Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Antarctic Krill Oil Complex 1500 mg Ingredients & Drug Interactions

by Thrive Naturals

Antarctic Krill Oil Complex 1500 mg label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Antarctic Krill Oil Complex 1500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Antarctic Krill Oil Complex 1500 mg is a dietary supplement by Thrive Naturals with 3 active ingredients. Its ingredients are commonly taken for antioxidant support, skin health and aging, eye health.Based on those ingredients, 838 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astaxanthin, Antarctic Krill Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Antarctic Krill Oil Complex 1500 mg by Thrive Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Antarctic Krill Oil Complex 1500 mg by Thrive Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Antarctic Krill Oil Complex 1500 mg by Thrive Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • “Antarctic Krill Oil” is listed as a grouped ingredient — the label gives one combined amount (1,500 mg) without saying how much of each component you get.

This softgel contains four active ingredients sourced from Antarctic krill and added astaxanthin. The krill oil itself provides eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both omega-3 fatty acids, plus phospholipids — compounds that help your body absorb and use those omega-3s.

Astaxanthin is a natural red pigment with antioxidant properties, added here to support the formula's overall antioxidant profile. The capsule itself is made from gelatin, and the blend includes lemon oil for flavor, glycerin, and purified water as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Astaxanthin's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Heart, joint, brain and eye health.
  • We looked for evidence on: Cardiovascular disease (CVD), Hypertriglyceridemia, Hyperlipidemia, Osteoarthritis, Rheumatoid arthritis (RA), Premenstrual syndrome (PMS) — and 4 related terms.
  • The closest evidence on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Age-related macular degeneration (AMD), Hyperlipidemia, Osteoarthritis, Rheumatoid arthritis (RA).

The evidence supporting astaxanthin for the conditions studied — age-related cognitive decline, macular degeneration, aging skin, Alzheimer disease, athletic performance, and carpal tunnel syndrome — is insufficient to rate at this time. That means the research so far hasn't established whether it works for these purposes, not that it's proven ineffective.

The omega-3 components (EPA and DHA) from krill oil are not covered in the data we hold for this product.

The evidence, ingredient by ingredient Astaxanthin Krill Oil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Astaxanthin is generally well tolerated in studies, though long-term safety data are limited. The most common side effects in trials were abdominal pain, diarrhea, and red-colored stools — which can occur at routine doses and more rarely at higher doses (40 mg daily has caused severe stomach pain in a small number of people).

During pregnancy, the safety data are not sufficient to recommend use, so it's best to avoid it. The same applies while breastfeeding — there isn't enough information to know either way.

Side effects, ingredient by ingredient Astaxanthin Krill Oil

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Astaxanthin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 672 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, you need to check with your doctor or pharmacist whether you take any medications broken down by your liver's CYP3A4 or CYP2B6 enzymes. These are Moderate severity interactions documented for astaxanthin.

The three other active ingredients in this product — the omega-3s and phospholipids from krill oil — have no interaction data on file, so we cannot check them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may interest you if you're looking for an omega-3 supplement with added antioxidant support, but the evidence for astaxanthin's claimed benefits isn't yet established. The bigger consideration is whether it's safe to combine with your current medications — 672 drugs could theoretically be affected.

Before you start, check your exact medication list with your doctor or pharmacist, and avoid this product during pregnancy and breastfeeding unless your healthcare provider advises otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Antarctic Krill Oil Complex 1500 mg, straight from the product label.

Brand Thrive Naturals
Barcode (UPC) 756519469714
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Feb 26, 2020
DSLD ID 214027
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Antarctic Krill Oil Complex 1500 mg by Thrive Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
30
UPC/BARCODE
756519469714
IngredientAmount% DV
Eicosapentaenoic Acid225 mg--
Docosahexaenoic Acid135 mg--
Phospholipids630 mg--
Astaxanthin2000 mcg--
Antarctic Krill Oil1500 mg--

Other ingredients: Lemon Oil, Gelatin, Glycerin, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement take two (2) softgels one time per day. For best results, take 20-30 min before a meal with an 8oz. glass of water or as directed by your healthcare professional.

Precautions

Caution: Do not exceed recommended dose.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement. Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Contains shellfish (krill) derivative.

Seals/Symbols

Formulated in the U.S.A.

