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Dietary supplement

Apple Cider Vinegar Complex 500 mg Ingredients & Drug Interactions

by Smoky Mountain Nutrition

Apple Cider Vinegar Complex 500 mg label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Apple Cider Vinegar Complex 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Apple Cider Vinegar Complex 500 mg is a dietary supplement by Smoky Mountain Nutrition with 5 active ingredients. Its ingredients are commonly taken for constipation and regularity, prebiotic gut health, blood sugar support.Based on those ingredients, 1,097 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are BioPerine, organic Cayenne Pepper powder, organic Apple Cider Vinegar powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Apple Cider Vinegar Complex 500 mg by Smoky Mountain Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Apple Cider Vinegar Complex 500 mg by Smoky Mountain Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Apple Cider Vinegar Complex 500 mg by Smoky Mountain Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains five active ingredients: organic inulin (a prebiotic fiber), BioPerine (a black pepper extract that enhances absorption), organic lemon powder, organic apple cider vinegar powder, and organic cayenne pepper powder. Together they're meant to support digestion and general wellness, though the evidence for most of their health claims is still being studied.

The remaining ingredients are organic Nu-FLOW and vegetable capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: weight loss, metabolism, heart and cholesterol health, digestion.
  • We looked for evidence on: Obesity, Dyslipidemia, Hypercholesterolemia, Hyperlipidemia, Hypertriglyceridemia, Cardiovascular disease (CVD) — and 4 related terms.
  • The strongest evidence on file: Inulin is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Inulin is rated "Possibly Effective" for Obesity.
  • Also on file: Lemon is rated "Insufficient Reliable Evidence To Rate" for Obesity.

The evidence on what this combination actually does is mixed. Inulin shows possibly effective evidence for blood sugar control, constipation, and weight management, though research on its effectiveness in supplements versus whole foods is still developing.

Cayenne pepper has the strongest evidence: it's rated likely effective for nerve pain after shingles (postherpetic neuralgia) and diabetic nerve damage, and possibly effective for cluster headaches and back pain. For the other ingredients—BioPerine, lemon powder, and apple cider vinegar—the data we hold shows insufficient reliable evidence to rate their effectiveness for the conditions studied.

The evidence doesn't establish what this specific five-ingredient blend does.

The evidence, ingredient by ingredient Inulin Black Pepper Lemon Apple Cider Vinegar Capsicum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Inulin is generally well tolerated but commonly causes gas, bloating, diarrhea, and cramping, especially at higher doses—these are the most common side effects you might notice. Apple cider vinegar is safe in food amounts but can cause heartburn and upper stomach discomfort; rare cases of long-term use at high doses have reported low potassium (a serious concern), high renin, and bone loss.

Cayenne pepper causes belching, bloating, burning sensation, diarrhea, nausea, and flushing as common side effects. Black pepper may cause a burning aftertaste and heartburn.

Lemon in food is safe, but fresh lemon juice taken as a medicinal amount caused heartburn in 21% and upper stomach pain in 8% of trial participants. For pregnancy and lactation: inulin is likely safe; black pepper pregnancy safety data is conflicting (some sources say likely safe, others possibly unsafe)—talk with your doctor; apple cider vinegar and lemon have no pregnancy/lactation rating on file; and cayenne is rated likely safe in pregnancy.

Side effects, ingredient by ingredient Inulin Black Pepper Lemon Apple Cider Vinegar Capsicum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Lemon, Black Pepper, Apple Cider Vinegar, Capsicum, Inulin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 1,098 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you take phenytoin (Dilantin) or other seizure medications, propranolol or other heart/blood pressure drugs, blood thinners or antiplatelet agents, diabetes medications, digoxin (Lanoxin), theophylline, antibiotics like ciprofloxacin or rifampin, HIV medications like nevirapine, antifungals like itraconazole, or immunosuppressants like cyclosporine. The black pepper and cayenne in this blend can significantly raise blood levels of many of these drugs.

