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Dietary supplement

Astragalus Root 500 mg Ingredients & Drug Interactions

by Herbal Authority

Astragalus Root 500 mg label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Astragalus Root 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Astragalus Root 500 mg is a dietary supplement by Herbal Authority with 1 active ingredient. Its ingredients are commonly taken for immune support, colds and flu, upper respiratory infections.Based on those ingredients, 208 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astragalus root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Astragalus Root 500 mg by Herbal Authority

Ask about any prescription or over-the-counter medication and we check it for interactions with Astragalus Root 500 mg by Herbal Authority — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Astragalus Root 500 mg by Herbal Authority

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: astragalus root extract at 500 mg per serving. Astragalus has been used in traditional medicine to support immune function and general wellness.

The liquid form also includes vegetable glycerin, water, and natural caramel color as inactive ingredients to preserve and flavor the product.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Astragalus product and its label doesn't state a use — see Astragalus's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold for astragalus covers several conditions — hay fever, amenorrhea (absent periods), aplastic anemia, angina, asthma, and beta-thalassemia — but for all of them, the data shows insufficient reliable evidence to rate how well it works. If you're considering astragalus for a specific health concern, talk with your doctor or pharmacist about whether the research supports its use for your situation.

The evidence, ingredient by ingredient Astragalus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Astragalus is generally well tolerated in the short term in healthy adults, though quality human safety data is limited. Some people have reported dizziness or skin reactions (rash, eczema, itching) in clinical studies, though these effects may not have been caused by the herb itself.

The safety data advises against using astragalus during pregnancy or while breastfeeding because there isn't enough reliable information to know it's safe for your baby.

Side effects, ingredient by ingredient Astragalus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Astragalus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 208 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start this product, check with your doctor or pharmacist if you take immunosuppressants (to prevent organ rejection or manage autoimmune disease), lithium (a mood stabilizer), cyclophosphamide (a chemotherapy drug), or any antidiabetes medications. These are all Moderate-severity interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Astragalus Root by Herbal Authority is worth considering if you're interested in immune support — but it's not right for everyone. If you take immunosuppressants, lithium, chemotherapy, or diabetes medications, you'll need to check with your doctor or pharmacist first.

Pregnant or breastfeeding women should avoid it. Talk over whether it fits your health goals and medications with your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Astragalus Root 500 mg, straight from the product label.

Brand Herbal Authority
Barcode (UPC) 074312778469
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD Nov 25, 2011
DSLD ID 1738
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Astragalus Root 500 mg by Herbal Authority, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
UPC/BARCODE
074312778469
IngredientAmount% DV
Astragalus root extract500 mg--

Other ingredients: Vegetable Glycerin, Water, natural Caramel color

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

CONCENTRATED EXTRACT

Liquid Herbal Supplement

Suggested/Recommended/Usage/Directions

DIRECTIONS: For adults, mix one (1) mL of extract in a little water one to six times daily, preferably with a meal.

SHAKE WELL

Precautions

Keep out of reach of children.

Not intended for use by persons under the age of 18.

WARNING: If you are pregnant, nursing or taking any medications, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Do not use if seal under cap is broken or missing.

Storage

REFRIGERATE AFTER OPENING

Store in a cool, dry place.

Formula

This bottle contains 100% pure cold processed Extract made from the finest selected herbs obtainable, in a base of pure vegetable glycerin. It is highly concentrated and gives you more herb power for your money!

General Statements

500 MG

Calibrated Dropper Inside

Each serving (1 mL) is equivalent to 500 mg of the dried herb.

PLEASE RECYCLE

These herbs are extracted using alcohol and water or other natural menstruums to capture active constituents. All alcohol is then removed.

General

PROD. # 7846 B7846 03C

Brand IP Statement(s)

©Herbal Authority(R) 2009

Formulation

ALCOHOL FREE

No animal testing, no animal ingredients.

No Artificial Flavor or Sweetener, No Preservatives, No Sugar, No Starch, No Milk, No Lactose, No Soy, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.

