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Dietary supplement

ATP-20 Ingredients & Drug Interactions

by Douglas Laboratories

ATP-20 label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking ATP-20 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

ATP-20 is a dietary supplement by Douglas Laboratories with 1 active ingredient. Its ingredients are commonly taken for energy and cellular function support, athletic performance and muscle energy, circulation support.Based on those ingredients, 47 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Adenosine Triphosphate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against ATP-20 by Douglas Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with ATP-20 by Douglas Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of ATP-20 by Douglas Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

ATP-20 contains one active ingredient: adenosine triphosphate (ATP), a molecule your cells use to produce energy. The tablet also includes several inactive ingredients — mannitol, microcrystalline cellulose, stearic acid, vegetable stearate, and silica — which serve as fillers and binders to hold the tablet together.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Adenosine's overall clinical evidence instead.

Strong

Strong clinical evidence supports Adenosine for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Cardiovascular disease diagnosis — rated "Effective" (Natural Medicines).
  • On file: Paroxysmal supraventricular tachycardia — rated "Effective" (Natural Medicines).
  • On file: Cachexia — rated "Possibly Effective" (Natural Medicines).

Adenosine is rated effective for two uses: managing paroxysmal supraventricular tachycardia (a type of rapid heartbeat that starts and stops suddenly) and aiding in cardiovascular disease diagnosis. However, the safety notes on file emphasize that evidence for the oral supplement form is limited, since the prescription injectable version — which is much more powerful — must be given only by medical professionals under controlled conditions.

The evidence, ingredient by ingredient Adenosine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The safety data comes with important caveats. The prescription injectable form of adenosine carries a risk of serious cardiovascular and respiratory side effects, including chest pain, dizziness, shortness of breath, flushing, headache, low blood pressure, nausea, and in rare cases, abnormal heart rhythms and heart attack.

When adenosine is given orally or by injection into muscle, no adverse effects have been reported — but a thorough safety evaluation hasn't been done. There isn't enough safety information to recommend this supplement during pregnancy or breastfeeding, so talk with your doctor or pharmacist before taking it if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Adenosine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Adenosine.
  • The most serious interaction on file is rated Major.
  • For scale: 47 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking ATP-20, check with your doctor or pharmacist if you take dipyridamole (Persantine) — a Major interaction — or carbamazepine (Tegretol), which carries a Moderate risk of heart block. Also avoid methylxanthines (caffeine, theophylline, aminophylline) for 24 hours before dosing, since they block adenosine's effects.

Use the medication checker on this page to confirm your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

ATP-20 is used in medical settings for heart rhythm problems and diagnostic cardiac stress tests, where it's considered effective. The oral supplement form hasn't been studied as thoroughly as the prescription injectable version, so safety data is limited.

If you take any heart medications, blood vessel dilators, anti-seizure drugs, or consume caffeine or theophylline, check with your doctor or pharmacist before starting this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ATP-20, straight from the product label.

Brand Douglas Laboratories
Barcode (UPC) 310539005217
Net contents 60 Dissolvable Tablet(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 232069
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ATP-20 by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Dissolvable Tablet(s)
Maximum serving Sizes:
1 Dissolvable Tablet(s)
Servings per container
60
UPC/BARCODE
310539005217
IngredientAmount% DV
Adenosine Triphosphate20 mg--

Other ingredients: Mannitol, Microcrystalline Cellulose, Stearic Acid, Vegetable Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: As a dietary supplement, adults take 1 tablet 1-3 times daily or as directed by your health professional. Allow tablet to dissolve in mouth and then swallow.

Precautions

Warning: If you are pregnant, nursing, have any health condition or taking any medication, consult your health professional before using this product.

Keep out of the reach of children.

Use only if safety seal is intact.

Storage

Store in a cool, dry place.

Formulation

Gluten-free, Non-GMO

Cellular energy

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity. Scan to learn about our manufacturing excellence

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

ATP-20 by Douglas Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

ATP-20 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in ATP-20 by Douglas Laboratories

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Dissolvable Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Adenosine Triphosphate

Interacts with
47 drugs
20 mg per serving

Adenosine is a natural building block your body uses for energy and cell signaling, and a prescription injectable version is used by doctors to treat...

Adenosine Triphosphate monograph & interactions

Other (inactive) ingredients: Mannitol, Microcrystalline Cellulose, Stearic Acid, Vegetable Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

ATP-20 by Douglas Laboratories Drug Interactions

Want to check YOUR meds against ATP-20?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
47Drugs
2 Major 1 Moderate 44 Minor

Ingredients driving the most interactions

Adenosine Triphosphate 47

Individual Drug Interactions

The ingredients in ATP-20 interact with 47 drugs. Click any drug to see the details.

1 of the 1 ingredient in ATP-20 interact with drugs. Each result below shows which ingredient is responsible. Adenosine Triphosphate

Each ingredient & the kinds of drugs it affects

For each ingredient in ATP-20 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Adenosine Triphosphate3 drug types · 47 drugs

Dipyridamole (Persantine)

Dipyridamole can increase the therapeutic and toxic effects of adenosine.
Dipyridamole decreases the metabolism of adenosine. Intravenous infusion of adenosine in patients who are taking dipyridamole can cause dizziness, bradycardia, and syncope. Dipyridamole should be discontinued for several days prior to a cardiac stress test using adenosine.