Moderate-severity interactions are the most common concern.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This blend combines digestive support ingredients with strong absorption enhancers, so it packs real medication interaction risk—especially if you take seizure drugs, heart medications, blood thinners, diabetes drugs, or HIV antiretrovirals. Cayenne has solid evidence for nerve pain; the others are less certain.

If you're on any regular medications, check them against the tool on this page or ask your pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Apple Cider Vinegar Complex 500 mg, straight from the product label.

Brand Smoky Mountain Nutrition
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD May 22, 2020
DSLD ID 219499
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Apple Cider Vinegar Complex 500 mg by Smoky Mountain Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
IngredientAmount% DV
organic Inulin125 mg--
BioPerine2.5 mg--
organic Lemon powder25 mg--
organic Apple Cider Vinegar powder500 mg--
organic Cayenne Pepper powder25 mg--

Other ingredients: organic Nu-FLOW, Vegetable capsules

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Men and women take one vegetable capsule daily. Taking ACV with food and a full glass of water is highly recommended.

Once-daily capsule

Formulation

Supports: Apple Cider Vinegar is a natural source of acetic acid, which may support: weight loss, metabolism, a healthy heart, healthy cholesterol levels, and digestion.

Digestion and metabolism support

GMO free Dairy free Gluten free Soy free

100% Vegan

Not manufactured with wheat, gluten, milk, eggs, shellfish, or tree nut ingredients.

Formula

What It Is: ACV Complex combines the strength of Apple Cider Vinegar, with support ingredients Inulin, Cayenne Pepper, Lemon, and BioPerine.

Precautions

Warning: Caution: Consult your healthcare provider before using this supplement especially if you are pregnant, nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Do not use if safety seal is missing or broken.

Brand IP Statement(s)

BioPerine is the registered trademark of Sabinsa Corporation protected by the US and international patents.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General Statements

Cruelty free 100% Money back guaranteed

Seals/Symbols

GMP Manufactured in a Certified Facility Made in the USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Apple Cider Vinegar Complex 500 mg by Smoky Mountain Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Apple Cider Vinegar Complex 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Apple Cider Vinegar Complex 500 mg by Smoky Mountain Nutrition

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Organic Inulin

Interacts with
86 drugs
125 mg per serving

Inulin is a type of plant fiber (a prebiotic) found naturally in foods like chicory root, onions, and garlic, and it is widely added to supplements an...

Organic Inulin monograph & interactions

BioPerine

Interacts with
1,019 drugs
2.5 mg per serving

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to he...

BioPerine monograph & interactions

Organic Lemon powder

Interacts with
1 drug
25 mg per serving

Lemon is a common citrus fruit that is a good source of vitamin C and citric acid, and it is widely used in food, drinks, and home remedies. While it...

Organic Lemon powder monograph & interactions

Organic Apple Cider Vinegar powder

Interacts with
162 drugs
500 mg per serving

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of...

Organic Apple Cider Vinegar powder monograph & interactions

Organic Cayenne Pepper powder

Interacts with
239 drugs
25 mg per serving

Capsicum (chili pepper) contains capsaicin, which is best known and best studied as a topical treatment for certain types of pain. Topical capsaicin p...

Organic Cayenne Pepper powder monograph & interactions

Other (inactive) ingredients: Organic Nu-FLOW, Vegetable capsules. These complete the product’s ingredient list but are not active constituents.

Interaction report

Apple Cider Vinegar Complex 500 mg by Smoky Mountain Nutrition Drug Interactions

Want to check YOUR meds against Apple Cider Vinegar Complex 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,097Drugs
1,043 Moderate 54 Minor

Ingredients driving the most interactions

BioPerine 1,019
organic Cayenne Pepper powder 239
organic Apple Cider Vinegar powder 162
organic Inulin 86
organic Lemon powder 1

Individual Drug Interactions

The ingredients in Apple Cider Vinegar Complex 500 mg interact with 1,097 drugs. Click any drug to see the details.

