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Dietary supplement

Anise Seed & Orris Combination Vanilla Flavor Ingredients & Drug Interactions

by TerraVita

Anise Seed & Orris Combination Vanilla Flavor label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Anise Seed & Orris Combination Vanilla Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Anise Seed & Orris Combination Vanilla Flavor is a dietary supplement by TerraVita with 2 active ingredients. Its ingredients are commonly taken for digestive upset and bloating, cough and respiratory complaints, sore throat.Based on those ingredients, 245 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Anise Seed Glycerite Liquid Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Anise Seed & Orris Combination Vanilla Flavor by TerraVita

Ask about any prescription or over-the-counter medication and we check it for interactions with Anise Seed & Orris Combination Vanilla Flavor by TerraVita — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Anise Seed & Orris Combination Vanilla Flavor by TerraVita

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (0.13 mL) without saying how much of each component you get.

This liquid formula contains 2 active ingredients: anise seed glycerite liquid extract and orris root glycerite liquid extract, both extracted into a base of glycerin and vanilla flavoring. Anise seed is traditionally used for digestive comfort, while orris root is primarily a fragrance ingredient.

The glycerin base makes this a liquid rather than a capsule or tablet.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The label doesn't state a purpose we can grade — see each ingredient's own graded uses on its monograph instead.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for what anise seed does is not established in the data we hold. Anise has been studied for migraine headaches, lice, menopausal symptoms, premenstrual syndrome, and period pain, but all ratings are insufficient reliable evidence to rate.

Orris root has also been studied for acne, aging skin, headache, respiratory infections, and blood sugar support, but likewise shows insufficient reliable evidence to rate. Neither ingredient has established proof of effectiveness for any condition in the data available to us.

The evidence, ingredient by ingredient Anise Orris

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Anise seed is generally well tolerated when used as a food or tea, though the concentrated essential oil requires more caution. A small number of people may experience contact dermatitis if applied to skin, and rarely, anise can trigger anaphylaxis in sensitive individuals.

Orris root is mainly used as a fragrance; internal safety data are limited, and the fresh root can cause severe skin and gut irritation. Taken orally, it may cause abdominal pain, vomiting, and bloody diarrhea.

Allergic reactions to orris-containing products have been reported in some individuals.

Side effects, ingredient by ingredient Anise Orris

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Anise.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 245 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check with your doctor or pharmacist if you take estrogens or hormonal birth control (Moderate interaction), antidiabetes drugs like metformin or insulin (Moderate), any antidepressant including fluoxetine or imipramine (Moderate), diazepam or other benzodiazepines (Moderate), codeine (Moderate), or rely on caffeine. No interactions are documented for orris root specifically.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is for people curious about traditional anise and orris uses, but effectiveness hasn't been proven for any condition in our data. If you take hormonal contraceptives, estrogen therapy, diabetes medication, antidepressants, anxiety medication, codeine, or caffeine regularly, you need to check with your doctor or pharmacist before adding this — the interactions are theoretical but documented.

Anyone with a known allergy to anise, orris, or licorice should avoid it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Anise Seed & Orris Combination Vanilla Flavor, straight from the product label.

Brand TerraVita
Barcode (UPC) 064435220495
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Mar 22, 2023
DSLD ID 283558
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Anise Seed & Orris Combination Vanilla Flavor by TerraVita, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
25 Drop(s)
Maximum serving Sizes:
40 Drop(s)
Servings per container
227
UPC/BARCODE
064435220495
IngredientAmount% DV
Proprietary Blend0.13 mL--
Anise Seed Glycerite Liquid Extract0 NP--
Orris Root Glycerite Liquid Extract0 NP--

Other ingredients: Glycerin, Vanilla flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Copyright 2018 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Formula

Glycerite liquid extract (1:5)

Formulation

Alcohol free

Suggested/Recommended/Usage/Directions

Suggested Use: Take 25-40 drops of extract in a small amount of warm water 3-4 times daily. Shake well before using.

Precautions

Keep away from children.

Do not use if safety seal around cap is broken or missing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Anise Seed & Orris Combination Vanilla Flavor by TerraVita label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Anise Seed & Orris Combination Vanilla Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Anise Seed & Orris Combination Vanilla Flavor by TerraVita

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size25 Drop(s) Dosage formLiquid Servings per container227 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

0.13 mL per serving

Other (inactive) ingredients: Glycerin, Vanilla flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

Anise Seed & Orris Combination Vanilla Flavor by TerraVita Drug Interactions

Want to check YOUR meds against Anise Seed & Orris Combination Vanilla Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
245Drugs
193 Moderate 52 Minor

Ingredients driving the most interactions

Anise Seed Glycerite Liquid Extract 245

Individual Drug Interactions

The ingredients in Anise Seed & Orris Combination Vanilla Flavor interact with 245 drugs. Click any drug to see the details.

