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Dietary supplement

Anise Seed & Hyssop Ingredients & Drug Interactions

by TerraVita

Anise Seed & Hyssop label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Anise Seed & Hyssop against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Anise Seed & Hyssop is a dietary supplement by TerraVita with 1 active ingredient. Its ingredients are commonly taken for digestive upset and bloating, cough and respiratory complaints, sore throat.Based on those ingredients, 245 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Anise Seed and Hyssop Glycerite Liquid Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Anise Seed & Hyssop by TerraVita

Ask about any prescription or over-the-counter medication and we check it for interactions with Anise Seed & Hyssop by TerraVita — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Anise Seed & Hyssop by TerraVita

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Anise Seed and Hyssop Glycerite Liquid Extract” is listed as a grouped ingredient — the label gives one combined amount (0.13 mL) without saying how much of each component you get.

This product contains 2 active ingredients: anise seed glycerite liquid extract and hyssop glycerite liquid extract. Both are delivered as glycerin-based liquid extracts, which means the herbs are steeped in glycerin to pull out their compounds.

The only inactive ingredient is glycerin itself, which is the carrier that keeps the extracts in liquid form.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The label doesn't state a purpose we can grade — see each ingredient's own graded uses on its monograph instead.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for what anise seed and hyssop actually do is not established in the data we hold. Anise seed has been studied for migraine headache, lice, menopausal symptoms, premenstrual syndrome, and period pain, but none of those uses have sufficient reliable evidence to rate.

Hyssop carries the same story — respiratory tract infections, cough, sore throat, urinary tract infections, and period pain are all listed with insufficient reliable evidence to rate. If you're considering this product for a specific purpose, talk with your pharmacist or doctor about what the current research actually shows.

The evidence, ingredient by ingredient Anise Hyssop

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Anise seed in food or tea form is generally well tolerated. However, the concentrated essential oil requires more caution.

The most common side effect when anise is taken by mouth is generally mild, though a small number of sensitive individuals have experienced rare serious reactions like anaphylaxis (severe allergic reaction). Topical contact with anise can cause skin irritation in sensitive people.

Hyssop is thought to be low-risk in small culinary or tea amounts, but the concentrated essential oil can be toxic and may cause seizures. The safety data for hyssop during breastfeeding is too limited to know either way — talk with your pharmacist or doctor before use if you're nursing.

Anise seed itself is rated likely safe during pregnancy and lactation, but hyssop is thought to stimulate the uterus and should be avoided in pregnancy.

Side effects, ingredient by ingredient Anise Hyssop

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Anise.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 245 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this, double-check if you use estrogen-based contraceptives or hormone replacement therapy, antidiabetes drugs, fluoxetine, caffeine-containing medications, codeine, diazepam, or imipramine — all show moderate-severity interactions with anise seed. Use the search tool on this page to confirm your specific medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take hormone-based birth control, hormone replacement therapy, diabetes medication, fluoxetine, or other psychiatric or pain medications, run them through the checker below before starting. If you're pregnant or breastfeeding, talk with your pharmacist about both ingredients first — anise is considered likely safe, but hyssop raises concerns.

This is not a product you should start without reviewing your complete medication list.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Anise Seed & Hyssop, straight from the product label.

Brand TerraVita
Barcode (UPC) 064435220426
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 280133
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Anise Seed & Hyssop by TerraVita, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
25 Drop(s)
Maximum serving Sizes:
40 Drop(s)
Servings per container
227
UPC/BARCODE
064435220426
IngredientAmount% DV
Anise Seed and Hyssop Glycerite Liquid Extract0.13 mL--
Anise Seed Glycerite Liquid Extract0 NP--
Hyssop Glycerite Liquid Extract0 NP--

Other ingredients: Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Copyright 2018 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Formula

Glycerite liquid extract (1:5)

Formulation

Alcohol free No flavor

Suggested/Recommended/Usage/Directions

Suggested Use: Take 25-40 drops of extract in a small amount of warm water 3-4 times daily. Shake well before using.

Precautions

Keep away from children.

Do not use if safety seal around cap is broken or missing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Anise Seed & Hyssop by TerraVita label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Anise Seed & Hyssop label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Anise Seed & Hyssop by TerraVita

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size25 Drop(s) Dosage formLiquid Servings per container227 Amounts shown are per serving.

Anise Seed and Hyssop Glycerite Liquid Extract

Interacts with
245 drugs
0.13 mL per serving

Anise is a fragrant, licorice-flavored seed used for centuries to ease digestion and soothe coughs. Most of its health claims are based on tradition a...