Seals/Symbols

QUALITY ASSURED

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Astragalus Root 500 mg by Herbal Authority label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Astragalus Root 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Astragalus Root 500 mg by Herbal Authority

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Amounts shown are per serving.

Astragalus root extract

Interacts with
208 drugs
500 mg per serving

Astragalus is a root used for centuries in traditional Chinese medicine, mainly to support the immune system and help the body cope with stress. While...

Astragalus root extract monograph & interactions

Other (inactive) ingredients: Vegetable Glycerin, Water, Natural Caramel color. These complete the product’s ingredient list but are not active constituents.

Interaction report

Astragalus Root 500 mg by Herbal Authority Drug Interactions

Want to check YOUR meds against Astragalus Root 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
208Drugs
208 Moderate

Ingredients driving the most interactions

Astragalus root extract 208

Individual Drug Interactions

The ingredients in Astragalus Root 500 mg interact with 208 drugs. Click any drug to see the details.

1 of the 1 ingredient in Astragalus Root 500 mg interact with drugs. Each result below shows which ingredient is responsible. Astragalus root extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Astragalus Root 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Astragalus root extract4 drug types · 208 drugs

Antidiabetes Drugs

Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research in humans shows that astragalus might have hypoglycemic effects. Theoretically, taking astragalus, especially in combination with other hypoglycemic agents, might increase the risk of hypoglycemia.

Likelihood Probable Evidence A
Cyclophosphamide

Theoretically, astragalus might interfere with cyclophosphamide therapy.
Evidence regarding the effect of astragalus on immunosuppression caused by cyclophosphamide is conflicting. Some animal research suggests that astragalus reverses cyclophosphamide-induced immunosuppression. However, other animal research shows no effect.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, astragalus might interfere with immunosuppressive therapy.
Astragalus seems to stimulate immune function. Theoretically, taking astragalus might decrease the effects of immunosuppressive therapy.

Likelihood Possible Evidence D
Lithium

Theoretically, astragalus might increase levels and adverse effects of lithium.
Animal research suggests that astragalus has diuretic properties. Theoretically, due to this diuretic effect, astragalus might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Astragalus root extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Astragalus Root 500 mg, from the product label.

Herbal Authority

See all Herbal Authority products
Name
Herbal Authority(R)
Street Address
4320 Veterans Memorial Hwy
City
Holbrook
State
NY
ZipCode
11741
Pharmacist Counseling Corner

Astragalus Root 500 mg by Herbal Authority: Common Questions

Does Astragalus Root 500 mg by Herbal Authority interact with any medications?
Yes. Based on its ingredients, Astragalus Root 500 mg has a known interaction with 208 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Astragalus Root 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is astragalus safe to use while I'm pregnant or breastfeeding?
No — the safety data advises against it. There isn't enough reliable information to know whether it's safe for your baby during pregnancy or while nursing. Talk with your doctor or pharmacist about what's right for your situation.
What are the side effects of astragalus?
In clinical studies, some people have reported dizziness or skin reactions like rash, eczema, and itching. However, it's not clear whether astragalus caused these effects or something else did. It's generally well tolerated in the short term in healthy adults.
Does astragalus actually work for hay fever, asthma, or other conditions?
We don't have enough reliable evidence to say. The data we hold shows insufficient evidence for hay fever, asthma, anemia, amenorrhea, angina, and beta-thalassemia. Your doctor can advise you on whether astragalus is worth trying for your specific condition.
Can I take this if I'm on a diabetes medication?
Not without checking first — astragalus may lower blood sugar on its own, so combining it with diabetes drugs could raise your risk of low blood sugar. Talk with your doctor or pharmacist before you start.
What exactly is in this liquid astragalus?
It's 500 mg of astragalus root extract per serving, plus vegetable glycerin, water, and natural caramel color to preserve and flavor it. There's one active ingredient — the astragalus itself.
Should I avoid it if I take lithium or immunosuppressant medications?
Yes — check with your doctor or pharmacist first. Astragalus might interfere with how both of these work, and these are Moderate-severity interactions. Your prescriber can tell you whether it's safe for you to use.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Astragalus Root 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Astragalus Root 500 mg label
Go deeper

The Full Monographs Behind Astragalus Root 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Astragalus

Interacts with 208 drugs

Astragalus is a root used for centuries in traditional Chinese medicine, mainly to support the immune system and help the body cope with stress. While early studies are interesting, strong h...