5 of the 5 ingredients in Apple Cider Vinegar Complex 500 mg interact with drugs. Each result below shows which ingredient is responsible. BioPerine organic Cayenne Pepper powder organic Apple Cider Vinegar powder organic Inulin organic Lemon powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Apple Cider Vinegar Complex 500 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

BioPerine17 drug types · 1,019 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit platelet aggregation. This has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that piperine, a constituent of black pepper, can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Atorvastatin (Lipitor)

Theoretically, black pepper might increase blood levels of atorvastatin.
Animal research shows that taking piperine, a constituent of black pepper, 35 mg/kg can increase the maximum serum concentration of atorvastatin three-fold. This has not been reported in humans.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, black pepper might increase the effects and side effects of cyclosporine.
In vitro research shows that piperine, a constituent of black pepper, increases the bioavailability of cyclosporine. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
In vitro research suggests that some constituents of black pepper inhibit CYP2D6. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
In vitro research and pharmacokinetic simulation data suggest that piperine, a constituent of black pepper, as well as the pepper fruit seem to inhibit CYP3A4. This has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, black pepper might increase blood levels of lithium due to its diuretic effects. The dose of lithium might need to be reduced.
Black pepper is thought to have diuretic properties.

Likelihood Probable Evidence D
Nevirapine (Viramune)

Black pepper might increase blood levels of nevirapine.
Clinical research shows that piperine, a constituent of black pepper, increases the plasma concentration of nevirapine. However, no adverse effects were observed in this study.

Likelihood Probable Evidence D
P-Glycoprotein Substrates

Theoretically, black pepper might increase levels of P-glycoprotein substrates.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit P-glycoprotein.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, black pepper might increase the sedative effects of pentobarbital.
Animal research shows that piperine, a constituent of black pepper, increases pentobarbital-induced sleeping time.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Black pepper might increase blood levels of phenytoin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption, slow elimination, and increase levels of phenytoin. Taking a single dose of black pepper 1 gram along with phenytoin seems to double the serum concentration of phenytoin. Consuming a soup with black pepper providing piperine 44 mg/200 mL of soup along with phenytoin also seems to increase phenytoin levels when compared with consuming the same soup without black pepper.

Likelihood Possible Evidence B
Propranolol (Inderal)

Black pepper might increase blood levels of propranolol.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of propranolol.

Likelihood Possible Evidence B
Rifampin (Rifadin)

Black pepper might increase blood levels of rifampin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and serum levels of rifampin.

Likelihood Possible Evidence B
Theophylline

Black pepper might increase blood levels of theophylline.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of theophylline.

Likelihood Possible Evidence D
Amoxicillin (Amoxil, Trimox)

Theoretically, black pepper might increase the effects and side effects of amoxicillin.
Animal research shows that taking piperine, a constituent of black pepper, with amoxicillin increases plasma levels of amoxicillin. This has not been reported in humans.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, black pepper might increase blood levels of carbamazepine, potentially increasing the effects and side effects of carbamazepine.
One clinical study in patients taking carbamazepine 300 mg or 500 mg twice daily shows that taking a single 20 mg dose of purified piperine, a constituent of black pepper, increases carbamazepine levels. Piperine may increase carbamazepine absorption by increasing blood flow to the GI tract, increasing the surface area of the small intestine, or inhibiting cytochrome P450 3A4 (CYP3A4) in the gut wall. Absorption was significantly increased by 7-10 mcg/mL/hour. The time to eliminate carbamazepine was also increased by 4-8 hours. Although carbamazepine levels were increased, this did not appear to increase side effects. In vitro research also shows that piperine can increase carbamazepine levels by 11% in a time-dependent manner.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that black pepper induces CYP1A2. This has not been reported in humans.

