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Dietary supplement

Bacopa Monnieri Ingredients & Drug Interactions

by Pure Encapsulations

Bacopa Monnieri label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bacopa Monnieri against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bacopa Monnieri is a dietary supplement by Pure Encapsulations with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, adhd symptoms.Based on those ingredients, 930 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bacopa Aerial Parts Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bacopa Monnieri by Pure Encapsulations

Ask about any prescription or over-the-counter medication and we check it for interactions with Bacopa Monnieri by Pure Encapsulations — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Bacopa Monnieri by Pure Encapsulations

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: bacopa aerial parts extract, which comes from the above-ground portions of the bacopa plant. Bacopa has been used in traditional medicine systems for cognitive support and overall wellness.

The capsule also contains inactive ingredients — plant fiber, cellulose, water, and ascorbyl palmitate (a form of vitamin C used as a preservative) — which serve as fillers and binders.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Bacopa product and its label doesn't state a use — see Bacopa's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for bacopa isn't established in the data we hold. The product is marketed for Alzheimer disease, sexual dysfunction, ADHD, back pain, cognitive function, and cognitive impairment, but current reliable evidence is insufficient to rate it for any of these uses.

If you're considering bacopa for a specific health concern, talk with your pharmacist or doctor about what the research actually shows and whether it's right for you.

The evidence, ingredient by ingredient Bacopa

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bacopa is generally well tolerated in studies, though quality and long-term safety data are limited. The most common side effects are gastrointestinal: abdominal cramps, diarrhea, nausea, and dry mouth appear frequently, with rates of stomach and bowel issues ranging from 12% to 30% across trials.

Some people also report headache, drowsiness, insomnia, vivid dreams, decreased appetite, and excessive thirst. The safety data advises against use during pregnancy and while breastfeeding because there isn't enough information to know whether it's safe in those situations — talk with your pharmacist or doctor for personalized advice if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Bacopa

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bacopa.
  • The most serious interaction on file is rated Moderate.
  • For scale: 931 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this bacopa product, check with your pharmacist if you're on cevimeline (Evoxac) for dry mouth — this is the most serious documented interaction. You should also double-check any drugs your liver breaks down through CYP1A2, CYP2C19, CYP2C9, or CYP3A4 enzymes — a category that includes blood thinners, statins, many antidepressants, and blood pressure drugs.

If you take anticholinergic drugs (for overactive bladder or Parkinson symptoms), cholinergic drugs (for myasthenia gravis), or thyroid hormone, those need checking too.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Bacopa might appeal to someone interested in traditional cognitive support, but the evidence for its effectiveness isn't solid. The bigger concern is its interactions with dozens of medication types through multiple liver pathways.

If you take any prescription drugs — especially blood thinners, statins, antidepressants, or blood pressure meds — check them against this product before you start. Talk to your pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bacopa Monnieri, straight from the product label.

Brand Pure Encapsulations
Barcode (UPC) 766298007083
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD May 23, 2024
DSLD ID 309485
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bacopa Monnieri by Pure Encapsulations, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
180
UPC/BARCODE
766298007083
IngredientAmount% DV
Bacopa Aerial Parts Extract200 mg--

Other ingredients: Plant Fiber, Cellulose, Water, Ascorbyl Palmitate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Recommendations: As a dietary supplement, take 1 capsule, 1-3 times daily, with meals.

Precautions

Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.

Keep out of the reach of children.

Use only if safety seal is intact.

General Statements

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity. Scan to learn about our hypoallergenic supplements

Formulation

GFCO.org (Gluten-Free Certification Organization) Certified gluten-free by the Gluten-Free Certification Organization, www.gluten.org

Traditional support for clarity and relaxation

Gluten-free, Non-GMO & hypoallergenic

Gluten-free, Non-GMO & hypoallergenic

Seals/Symbols

GFCO.org (Gluten-Free Certification Organization)

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bacopa Monnieri by Pure Encapsulations label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bacopa Monnieri label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bacopa Monnieri by Pure Encapsulations

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.

Bacopa Aerial Parts Extract

Interacts with
930 drugs
200 mg per serving Form: Bacopa monnieri Aerial Extract, Bacosides

Bacopa is an Ayurvedic herb most often used for memory and thinking. Some small studies suggest it may modestly help memory when taken regularly for s...

Bacopa Aerial Parts Extract monograph & interactions

Other (inactive) ingredients: Plant Fiber, Cellulose, Water, Ascorbyl Palmitate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bacopa Monnieri by Pure Encapsulations Drug Interactions

Want to check YOUR meds against Bacopa Monnieri?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
930Drugs
917 Moderate 13 Minor

Ingredients driving the most interactions

Bacopa Aerial Parts Extract 930

Individual Drug Interactions

The ingredients in Bacopa Monnieri interact with 930 drugs. Click any drug to see the details.

1 of the 1 ingredient in Bacopa Monnieri interact with drugs. Each result below shows which ingredient is responsible. Bacopa Aerial Parts Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Bacopa Monnieri with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bacopa Aerial Parts Extract8 drug types · 930 drugs

Anticholinergic Drugs

Theoretically, concurrent use might decrease the effectiveness of both agents.
Bacopa seems to inhibit acetylcholinesterase and might increase acetylcholine levels, which could counteract the effects of anticholinergic drugs. Similarly, anticholinergic drugs might counteract the cholinergic effects of bacopa.