Anise Seed and Hyssop Glycerite Liquid Extract monograph & interactions

Other (inactive) ingredients: Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Anise Seed & Hyssop by TerraVita Drug Interactions

Want to check YOUR meds against Anise Seed & Hyssop?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
245Drugs
193 Moderate 52 Minor

Ingredients driving the most interactions

Anise Seed and Hyssop Glycerite Liquid Extract 245

Individual Drug Interactions

The ingredients in Anise Seed & Hyssop interact with 245 drugs. Click any drug to see the details.

1 of the 1 ingredient in Anise Seed & Hyssop interact with drugs. Each result below shows which ingredient is responsible. Anise Seed and Hyssop Glycerite Liquid Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Anise Seed & Hyssop with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Anise Seed and Hyssop Glycerite Liquid Extract11 drug types · 245 drugs

Antidiabetes Drugs

Theoretically, anise seed might increase the risk of hypoglycemia when taken with antidiabetes drugs.
A small clinical study shows that anise seed powder decreases fasting blood glucose levels by 36% when compared to baseline.

Likelihood Possible Evidence B
Caffeine

Theoretically, anise oil might decrease the efficacy of caffeine.
Animal research shows that taking anise oil with caffeine decreases the bioavailability of caffeine. Whether this interaction will occur in humans is unclear.

Likelihood Possible Evidence D
Codeine

Theoretically, anise oil might increase the effects and adverse effects of codeine.
Animal research shows that anise oil increases the analgesic effects of codeine, possibly by inducing its phase I metabolism and increasing conversion to morphine. Whether this interaction occurs in humans is unclear.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, anise might interfere with contraceptive drug therapy.
Some in vitro research suggests that anise has estrogenic effects, while other in vitro research suggests that anise has antiestrogenic effects.

Likelihood Possible Evidence D
Diazepam (Valium)

Theoretically, anise oil might increase the effects and adverse effects of diazepam.
Animal research shows that taking anise oil with diazepam increases the motor impairment associated with diazepam, possibly by inhibiting its breakdown by cytochrome P450 3A4. Whether this interaction occurs in humans is unclear.

Likelihood Possible Evidence D
Estrogens

Theoretically, anise might interfere with estrogen-based hormone replacement therapy.
Some in vitro research suggests that anise has estrogenic effects, while other in vitro research suggests that anise has antiestrogenic effects.

Likelihood Possible Evidence D
Fluoxetine (Prozac)

Theoretically, anise oil might decrease the efficacy of fluoxetine.
Animal research shows that taking anise oil with fluoxetine reduces the antidepressant effects of fluoxetine, possibly by promoting its breakdown by cytochrome P450 2D6. Whether this interaction occurs in humans is unclear.

Likelihood Possible Evidence D
Imipramine (Tofranil)

Theoretically, anise oil might decrease the efficacy of imipramine.
Animal research shows that taking anise oil with imipramine reduces the antidepressant effects of imipramine, possibly by promoting its breakdown by cytochrome P450 2D6. Whether this interaction occurs in humans is unclear.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, anise oil might increase the effects and adverse effects of midazolam.
Animal research shows that taking anise oil with midazolam increases the motor impairment associated with midazolam, possibly by inhibiting its breakdown by cytochrome P450 3A4. Whether this interaction occurs in humans is unclear.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, anise might interfere with tamoxifen therapy.
Some in vitro research suggests that anise has estrogenic effects, while other in vitro research suggests that anise has antiestrogenic effects.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

Theoretically, anise oil might decrease the levels and clinical effects of acetaminophen.
Animal research shows that taking anise oil with acetaminophen decreases peak plasma levels of acetaminophen but does not reduce overall bioavailability. Whether this interaction will occur in humans is unclear.

Likelihood Possible Evidence D
Anise Seed and Hyssop Glycerite Liquid Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Anise Seed & Hyssop, from the product label.

