Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Astaxanthin Ingredients & Drug Interactions

by Pure Encapsulations

Astaxanthin label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Astaxanthin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Astaxanthin is a dietary supplement by Pure Encapsulations with 1 active ingredient. Its ingredients are commonly taken for antioxidant support, skin health and aging, eye health.Based on those ingredients, 671 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Astaxanthin by Pure Encapsulations

Ask about any prescription or over-the-counter medication and we check it for interactions with Astaxanthin by Pure Encapsulations — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Astaxanthin by Pure Encapsulations

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Pure Encapsulations Astaxanthin contains one active ingredient: astaxanthin, a red pigment found naturally in algae and seafood. The softgel capsule also holds extra virgin olive oil and gelatin as inactive ingredients to deliver the astaxanthin.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Astaxanthin's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: skin, joint and eye health.
  • We looked for evidence on: Age-related macular degeneration (AMD), Aging skin, Dry eye, Exercise-induced muscle soreness, Osteoarthritis, Rheumatoid arthritis (RA) — and 4 related terms.
  • The closest evidence on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Aging skin, Dry eye, Exercise-induced muscle soreness, Osteoarthritis, and more.

The evidence we have on file is not yet established for astaxanthin across the conditions listed — age-related cognitive decline, age-related macular degeneration, aging skin, Alzheimer disease, athletic performance, and carpal tunnel syndrome all show insufficient reliable evidence to rate whether it works. That doesn't mean it doesn't; it means we don't have strong clinical data backing its use for these purposes right now.

The evidence, ingredient by ingredient Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Astaxanthin is generally well tolerated in studies, though long-term safety data are limited. Some people report abdominal pain, diarrhea, or a red color to their stool — these are mild and infrequent, but at higher doses (40 mg daily) severe stomach pain has occurred in a small number of users.

Due to insufficient safety data, the evidence advises against astaxanthin during pregnancy and while breastfeeding. If you're pregnant, planning pregnancy, or nursing, talk with your pharmacist or doctor before starting this supplement.

Side effects, ingredient by ingredient Astaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Astaxanthin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 672 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Pure Encapsulations Astaxanthin, check whether you take any drugs broken down by the liver enzymes CYP3A4 or CYP2B6 — these include a large range of common medications. Use the interaction tool on this page to search your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Astaxanthin may be worth considering if you're curious about antioxidant support, but you'll want to check it against any medications you're taking first — the interaction potential is broad. Anyone on regular prescriptions should run this through the checker below before starting.

Pregnant or breastfeeding? Skip it for now and ask your pharmacist or doctor.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Astaxanthin, straight from the product label.

Brand Pure Encapsulations
Barcode (UPC) 766298006147
Net contents 120 Softgel Capsule(s)
Market status On market
Date entered into DSLD Nov 21, 2018
DSLD ID 183770
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Astaxanthin by Pure Encapsulations, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel Capsule(s)
Maximum serving Sizes:
1 Softgel Capsule(s)
Servings per container
120
UPC/BARCODE
766298006147
IngredientAmount% DV
Astaxanthin4 mg--

Other ingredients: extra virgin Olive Oil, Gelatin Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Recommendations: As a dietary supplement, take 1 capsule, 1-3 times daily, with meals.

Precautions

Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.

Keep out of the reach of children.

Use only if safety seal is intact.

Gluten-Free, Non-GMO & Hypoallergenic

General Statements

Scan to learn about our hypoallergenic supplements

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.

Stable, fat-soluable antioxidant; Skin, join and eye health

Formulation

Gluten-Free, Non-GMO & Hypoallergenic

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General

v7 code: AST1

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Astaxanthin by Pure Encapsulations label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Astaxanthin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Astaxanthin by Pure Encapsulations

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel Capsule(s) Dosage formSoftgel Capsule Servings per container120 Amounts shown are per serving.

Astaxanthin

Interacts with
671 drugs
4 mg per serving Form: Haematococcus pluvialis microalgae

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin monograph & interactions

Other (inactive) ingredients: Extra virgin Olive Oil, Gelatin Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Astaxanthin by Pure Encapsulations Drug Interactions

Want to check YOUR meds against Astaxanthin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
671Drugs
671 Moderate

Ingredients driving the most interactions

Astaxanthin 671

Individual Drug Interactions

The ingredients in Astaxanthin interact with 671 drugs. Click any drug to see the details.

1 of the 1 ingredient in Astaxanthin interact with drugs. Each result below shows which ingredient is responsible. Astaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Astaxanthin with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Astaxanthin, from the product label.

Pure Encapsulations

See all Pure Encapsulations products
Name
Pure Encapsulations
Street Address
490 Boston Post Road
City
Sudbury
State
MA
Phone Number
1-800-753-2277
Web Address
www.PureEncapsulations.com
Pharmacist Counseling Corner

Astaxanthin by Pure Encapsulations: Common Questions

Does Astaxanthin by Pure Encapsulations interact with any medications?
Yes. Based on its ingredients, Astaxanthin has a known interaction with 671 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Astaxanthin contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does astaxanthin do in this supplement?
Astaxanthin is a red pigment that acts as an antioxidant. The supplement is marketed for potential benefits to aging skin, eye health, brain function, and athletic performance, though the clinical evidence supporting these uses isn't yet established.
What side effects might I experience?
Most people tolerate astaxanthin well. The most common side effects are mild — abdominal pain, diarrhea, or a red color to your stool. Higher doses have occasionally caused severe stomach pain in a small number of people.
Can I take this if I'm pregnant or breastfeeding?
No — there isn't enough safety data to know whether astaxanthin is safe during pregnancy or while nursing. The evidence advises against it, so talk with your doctor or pharmacist before taking it in either situation.
How many active ingredients are in this?
One — astaxanthin. The rest of the softgel is olive oil and gelatin, which are inactive ingredients that help deliver the astaxanthin.
Is long-term use of this supplement safe?
Astaxanthin appears well tolerated in the studies we have, but long-term safety data are limited. If you plan to take it regularly over months or years, it's a good idea to check in with your pharmacist or doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Astaxanthin is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Astaxanthin label
Go deeper

The Full Monographs Behind Astaxanthin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph →
Sources

Sources & How We Checked

Astaxanthin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team