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Dietary supplement

Best Serrapeptase Ingredients & Drug Interactions

by Doctor's Best

Best Serrapeptase label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Best Serrapeptase against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Best Serrapeptase is a dietary supplement by Doctor's Best with 1 active ingredient. Its ingredients are commonly taken for inflammation and swelling, sinus and respiratory congestion, pain after surgery or injury.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Serrapeptase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Best Serrapeptase by Doctor's Best

Ask about any prescription or over-the-counter medication and we check it for interactions with Best Serrapeptase by Doctor's Best — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Best Serrapeptase by Doctor's Best

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Best Serrapeptase is a single-ingredient supplement containing serrapeptase, an enzyme with fibrinolytic activity — meaning it can break down fibrin, a protein involved in blood clots and inflammation. The capsule itself is made up of inactive ingredients: cellulose, modified cellulose, and an enteric coating (a protective layer designed to help the enzyme survive stomach acid and dissolve in the small intestine).

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Serrapeptase product and its label doesn't state a use — see Serrapeptase's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for serrapeptase is currently insufficient to establish it works for the conditions it's marketed for. Our data shows insufficient reliable evidence for chronic bronchitis, asthma, atherosclerosis, back pain, and osteoporosis.

That doesn't mean it's ineffective — it means the studies we have aren't robust enough to say one way or the other. If you're considering this supplement for a specific condition, talk it over with your doctor or pharmacist to weigh what evidence exists against your individual needs.

The evidence, ingredient by ingredient Serrapeptase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Serrapeptase appears generally well tolerated in short-term use. The most common side effects reported in trials — epigastric pain (upper belly discomfort), gastrointestinal upset, and nausea — occur at about the same rate as placebo, suggesting they may not be directly caused by the supplement.

A rare serious side effect (bullous pemphigoid, a blistering skin condition) has been reported. Long-term safety hasn't been well studied, so caution is warranted if you're planning to take this for months at a time.

The safety data during pregnancy advises against it, and there isn't reliable safety information for breastfeeding either — talk with your doctor or pharmacist for personalized guidance if you're pregnant or nursing.

Side effects, ingredient by ingredient Serrapeptase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Serrapeptase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you're on blood thinners or antiplatelet drugs — including aspirin, warfarin, dabigatran, apixaban, clopidogrel, ticagrelor, or similar medications — double-check with your pharmacist before taking serrapeptase. This is the only documented drug interaction in our data, but it's a Moderate severity concern.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Best Serrapeptase is a single-enzyme supplement that's generally well tolerated short-term but has insufficient evidence behind most of its marketed uses. The main caution is with blood thinners and antiplatelet drugs, where it may increase bleeding risk.

If you take any such medication, or if you're pregnant or breastfeeding, check with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Best Serrapeptase, straight from the product label.

Brand Doctor's Best
Barcode (UPC) 753950002920
Net contents 10 Veggie Cap(s)
Market status On market
Date entered into DSLD Sep 25, 2013
DSLD ID 25222
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Best Serrapeptase by Doctor's Best, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
10
UPC/BARCODE
753950002920
IngredientAmount% DV
Serrapeptase40000 Unit(s)--

Other ingredients: Cellulose, Modified Cellulose, Enteric Coating

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Science-Based Nutrition(TM)

Formula

40,000 SERRATIO UNITS PER VEGGIE CAP

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Non-GMO and Gluten Free

Suitable for Vegetarians

General Statements

CONTAINS NOTHING OTHER THAN LISTED INGREDIENTS

Suggested/Recommended/Usage/Directions

Suggested Adult Use: Take 1 to 3 capsules daily away from food.

General

R 10/12

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Best Serrapeptase by Doctor's Best label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Best Serrapeptase label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Best Serrapeptase by Doctor's Best

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container10 Amounts shown are per serving.

Serrapeptase

Interacts with
122 drugs
40000 Unit(s) per serving

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you...

Serrapeptase monograph & interactions

Other (inactive) ingredients: Cellulose, Modified Cellulose, Enteric Coating. These complete the product’s ingredient list but are not active constituents.

Interaction report

Best Serrapeptase by Doctor's Best Drug Interactions

Want to check YOUR meds against Best Serrapeptase?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Serrapeptase 122

Individual Drug Interactions

The ingredients in Best Serrapeptase interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Best Serrapeptase interact with drugs. Each result below shows which ingredient is responsible. Serrapeptase

Each ingredient & the kinds of drugs it affects

For each ingredient in Best Serrapeptase with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Serrapeptase1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking serrapeptase with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising and bleeding.
In vitro research shows that serrapeptase has fibrinolytic activity.

Likelihood Possible Evidence D
Serrapeptase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Best Serrapeptase, from the product label.

Doctor's Best

See all Doctor's Best products
Name
Doctor's Best, Inc.
City
San Clemente
State
CA
ZipCode
92673
Phone Number
(800) 777-2474
Web Address
www.drbvitamins.com
Pharmacist Counseling Corner

Best Serrapeptase by Doctor's Best: Common Questions

Does Best Serrapeptase by Doctor's Best interact with any medications?
Yes. Based on its ingredients, Best Serrapeptase has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Best Serrapeptase contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is serrapeptase?
Serrapeptase is an enzyme with fibrinolytic activity, meaning it can break down fibrin — a protein involved in blood clots. It's derived from silkworm cocoons and marketed to support inflammation response and circulation.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against serrapeptase during pregnancy. For breastfeeding, there isn't reliable safety information available. Talk with your doctor or pharmacist — they can help you weigh what you need against the unknowns here.
Does this supplement actually work for the conditions it claims to help?
The evidence isn't established yet. Our data shows insufficient reliable evidence for chronic bronchitis, asthma, atherosclerosis, back pain, and osteoporosis — the conditions it's commonly marketed for. That means the studies to date aren't strong enough to say whether it works or not.
What side effects should I watch for?
Most people tolerate it well. The most common reported side effects — upper belly discomfort, nausea, and general stomach upset — happen about as often with placebo, so they may not be from the supplement itself. A rare serious side effect (a blistering skin condition) has been reported, though it's uncommon.
Is it safe to take long-term?
Long-term safety hasn't been well studied, so we can't say for certain. If you're planning to take this for months at a time, mention it to your doctor or pharmacist so they can monitor you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Best Serrapeptase is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Best Serrapeptase label
Go deeper

The Full Monographs Behind Best Serrapeptase’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Serrapeptase

Interacts with 122 drugs

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you want to try it, choose an enteric-coate...

Read the full Serrapeptase monograph →
Sources

Sources & How We Checked

Best Serrapeptase's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Serrapeptase 2 references
  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

See these in context on the Serrapeptase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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