Likelihood Likely Evidence D
Carbamazepine (Tegretol)

Carbamazepine might increase the risk of heart block when used concomitantly with adenosine.
Carbamazepine and adenosine can both cause heart block. Giving them concurrently might produce an additive effect.

Likelihood Possible Evidence D
Methylxanthines

Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
The methylxanthines, aminophylline, caffeine, and theophylline, can block the effects of adenosine by acting as competitive antagonists at adenosine cell surface receptors. It is recommended that methylxanthines be avoided for 24 hours prior to cardiac stress tests.

Likelihood Possible Evidence D
Adenosine Triphosphate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for ATP-20, from the product label.

Douglas Laboratories

See all Douglas Laboratories products
Name
Douglas Laboratories
Street Address
600 Boyce Road
City
Pittsburgh
State
PA
ZipCode
15205
Phone Number
1.800.245.4440
Web Address
www.douglaslabs.com
Pharmacist Counseling Corner

ATP-20 by Douglas Laboratories: Common Questions

Does ATP-20 by Douglas Laboratories interact with any medications?
Yes. Based on its ingredients, ATP-20 has a known interaction with 47 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ATP-20 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is adenosine triphosphate (ATP) and what does it do in the body?
ATP is a molecule your cells use to create energy. In ATP-20, it's supplied as a supplement to support energy production, and in medical settings it's used to help diagnose heart disease and manage certain fast heartbeat conditions.
Can I take ATP-20 if I'm pregnant or breastfeeding?
There isn't enough safety information to recommend this supplement during pregnancy or while breastfeeding. Talk with your doctor or pharmacist before taking it in either situation so they can give you personalized advice.
What side effects should I watch for?
When adenosine is given by mouth or injection into muscle, no adverse effects have been reported — but full safety testing hasn't been completed. If you experience chest pain, dizziness, shortness of breath, headache, low blood pressure, or nausea, stop and contact your healthcare provider right away.
Should I avoid caffeine while taking ATP-20?
Yes. Caffeine blocks adenosine's effects by competing at the same cellular receptors, so avoid caffeine (and theophylline or aminophylline) for at least 24 hours before taking this product.
Is this the same as the adenosine doctors use for stress tests?
No. The prescription injectable form doctors use for stress tests is much more powerful and must be given only in a medical setting under direct supervision. This oral supplement is a different form, and its safety has not been studied as thoroughly as the prescription version.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ATP-20 label
Go deeper

The Full Monographs Behind ATP-20’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Adenosine

Interacts with 47 drugs

Adenosine is a natural building block your body uses for energy and cell signaling, and a prescription injectable version is used by doctors to treat certain fast heart rhythms. As an over-t...

Read the full Adenosine monograph →
Sources

Sources & How We Checked

ATP-20's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Adenosine 10 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Agteresch HJ, Dagnelie PC, van den Berg JW, Wilson JH. Adenosine triphosphate: established and potential clinical applications. Drugs 1999;58:211-32.. PubMed
  3. Agteresch HJ, Dagnelie PC, van der Gaast A, et al. Randomized clinical trial of adenosine 5'-triphosphate in patients with advanced non-small-cell lung cancer. J Natl Cancer Inst 2000;92:321-8.. PubMed
  4. Haskell CM, Wong M, Williams A, Lee LY. Phase I trial of extracellular adenosine 5'-triphosphate in patients with advanced cancer. Med Pediatr Oncol 1996;27:165-73.. DOI
  5. Haskell CM, Mendoza E, Pisters KM, et al. Phase II study of intravenous adenosine 5'-triphosphate in patients with previously untreated stage IIIB and stage IV non-small cell lung cancer. Invest New Drugs 1998;16:81-5.. PubMed
  6. Eisenach JC, Curry R, Hood DD. Dose response of intrathecal adenosine in experimental pain and allodynia. Anesthesiology 2002;97:938-42.. PubMed
  7. Agteresch HJ, Dagnelie PC, Rietveld T, et al. Pharmacokinetics of intravenous ATP in cancer patients. Eur J Clin Pharmacol 2000;56:49-55.. PubMed
  8. Underwood DA. Which medications should be held before a pharmacologic or exercise stress test? Cleve Clin J Med 2002;69:449-50. PubMed
  9. Litmann L, Anderson JD, Monroe MH. Adenosine and Aggrenox: A hazardous combination. Ann Intern Med 2002;137:E-76. PubMed
  10. Faghihi G, Iraji F, Rajaee Harandi M, et al. Comparison of the efficacy of topical minoxidil 5% and adenosine 0.75% solutions on male androgenic alopecia and measuring patient satisfaction rate. Acta Dermatovenerol Croat 2013;21(3):155-9.

See these in context on the Adenosine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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