TerraVita

See all TerraVita products
Name
ZooScape LLC
Phone Number
844-449-0444
Web Address
www.ZooScape.com
Pharmacist Counseling Corner

Anise Seed & Hyssop by TerraVita: Common Questions

Does Anise Seed & Hyssop by TerraVita interact with any medications?
Yes. Based on its ingredients, Anise Seed & Hyssop has a known interaction with 245 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Anise Seed & Hyssop contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
Anise seed is rated likely safe during pregnancy, but hyssop is traditionally thought to stimulate the uterus and should be avoided. Because this product contains both, talk with your pharmacist or doctor before taking it — they can help you weigh the ingredients and decide what's right for you.
Can I take this while breastfeeding?
Anise seed is rated likely safe during breastfeeding. Hyssop, however, does not have enough safety information available, so it's best avoided while nursing. Talk with your pharmacist or doctor to discuss whether this product works for you.
What is hyssop used for?
In traditional use, hyssop is associated with respiratory tract infections, cough, sore throat, urinary tract infections, and period pain. However, we don't have sufficient reliable evidence in our data to confirm it actually works for any of these.
Is anise seed safe to use long-term?
Anise seed is generally well tolerated when taken by mouth. Most people don't experience side effects, but the concentrated essential oil needs more caution. If you're thinking of using this regularly, check with your pharmacist about your specific situation.
What if I'm allergic to anise or sesame?
Anise can trigger allergic reactions in sensitive individuals, including contact dermatitis, asthma, and in rare cases anaphylaxis. If you know you're sensitive to anise or related plants, avoid this product and talk with your pharmacist or doctor about safer alternatives.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Anise Seed & Hyssop is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Anise Seed & Hyssop label
Go deeper

The Full Monographs Behind Anise Seed & Hyssop’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Anise

Interacts with 245 drugs

Anise is a fragrant, licorice-flavored seed used for centuries to ease digestion and soothe coughs. Most of its health claims are based on tradition and small or laboratory studies rather th...

Read the full Anise monograph → Herb & supplement monograph

Hyssop

Hyssop is a Mediterranean mint-family herb traditionally used for coughs, colds, and digestive complaints, but solid human evidence for these uses is lacking. The dried herb in tea is genera...

Read the full Hyssop monograph →
Sources

Sources & How We Checked

Anise Seed & Hyssop's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Anise 12 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Kassi E, Papoutsi Z, Fokialakis N, et al. Greek plant extracts exhibit selective estrogen receptor modulator (SERM)-like properties. J Agric Food Chem 2004;52:6956-61. PubMed
  3. Mumcuoglu KY, Miller J, Zamir C, et al. The in vivo pediculicidal efficacy of a natural remedy. Isr Med Assoc J 2002;4:790-3.
  4. Garcia-Gonzalez JJ, Bartolome-Zavala B, Fernandez-Melendez S, et al. Occupational rhinoconjunctivitis and food allergy because of aniseed sensitization. Ann Allergy Asthma Immunol 2002;88:518-22. . PubMed
  5. Tabanca N, Khan SI, Bedir E, et al. Estrogenic activity of isolated compounds and essential oils of Pimpinella species from Turkey, evaluated using a recombinant yeast screen. Planta Med 2004;70:728-35.
  6. Gonzalez-Gutierrez, M. L., Sanchez-Fernandez, C., Esteban-Lopez, M. I., Sempere-Ortells, J. M., and Diaz-Alperi, P. Allergy to anis. Allergy 2000;55(2):195-196.
  7. Anliker, M. D., Borelli, S., and Wuthrich, B. Occupational protein contact dermatitis from spices in a butcher: a new presentation of the mugwort-spice syndrome. Contact Dermatitis 2002;46(2):72-74. PubMed
  8. Poon, T. S. and Freeman, S. Cheilitis caused by contact allergy to anethole in spearmint flavoured toothpaste. Australas.J Dermatol. 2006;47(4):300-301. PubMed
  9. Andersen, K. E. Contact allergy to toothpaste flavors. Contact Dermatitis 1978;4(4):195-198. PubMed
  10. Samojlik I, Mijatovic V, Petkovic S, et al. The influence of essential oil of aniseed (Pimpinella anisum, L.) on drug effects on the central nervous system. Fitoterapia 2012;83:1466-73. PubMed
  11. Samojlik I, Petkovic S, Stilinovic N, et al. Pharmacokinetic herb-drug interaction between essential oil of aniseed (Pimpinella anisum L., Apiaceae) and acetaminophen and caffeine: A potential risk for clinical practice. Phytother Res 2016;30:253-9.
  12. Rajeshwari U, Shobha I, Andallu B. Comparison of aniseeds and coriander seeds for antidiabetic, hypolipidemic and antioxidant activities. Spatula DD-Peer Reviewed Journal on Complementary Medicine and Drug Discovery 2011;1:9-16. DOI

See these in context on the Anise monograph →

Hyssop 1 reference
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

See these in context on the Hyssop monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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