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Dietary supplement

ArcticPure Krill Oil 500 mg Ingredients & Drug Interactions

by Source Naturals

ArcticPure Krill Oil 500 mg label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking ArcticPure Krill Oil 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

ArcticPure Krill Oil 500 mg is a dietary supplement by Source Naturals with 1 active ingredient. Its ingredients are commonly taken for heart and cholesterol support, high triglycerides, joint pain and inflammation.Based on those ingredients, 838 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are ArcticPure Krill Oil Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against ArcticPure Krill Oil 500 mg by Source Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with ArcticPure Krill Oil 500 mg by Source Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of ArcticPure Krill Oil 500 mg by Source Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • “Total Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (300 mg) without saying how much of each component you get.
  • “ArcticPure Krill Oil Blend” is a proprietary blend — the label gives one combined amount (1 Gram(s)) without saying how much of each component you get.
  • “Phospholipids” is listed as a grouped ingredient — the label gives one combined amount (420 mg) without saying how much of each component you get.

ArcticPure Krill Oil contains three active ingredients: eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and total omega-3 fatty acids—all sourced from the krill oil blend. These are omega-3 fats commonly used to support heart and brain health.

The product also includes astaxanthin, a natural antioxidant pigment. The remaining ingredients are inactive—gelatin capsule, fish oil, medium-chain triglyceride, glycerin, sorbitol, purified water, mixed tocopherols, and ascorbyl palmitate—which serve as fillers, binders, and preservatives.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Astaxanthin's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: heart and brain health, PMS and menstrual discomfort.
  • We looked for evidence on: Cardiovascular disease (CVD), Age-related cognitive decline, Cognitive function, Premenstrual syndrome (PMS), Dysmenorrhea, Hyperlipidemia — and 3 related terms.
  • The closest evidence on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia.

The effectiveness data we hold shows insufficient reliable evidence to rate astaxanthin for age-related cognitive decline, age-related macular degeneration, aging skin, Alzheimer disease, athletic performance, and carpal tunnel syndrome. We have no effectiveness ratings on file for the omega-3 fatty acids in this product, so we cannot speak to their proven benefits based on our data.

The evidence, ingredient by ingredient Krill Oil Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Astaxanthin is generally well tolerated in studies, though long-term safety data are limited. The most common side effects reported are abdominal pain, diarrhea, and red-colored stools.

A small number of trial participants at higher doses (40 mg daily) experienced severe stomach or abdominal pain. There isn't enough safety data to recommend this product during pregnancy or while breastfeeding—talk with your doctor or pharmacist about whether it's right for you if you're pregnant, trying to become pregnant, or nursing.

Side effects, ingredient by ingredient Krill Oil Astaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Astaxanthin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 672 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take any medications broken down by the liver enzyme CYP3A4 or CYP2B6. Astaxanthin may theoretically decrease levels of these drugs, though this hasn't been confirmed in humans.

The other omega-3 ingredients could not be checked against our interaction data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This krill oil supplement is designed for omega-3 support with added astaxanthin. If you take medications metabolized by your liver—especially through the CYP3A4 or CYP2B6 pathways—you'll want to check your specific drugs and discuss them with your doctor or pharmacist before starting.

It's generally well tolerated, but long-term safety data are limited, and it's not recommended in pregnancy or while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ArcticPure Krill Oil 500 mg, straight from the product label.

Brand Source Naturals
Barcode (UPC) 021078021643
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD Aug 23, 2023
DSLD ID 295576
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ArcticPure Krill Oil 500 mg by Source Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
15
UPC/BARCODE
021078021643
IngredientAmount% DV
Calories10 Calorie(s)--
Calories from Fat5 Calorie(s)--
Eicosapentaenoic Acid150 mg--
Docosahexaenoic Acid90 mg--
Total Omega-3 Fatty Acids300 mg--
Total Fat1 Gram(s)2%
Astaxanthin1.5 mg--
ArcticPure Krill Oil Blend1 Gram(s)--
Phospholipids420 mg--

Other ingredients: Gelatin, Fish Oil, Medium Chain Triglyceride, Glycerin, Sorbitol, Water, Purified, Mixed Tocopherols, Ascorbyl Palmitate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Contains shellfish (krill), fish and soy.

Caution: If you are pregnant, may become pregnant, breastfeeding, allergic to shellfish, have a blood coagulation condition or are taking anticoagulants such as warfarin (Coumadin), consult a health care professional before using this product.

Caution: If you are pregnant, may become pregnant, breastfeeding, allergic to shellfish, have a blood coagulation condition or are taking anticoagulants such as warfarin (Coumadin), consult a health care professional before using this product.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

Suggested/Recommended/Usage/Directions

Suggested use: 2 softgels daily with a meal.

