Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Big Noise Unflavored Ingredients & Drug Interactions

by Redcon1

Big Noise Unflavored label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Big Noise Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Big Noise Unflavored is a dietary supplement by Redcon1 with 8 active ingredients. Its ingredients are commonly taken for constipation (laxative), dry skin (moisturizer), dry, irritated eyes.Based on those ingredients, 1,367 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rhodiola rosea root extract, Beet (Beta vulgaris) root extract, Agmatine Sulfate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Big Noise Unflavored by Redcon1

Ask about any prescription or over-the-counter medication and we check it for interactions with Big Noise Unflavored by Redcon1 — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Big Noise Unflavored by Redcon1

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 8 of its 8 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Big Noise Unflavored contains 8 active ingredients formulated to support focus and performance. Glycerol monostearate and betaine anhydrous function as hydration and osmotic agents.

Agmatine sulfate and alpha-GPC (L-alpha glycerylphosphorylcholine) support cognitive function and nitric oxide signaling. Rhodiola rosea root extract is an adaptogen, huperzine A is an acetylcholinesterase inhibitor that supports acetylcholine levels, and choline supports cognitive and neuromuscular function.

Beet root extract supplies nitrates for blood flow support. The product also contains inactive ingredients including maltodextrin, silica, disodium phosphate, sucralose, and acesulfame-K for texture and taste.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: muscle pumps mental clarity and focus.
  • We looked for evidence on: Athletic performance, Cognitive function, Exercise-induced muscle damage, Exercise-induced muscle soreness, Fatigue, Memory — and 4 related terms.
  • The strongest evidence on file: Glycerol is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Beet is rated "Possibly Effective" for Athletic performance, Exercise-induced muscle soreness.
  • Also on file: Choline is rated "Possibly Ineffective" for Athletic performance.

The evidence supporting these ingredients varies widely. Rhodiola, alpha-GPC, and huperzine A have 'Insufficient Reliable Evidence' ratings for most cognitive and performance claims in our data, though alpha-GPC is rated 'Possibly Effective' for Alzheimer disease and huperzine A is 'Possibly Effective' for Alzheimer disease as well.

Glycerol is 'Likely Effective' for constipation but 'Possibly Ineffective' for meningitis and stroke. Beet is 'Possibly Effective' for athletic performance and exercise-induced muscle soreness.

For most other conditions and uses listed, effectiveness evidence is not established or is insufficient in the data we hold.

The evidence, ingredient by ingredient Glycerol Agmatine Rhodiola Alpha-gpc Beet Choline Huperzine A Betaine Anhydrous

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Glycerol is generally well tolerated in normal amounts but can cause stomach upset and dehydration with large doses; orally it may cause bloating, diarrhea, nausea, vomiting, dizziness, and headache. Agmatine is well tolerated short-term; diarrhea, indigestion, and nausea occurred in small trial numbers.

Rhodiola is generally well tolerated short-term and may cause dizziness or changes in saliva production. Alpha-GPC is generally well tolerated but has rarely been associated with dizziness, headache, insomnia, and (with use of 2+ months) an elevated stroke risk.

Beet is generally well tolerated and commonly causes harmless red or black stools; large amounts theoretically risk kidney damage. Huperzine A causes dose-dependent cholinergic effects (nausea, vomiting, diarrhea, blurred vision, dry mouth, constipation).

Choline is well tolerated in food amounts but high doses (over 3.5 grams daily) cause fishy body odor, nausea, and gastrointestinal distress. Betaine is generally well tolerated but may cause body odor, nausea, vomiting, and GI distress.

Side effects, ingredient by ingredient Glycerol Agmatine Rhodiola Alpha-gpc Beet Choline Huperzine A Betaine Anhydrous

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 8 matched ingredients can interact with medications — Beet, Choline, Huperzine A, Rhodiola, Alpha-gpc, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,368 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check any antihypertensive drugs (Moderate severity—agmatine and rhodiola may lower blood pressure further), antidiabetes medications (Moderate—agmatine and rhodiola may increase hypoglycemia risk), and drugs metabolized by liver enzyme CYP3A4 (Moderate—beet and rhodiola may raise levels). Also check anticholinergic and cholinergic medications (huperzine A has Moderate interactions with both), immunosuppressants (rhodiola has Moderate interaction), losartan specifically, and P-glycoprotein substrates.

Minor interactions exist with scopolamine patches and atropine. No interactions are documented for betaine anhydrous.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-ingredient cognitive and performance formula with notable interaction potential—especially with blood pressure, blood sugar, and liver-metabolized drugs. If you take any prescription medications, run them through the checker below before starting, particularly if you're on antihypertensives, diabetes drugs, or cholinergic agents.

Talk to your pharmacist about whether the combination is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Big Noise Unflavored, straight from the product label.

