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Dietary supplement

Astragalus Root Extract 300 mg Ingredients & Drug Interactions

by SMNutrition

Astragalus Root Extract 300 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Astragalus Root Extract 300 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Astragalus Root Extract 300 mg is a dietary supplement by SMNutrition with 1 active ingredient. Its ingredients are commonly taken for immune support, colds and flu, upper respiratory infections.Based on those ingredients, 208 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astragalus root 10:1 extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Astragalus Root Extract 300 mg by SMNutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Astragalus Root Extract 300 mg by SMNutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Astragalus Root Extract 300 mg by SMNutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: astragalus root as a 10:1 concentrated extract, delivering 300 mg per capsule. Astragalus is a plant used in traditional medicine, and the 10:1 concentration means the extract is made by processing ten parts of the herb down to one.

The capsule also holds three inactive ingredients — vegetable cellulose (the capsule itself) and two additives, NuFlow and NuMag.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Astragalus's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Support immune, cardiovascular and cellular health.
  • We looked for evidence on: Upper respiratory tract infection (URTI), Heart failure, Myocardial infarction (MI), Angina, Myocarditis, Anthracycline cardiotoxicity — and 4 related terms.
  • The closest evidence on file: Astragalus is rated "Insufficient Reliable Evidence To Rate" for Angina (Natural Medicines).
  • Also on file: Astragalus is rated "Insufficient Reliable Evidence To Rate" for Chronic fatigue syndrome (CFS), Upper respiratory tract infection (URTI), Heart failure, Myocardial infarction (MI), and more.

The evidence on astragalus for the conditions it's marketed for — allergic rhinitis (hay fever), amenorrhea, aplastic anemia, angina, asthma, and beta-thalassemia — is insufficient. That means the reliable human research isn't there yet to say whether it works for any of these.

If you're considering it for a specific health goal, your doctor or pharmacist can help you weigh what limited data exists.

The evidence, ingredient by ingredient Astragalus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Astragalus is generally well tolerated in short-term use in healthy adults, but human safety data is limited. Some people have reported dizziness and, in one trial, a temporary narrowing of heart arteries (lacunar angina), though these may not have been caused by the supplement itself.

Intravenous forms (not this oral extract) have been associated with rash and itching. During pregnancy and breastfeeding, there isn't enough reliable safety data, so astragalus should be avoided.

If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this.

Side effects, ingredient by ingredient Astragalus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Astragalus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 208 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this, check with your doctor or pharmacist if you take immunosuppressants, lithium, cyclophosphamide, or any blood-sugar-lowering drugs. Astragalus interacts with all of these (Moderate severity), and the interactions could either reduce how well your medication works or raise your risk of side effects like low blood sugar.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is a single-ingredient extract of astragalus with limited human safety and effectiveness data. It's worth considering only if your doctor or pharmacist recommends it for a specific reason — and only after you've checked it against your current medications, especially immunosuppressants, lithium, cyclophosphamide, or blood-sugar drugs.

If you take any prescription medication, run it through the checker on this page and talk it over with your doctor or pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Astragalus Root Extract 300 mg, straight from the product label.

Brand SMNutrition
Barcode (UPC) 850005458432
Net contents 200 Capsule(s)
Market status On market
Date entered into DSLD Jan 22, 2022
DSLD ID 258929
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Astragalus Root Extract 300 mg by SMNutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetable Capsule(s)
Maximum serving Sizes:
1 Vegetable Capsule(s)
Servings per container
200
UPC/BARCODE
850005458432
IngredientAmount% DV
Astragalus root 10:1 extract300 mg--

Other ingredients: Vegetable Cellulose, NuFlow, NuMag

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Astragalus Root Extract 300 mg may help support Immune health Cardiovascular health Cellular health

Immunity & vitality support

Gluten free

Formulated in the U.S.A.

100% vegetarian

NON-GMO

Suggested/Recommended/Usage/Directions

Suggested Use: For adults, take one (1) capsule daily with a meal. Please discuss the supplements and medications you take with your healthcare providers.

Once-daily capsule

Precautions

Caution: Consult your healthcare provider before using this supplement especially if you are pregnant, nursing, taking medication, or have a medical condition.