Good Manufacturing Practice Quality assured Sourced from a GMP registered facility

Made in FDA registered facilities

General Statements

Please recycle

Formula

Antarctic Krill Oil Complex 1500 mg formula

Omega-3 EPA, DHA & Phospholipids 2,000 mcg of Astaxanthin antioxidant

Easy to swallow lemon-coated softgels

Formulation

Supports heart, joint & brain health Maximum strength

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Antarctic Krill Oil Complex 1500 mg by Thrive Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Antarctic Krill Oil Complex 1500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Antarctic Krill Oil Complex 1500 mg by Thrive Naturals

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Phospholipids

630 mg per serving

Astaxanthin

Interacts with
671 drugs
2000 mcg per serving

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin monograph & interactions

Antarctic Krill Oil

Interacts with
208 drugs
1500 mg per serving

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglyce...

Antarctic Krill Oil monograph & interactions
  • › Eicosapentaenoic Acid
  • › Docosahexaenoic Acid

Other (inactive) ingredients: Lemon Oil, Gelatin, Glycerin, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Antarctic Krill Oil Complex 1500 mg by Thrive Naturals Drug Interactions

Want to check YOUR meds against Antarctic Krill Oil Complex 1500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
838Drugs
838 Moderate

Ingredients driving the most interactions

Astaxanthin 671
Antarctic Krill Oil 208

Individual Drug Interactions

The ingredients in Antarctic Krill Oil Complex 1500 mg interact with 838 drugs. Click any drug to see the details.

2 of the 3 ingredients in Antarctic Krill Oil Complex 1500 mg interact with drugs. Each result below shows which ingredient is responsible. Astaxanthin Antarctic Krill Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Antarctic Krill Oil Complex 1500 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin full monograph & interactions

Antarctic Krill Oil2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
Antarctic Krill Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Antarctic Krill Oil Complex 1500 mg, from the product label.

Thrive Naturals

See all Thrive Naturals products
Name
Thrive Naturals
City
San Diego
State
CA
ZipCode
92109
Phone Number
800-371-8131
Web Address
www.thrivenaturals.com
Pharmacist Counseling Corner

Antarctic Krill Oil Complex 1500 mg by Thrive Naturals: Common Questions

Does Antarctic Krill Oil Complex 1500 mg by Thrive Naturals interact with any medications?
Yes. Based on its ingredients, Antarctic Krill Oil Complex 1500 mg has a known interaction with 838 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Antarctic Krill Oil Complex 1500 mg contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant?
The safety data for astaxanthin during pregnancy aren't sufficient to know either way, so it's best to avoid it. Talk with your doctor or pharmacist about whether this product is right for you if you're pregnant or planning to be.
Can I take this while breastfeeding?
There isn't enough information to know whether astaxanthin is safe while breastfeeding. For personalized guidance, check with your doctor or pharmacist before starting.
What are the most common side effects?
In trials, astaxanthin caused abdominal pain, diarrhea, and red-colored stools in a small number of people. These effects were mild in most cases, though higher doses have rarely caused severe stomach pain.
Does astaxanthin actually work for anti-aging or brain health?
The evidence so far is insufficient to say whether astaxanthin works for age-related cognitive decline, macular degeneration, aging skin, Alzheimer disease, athletic performance, or carpal tunnel syndrome. That means more research is needed before we can confirm a benefit.
What's in this product besides the krill oil?
The main active ingredients are EPA and DHA (omega-3 fatty acids from krill), phospholipids, and astaxanthin, an antioxidant. The capsule also contains gelatin, glycerin, lemon oil, and purified water as inactive ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Antarctic Krill Oil Complex 1500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Antarctic Krill Oil Complex 1500 mg label
Go deeper

The Full Monographs Behind Antarctic Krill Oil Complex 1500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph → Herb & supplement monograph

Krill Oil

Interacts with 208 drugs

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglycerides and supporting heart health, but t...

Read the full Krill Oil monograph →
Sources

Sources & How We Checked

Antarctic Krill Oil Complex 1500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Krill Oil 13 references
  1. Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
  2. Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
  3. Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
  4. Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8.
  5. Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9.
  6. Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. PubMed
  7. Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. PubMed
  8. Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.R PubMed
  9. Albert BB, Derraik JG, Brennan CM, et al. Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men. Am J Clin Nutr 2015;102(1):49-57.
  10. Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 2014;34(2):126-33. PubMed
  11. Lobraico JM, DiLello LC, Butler AD, Cordisco ME, Petrini JR, Ahmadi R. Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 PubMed
  12. van der Wurff ISM, von Schacky C, Bergeland T, Zeegers MP, Kirschner PA, de Groot RHM. Krill oil supplementation's effect on school grades in typically developing adolescents. Prostaglandins Leukot Essent Fatty Acids 2023;191:102553. PubMed
  13. van der Wurff ISM, von Schacky C, Bergeland T, et al. Effect of 1 year krill oil supplementation on cognitive achievement of Dutch adolescents: A double-blind randomized controlled trial. Nutrients. 2019;11(6):1230. PubMed

See these in context on the Krill Oil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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