Brand Redcon1
Barcode (UPC) 810044571059
Net contents 11.1 Ounce(s); 315 Gram(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 269107
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Big Noise Unflavored by Redcon1, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
10.5 Gram(s)
Maximum serving Sizes:
10.5 Gram(s)
Servings per container
30
UPC/BARCODE
810044571059
IngredientAmount% DV
Glycerol Monostearate3 Gram(s)--
Agmatine Sulfate1 Gram(s)--
Rhodiola rosea root extract200 mg--
L-Alpha Glycerylphosphorylcholine300 mg--
Beet (Beta vulgaris) root extract1 Gram(s)--
Choline250 mg45%
Huperzine A200 mcg--
Betaine Anhydrous2.5 Gram(s)--

Other ingredients: Disodium Phosphate, Sucralose, Acesulfame-K, Maltodextrin, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

The Objective: Non-stimulant preworkout pump with the power of nootropics. The combination brings massive pumps with intense mental clarity and focus.

Blood flow/pumps Increase blood oxygen Mental focus

Suggested/Recommended/Usage/Directions

Big Noise Suggested Use: To maximum pre-workout pumps and muscular volume, mix (1) scoop with 4-6 ounces of water 30 minutes prior to training. Do not exceed more than (1) scoop per day.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Nutravigilance Verified Supplement Safety Solutions

General Statements

Pump up the volume, bring the noise Pump

Product does not completely fill container. Settling occurs in shipping.

FDA Statement of Identity

Dietary Supplement

Precautions

Warning: This product is intended to be consumed by healthy adults 18 years of age or older.

Do not use if you are pregnant, nursing, taking any prescription or over-the-counter medications, or if you have or suspect you may have a medical condition.

As with any dietary supplement, consut a healthcare proessional before using this product. Discontinue 2 weeks prior to surgery. Immediately discontinue use and consult a healthcare professional if you experience any adverse reactions.

Keep out of reach of children.

Storage

Store at 59-86 degrees F (15-30 degrees C). Protect from light and moisture.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Big Noise Unflavored by Redcon1 label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Big Noise Unflavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Big Noise Unflavored by Redcon1

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size10.5 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Glycerol Monostearate

No known
interactions
3 Gram(s) per serving

Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well establis...

Glycerol Monostearate monograph & interactions

Agmatine Sulfate

Interacts with
258 drugs
1 Gram(s) per serving

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most...

Agmatine Sulfate monograph & interactions

Rhodiola rosea root extract

Interacts with
1,271 drugs
200 mg per serving

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue...

Rhodiola rosea root extract monograph & interactions

L-Alpha Glycerylphosphorylcholine

Interacts with
16 drugs
300 mg per serving

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

L-Alpha Glycerylphosphorylcholine monograph & interactions

Beet (Beta vulgaris) root extract

Interacts with
861 drugs
1 Gram(s) per serving

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some peopl...

Beet (Beta vulgaris) root extract monograph & interactions

Choline

Interacts with
16 drugs
250 mg per serving Form: CDP-Choline

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline monograph & interactions

Huperzine A

Interacts with
219 drugs
200 mcg per serving Form: Huperzia serrata

Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription A...

Huperzine A monograph & interactions

Betaine Anhydrous

No known
interactions
2.5 Gram(s) per serving

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and a...

Betaine Anhydrous monograph & interactions

Other (inactive) ingredients: Disodium Phosphate, Sucralose, Acesulfame-K, Maltodextrin, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Big Noise Unflavored by Redcon1 Drug Interactions

Want to check YOUR meds against Big Noise Unflavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,367Drugs
1,195 Moderate 172 Minor

Ingredients driving the most interactions

Rhodiola rosea root extract 1,271
Beet (Beta vulgaris) root extract 861
Agmatine Sulfate 258
Huperzine A 219
L-Alpha Glycerylphosphorylcholine 16

Individual Drug Interactions

The ingredients in Big Noise Unflavored interact with 1,367 drugs. Click any drug to see the details.

6 of the 8 ingredients in Big Noise Unflavored interact with drugs. Each result below shows which ingredient is responsible. Rhodiola rosea root extract Beet (Beta vulgaris) root extract Agmatine Sulfate Huperzine A L-Alpha Glycerylphosphorylcholine Choline

Each ingredient & the kinds of drugs it affects

For each ingredient in Big Noise Unflavored with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Rhodiola rosea root extract10 drug types · 1,271 drugs

Antidiabetes Drugs

Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
In vitro and animal research shows that rhodiola extract can decrease blood glucose due to alpha-glucosidase activity.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
In vitro and animal research shows that rhodiola extract inhibits angiotensin-converting enzyme (ACE) and might lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that rhodiola inhibits CYP2C9. This effect is highly variable and appears to be dependent on the rhodiola product studied. Also, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.
In vitro and animal research show that rhodiola has immunostimulatory effects.

Likelihood Possible Evidence D
Losartan (Cozaar)

Rhodiola might increase the levels and adverse effects of losartan.
A clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Probable Evidence B
P-Glycoprotein Substrates

Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
In vitro research shows that rhodiola inhibits P-glycoprotein. Theoretically, using rhodiola with P-glycoprotein substrates might increase drug levels and potentially increase the risk of adverse effects.

