Berberine+ Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Berberine+ against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Berberine+ is a dietary supplement by Nutritional Frontiers with 2 active ingredients. Its ingredients are commonly taken for blood sugar support, high cholesterol, indigestion and gas.Based on those ingredients, 1,210 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Barberry, Cinnamon. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Berberine+ by Nutritional Frontiers
Ask about any prescription or over-the-counter medication and we check it for interactions with Berberine+ by Nutritional Frontiers — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Berberine+ by Nutritional Frontiers
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Berberine+ contains 2 active ingredients: cinnamon (Ceylon cinnamon) and barberry (European barberry). Cinnamon is a common spice that's been studied for effects on blood sugar and weight, while barberry is a plant whose berries have been used traditionally; the active compound of interest in barberry is berberine, an alkaloid.
The product is formulated as a liquid and contains alcohol as an inactive ingredient.
Does it work?
Couldn't assess
The evidence for what this product actually does is limited. For cinnamon, the data we hold rates it possibly ineffective for obesity and diabetes — the two conditions most often cited.
For hay fever, COPD, and common cold, we don't have enough reliable evidence to say whether it works. Barberry's effectiveness is similarly unclear; we hold insufficient evidence to rate it for acne, bacterial vaginosis, breast cancer, dental plaque, or diabetes.
Neither ingredient has strong proof behind it for its typical uses in supplements.
How safe is it?
Well-documented data
Cinnamon is generally well tolerated at food amounts; the most common side effects from higher doses are bloating, upset stomach, and nausea. Rare cases of skin reactions (rashes, itching) and one report of bleeding after long-term use have been documented.
Barberry has less safety data, especially for long-term use. One case of severe liver injury linked to barberry has been reported.
This product contains alcohol, which matters if you avoid it for any reason. Pregnancy and breastfeeding: Ceylon cinnamon is rated likely safe in pregnancy, but barberry is rated likely unsafe — the berberine it contains may cross the placenta and has been linked to newborn concerns.
For breastfeeding, cinnamon is likely safe at food doses, but barberry is likely unsafe and may pass into breast milk. Do not use this product if you are pregnant or nursing.
Meds to double-check
Moderate interaction found
Before you take this, double-check with your pharmacist if you're on blood thinners or antiplatelet drugs like warfarin or aspirin (Moderate). Also check if you take antihypertensive drugs for blood pressure, antidiabetes drugs, sedatives or anti-anxiety medications, anticholinergic or cholinergic drugs, cyclosporine, or any medications broken down by your liver — barberry may affect how these work.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Berberine+ has two ingredients with moderate interactions affecting blood thinners, blood pressure drugs, and diabetes medications — the biggest concern. Neither ingredient has strong evidence it works for its typical uses.
If you take any prescription medication, especially blood thinners, blood pressure drugs, diabetes drugs, or liver-metabolized medications, check with your pharmacist before starting. Avoid this product entirely if you're pregnant or breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Berberine+, straight from the product label.
| Brand | Nutritional Frontiers |
|---|---|
| Barcode (UPC) | 815317015728 |
| Net contents | 96 Liquid Serving(s); 4 Fluid Ounce(s); 118.29 Milliliter(s) |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2023 |
| DSLD ID | 299488 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Berberine+ by Nutritional Frontiers, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
Warning: If you are pregnant or nursing, consult your health care practitioner before taking this or any herbal product.
FDA Disclaimer Statement
This product has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formula
Tincture
FDA Statement of Identity
Professional Grade Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: 1-2 full droppers 1-2 times per day.
General Statements
cbdnf.com
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Berberine+ by Nutritional Frontiers label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Berberine+ by Nutritional Frontiers
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Full Dropper(s) Dosage formLiquid Servings per container96 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Cinnamon
Interacts with258 drugs
Ceylon cinnamon is the so-called 'true' cinnamon, valued as a spice and used in traditional medicine for blood sugar, cholesterol, and digestion. Evid...
Cinnamon monograph & interactionsBarberry
Interacts with1,210 drugs
European barberry is a shrub whose root, bark, and berries contain berberine, a bitter plant alkaloid that has been studied mostly in isolated form. S...
