J., and Shan, G. [Clinical efficacy and safety of huperzine Alpha in treatment of mild to moderate Alzheimer disease, a placebo-controlled, double-blind, randomized trial]. Zhonghua Yi Xue Za Zhi 7-25-2002;82
  9. Cheng, D. H., Ren, H., and Tang, X. C. Huperzine A, a novel promising acetylcholinesterase inhibitor. Neuroreport 12-20-1996;8(1):97-101. PubMed
  10. Wang BS, Wang H, Wei ZH, Song YY, Zhang L, Chen HZ. Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: an updated meta-analysis. J Neural Transm (Vienna) 2009;116(4):457-65. PubMed
  11. Xu ZQ, Liang XM, Juan-Wu, Zhang YF, Zhu CX, Jiang XJ. Treatment with Huperzine A improves cognition in vascular dementia patients. Cell Biochem Biophys 2012;62(1):55-8. PubMed
  12. Yang G, Wang Y, Tian J, Liu JP. Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials. PLoS One 2013;8(9):e74916. PubMed
  13. Xing SH, Zhu CX, Zhang R, An L. Huperzine a in the treatment of Alzheimer's disease and vascular dementia: a meta-analysis. Evid Based Complement Alternat Med 2014;2014:363985. PubMed

See these in context on the Huperzine A monograph →

Glycerol 8 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Wagner DR. Hyperhydrating with glycerol: implications for athletic performance. J Am Diet Assoc 1999;99:207-12. PubMed
  3. Yu YL, Kumana CR, Lauder IJ, et al. Treatment of acute cortical infarct with intravenous glycerol. A double-blind, placebo-controlled randomized trial. Stroke 1993;24:1119-24. PubMed
  4. Frei A, Cottier C, Wunderlich P, Ludin E. Glycerol and dextran combined in the therapy of acute stroke. A placebo-controlled, double-blind trial with a planned interim analysis. Stroke 1987;18:373-9. PubMed
  5. Balaskas E, Szepietowski JC, Bessis D, Ioannides D, Ponticelli C, Ghienne C, Taberly A, Dupuy P. Randomized, double-blind study with glycerol and paraffin in uremic xerosis. Clin J Am Soc Nephrol. 2011 Apr;6(4):748-52. PubMed
  6. Blanchet-Bardon C, Tadini G, Machado Matos M, Delarue A. Association of glycerol and paraffin in the treatment of ichthyosis in children: an international, multicentric, randomized, controlled, double-blind study. J Eur Acad Dermatol Venereol. 2012 Aug;26 PubMed
  7. Kajita N, Kanamori K, Yamamoto S, Yoshida K. Generalized Urticaria Caused by a Glycerin Enema in an Infant. J Investig Allergol Clin Immunol 2022;32(4):318-319. PubMed
  8. Suzuki R, Fukuyama K, Miyazaki Y, Namiki T. Contact urticaria syndrome and protein contact dermatitis caused by glycerin enema. JAAD Case Reports. 2016;2:108-10. PubMed

See these in context on the Glycerol monograph →

Alpha-gpc 4 references
  1. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
  2. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
  3. Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.
  4. Lee G, Choi S, Chang J, et al. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. JAMA Netw Open 2021;4(11):e2136008.

See these in context on the Alpha-gpc monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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