Ashwagandha Ingredients & Drug Interactions
by Herb Pharm
What is this page for?
First and foremost: checking Ashwagandha against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Ashwagandha is a dietary supplement by Herb Pharm with 1 active ingredient. Its ingredients are commonly taken for stress and anxiety, sleep problems, fatigue and low energy.Based on those ingredients, 1,372 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ashwagandha root (Withania somnifera) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Ashwagandha by Herb Pharm
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AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Ashwagandha by Herb Pharm
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: ashwagandha root extract from Withania somnifera. It's delivered as a liquid in a base of certified organic cane alcohol and distilled water.
Does it work?
Moderate evidence
The evidence suggests ashwagandha is possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder (GAD). For bipolar disorder, the evidence we have isn't strong enough to rate it one way or the other.
How safe is it?
Well-documented data
Ashwagandha is generally well tolerated in the short term by healthy adults, but long-term safety data are limited. The most common side effects — when they do happen — are mild digestive ones like diarrhea, nausea, or vomiting, though they're uncommon at typical doses.
Rare serious side effects including liver damage and a type of brain blood vessel problem have been reported. The data also note that ashwagandha may cause drowsiness.
During pregnancy, the safety data advise against it — it's traditionally thought to carry a miscarriage risk. While breastfeeding, there isn't enough safety information, so it's best to avoid it and talk with your doctor or pharmacist for personalized advice.
Meds to double-check
Moderate interaction found
Before taking this ashwagandha, double-check with your pharmacist if you take immunosuppressants (drugs that suppress your immune system), blood pressure medications, benzodiazepines or other sedatives and anti-anxiety drugs, diabetes medications, thyroid hormone, drugs that are hard on the liver, or drugs processed through the CYP1A2 liver enzyme.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Ashwagandha may help with insomnia, anxiety, and stress, and it's generally well tolerated. But if you take blood pressure meds, sedatives, diabetes drugs, thyroid hormone, immune-suppressing drugs, or anything processed through your liver, check with us first — this herb can amplify or interfere with how they work.
Pregnant people and those breastfeeding should avoid it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Ashwagandha, straight from the product label.
| Brand | Herb Pharm |
|---|---|
| Barcode (UPC) | 090700000059 |
| Net contents | 1 Fluid Ounce(s); 30 Milliliter(s) |
| Market status | On market |
| Date entered into DSLD | Feb 22, 2024 |
| DSLD ID | 307428 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Organic, Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Ashwagandha by Herb Pharm, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Ashwagandha root (Withania somnifera) extract | 626 mg | -- |
Other ingredients: certified organic Cane Alcohol, distilled Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use Shake well before using Add 1 squeeze of the dropper bulb to 2 oz. of water or juice, 2 or 3 times per day. Best taken between meals.
Precautions
Keep out of the reach of children.
Storage
Store away from heat & light
Formula
Withania somnifera
Formulation
Energy & vitality
USDA Organic
Gluten-free
Certified organic by Organic Certifiers
Seals/Symbols
USDA Organic
FDA Statement of Identity
Herbal Supplement
FDA Disclaimer Statement
This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Ashwagandha by Herb Pharm label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Ashwagandha by Herb Pharm
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size0.7 mL Dosage formLiquid Servings per container42 Amounts shown are per serving.
Ashwagandha root (Withania somnifera) extract
Interacts with1,372 drugs
Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...
Ashwagandha root (Withania somnifera) extract monograph & interactionsOther (inactive) ingredients: Certified organic Cane Alcohol, Distilled Water. These complete the product’s ingredient list but are not active constituents.
Ashwagandha by Herb Pharm Drug Interactions
HelloPharmacist Interaction Report
Herb Pharm's Ashwagandha liquid does interact with medications — there's one active ingredient here, and it has documented interactions across several drug types.
The most serious concern is with drugs that suppress the immune system (immunosuppressants): ashwagandha appears to stimulate immunity, which could work against what those drugs are meant to do.
Read the full breakdown — every affected drug type, severity by severity
You'll also want to check before combining this with blood pressure medications (antihypertensive drugs), sedatives and anti-anxiety drugs including benzodiazepines like Valium or Klonopin, diabetes medications, or thyroid hormones — ashwagandha may add to the effects of each, raising the risk of low blood pressure (hypotension), excess sedation, low blood sugar (hypoglycemia), or thyroid hormone overload. There's also a theoretical concern with drugs processed through a specific liver enzyme (CYP1A2 substrates), where ashwagandha might lower their levels.
One more thing: ashwagandha has been linked in rare cases to liver damage, so combining it with drugs known to be hard on the liver warrants caution. Altogether, these interactions span 1,351 individual medications.
Use the medication checker below to see if any of yours are affected before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Ashwagandha?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Ashwagandha interact with 1,372 drugs. Click any drug to see the details.