Formula

ArcticPure Krill Oil is a premium source of potent omega-3s and phospholipids, which provide support for heart and brain health, as well as for PMS and menstrual discomfort. Krill oil additionally contains astaxanthin, a unique lipid-soluble antioxidant which may help protect cells from harmful free radicals.

Krill oil blend Premium omega-3 for heart, brain & PMS

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Copyright Source Naturals, Inc.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

ArcticPure Krill Oil 500 mg by Source Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

ArcticPure Krill Oil 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in ArcticPure Krill Oil 500 mg by Source Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container15 Amounts shown are per serving.

ArcticPure Krill Oil Blend

Interacts with
208 drugs
1 Gram(s) per serving

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglyce...

ArcticPure Krill Oil Blend monograph & interactions

Other (inactive) ingredients: Gelatin, Fish Oil, Medium Chain Triglyceride, Glycerin, Sorbitol, Water, Purified, Mixed Tocopherols, Ascorbyl Palmitate. These complete the product’s ingredient list but are not active constituents.

Interaction report

ArcticPure Krill Oil 500 mg by Source Naturals Drug Interactions

Want to check YOUR meds against ArcticPure Krill Oil 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
838Drugs
838 Moderate

Ingredients driving the most interactions

ArcticPure Krill Oil Blend 208

Individual Drug Interactions

The ingredients in ArcticPure Krill Oil 500 mg interact with 838 drugs. Click any drug to see the details.

1 of the 1 ingredient in ArcticPure Krill Oil 500 mg interact with drugs. Each result below shows which ingredient is responsible. ArcticPure Krill Oil Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in ArcticPure Krill Oil 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

ArcticPure Krill Oil Blend2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
ArcticPure Krill Oil Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for ArcticPure Krill Oil 500 mg, from the product label.

Source Naturals

Name
Source Naturals, Inc.
Street Address
P. O. Box 2118
City
Santa Cruz
State
CA
ZipCode
95062
Web Address
www.sourcenaturals.com
Pharmacist Counseling Corner

ArcticPure Krill Oil 500 mg by Source Naturals: Common Questions

Does ArcticPure Krill Oil 500 mg by Source Naturals interact with any medications?
Yes. Based on its ingredients, ArcticPure Krill Oil 500 mg has a known interaction with 838 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ArcticPure Krill Oil 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
No—there isn't enough safety data on astaxanthin to recommend it during pregnancy or while breastfeeding. Talk with your doctor or pharmacist about what's safe for you and your baby.
What are EPA and DHA?
EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) are omega-3 fatty acids found in krill oil. They're commonly used in supplements to support heart and brain health.
What's astaxanthin?
Astaxanthin is a natural antioxidant pigment—the compound that gives krill and certain algae their reddish color. It's included in this formula for its antioxidant properties.
What side effects might I experience?
The most common are abdominal pain, diarrhea, and red-colored stools. A small number of people taking higher doses have reported severe stomach pain. Most people tolerate it well.
Does this product have fillers?
Yes—it contains inactive ingredients like gelatin, fish oil, glycerin, sorbitol, and others that serve as binders, preservatives, and capsule material.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if ArcticPure Krill Oil 500 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ArcticPure Krill Oil 500 mg label
Go deeper

The Full Monographs Behind ArcticPure Krill Oil 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Krill Oil

Interacts with 208 drugs

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglycerides and supporting heart health, but t...

Read the full Krill Oil monograph → Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph →
Sources

Sources & How We Checked

ArcticPure Krill Oil 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Krill Oil 13 references
  1. Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
  2. Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
  3. Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
  4. Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8.
  5. Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9.
  6. Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. PubMed
  7. Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. PubMed
  8. Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.R PubMed
  9. Albert BB, Derraik JG, Brennan CM, et al. Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men. Am J Clin Nutr 2015;102(1):49-57.
  10. Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 2014;34(2):126-33. PubMed
  11. Lobraico JM, DiLello LC, Butler AD, Cordisco ME, Petrini JR, Ahmadi R. Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 PubMed
  12. van der Wurff ISM, von Schacky C, Bergeland T, Zeegers MP, Kirschner PA, de Groot RHM. Krill oil supplementation's effect on school grades in typically developing adolescents. Prostaglandins Leukot Essent Fatty Acids 2023;191:102553. PubMed
  13. van der Wurff ISM, von Schacky C, Bergeland T, et al. Effect of 1 year krill oil supplementation on cognitive achievement of Dutch adolescents: A double-blind randomized controlled trial. Nutrients. 2019;11(6):1230. PubMed

See these in context on the Krill Oil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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