Likelihood Possible Evidence D
BioPerine full monograph & interactions

organic Cayenne Pepper powder6 drug types · 239 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro research shows that capsicum might increase the effects of antiplatelet drugs. Also, population research shows that capsicum is associated with an increased risk of self-reported bleeding in patients taking warfarin. However, clinical research shows that taking a single dose of capsaicin (Asian Herbex Ltd.), the active ingredient in capsicum, 400-800 mcg orally in combination with aspirin 500 mg does not decrease platelet aggregation when compared with taking aspirin 500 mg alone. Also, there was no notable effect on measures of platelet aggregation with capsaicin. It is unclear whether capsaicin must be used in more than a single dose to affect platelet aggregation.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking capsicum with antidiabetes drugs might increase the risk of hypoglycemia.
Preliminary clinical research shows that consuming capsicum 5 grams along with a glucose drink attenuates the rise in plasma glucose after 30 minutes by 21%, decreases the 2-hour postprandial area under the curve of plasma glucose by 11%, and increases the 2-hour postprandial area under the curve of plasma insulin by 58% in healthy individuals when compared with placebo. Other clinical research shows that taking capsicum 5 mg daily for 28 days significantly reduces postprandial blood glucose and insulin levels, but not fasting blood glucose and insulin levels, in patients with gestational diabetes.

Likelihood Possible Evidence B
Aspirin

Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Animal research shows that acute or chronic intake of capsicum pepper reduces oral aspirin bioavailability. This has not been shown in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, taking capsicum with theophylline might increase the levels and adverse effects of theophylline.
In animal research, oral administration of capsicum reduced excretion of theophylline. However, capsicum does not seem to affect the pharmacokinetics of theophylline when administered intravenously.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, using topical capsaicin may increase the risk of ACE inhibitor-induced cough.
There is one case report of a topically applied capsaicin cream contributing to the cough reflex in a patient using an ACEI. However, it is unclear if this interaction is clinically significant.

Likelihood Unlikely Evidence D
Ciprofloxacin (Cipro)

Theoretically, taking capsicum with ciprofloxacin might increase levels and adverse effects of ciprofloxacin.
Animal research shows that concomitant use of capsaicin, the active constituent of capsicum, and ciprofloxacin increases the bioavailability of ciprofloxacin by up to 70%.

Likelihood Possible Evidence D
organic Cayenne Pepper powder full monograph & interactions

organic Apple Cider Vinegar powder4 drug types · 162 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of apple cider vinegar with digoxin might increase the risk of cardiac toxicity.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar could decrease potassium levels, increasing the risk of toxicity with digoxin.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. There is some concern that people taking apple cider vinegar along with potassium depleting diuretics might have an increased risk for hypokalemia.

Likelihood Possible Evidence D
Insulin

Theoretically, concomitant use of apple cider vinegar with insulin might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar concomitantly with insulin might increase the risk of hypokalemia.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.
Apple cider vinegar might reduce fasting and postprandial blood glucose levels and decrease gastric emptying in people with diabetes. However, not all research agrees. Theoretically, it might have additive effects on glucose levels when used with antidiabetes drugs.

Likelihood Possible Evidence B
organic Apple Cider Vinegar powder full monograph & interactions

organic Inulin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, inulin might increase the risk of hypoglycemia with antidiabetes drugs.
Some clinical research shows that inulin improves glycemic control in patients with diabetes; however, it is unclear if it has hypoglycemic effects.

Likelihood Unlikely Evidence D
organic Inulin full monograph & interactions

organic Lemon powder1 drug type · 1 drug

Itraconazole (Sporanox)

Theoretically, taking itraconazole capsules or tablets with a beverage containing lemon might increase the levels and clinical effects of itraconazole.
In one case report, dissolving itraconazole tablets in a small amount of specific beverages containing lemon prior to administration increased the level of itraconazole in a lung transplant patient. In this case, the increased bioavailability was desirable and was likely due to improved tablet dissolution in the acidic beverage.

Likelihood Possible Evidence D
organic Lemon powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Apple Cider Vinegar Complex 500 mg, from the product label.