1 of the 2 ingredients in Anise Seed & Orris Combination Vanilla Flavor interact with drugs. Each result below shows which ingredient is responsible. Anise Seed Glycerite Liquid Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Anise Seed & Orris Combination Vanilla Flavor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Anise Seed Glycerite Liquid Extract11 drug types · 245 drugs

Antidiabetes Drugs

Theoretically, anise seed might increase the risk of hypoglycemia when taken with antidiabetes drugs.
A small clinical study shows that anise seed powder decreases fasting blood glucose levels by 36% when compared to baseline.

Likelihood Possible Evidence B
Caffeine

Theoretically, anise oil might decrease the efficacy of caffeine.
Animal research shows that taking anise oil with caffeine decreases the bioavailability of caffeine. Whether this interaction will occur in humans is unclear.

Likelihood Possible Evidence D
Codeine

Theoretically, anise oil might increase the effects and adverse effects of codeine.
Animal research shows that anise oil increases the analgesic effects of codeine, possibly by inducing its phase I metabolism and increasing conversion to morphine. Whether this interaction occurs in humans is unclear.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, anise might interfere with contraceptive drug therapy.
Some in vitro research suggests that anise has estrogenic effects, while other in vitro research suggests that anise has antiestrogenic effects.

Likelihood Possible Evidence D
Diazepam (Valium)

Theoretically, anise oil might increase the effects and adverse effects of diazepam.
Animal research shows that taking anise oil with diazepam increases the motor impairment associated with diazepam, possibly by inhibiting its breakdown by cytochrome P450 3A4. Whether this interaction occurs in humans is unclear.

Likelihood Possible Evidence D
Estrogens

Theoretically, anise might interfere with estrogen-based hormone replacement therapy.
Some in vitro research suggests that anise has estrogenic effects, while other in vitro research suggests that anise has antiestrogenic effects.

Likelihood Possible Evidence D
Fluoxetine (Prozac)

Theoretically, anise oil might decrease the efficacy of fluoxetine.
Animal research shows that taking anise oil with fluoxetine reduces the antidepressant effects of fluoxetine, possibly by promoting its breakdown by cytochrome P450 2D6. Whether this interaction occurs in humans is unclear.

Likelihood Possible Evidence D
Imipramine (Tofranil)

Theoretically, anise oil might decrease the efficacy of imipramine.
Animal research shows that taking anise oil with imipramine reduces the antidepressant effects of imipramine, possibly by promoting its breakdown by cytochrome P450 2D6. Whether this interaction occurs in humans is unclear.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, anise oil might increase the effects and adverse effects of midazolam.
Animal research shows that taking anise oil with midazolam increases the motor impairment associated with midazolam, possibly by inhibiting its breakdown by cytochrome P450 3A4. Whether this interaction occurs in humans is unclear.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, anise might interfere with tamoxifen therapy.
Some in vitro research suggests that anise has estrogenic effects, while other in vitro research suggests that anise has antiestrogenic effects.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

Theoretically, anise oil might decrease the levels and clinical effects of acetaminophen.
Animal research shows that taking anise oil with acetaminophen decreases peak plasma levels of acetaminophen but does not reduce overall bioavailability. Whether this interaction will occur in humans is unclear.

Likelihood Possible Evidence D
Anise Seed Glycerite Liquid Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Anise Seed & Orris Combination Vanilla Flavor, from the product label.

TerraVita

See all TerraVita products
Name
ZooScape LLC
Phone Number
844-449-0444
Web Address
www.ZooScape.com
Pharmacist Counseling Corner