Not intended for use by persons under the age of 18. Keep out of the reach of children.

Contains desiccant packet for freshness. Do not eat packet. Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

3000 mg astragalus root equivalent per capsule

Seals/Symbols

GMP Sourced from a GMP Certified Facility

FDA Manufactured in an FDA Registered Facility

3rd-Party Tested

FDA Statement of Identity

Dietary Supplement

General Statements

Built on trust. Crafted with care.

Money back guarantee Find us on: Facebook Instagram

Brand IP Statement(s)

Nu-FLOW is a registered trademark of RIBUS, Inc. Nu-MAG is a registered trademark of RIBUS, Inc.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Astragalus Root Extract 300 mg by SMNutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Astragalus Root Extract 300 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Astragalus Root Extract 300 mg by SMNutrition

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetable Capsule(s) Dosage formCapsule Servings per container200 Amounts shown are per serving.

Astragalus root 10:1 extract

Interacts with
208 drugs
300 mg per serving

Astragalus is a root used for centuries in traditional Chinese medicine, mainly to support the immune system and help the body cope with stress. While...

Astragalus root 10:1 extract monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, NuFlow, NuMag. These complete the product’s ingredient list but are not active constituents.

Interaction report

Astragalus Root Extract 300 mg by SMNutrition Drug Interactions

Want to check YOUR meds against Astragalus Root Extract 300 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
208Drugs
208 Moderate

Ingredients driving the most interactions

Astragalus root 10:1 extract 208

Individual Drug Interactions

The ingredients in Astragalus Root Extract 300 mg interact with 208 drugs. Click any drug to see the details.

1 of the 1 ingredient in Astragalus Root Extract 300 mg interact with drugs. Each result below shows which ingredient is responsible. Astragalus root 10:1 extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Astragalus Root Extract 300 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Astragalus root 10:1 extract4 drug types · 208 drugs

Antidiabetes Drugs

Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research in humans shows that astragalus might have hypoglycemic effects. Theoretically, taking astragalus, especially in combination with other hypoglycemic agents, might increase the risk of hypoglycemia.

Likelihood Probable Evidence A
Cyclophosphamide

Theoretically, astragalus might interfere with cyclophosphamide therapy.
Evidence regarding the effect of astragalus on immunosuppression caused by cyclophosphamide is conflicting. Some animal research suggests that astragalus reverses cyclophosphamide-induced immunosuppression. However, other animal research shows no effect.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, astragalus might interfere with immunosuppressive therapy.
Astragalus seems to stimulate immune function. Theoretically, taking astragalus might decrease the effects of immunosuppressive therapy.

Likelihood Possible Evidence D
Lithium

Theoretically, astragalus might increase levels and adverse effects of lithium.
Animal research suggests that astragalus has diuretic properties. Theoretically, due to this diuretic effect, astragalus might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Astragalus root 10:1 extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Astragalus Root Extract 300 mg, from the product label.

SMNutrition

See all SMNutrition products
Name
Smoky Mountain Nutrition
Street Address
P.O. Box 101335
City
Nashville
State
TN
ZipCode
37224
Web Address
SMNutrition.com
Pharmacist Counseling Corner

Astragalus Root Extract 300 mg by SMNutrition: Common Questions

Does Astragalus Root Extract 300 mg by SMNutrition interact with any medications?
Yes. Based on its ingredients, Astragalus Root Extract 300 mg has a known interaction with 208 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Astragalus Root Extract 300 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No — there isn't enough reliable safety data for astragalus during pregnancy or breastfeeding, so it's best avoided. Talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or nursing before taking any supplement.
What does a 10:1 extract mean?
It means the astragalus root was concentrated by processing ten parts of the plant material down to one part. You're getting a more potent dose than you would from the raw herb.
Has astragalus been shown to work for allergies or the other conditions listed?
The reliable human evidence isn't there yet — the research is insufficient to say either way. If you're interested in it for a specific condition, ask your doctor or pharmacist what the current thinking is.
What side effects has astragalus caused?
Dizziness and, in one trial, a temporary narrowing of heart arteries have been reported, though these may not have been caused by astragalus itself. The supplement is generally well tolerated short-term, but human safety data is limited.
Why does astragalus interact with so many blood-pressure and immune drugs?
Astragalus appears to stimulate immune function and has diuretic properties (it may increase urination). These effects can interfere with how your body clears certain medications or weaken others' effectiveness.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Astragalus Root Extract 300 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Astragalus Root Extract 300 mg label
Go deeper