Likelihood Possible Evidence D
Cevimeline (Evoxac)

Theoretically, bacopa might increase the effects and adverse effects of cevimeline.
In one case, a 58-year-old female taking cevimeline long-term for Sjogren syndrome experienced hyperhidrosis, malaise, nausea, and tachycardia shortly after taking a single dose of bacopa. Symptoms resolved after two days. Cevimeline is metabolized by cytochrome P450 (CYP) 2D6 and CYP3A4, and researchers theorize that bacopa may have inhibited these isoenzymes. However, it is unclear if bacopa causes clinically significant inhibition of either CYP2D6 or CYP3A4.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of bacopa with other cholinergic drugs might have additive effects.
Bacopa seems to inhibit acetylcholinesterase and might increase acetylcholine levels. Theoretically, this could result in additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Research on the effects of bacopa extracts on CYP1A2 enzymes is conflicting. Some in vitro evidence shows that bacopa extract can moderately and non-competitively inhibit CYP1A2, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP2C19 substrates.
In vitro evidence suggests that bacopa extract can moderately and non-competitively inhibit CYP2C19 enzymes. It is not known whether this is clinically significant.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP2C9 substrates.
Research on the effect of bacopa extracts on CYP2C9 enzymes is conflicting. Some in vitro evidence suggests that bacopa extract can moderately and non-competitively inhibit CYP2C9, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Research on the effects of bacopa extracts on CYP3A4 enzymes is conflicting. Some in vitro evidence suggests that bacopa extract can moderately and competitively inhibit CYP3A4, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, bacopa might have additive effects when used with thyroid hormone.
Animal research suggests that bacopa increases thyroxine (T4) levels in mice by about 40%.

Likelihood Possible Evidence D
Bacopa Aerial Parts Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bacopa Monnieri, from the product label.

Pure Encapsulations

See all Pure Encapsulations products
Name
Pure Encapsulations
Street Address
490 Boston Post Road
City
Sudbury
State
MA
Phone Number
1-800-753-2277
Web Address
www.PureEncapsulations.com
Pharmacist Counseling Corner

Bacopa Monnieri by Pure Encapsulations: Common Questions

Does Bacopa Monnieri by Pure Encapsulations interact with any medications?
Yes. Based on its ingredients, Bacopa Monnieri has a known interaction with 930 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bacopa Monnieri contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's in each capsule?
One active ingredient: bacopa aerial parts extract. The rest is inactive — plant fiber, cellulose, water, and ascorbyl palmitate as a preservative.
What side effects should I expect?
Most common are stomach issues: cramps, diarrhea, nausea, and dry mouth. Some people also report headache, drowsiness, insomnia, or vivid dreams. Stomach and bowel problems show up in 12% to 30% of people who take it in studies.
Is bacopa safe during pregnancy or breastfeeding?
There isn't enough safety information, so it's best to avoid it during pregnancy and while breastfeeding. Talk with your doctor or pharmacist for personalized advice if you're pregnant, planning to become pregnant, or nursing.
Does bacopa actually improve memory or focus?
The reliable evidence isn't there yet to say it does. It's marketed for cognitive function and ADHD, but current studies don't support those claims.
Will bacopa interact with my medications?
It can interact with a lot of drug types — blood thinners, statins, many antidepressants, blood pressure drugs, diabetes drugs, and others — through the way your liver breaks them down. Use the checker on this page with your exact medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bacopa Monnieri label
Go deeper

The Full Monographs Behind Bacopa Monnieri’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacopa

Interacts with 930 drugs

Bacopa is an Ayurvedic herb most often used for memory and thinking. Some small studies suggest it may modestly help memory when taken regularly for several weeks, but the evidence is limite...

Read the full Bacopa monograph →
Sources

Sources & How We Checked

Bacopa Monnieri's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacopa 12 references
  1. Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology 2001;156:481-4..
  2. Yadav SK, Jain AK, Tripathi SN, Gupta JP. Irritable bowel syndrome: therapeutic evaluation of indigenous drugs. Indian J Med Res 1989;90:496-503..
  3. Morgan A, Stevens J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. J Altern Complement Med 2010;16:753-9.
  4. Kar, A., Panda, S., and Bharti, S. Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. J Ethnopharmacol. 2002;81(2):281-285. PubMed
  5. Mukherjee, G. D. and Dey, C. D. Clinical trial on Brahmi. I. J.Exp.Med.Sci. 1966;10(1):5-11.
  6. Kar A, Pandit S, Mukherjee K, Bahadur S, Mukherjee PK. Safety assessment of selected medicinal food plants used in Ayurveda through CYP450 enzyme inhibition study. J Sci Food Agric 2017;97(1):333-40. doi: 10.1002/jsfa.7739. PubMed
  7. Kongkeaw C, Dilokthornsakul P, Thanarangsarit P, et al. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. J Ethnopharmacol 2014;151(1):528-35. PubMed
  8. Ramasamy S, Kiew LV, Chung LY. Inhibition of human cytochrome P450 enzymes by Bacopa monnieri standardized extract and constituents. Molecules 2014;19(2):2588-601. PubMed
  9. Prabhakar S, Vishnu VY, Modi M, et al. Efficacy of Bacopa monnieri (Brahmi) and donepezil in Alzheimer's disease and mild cognitive impairment: a randomized double-blind parallel phase 2b study. Ann Indian Acad Neurol 2020;23(6):767-73. PubMed
  10. Acquarulo B, Tandon P, Macica CM. Suspected cholinergic toxicity due to cevimeline hydrochloride and Bacopa monnieri interaction: a case report. J Med Case Rep 2022;16(1):253. PubMed
  11. Keegan AP, Stough C, Paris D, et al. Bacopa monnieri supplementation has no effect on serum brain-derived neurotrophic factor levels but beneficially modulates nuclear factor kappa B and cyclic AMP response element-binding protein levels in healthy elderl
  12. Yaworski AM, Blyumin M, Chang T, Mammen AL, Greene M. Necrotizing myopathy with elevated anti-HMGCR antibodies following exposure to the supplement Bacopa. Muscle Nerve 2023;67(2):E1-E3.

See these in context on the Bacopa monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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