1 of the 1 ingredient in Ashwagandha interact with drugs. Each result below shows which ingredient is responsible. Ashwagandha root (Withania somnifera) extract
Acetaminophen, OrphenadrineOrfenagesic
How Acetaminophen, Orphenadrine interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Ashwagandha Root (withania Somnifera) Extract + Acetaminophen, Orphenadrine interactionAcetaminophen, OxycodonePercocet, Roxicet, Tylox, Xartemis XR
How Acetaminophen, Oxycodone interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractHepatotoxic Drugs, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root (withania Somnifera) Extract + Acetaminophen, Oxycodone interactionAcetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
How Acetaminophen, Pamabrom, Pyrilamine interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Ashwagandha Root (withania Somnifera) Extract + Acetaminophen, Pamabrom, Pyrilamine interactionAcetaminophen, PentazocineTalacen
How Acetaminophen, Pentazocine interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Ashwagandha Root (withania Somnifera) Extract + Acetaminophen, Pentazocine interactionAcetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
How Acetaminophen, Phenylephrine, Chlorpheniramine interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root (withania Somnifera) Extract + Acetaminophen, Phenylephrine, Chlorpheniramine interactionAcetaminophen, PhenylpropanolamineTetra Caps
How Acetaminophen, Phenylpropanolamine interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Ashwagandha Root (withania Somnifera) Extract + Acetaminophen, Phenylpropanolamine interactionAcetaminophen, Phenylpropanolamine, PhenyltoloxamineSinubid
How Acetaminophen, Phenylpropanolamine, Phenyltoloxamine interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root (withania Somnifera) Extract + Acetaminophen, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, PhenyltoloxaminePercogesic, Relagesic
How Acetaminophen, Phenyltoloxamine interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root (withania Somnifera) Extract + Acetaminophen, Phenyltoloxamine interactionAcetaminophen, Phenyltoloxamine, SalicylamideLobac
How Acetaminophen, Phenyltoloxamine, Salicylamide interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Ashwagandha Root (withania Somnifera) Extract + Acetaminophen, Phenyltoloxamine, Salicylamide interactionAcetaminophen, PropoxypheneDarvocet-N 100, Darvocet-N 50, E-Lor, Wygesic
How Acetaminophen, Propoxyphene interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root (withania Somnifera) Extract + Acetaminophen, Propoxyphene interactionAcetaminophen, PseudoephedrineChildren's Tylenol Sinus, Dristan N.D., Non-Aspirin Sinus, Ornex, Ornex-Max, Sinutab +5 more
How Acetaminophen, Pseudoephedrine interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Ashwagandha Root (withania Somnifera) Extract + Acetaminophen, Pseudoephedrine interactionAcetaminophen, Pseudoephedrine, TriprolidineActifed Plus ES
How Acetaminophen, Pseudoephedrine, Triprolidine interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Ashwagandha Root (withania Somnifera) Extract + Acetaminophen, Pseudoephedrine, Triprolidine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractAntihypertensive Drugs, Cns Depressants Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Ashwagandha Root (withania Somnifera) Extract + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractHepatotoxic Drugs, Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root (withania Somnifera) Extract + Acetohexamide interactionAdagrasibKrazati
How Adagrasib interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root (withania Somnifera) Extract + Adagrasib interactionAdalimumabHumira
How Adalimumab interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Ashwagandha Root (withania Somnifera) Extract + Adalimumab interactionAdalimumab-adazHyrimoz
How Adalimumab-adaz interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Ashwagandha Root (withania Somnifera) Extract + Adalimumab-adaz interactionAdalimumab-adbmCyltezo
How Adalimumab-adbm interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Ashwagandha Root (withania Somnifera) Extract + Adalimumab-adbm interactionAdalimumab-afzbAbrilada
How Adalimumab-afzb interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Ashwagandha Root (withania Somnifera) Extract + Adalimumab-afzb interactionAdalimumab-attoAmjevita
How Adalimumab-atto interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Ashwagandha Root (withania Somnifera) Extract + Adalimumab-atto interactionAdalimumab-bwwdHadlima
How Adalimumab-bwwd interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Ashwagandha Root (withania Somnifera) Extract + Adalimumab-bwwd interactionAdalimumab-fkjpHulio
How Adalimumab-fkjp interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Ashwagandha Root (withania Somnifera) Extract + Adalimumab-fkjp interactionAlbiglutideTanzeum
How Albiglutide interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Ashwagandha Root (withania Somnifera) Extract + Albiglutide interactionAldesleukinProleukin
How Aldesleukin interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root (withania Somnifera) Extract + Aldesleukin interactionAlectinib HydrochlorideAlecensa
How Alectinib Hydrochloride interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root (withania Somnifera) Extract + Alectinib Hydrochloride interactionAlefaceptAmevive
How Alefacept interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Ashwagandha Root (withania Somnifera) Extract + Alefacept interactionAlemtuzumabCampath
How Alemtuzumab interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Read the full Ashwagandha Root (withania Somnifera) Extract + Alemtuzumab interactionAlfentanilAlfenta
How Alfentanil interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root (withania Somnifera) Extract + Alfentanil interactionAliskirenTekturna
How Aliskiren interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root (withania Somnifera) Extract + Aliskiren interactionAllopurinolCaplenal, Cosuric, Rimapurinol, Zyloprim, Zyloric
How Allopurinol interacts with Ashwagandha — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root (withania Somnifera) ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Ashwagandha Root (withania Somnifera) Extract + Allopurinol interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Ashwagandha with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Ashwagandha root (Withania somnifera) extract
Antidiabetes Drugs
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.
Antihypertensive Drugs
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Benzodiazepines
Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.
Cns Depressants
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.
Hepatotoxic Drugs
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.
Immunosuppressants
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.
Thyroid Hormone
Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.
Serotonergic Drugs
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]
Brand information
Manufacturer and brand details for Ashwagandha, from the product label.
Herb Pharm
See all Herb Pharm products- Name
- Herb Pharm
- City
- Williams
- State
- OR
- ZipCode
- 97544
- Phone Number
- 800-348-4372
Ashwagandha by Herb Pharm: Common Questions
Does Ashwagandha by Herb Pharm interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
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Does this liquid contain alcohol?
Will this help my anxiety?
Is long-term use safe?
What if I'm on thyroid medication?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Ashwagandha is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Ashwagandha’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Ashwagandha's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 32 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Ashwagandha 32 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Upton R, ed. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25.
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