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Dietary supplement

Blessed Thistle Ingredients & Drug Interactions

by Herb Pharm

Blessed Thistle label
See full label image
Liquid Category: Botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Blessed Thistle against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Blessed Thistle is a dietary supplement by Herb Pharm with 1 active ingredient. Its ingredients are commonly taken for digestive upset and poor appetite, boosting bile flow, general bitter tonic.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Blessed Thistle flowering herb (Centaurea benedicta) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Blessed Thistle by Herb Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Blessed Thistle by Herb Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Blessed Thistle by Herb Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: blessed thistle flowering herb extract (from Centaurea benedicta). The liquid form also includes certified organic cane alcohol and distilled water as inactive ingredients to preserve and deliver the herb.

Does it work?

No specific claim
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
General wellness

This Blessed Thistle product is marketed for general wellness, not a specific health condition, so there's no single claim to grade — see Blessed Thistle's own graded uses on its monograph.

Why this rating?
  • The label markets general wellness (“optimal well-being”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.

The evidence supporting blessed thistle for dyspepsia (indigestion or stomach upset) is insufficient. We don't have reliable data showing it works for this purpose, so it's not clear whether it will help your digestive symptoms.

The evidence, ingredient by ingredient Blessed Thistle

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Blessed thistle is often well tolerated in small amounts, but human safety data are limited. Large doses can cause nausea or vomiting, and doses higher than 5 grams per cup of tea may cause stomach irritation.

Some people sensitive to the ragweed family (Asteraceae/Compositae) — which includes daisies, chrysanthemums, marigolds, and other plants — can develop an allergic skin reaction if they apply blessed thistle topically. During pregnancy, the safety data advises against it; blessed thistle is traditionally thought to affect the uterus, and we lack adequate safety information.

For breastfeeding, it's been used traditionally to support milk supply, but safety hasn't been well studied — talk with your doctor or pharmacist before using it.

Side effects, ingredient by ingredient Blessed Thistle

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Blessed Thistle.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take H2-blockers (like famotidine or ranitidine), antacids, or proton pump inhibitors (like omeprazole or lansoprazole), check your exact medications with the search tool below before using this product. All three interactions are Minor, but they could reduce how well your stomach medication works.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula marketed for general wellness rather than one specific gradeable purpose. Only minor medication interactions are documented, and safety information is well characterized.

Blessed thistle may appeal to those seeking traditional digestive support, but the evidence for it is thin and we don't know it works. If you take acid-suppressing medications — H2-blockers, antacids, or PPIs — check with us before starting.

Avoid it in pregnancy, and ask your doctor before using it while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 28, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Blessed Thistle, straight from the product label.

Brand Herb Pharm
Barcode (UPC) 090700001094
Net contents 4 fl. Oz.; 120 mL
Market status On market
Date entered into DSLD May 28, 2019
DSLD ID 203079
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Blessed Thistle by Herb Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
0.7 mL
Servings per container
168
UPC/BARCODE
090700001094
IngredientAmount% DV
Blessed Thistle flowering herb (Centaurea benedicta) extract664 mg--

Other ingredients: certified organic Cane Alcohol, distilled Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use Shake well before using Add 1 full squeeze of the dropper bulb to 2 oz. of water or juice, 2 to 4 times per day. Best taken between meals.

Precautions

Keep out of the reach of children

Storage

Store away from heat & light

General

009

Formula

Centaurea benedicta

Blessed Thistle liquid extract

We prepare our Blessed Thistle extract from the flowering herb of certified organically grown Centaurea benedicta plants.

General Statements

Optimal well-being

Dry herb/menstruum ratio: 1:5

Seals/Symbols

USDA Organic

FDA Statement of Identity

Herbal Supplement

Formulation

Gluten-Free

Certified organic by Organic Certifiers

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Blessed Thistle by Herb Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Blessed Thistle label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Blessed Thistle by Herb Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container168 Amounts shown are per serving.

Blessed Thistle flowering herb (Centaurea benedicta) extract

Interacts with
36 drugs
664 mg per serving

Blessed thistle is a bitter herb traditionally used to stimulate appetite and ease mild digestive complaints. High-quality human studies are lacking,...

Blessed Thistle flowering herb (Centaurea benedicta) extract monograph & interactions

Other (inactive) ingredients: Certified organic Cane Alcohol, Distilled Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Blessed Thistle by Herb Pharm Drug Interactions

Want to check YOUR meds against Blessed Thistle?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Blessed Thistle flowering herb (Centaurea benedicta) extract 36

Individual Drug Interactions

The ingredients in Blessed Thistle interact with 36 drugs. Click any drug to see the details.

1 of the 1 ingredient in Blessed Thistle interact with drugs. Each result below shows which ingredient is responsible. Blessed Thistle flowering herb (Centaurea benedicta) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Blessed Thistle with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Blessed Thistle flowering herb (Centaurea benedicta) extract3 drug types · 36 drugs

Antacids

Theoretically, blessed thistle might decrease the effectiveness of antacids.
There are reports that blessed thistle increases stomach acid.

Likelihood Possible Evidence D
H2-Blockers

Theoretically, blessed thistle might decrease the effectiveness of H2-blockers.
There are reports that blessed thistle increases stomach acid.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Theoretically, blessed thistle might decrease the effectiveness of PPIs.
There are reports that blessed thistle increases stomach acid.

Likelihood Possible Evidence D
Blessed Thistle flowering herb (Centaurea benedicta) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Blessed Thistle, from the product label.

Herb Pharm

See all Herb Pharm products
Name
Herb Pharm
City
Williams
State
OR
ZipCode
97544
Phone Number
800-348-4372
Web Address
www.herb-pharm.com
Pharmacist Counseling Corner

Blessed Thistle by Herb Pharm: Common Questions

Does Blessed Thistle by Herb Pharm interact with any medications?
Yes. Based on its ingredients, Blessed Thistle has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Blessed Thistle contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is blessed thistle safe to take while I'm pregnant?
No. Blessed thistle is traditionally thought to affect the uterus, and the safety data advises against using it during pregnancy. Talk with your doctor before considering any herbal supplement while pregnant.
Can I use this if I'm breastfeeding?
Blessed thistle has been used traditionally to support milk supply, but safety hasn't been well studied. Check with your doctor or pharmacist first — they can give you personalized advice for your situation.
What does blessed thistle do?
It's traditionally used to support digestion and stomach comfort, but we don't have reliable evidence showing it actually works for indigestion or dyspepsia.
Can blessed thistle cause side effects?
In small amounts it's usually well tolerated, but large doses can cause nausea, vomiting, or stomach irritation. If you're sensitive to ragweed or related plants, applying it to your skin could trigger an allergic reaction like dermatitis.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Blessed Thistle label
Go deeper

The Full Monographs Behind Blessed Thistle’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Blessed Thistle

Interacts with 36 drugs

Blessed thistle is a bitter herb traditionally used to stimulate appetite and ease mild digestive complaints. High-quality human studies are lacking, so its benefits are not well proven. It...

Read the full Blessed Thistle monograph →
Sources

Sources & How We Checked

Blessed Thistle's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Blessed Thistle 2 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

See these in context on the Blessed Thistle monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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