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Dietary supplement

Blessed Thistle 2,000 mg Ingredients & Drug Interactions

by Nature's Answer

Blessed Thistle 2,000 mg label
See full label image
Liquid Category: Botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Blessed Thistle 2,000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Blessed Thistle 2,000 mg is a dietary supplement by Nature's Answer with 1 active ingredient. Its ingredients are commonly taken for digestive upset and poor appetite, boosting bile flow, general bitter tonic.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Blessed Thistle (Cnicus benedictus) aerial parts extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Blessed Thistle 2,000 mg by Nature's Answer

Ask about any prescription or over-the-counter medication and we check it for interactions with Blessed Thistle 2,000 mg by Nature's Answer — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Blessed Thistle 2,000 mg by Nature's Answer

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: blessed thistle (Cnicus benedictus) aerial parts extract at 2,000 mg per serving. Blessed thistle is a plant traditionally used to support digestion.

The liquid also contains purified water, vegetable glycerin, and 12–15% certified organic alcohol as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Blessed Thistle product and its label doesn't state a use — see Blessed Thistle's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for blessed thistle in treating indigestion (dyspepsia) is insufficient to rate. We don't have reliable data showing whether it actually works for that purpose.

The evidence, ingredient by ingredient Blessed Thistle

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Blessed thistle is often well tolerated in small amounts, but human safety data are limited. At high doses — more than 5 grams per cup of tea — it can cause stomach irritation and vomiting.

Topically, it can trigger an allergic skin reaction in people sensitive to plants in the ragweed and daisy family (Asteraceae). The safety data advises against blessed thistle during pregnancy because it is traditionally thought to affect the uterus and lacks safety study.

For breastfeeding, blessed thistle has been used traditionally to support milk supply, but safety has not been well studied — talk with your doctor or pharmacist before using it.

Side effects, ingredient by ingredient Blessed Thistle

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Blessed Thistle.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you're on any H2-blockers (acid reducers like famotidine), antacids, or proton pump inhibitors (PPIs like omeprazole). Blessed thistle may reduce how well these work by increasing stomach acid.

All three types are Minor interactions, but they're still worth discussing with your pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Blessed thistle may be worth considering if you're looking for traditional digestive support and you don't take acid-reducing medications. If you do take H2-blockers, antacids, or PPIs, check with your pharmacist first.

Avoid it during pregnancy, and discuss it with your doctor if you're breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Blessed Thistle 2,000 mg, straight from the product label.

Brand Nature's Answer
Barcode (UPC) 083000001451
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD Apr 22, 2016
DSLD ID 58953
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Blessed Thistle 2,000 mg by Nature's Answer, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
2 mL
Servings per container
15
UPC/BARCODE
083000001451
IngredientAmount% DV
Blessed Thistle (Cnicus benedictus) aerial parts extract2000 mg--

Other ingredients: purified Water, Vegetable Glycerin, 12-15% certified organic Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1-2 mL (28-56 drops) three (3) times a day in a small amount of water. Shake well.

Precautions

Keep out of reach of children.

Warning: Do not use is pregnant or nursing.

Do not use if safety seal is damaged or missing.

Brand IP Statement(s)

2015 Nature's Answer

Advanced Botanical Fingerprint

Discover Nature's Answer

Our organic alcohol extracts are produced using our cold Bio-Chelated proprietary extraction process, yielding a Holistically Balanced Advanced Botanical Fingerprint extract in the same synergistic ratios as in the plant.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Gluten Free

Bio-Chelated Cold Extraction Process

K Parve

Formula

K Parve

Cnicus benedictus

Low Alcohol

General

9209 Rev. 215 1016

General Statements

Since 1972

Super Concentrated 2,000 mg

Our facility is cGMP certified, organic and kosher certified.

Formulation

Gluten-Free

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Blessed Thistle 2,000 mg by Nature's Answer label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Blessed Thistle 2,000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Blessed Thistle 2,000 mg by Nature's Answer

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container15 Amounts shown are per serving.

Blessed Thistle (Cnicus benedictus) aerial parts extract

Interacts with
36 drugs
2000 mg per serving

Blessed thistle is a bitter herb traditionally used to stimulate appetite and ease mild digestive complaints. High-quality human studies are lacking,...

Blessed Thistle (Cnicus benedictus) aerial parts extract monograph & interactions

Other (inactive) ingredients: Purified Water, Vegetable Glycerin, 12-15% certified organic Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Blessed Thistle 2,000 mg by Nature's Answer Drug Interactions

Want to check YOUR meds against Blessed Thistle 2,000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Blessed Thistle (Cnicus benedictus) aerial parts extract 36

Individual Drug Interactions

The ingredients in Blessed Thistle 2,000 mg interact with 36 drugs. Click any drug to see the details.

1 of the 1 ingredient in Blessed Thistle 2,000 mg interact with drugs. Each result below shows which ingredient is responsible. Blessed Thistle (Cnicus benedictus) aerial parts extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Blessed Thistle 2,000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Blessed Thistle (Cnicus benedictus) aerial parts extract3 drug types · 36 drugs

Antacids

Theoretically, blessed thistle might decrease the effectiveness of antacids.
There are reports that blessed thistle increases stomach acid.

Likelihood Possible Evidence D
H2-Blockers

Theoretically, blessed thistle might decrease the effectiveness of H2-blockers.
There are reports that blessed thistle increases stomach acid.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Theoretically, blessed thistle might decrease the effectiveness of PPIs.
There are reports that blessed thistle increases stomach acid.

Likelihood Possible Evidence D
Blessed Thistle (Cnicus benedictus) aerial parts extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Blessed Thistle 2,000 mg, from the product label.

Nature's Answer

See all Nature's Answer products
Name
Nature's Answer
City
Hauppauge
State
NY
ZipCode
11788-3943
Phone Number
(800) 439-2324
Web Address
www.naturesanswer.com
Pharmacist Counseling Corner

Blessed Thistle 2,000 mg by Nature's Answer: Common Questions

Does Blessed Thistle 2,000 mg by Nature's Answer interact with any medications?
Yes. Based on its ingredients, Blessed Thistle 2,000 mg has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Blessed Thistle 2,000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is blessed thistle safe to take while I'm breastfeeding?
Blessed thistle has been used traditionally to support milk supply, but its safety hasn't been well studied during breastfeeding. There isn't enough data to know either way, so talk with your doctor or pharmacist for personalized advice before starting it.
Can I take this if I'm pregnant?
No. The safety data advises against blessed thistle during pregnancy because it is traditionally thought to affect the uterus and lacks safety study.
What are the side effects of blessed thistle?
In small amounts, it's often well tolerated. At high doses — more than 5 grams per cup of tea — it can cause stomach irritation and vomiting. Topically, it may trigger an allergic skin reaction in people sensitive to ragweed, daisies, and related plants.
Does blessed thistle actually work for indigestion?
The evidence is insufficient to rate. We don't have reliable data showing whether it works for that purpose.
What is blessed thistle used for?
Blessed thistle is traditionally used to support digestion, though reliable evidence for its effectiveness is limited.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Blessed Thistle 2,000 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Blessed Thistle 2,000 mg label
Go deeper

The Full Monographs Behind Blessed Thistle 2,000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Blessed Thistle

Interacts with 36 drugs

Blessed thistle is a bitter herb traditionally used to stimulate appetite and ease mild digestive complaints. High-quality human studies are lacking, so its benefits are not well proven. It...

Read the full Blessed Thistle monograph →
Sources

Sources & How We Checked

Blessed Thistle 2,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Blessed Thistle 2 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

See these in context on the Blessed Thistle monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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