Smoky Mountain Nutrition

See all Smoky Mountain Nutrition products
Name
Smoky Mountain Nutrition
Street Address
P.O. Box 101335
City
Nashville
State
TN
Web Address
SmokyMountainNutrition.com
Pharmacist Counseling Corner

Apple Cider Vinegar Complex 500 mg by Smoky Mountain Nutrition: Common Questions

Does Apple Cider Vinegar Complex 500 mg by Smoky Mountain Nutrition interact with any medications?
Yes. Based on its ingredients, Apple Cider Vinegar Complex 500 mg has a known interaction with 1,097 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Apple Cider Vinegar Complex 500 mg contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my digestion?
Inulin, one of the five ingredients, is rated possibly effective for constipation. The other four ingredients don't have reliable evidence for digestive benefits in our data. Be aware that inulin commonly causes bloating, gas, and cramping, especially when you first start it.
Can I take this if I'm on blood pressure medication?
Not without checking first. The black pepper extract (BioPerine) in this product can increase blood levels of propranolol and some other heart and blood pressure drugs. Talk to your pharmacist before adding this supplement.
Is this safe during pregnancy?
Inulin is rated likely safe in pregnancy. Cayenne pepper is likely safe. However, black pepper safety data is conflicting—some sources say likely safe, others say possibly unsafe. Lemon and apple cider vinegar don't have pregnancy safety information on file. Discuss this product with your doctor before use in pregnancy.
What are the most common side effects I might feel?
Gas, bloating, and cramping from the inulin are the most likely. You may also notice a burning sensation, diarrhea, nausea, or flushing from the cayenne and black pepper. Heartburn and upper stomach discomfort can happen with the apple cider vinegar and lemon.
Does this help with nerve pain?
Cayenne pepper—one ingredient in this blend—is rated likely effective for nerve pain after shingles and diabetic nerve damage, and possibly effective for cluster headaches. The other four ingredients don't have reliable evidence for pain relief in our data.
Can I take this with my diabetes medication?
Not without checking first. Inulin, apple cider vinegar, and cayenne all have documented interactions with diabetes drugs and may increase low blood sugar risk. Talk to your pharmacist or doctor before starting this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Apple Cider Vinegar Complex 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Apple Cider Vinegar Complex 500 mg label
Go deeper

The Full Monographs Behind Apple Cider Vinegar Complex 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Inulin

Interacts with 86 drugs

Inulin is a type of plant fiber (a prebiotic) found naturally in foods like chicory root, onions, and garlic, and it is widely added to supplements and processed foods. It may help with regu...

Read the full Inulin monograph → Herb & supplement monograph

Black Pepper

Interacts with 1,019 drugs

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to help the body absorb other ingredients (li...

Read the full Black Pepper monograph → Herb & supplement monograph

Lemon

Interacts with 1 drug

Lemon is a common citrus fruit that is a good source of vitamin C and citric acid, and it is widely used in food, drinks, and home remedies. While it can support hydration and a healthy diet...

Read the full Lemon monograph → Herb & supplement monograph

Apple Cider Vinegar

Interacts with 162 drugs

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of these uses is limited and mixed, and the...

Read the full Apple Cider Vinegar monograph → Herb & supplement monograph

Capsicum

Interacts with 239 drugs

Capsicum (chili pepper) contains capsaicin, which is best known and best studied as a topical treatment for certain types of pain. Topical capsaicin products are supported by reasonable evid...

Read the full Capsicum monograph →
Sources

Sources & How We Checked

Apple Cider Vinegar Complex 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 148 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Inulin 17 references
  1. Williams CM. Effects of inulin on lipid parameters in humans. J Nutr 1999 Jul;129(7 Suppl):1471S-3S. PubMed
  2. Pedersen A, Sandstrom B, Van Amelsvoort JM. The effect of ingestion of inulin on blood lipids and gastrointestinal symptoms in healthy females. Br J Nutr 1997;78:215-22. PubMed
  3. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  4. Bonnema AL, Kolberg LW, Thomas W, Slavin JL. Gastrointestinal tolerance of chicory inulin products. J Am Diet Assoc 2010;110(6):865-8. PubMed
  5. Dehghan P, Gargari BP, Jafar-Abadi MA, Aliasgharzadeh A. Inulin controls inflammation and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized-controlled clinical trial. Int J Food Sci Nutr 2014;65(1):117-23. PubMed
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Black Pepper 29 references
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Lemon 2 references
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Apple Cider Vinegar 11 references
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Capsicum 89 references
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See these in context on the Capsicum monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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