Read the full Astragalus monograph →
Sources

Sources & How We Checked

Astragalus Root 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Astragalus 13 references
  1. Upton R, ed. Astragalus Root: Analytical, quality control, and therapeutic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia. 1999:1-25.
  2. Khoo KS, Ang PT. Extract of astragalus membranaceus and ligustrum lucidum does not prevent cyclophosphamide-induced myelosuppression. Singapore Med J 1995;36:387-90.
  3. Chu DT, Wong WL, Mavligit GM. Immunotherapy with Chinese medicinal herbs. II. Reversal of cyclophosphamide-induced immune suppression by administration of fractionated Astragalus membranaceus in vivo. J Clin Lab Immunol 1988;25:125-9.
  4. Sun Y, Hersh EM, Lee SL, et al. Preliminary observations on the effects of the Chinese medicinal herbs Astragalus membranaceus and Ligustrum lucidum on lymphocyte blastogenic responses. J Biol Response Mod 1983;2:227-37..
  5. Ma J, Peng A, Lin S. Mechanisms of the therapeutic effect of astragalus membranaceus on sodium and water retention in experimental heart failure. Chin Med J (Engl) 1998;111:17-23.
  6. Matkovic Z, Zivkovic V, Korica M, et al. Efficacy and safety of Astragalus membranaceus in the treatment of patients with seasonal allergic rhinitis. Phytother Res 2010;24:175-81.
  7. Zhang, J. G., Yang, N., He, H., Wei, G. H., Gao, D. S., Wang, X. L., Wang, X. Z., and Song, G. Y. [Effect of Astragalus injection on plasma levels of apoptosis-related factors in aged patients with chronic heart failure.]. Chin J Integr.Med 2005;11(3):18 PubMed
  8. Chen, H. W., Lin, I. H., Chen, Y. J., Chang, K. H., Wu, M. H., Su, W. H., Huang, G. C., and Lai, Y. L. A novel infusible botanically-derived drug, PG2, for cancer-related fatigue: a phase II double-blind, randomized placebo-controlled study. Clin Invest PubMed
  9. Tian H, Lu J, He H, et al.The effect of Astragalus as an adjuvant treatment in type 2 diabetes mellitus: A (preliminary) meta-analysis. J Ethnopharmacol. 2016;191:206-215. doi: 10.1016/j.jep.2016.05.062. PubMed
  10. Hong KF, Liu PY, Zhang W, Gui DK, Xu YH. The Efficacy and Safety of Astragalus as an Adjuvant Treatment for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. J Integr Complement Med 2023. PubMed
  11. Chan KW, Kwong ASK, Tsui PN, et al. Add-on astragalus in type 2 diabetes and chronic kidney disease: A multi-center, assessor-blind, randomized controlled trial. Phytomedicine 2024;130:155457. PubMed
  12. Han X, Yu T, Chen X, Du Z, Yu M, Xiong J. Effect of Astragalus membranaceus on left ventricular remodeling in HFrEF: a systematic review and meta-analysis. Front Pharmacol 2024;15:1345797. PubMed
  13. Jing P, Hongzheng H, Zhenqi WU, Meijuan Z, Zuojing LI, Gang C. Long-term efficacy and safety of Huangqi ()-based Traditional Chinese Medicine in diabetic peripheral neuropathy: a Meta-analysis of randomized controlled trials. J Tradit Chin Med 2024;44(2):

See these in context on the Astragalus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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