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Dietary supplement

Astaxanthin Plus 4 mg Ingredients & Drug Interactions

by Natural Factors

Astaxanthin Plus 4 mg label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Astaxanthin Plus 4 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Astaxanthin Plus 4 mg is a dietary supplement by Natural Factors with 3 active ingredients. Its ingredients are commonly taken for eye health, age-related macular degeneration, cataract prevention.Based on those ingredients, 751 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astaxanthin, Zeaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Astaxanthin Plus 4 mg by Natural Factors

Ask about any prescription or over-the-counter medication and we check it for interactions with Astaxanthin Plus 4 mg by Natural Factors — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Astaxanthin Plus 4 mg by Natural Factors

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Astaxanthin Plus 4 mg contains three active ingredients: lutein, zeaxanthin, and astaxanthin. Lutein and zeaxanthin are carotenoids (plant pigments) that concentrate in the eye and may support vision health, especially as we age.

Astaxanthin is another carotenoid with antioxidant properties. The softgel is filled with organic flaxseed oil, which serves as an inactive carrier and excipient.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: antioxidant support for cardiovascular, immune, skin and eye health.
  • We looked for evidence on: Cardiovascular disease (CVD), Age-related macular degeneration (AMD), Cataracts, Aging skin, Sunburn, Asthenopia (eye strain) — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

The evidence for these ingredients is mixed. Lutein is rated possibly effective for age-related macular degeneration (AMD) and cataracts, but the data for astaxanthin on these same conditions is insufficient to establish effectiveness in our data.

Zeaxanthin is also possibly effective for AMD. For other uses — cognitive decline, Alzheimer's disease, asthma, and several others — the evidence we hold is too limited to rate.

Talk with your eye doctor or pharmacist about whether this product matches what you're trying to achieve.

The evidence, ingredient by ingredient Lutein Zeaxanthin Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lutein is generally well tolerated at typical doses, with doses up to 20 mg daily showing no adverse effects in trials. Zeaxanthin is also well tolerated at standard supplement amounts.

Astaxanthin appears well tolerated overall, though some trial participants reported abdominal pain, diarrhea, or red-colored stools — the latter is cosmetic and harmless. Long-term safety data for astaxanthin are limited.

For pregnancy, lutein and zeaxanthin are rated likely safe, but astaxanthin has insufficient safety data and the data advises against use during pregnancy and breastfeeding. If you're pregnant or nursing, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Lutein Zeaxanthin Astaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Astaxanthin, Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 752 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist if you're on antidiabetes drugs (there's a theoretical risk of low blood sugar) or any medications metabolized by CYP3A4 or CYP2B6 liver enzymes — astaxanthin may reduce their effectiveness. These include some immunosuppressants, certain cancer and heart medications, and some cholesterol drugs, though you'll need to verify your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is mainly for people interested in eye health support, especially if you're concerned about age-related vision changes. If you take blood-sugar-lowering medications or drugs metabolized by your liver, check your medications with the tool below first.

Pregnant or breastfeeding individuals should talk with their doctor or pharmacist — astaxanthin safety data are limited in those situations.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Astaxanthin Plus 4 mg, straight from the product label.

Brand Natural Factors
Barcode (UPC) 068958010137
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Jun 23, 2017
DSLD ID 74714
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Astaxanthin Plus 4 mg by Natural Factors, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
068958010137
IngredientAmount% DV
Lutein1 mg--
Zeaxanthin170 mcg--
Astaxanthin4 mg--

Other ingredients: Softgel, organic Flaxseed Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Isura

Formulation

Non-GMO

Contains no artificial colors, preservatives, or sweeteners; no dairy, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, salt, tree nuts, or GMOs.

General Statements

Mass spec Documentation Lab tested

Clinical studies have demonstrated that astaxanthin, a member of the carotenoid family, supports cardiovascular and immune health, as well as protects the skin from premature aging and other health risks associated with exposure to the sun’s UV rays.

Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Product of Canada Recyclable container and label.

Powerful cell protection

Suggested/Recommended/Usage/Directions

Suggested Use: 1 softgel per day or as directed by a health professional.

Precautions

Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding, or trying to conceive, or if you are taking medication, have a medical condition, or anticipate a surgery.

Keep out of the reach of children.

Sealed for your protection. Do not use if seal is broken.

Formula

Astaxanthin Plus combines one of nature’s most supportive antioxidants, astaxanthin, with lutein and zeaxanthin for the maintenance of good health.

Astaxanthin Plus contains natural astaxanthin, which possesses greater biological activity than the artificial synthetic astaxanthin that many products use.

Storage

For freshness, store in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Purity & potency guaranteed

FDA Statement of Identity

Dietary Supplement

General

R1

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Astaxanthin Plus 4 mg by Natural Factors label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Astaxanthin Plus 4 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Astaxanthin Plus 4 mg by Natural Factors

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lutein

No known
interactions
1 mg per serving Form: Marigold

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutein monograph & interactions

Zeaxanthin

Interacts with
86 drugs
170 mcg per serving Form: Marigold

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin monograph & interactions

Astaxanthin

Interacts with
671 drugs
4 mg per serving Form: Haematococcus pluvialis

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin monograph & interactions

Other (inactive) ingredients: Softgel, Organic Flaxseed Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Astaxanthin Plus 4 mg by Natural Factors Drug Interactions

Want to check YOUR meds against Astaxanthin Plus 4 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
751Drugs
751 Moderate

Ingredients driving the most interactions

Astaxanthin 671
Zeaxanthin 86

Individual Drug Interactions

The ingredients in Astaxanthin Plus 4 mg interact with 751 drugs. Click any drug to see the details.

2 of the 3 ingredients in Astaxanthin Plus 4 mg interact with drugs. Each result below shows which ingredient is responsible. Astaxanthin Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Astaxanthin Plus 4 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin full monograph & interactions

Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Astaxanthin Plus 4 mg, from the product label.

Natural Factors

See all Natural Factors products
Name
Natural Factors Canada
Pharmacist Counseling Corner

Astaxanthin Plus 4 mg by Natural Factors: Common Questions

Does Astaxanthin Plus 4 mg by Natural Factors interact with any medications?
Yes. Based on its ingredients, Astaxanthin Plus 4 mg has a known interaction with 751 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Astaxanthin Plus 4 mg contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my vision or prevent macular degeneration?
Lutein and zeaxanthin are possibly effective for age-related macular degeneration based on available evidence. Astaxanthin's evidence for vision is insufficient to rate. The data we hold doesn't establish it for other eye conditions. Talk with your eye doctor about whether this fits your specific situation.
Can I take this if I'm pregnant or breastfeeding?
Lutein and zeaxanthin are rated likely safe in pregnancy and lactation, but astaxanthin safety data are limited — the data advise against it during pregnancy and breastfeeding. Because this product contains astaxanthin, check with your doctor or pharmacist for personalized advice before starting it.
What are the side effects?
Astaxanthin may cause abdominal pain, diarrhea, or red-colored stools. The red color is harmless — it's just from the pigment. Most people tolerate these ingredients well at typical doses, but long-term safety data for astaxanthin are limited.
Is lutein the main ingredient?
This product has three active carotenoids — lutein, zeaxanthin, and astaxanthin — each contributing to the supplement's intended effects. Lutein and zeaxanthin have more established evidence for eye health; astaxanthin's evidence is less clear in the data we hold.
Does this product have fillers or other ingredients?
Yes — the softgel capsule itself is an inactive ingredient, and it's filled with organic flaxseed oil as a carrier. Those are the only inactive ingredients listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Astaxanthin Plus 4 mg label
Go deeper

The Full Monographs Behind Astaxanthin Plus 4 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph → Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph →
Sources

Sources & How We Checked

Astaxanthin Plus 4 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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