Barberry monograph & interactionsOther (inactive) ingredients: Alcohol. These complete the product’s ingredient list but are not active constituents.
Berberine+ by Nutritional Frontiers Drug Interactions
HelloPharmacist Interaction Report
Berberine+ by Nutritional Frontiers contains two active ingredients, and both have documented interactions with medications.
The most serious concern is barberry's interaction with blood thinners and antiplatelet drugs (aspirin, warfarin, clopidogrel) — there's preliminary evidence that berberine, its main compound, may inhibit platelet clumping and theoretically raise your bleeding risk. Both cinnamon and barberry may lower blood pressure, so if you're on antihypertensive drugs (like lisinopril or amlodipine), either one could add to that effect and cause dizziness or low blood pressure (hypotension).
Read the full breakdown — every affected drug type, severity by severity
Both ingredients also interact with diabetes medications. Cinnamon and barberry may lower blood sugar levels, so combined with drugs like metformin or insulin, you could face low blood sugar (hypoglycemia) — dose adjustments might be needed.
Barberry has several other interactions worth checking: it may increase levels of certain medications broken down by your liver (CYP3A4 substrates, including some statins and immunosuppressants), theoretically raise the sedative effects of sleep aids or anti-anxiety drugs, and interfere with anticholinergic or cholinergic drugs used for conditions like urinary retention or myasthenia gravis.
Altogether, these interactions span 1,197 individual medications. Use the search tool below to check your exact prescriptions before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Berberine+?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Berberine+ interact with 1,210 drugs. Click any drug to see the details.
2 of the 2 ingredients in Berberine+ interact with drugs. Each result below shows which ingredient is responsible. Barberry Cinnamon
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Barberry + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, European barberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Barberry + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Barberry + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Barberry + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Barberry + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, European barberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Barberry + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Barberry + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Berberine+ — through 2 ingredients. Tap an ingredient for the detail:
BarberryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking European barberry with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Barberry + Acarbose interactionCinnamonAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon may have additive effects with antidiabetes drugs.
Read the full Cinnamon + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Berberine+ — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Cinnamon + Acebutolol interactionBarberryAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking European barberry with antihypertensive drugs might increase the risk of hypotension.
Read the full Barberry + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, European barberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Barberry + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryAnticholinergic Drugs, Cns Depressants Moderate
Interaction Summary
Theoretically, taking European barberry with anticholinergic drugs might cause additive effects.
Read the full Barberry + Acepromazine interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, European barberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Barberry + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Barberry + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Barberry + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Barberry + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Barberry + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Barberry + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Barberry + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Barberry + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Barberry + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Barberry + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Barberry + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryCytochrome P450 3a4 (cyp3a4) Substrates, Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Barberry + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryAnticholinergic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking European barberry with anticholinergic drugs might cause additive effects.
Read the full Barberry + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Barberry + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryCytochrome P450 3a4 (cyp3a4) Substrates, Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Barberry + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryAnticholinergic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking European barberry with anticholinergic drugs might cause additive effects.
Read the full Barberry + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryAnticholinergic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking European barberry with anticholinergic drugs might cause additive effects.
Read the full Barberry + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryCytochrome P450 3a4 (cyp3a4) Substrates, Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Barberry + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Berberine+ — through 1 ingredient. Tap an ingredient for the detail:
BarberryCytochrome P450 3a4 (cyp3a4) Substrates, Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Barberry + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Berberine+ with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Barberry
Anticholinergic Drugs
Theoretically, taking European barberry with anticholinergic drugs might cause additive effects.
In vitro evidence suggests that European barberry might have anticholinergic properties.
Anticoagulant/Antiplatelet Drugs
Theoretically, European barberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal evidence suggest that berberine, a constituent of European barberry, might inhibit platelet aggregation. Theoretically, European barberry might have a similar effect.
Antidiabetes Drugs
Theoretically, taking European barberry with antidiabetes drugs might increase the risk of hypoglycemia.
Preliminary clinical evidence suggests that European barberry juice reduces fasting glucose levels in patients with type 2 diabetes who are also taking antidiabetes drugs. Additionally, some animal studies show that berberine, a constituent of European barberry, has antiglycemic potential. Monitor blood glucose levels closely.