The Full Monographs Behind Astragalus Root Extract 300 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Astragalus

Interacts with 208 drugs

Astragalus is a root used for centuries in traditional Chinese medicine, mainly to support the immune system and help the body cope with stress. While early studies are interesting, strong h...

Read the full Astragalus monograph →
Sources

Sources & How We Checked

Astragalus Root Extract 300 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Astragalus 13 references
  1. Upton R, ed. Astragalus Root: Analytical, quality control, and therapeutic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia. 1999:1-25.
  2. Khoo KS, Ang PT. Extract of astragalus membranaceus and ligustrum lucidum does not prevent cyclophosphamide-induced myelosuppression. Singapore Med J 1995;36:387-90.
  3. Chu DT, Wong WL, Mavligit GM. Immunotherapy with Chinese medicinal herbs. II. Reversal of cyclophosphamide-induced immune suppression by administration of fractionated Astragalus membranaceus in vivo. J Clin Lab Immunol 1988;25:125-9.
  4. Sun Y, Hersh EM, Lee SL, et al. Preliminary observations on the effects of the Chinese medicinal herbs Astragalus membranaceus and Ligustrum lucidum on lymphocyte blastogenic responses. J Biol Response Mod 1983;2:227-37..
  5. Ma J, Peng A, Lin S. Mechanisms of the therapeutic effect of astragalus membranaceus on sodium and water retention in experimental heart failure. Chin Med J (Engl) 1998;111:17-23.
  6. Matkovic Z, Zivkovic V, Korica M, et al. Efficacy and safety of Astragalus membranaceus in the treatment of patients with seasonal allergic rhinitis. Phytother Res 2010;24:175-81.
  7. Zhang, J. G., Yang, N., He, H., Wei, G. H., Gao, D. S., Wang, X. L., Wang, X. Z., and Song, G. Y. [Effect of Astragalus injection on plasma levels of apoptosis-related factors in aged patients with chronic heart failure.]. Chin J Integr.Med 2005;11(3):18 PubMed
  8. Chen, H. W., Lin, I. H., Chen, Y. J., Chang, K. H., Wu, M. H., Su, W. H., Huang, G. C., and Lai, Y. L. A novel infusible botanically-derived drug, PG2, for cancer-related fatigue: a phase II double-blind, randomized placebo-controlled study. Clin Invest PubMed
  9. Tian H, Lu J, He H, et al.The effect of Astragalus as an adjuvant treatment in type 2 diabetes mellitus: A (preliminary) meta-analysis. J Ethnopharmacol. 2016;191:206-215. doi: 10.1016/j.jep.2016.05.062. PubMed
  10. Hong KF, Liu PY, Zhang W, Gui DK, Xu YH. The Efficacy and Safety of Astragalus as an Adjuvant Treatment for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. J Integr Complement Med 2023. PubMed
  11. Chan KW, Kwong ASK, Tsui PN, et al. Add-on astragalus in type 2 diabetes and chronic kidney disease: A multi-center, assessor-blind, randomized controlled trial. Phytomedicine 2024;130:155457. PubMed
  12. Han X, Yu T, Chen X, Du Z, Yu M, Xiong J. Effect of Astragalus membranaceus on left ventricular remodeling in HFrEF: a systematic review and meta-analysis. Front Pharmacol 2024;15:1345797. PubMed
  13. Jing P, Hongzheng H, Zhenqi WU, Meijuan Z, Zuojing LI, Gang C. Long-term efficacy and safety of Huangqi ()-based Traditional Chinese Medicine in diabetic peripheral neuropathy: a Meta-analysis of randomized controlled trials. J Tradit Chin Med 2024;44(2):

See these in context on the Astragalus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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