Anise Seed & Orris Combination Vanilla Flavor by TerraVita: Common Questions

Does Anise Seed & Orris Combination Vanilla Flavor by TerraVita interact with any medications?
Yes. Based on its ingredients, Anise Seed & Orris Combination Vanilla Flavor has a known interaction with 245 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Anise Seed & Orris Combination Vanilla Flavor contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is anise seed safe during pregnancy?
The safety data advises against medicinal amounts and concentrated anise oil during pregnancy due to limited safety information. However, anise as a food or occasional tea is likely safe. Talk with your doctor about what's right for your situation.
Can I use this if I'm breastfeeding?
Anise seed is likely safe while breastfeeding. However, there isn't enough safety data on orris root during breastfeeding, so it's best to avoid medicinal use of it. Check with your pharmacist or doctor if you're unsure about using this product while nursing.
What are the side effects I should watch for?
Anise is generally well tolerated taken by mouth. Topically, it can cause contact dermatitis in sensitive people. Rarely, anise can trigger a severe allergic reaction (anaphylaxis). Orris root can cause severe irritation of the mouth and stomach if swallowed. Anyone with a known allergy to anise, orris, or licorice should not use this product.
Does this actually work for anything?
The evidence isn't clear. Anise has been studied for migraine, lice, hot flashes, period pain, and PMS, but all ratings are insufficient reliable evidence. Orris has been studied for skin and respiratory issues, but again, the evidence isn't established. This product is based on traditional use, not proven benefits.
Why is it a liquid instead of a capsule?
Both ingredients are extracted into glycerin, which creates a liquid form. Glycerin is a common base for herbal extracts and helps preserve the plant compounds. You can take it directly or mix it with a little water or juice.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Anise Seed & Orris Combination Vanilla Flavor label
Go deeper

The Full Monographs Behind Anise Seed & Orris Combination Vanilla Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Anise

Interacts with 245 drugs

Anise is a fragrant, licorice-flavored seed used for centuries to ease digestion and soothe coughs. Most of its health claims are based on tradition and small or laboratory studies rather th...

Read the full Anise monograph → Herb & supplement monograph

Orris

Orris is the dried, aged rhizome of certain iris species, valued mainly for its violet-like scent in perfumes, cosmetics, and flavorings rather than for proven health benefits. There is very...

Read the full Orris monograph →
Sources

Sources & How We Checked

Anise Seed & Orris Combination Vanilla Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Anise 12 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Kassi E, Papoutsi Z, Fokialakis N, et al. Greek plant extracts exhibit selective estrogen receptor modulator (SERM)-like properties. J Agric Food Chem 2004;52:6956-61. PubMed
  3. Mumcuoglu KY, Miller J, Zamir C, et al. The in vivo pediculicidal efficacy of a natural remedy. Isr Med Assoc J 2002;4:790-3.
  4. Garcia-Gonzalez JJ, Bartolome-Zavala B, Fernandez-Melendez S, et al. Occupational rhinoconjunctivitis and food allergy because of aniseed sensitization. Ann Allergy Asthma Immunol 2002;88:518-22. . PubMed
  5. Tabanca N, Khan SI, Bedir E, et al. Estrogenic activity of isolated compounds and essential oils of Pimpinella species from Turkey, evaluated using a recombinant yeast screen. Planta Med 2004;70:728-35.
  6. Gonzalez-Gutierrez, M. L., Sanchez-Fernandez, C., Esteban-Lopez, M. I., Sempere-Ortells, J. M., and Diaz-Alperi, P. Allergy to anis. Allergy 2000;55(2):195-196.
  7. Anliker, M. D., Borelli, S., and Wuthrich, B. Occupational protein contact dermatitis from spices in a butcher: a new presentation of the mugwort-spice syndrome. Contact Dermatitis 2002;46(2):72-74. PubMed
  8. Poon, T. S. and Freeman, S. Cheilitis caused by contact allergy to anethole in spearmint flavoured toothpaste. Australas.J Dermatol. 2006;47(4):300-301. PubMed
  9. Andersen, K. E. Contact allergy to toothpaste flavors. Contact Dermatitis 1978;4(4):195-198. PubMed
  10. Samojlik I, Mijatovic V, Petkovic S, et al. The influence of essential oil of aniseed (Pimpinella anisum, L.) on drug effects on the central nervous system. Fitoterapia 2012;83:1466-73. PubMed
  11. Samojlik I, Petkovic S, Stilinovic N, et al. Pharmacokinetic herb-drug interaction between essential oil of aniseed (Pimpinella anisum L., Apiaceae) and acetaminophen and caffeine: A potential risk for clinical practice. Phytother Res 2016;30:253-9.
  12. Rajeshwari U, Shobha I, Andallu B. Comparison of aniseeds and coriander seeds for antidiabetic, hypolipidemic and antioxidant activities. Spatula DD-Peer Reviewed Journal on Complementary Medicine and Drug Discovery 2011;1:9-16. DOI

See these in context on the Anise monograph →

Orris 3 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Baudy A, Samaran Q, Dereure O, Raison-Peyron N. Allergic contact dermatitis to Iris germanica root in a "natural" cosmetic. Contact Dermatitis 2021;85(1):111-112.

See these in context on the Orris monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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