Antihypertensive Drugs
Theoretically, taking European barberry with antihypertensive drugs might increase the risk of hypotension.
Animal and human research suggests that European barberry extracts can have hypotensive effects.
Cholinergic Drugs
Theoretically, taking European barberry with cholinergic drugs might decrease the effects of cholinergic drugs.
In vitro evidence suggests that European barberry might have anticholinergic properties.
Cns Depressants
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Animal research suggests that berberine, a constituent of European barberry, might have sedative effects. Theoretically, European barberry might have a similar effect.
Cyclosporine (Neoral, Sandimmune)
Theoretically, concomitant use with cyclosporine may cause additive effects.
Berberine, a constituent of European barberry, can reduce the metabolism and increase serum levels of cyclosporine. This effect is attributed to the ability of berberine to inhibit cytochrome P450 3A4 (CYP3A4), which metabolizes cyclosporine. Theoretically, European barberry might have a similar effect.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.
There is very preliminary evidence suggesting that berberine, a constituent of European barberry, might inhibit the CYP3A4 enzyme. Theoretically, European barberry might have a similar effect.
Cinnamon
Antidiabetes Drugs
Theoretically, Ceylon cinnamon may have additive effects with antidiabetes drugs.
Ceylon cinnamon may lower blood glucose levels. Dose adjustments might be necessary.
Antihypertensive Drugs
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Animal research shows that Ceylon cinnamon extract has vasorelaxant properties and reduces blood pressure in rat models of hypertension, possibly via inhibition of calcium influx through L-type voltage-sensitive channels.
Brand information
Manufacturer and brand details for Berberine+, from the product label.
Nutritional Frontiers
See all Nutritional Frontiers products- Name
- Nutritional Frontiers LLC
- Street Address
- 3191 Washington Pike
- City
- Bridgeville
- State
- PA
- ZipCode
- 15017
- Phone Number
- (412) 922-2566
- Web Address
- nutritionalfrontiers.com
Berberine+ by Nutritional Frontiers: Common Questions
Does Berberine+ by Nutritional Frontiers interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take Berberine+ if I'm pregnant or breastfeeding?
What are the side effects of cinnamon in this product?
Does this product actually work for diabetes or blood sugar?
What's in this product besides the active ingredients?
Can I take this with blood pressure or diabetes medication?
Is there any safety concern specific to barberry?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Berberine+ is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Berberine+’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Ceylon Cinnamon
Interacts with 258 drugsCeylon cinnamon is the so-called 'true' cinnamon, valued as a spice and used in traditional medicine for blood sugar, cholesterol, and digestion. Evidence for most health benefits is limited...
Read the full Ceylon Cinnamon monograph → Herb & supplement monographEuropean Barberry
Interacts with 1,210 drugsEuropean barberry is a shrub whose root, bark, and berries contain berberine, a bitter plant alkaloid that has been studied mostly in isolated form. Some early research on berberine is promi...
Read the full European Barberry monograph →Sources & How We Checked
Berberine+'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 37 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Ceylon Cinnamon 22 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Choi HK, Jung GW, Moon KH, et al. Clinical study of SS-Cream in patients with lifelong premature ejaculation. Urology 2000;55:257-61. PubMed
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Anderson RA, Broadhurst CL, Polansky MM, et al. Isolation and Characterization of Polyphenol Type-A Polymers from Cinnamon with Insulin-like Biological Activity. J Agric Food Chem 2004;52:65-70. PubMed
- Jarvill-Taylor KJ, Anderson RA, Graves DJ. A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. J Am Coll Nutr 2001;20:327-36. PubMed
- Onderoglu S, Sozer S, Erbil KM, et al. The evaluation of long-term effcts of cinnamon bark and olive leaf on toxicity induced by streptozotocin administration to rats. J Pharm Pharmacol 1999;51:1305-12.
- Kanerva L, Estlander T, Jolanki R. Occupational allergic contact dermatitis from spices. Contact Dermatitis 1996;35:157-62. PubMed
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