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Dietary supplement

Blessed Thistle 780 mg Ingredients & Drug Interactions

by Nature's Way

Blessed Thistle 780 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Blessed Thistle 780 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Blessed Thistle 780 mg is a dietary supplement by Nature's Way with 1 active ingredient. Its ingredients are commonly taken for digestive upset and poor appetite, boosting bile flow, general bitter tonic.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Blessed Thistle. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Blessed Thistle 780 mg by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Blessed Thistle 780 mg by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Blessed Thistle 780 mg by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: blessed thistle at 780 mg per capsule. Blessed thistle is a plant traditionally used to support digestive function.

The capsule itself is plant-derived.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Blessed Thistle's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: traditional digestive aid.
  • We looked for evidence on: Dyspepsia, indigestion, poor appetite, digestive upset.
  • The closest evidence on file: Blessed Thistle is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).

The evidence for blessed thistle in treating dyspepsia (stomach discomfort and indigestion) is insufficient to establish whether it works. We hold no effectiveness data beyond that assessment in our monograph.

The evidence, ingredient by ingredient Blessed Thistle

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Blessed thistle is generally well tolerated in small amounts, though human safety data are limited. In larger doses — particularly above 5 grams per cup of tea — it can cause stomach irritation, nausea, and vomiting.

Topically, it may trigger an allergic reaction in people sensitive to ragweed or other plants in the daisy family. The safety data advise against blessed thistle during pregnancy because it's traditionally thought to affect the uterus and lacks adequate study in pregnant people.

It's used traditionally to support milk supply, but safety in breastfeeding has not been well studied — talk with your doctor or pharmacist before taking it while nursing.

Side effects, ingredient by ingredient Blessed Thistle

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Blessed Thistle.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take H2-blockers (like famotidine), antacids, or proton pump inhibitors (PPIs, like omeprazole) for heartburn or reflux, check those exact medications with the tool below — blessed thistle may reduce how well they work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Blessed thistle is an option if you're interested in traditional digestive support, but evidence for its effectiveness is thin. If you take stomach acid medications (H2-blockers, antacids, or PPIs), double-check this supplement with your pharmacist first.

Avoid it if you're pregnant, and ask your doctor before using it while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 27, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Blessed Thistle 780 mg, straight from the product label.

Brand Nature's Way
Barcode (UPC) 033674107003
Net contents 100 Vegan Capsule(s)
Market status On market
Date entered into DSLD Jul 27, 2021
DSLD ID 251522
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Blessed Thistle 780 mg by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
50
UPC/BARCODE
033674107003
IngredientAmount% DV
Blessed Thistle780 mg--

Other ingredients: plant-derived Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Traditional digestive aid At Nature's Way, we believe nature knows best. That's why our mission is to seek out the best herbs the earth has to give. We will go to any continent or country to find where herbs grow best, so we can bring you the purest botanicals possible. It's the way we deliver uncompromising quality and the way to help you live healthier. It's not just our way, it's Nature's Way.

Non GMO Project Verified - nongmoproject.org

Gluten free. No sugar, salt, yeast, wheat, corn, soy, dairy products, or artificial colors, flavors, or preservatives.

Vegan

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Nature's Way - Since 1969

Bottles made from 97% post-consumer recycled plastic

Seals/Symbols

Certified Authentic Tru-ID Non GMO Project Verified - nongmoproject.org

Quality Global Sourcing - Bottled & Tested in the USA

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Take 2 capsules three times daily.

Precautions

Caution: Individuals with allergies to plants of the Asteraceae (Compositae) family, including ragweed, should use this product with caution.

Caution: If you are pregnant, nursing, or taking any medications, consult a healthcare professional before use.

Keep out of reach of children.

Safety sealed with printed inner seal. Do not use if seal is broken or missing.

Brand IP Statement(s)

2019 Nature’s Way Brands, LLC

Formula

Blessed Thistle 780 mg per serving

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Blessed Thistle 780 mg by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Blessed Thistle 780 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Blessed Thistle 780 mg by Nature's Way

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Blessed Thistle

Interacts with
36 drugs
780 mg per serving

Blessed thistle is a bitter herb traditionally used to stimulate appetite and ease mild digestive complaints. High-quality human studies are lacking,...

Blessed Thistle monograph & interactions

Other (inactive) ingredients: Plant-derived Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Blessed Thistle 780 mg by Nature's Way Drug Interactions

Want to check YOUR meds against Blessed Thistle 780 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Blessed Thistle 36

Individual Drug Interactions

The ingredients in Blessed Thistle 780 mg interact with 36 drugs. Click any drug to see the details.

1 of the 1 ingredient in Blessed Thistle 780 mg interact with drugs. Each result below shows which ingredient is responsible. Blessed Thistle

Each ingredient & the kinds of drugs it affects

For each ingredient in Blessed Thistle 780 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Blessed Thistle3 drug types · 36 drugs

Antacids

Theoretically, blessed thistle might decrease the effectiveness of antacids.
There are reports that blessed thistle increases stomach acid.

Likelihood Possible Evidence D
H2-Blockers

Theoretically, blessed thistle might decrease the effectiveness of H2-blockers.
There are reports that blessed thistle increases stomach acid.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Theoretically, blessed thistle might decrease the effectiveness of PPIs.
There are reports that blessed thistle increases stomach acid.

Likelihood Possible Evidence D
Blessed Thistle full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Blessed Thistle 780 mg, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Blessed Thistle 780 mg by Nature's Way: Common Questions

Does Blessed Thistle 780 mg by Nature's Way interact with any medications?
Yes. Based on its ingredients, Blessed Thistle 780 mg has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Blessed Thistle 780 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data advise against blessed thistle during pregnancy because it's traditionally thought to affect the uterus and hasn't been adequately studied in pregnant people. During breastfeeding, it's used traditionally to support milk supply, but safety hasn't been well studied — talk with your doctor or pharmacist for personalized advice.
What are the side effects?
In small amounts, blessed thistle is generally well tolerated. Higher doses — particularly above 5 grams per cup of tea — can cause stomach irritation, nausea, and vomiting. Topically, it may cause an allergic reaction (like dermatitis) in people sensitive to ragweed or other plants in the daisy family.
Does blessed thistle actually work for indigestion?
The evidence is insufficient to establish whether blessed thistle helps with dyspepsia (stomach discomfort). There isn't enough reliable data in our records to say whether it's effective for that use.
Why might this interact with my acid reflux medication?
Blessed thistle is reported to increase stomach acid, which could theoretically work against H2-blockers, antacids, and PPIs — making those medications less effective. It's a Minor interaction, but worth checking with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Blessed Thistle 780 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Blessed Thistle 780 mg label
Go deeper

The Full Monographs Behind Blessed Thistle 780 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Blessed Thistle

Interacts with 36 drugs

Blessed thistle is a bitter herb traditionally used to stimulate appetite and ease mild digestive complaints. High-quality human studies are lacking, so its benefits are not well proven. It...

Read the full Blessed Thistle monograph →
Sources

Sources & How We Checked

Blessed Thistle 780 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Blessed Thistle 2 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

See these in context on the Blessed Thistle monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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