Likelihood Possible Evidence D
Antidepressant Drugs

Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.
A review of adverse event reports in Poland identified cases of tachyarrhythmias, myalgia, arthralgia, gum pain, restless leg syndrome, swallowing disorders, and changes in consciousness when rhodiola was taken in combination with paroxetine, escitalopram, fluoxetine, sertraline, trazodone, and/or duloxetine.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
A review of adverse event reports in Poland identified cases of excessive sedation, myoclonus, hypotension, and hallucinations when rhodiola was taken with haloperidol, diazepam, or alprazolam.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that rhodiola inhibits CYP1A2. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of caffeine, a CYP1A2 substrate.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that rhodiola inhibits CYP3A4. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of midazolam, a CYP3A4 substrate.

Likelihood Possible Evidence B
Rhodiola rosea root extract full monograph & interactions

Beet (Beta vulgaris) root extract3 drug types · 861 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.
In vitro research suggests that betanin, the major pigment in beet, competitively inhibits CYP3A4 in a dose-dependent manner similarly to strong CYP3A4 inhibitor ketoconazole.

Likelihood Possible Evidence D
Antihypertensive Drugs

Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure. However, a study published in the European Journal of Clinical Nutrition using concentrated beetroot juice found no significant impact on blood pressure or heart rate in different age groups. Other small clinical studies suggest that while beet consumption might transiently lower blood pressure due to vessel dilation, there's no consistent evidence of a lasting effect. Overall, the theoretical risk of reduced blood pressure due to beet's nitrate content exists, but studies generally indicate a low and temporary impact rather than a sustained decrease.

Likelihood Possible Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research suggests that beet induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Beet (Beta vulgaris) root extract full monograph & interactions

Agmatine Sulfate2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggest that agmatine has mild hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that agmatine can modestly decrease heart rate and blood pressure.

Likelihood Possible Evidence D
Agmatine Sulfate full monograph & interactions

Huperzine A2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Huperzine A has acetylcholinesterase (AChE) inhibiting effects. In animal models, huperzine A reversed cognitive deficits induced by scopolamine, an anticholinergic drug.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of huperzine A with cholinergic drugs might increase the effects and side effects of these medications.
Huperzine A can inhibit acetylcholinesterase (AChE) and might cause cumulative effects if used with cholinergic drugs.

Likelihood Possible Evidence B
Huperzine A full monograph & interactions

L-Alpha Glycerylphosphorylcholine1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
L-Alpha Glycerylphosphorylcholine full monograph & interactions

Choline1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Big Noise Unflavored, from the product label.

Redcon1

See all Redcon1 products
Name
Redcon1, LLC
Street Address
701 Park of Commerce Blvd., Suite 101
City
Boca Raton
State
FL
ZipCode
33487
Phone Number
1(855)733-2661
Web Address
www.Redcon1.com
Pharmacist Counseling Corner

Big Noise Unflavored by Redcon1: Common Questions

Does Big Noise Unflavored by Redcon1 interact with any medications?
Yes. Based on its ingredients, Big Noise Unflavored has a known interaction with 1,367 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Big Noise Unflavored contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to use if I'm pregnant or breastfeeding?
Safety data during pregnancy and breastfeeding is limited or absent for most ingredients here. Agmatine and rhodiola safety data advises against use in pregnancy and while breastfeeding. Alpha-GPC and huperzine A lack sufficient safety information—you should avoid them unless your doctor directs otherwise. Choline is rated Likely Safe and is actually important during pregnancy and breastfeeding, but use only prenatal doses or supplement doses advised by your doctor. Talk with your pharmacist or doctor about your specific situation before starting.
What does alpha-GPC (alpha-glycerylphosphorylcholine) do?
Alpha-GPC is included to support cognitive function. It's rated Possibly Effective for Alzheimer disease in our data. It's generally well tolerated in studies, though long-term safety isn't fully established. Rarely, it's been associated with dizziness, headache, and insomnia, and there's a rare elevated stroke risk with use of 2 or more months.
Can I expect this to improve my athletic performance?
Evidence for most ingredients here on athletic performance is rated Insufficient or Possibly Ineffective in our data. Beet is rated Possibly Effective for athletic performance and exercise-induced muscle soreness. For the others—agmatine, rhodiola, huperzine A, choline, and glycerol—we don't hold strong evidence for performance gains.
What are the common side effects I might experience?
The most frequent side effects across these ingredients are gastrointestinal: diarrhea, nausea, vomiting, and indigestion. Huperzine A can cause cholinergic effects like dry mouth, blurred vision, and constipation. Glycerol may cause dizziness and headache. Rhodiola may cause dizziness or dry mouth. Beet commonly causes harmless red or black stools. Choline and betaine at high doses can cause fishy body odor.
Why does this product have so many interactions with medications?
Several ingredients here—rhodiola, beet, and huperzine A—affect how your liver metabolizes drugs or how your body's chemical messengers work. Rhodiola and agmatine also affect blood pressure and blood sugar. When a supplement influences these systems, it can change how many different drugs behave. That's why checking your exact medications before starting is important.
Is betaine anhydrous safe to use with my other medications?
Betaine anhydrous shows no known interactions in our data. However, it can cause body odor, nausea, vomiting, and GI distress, and safety during pregnancy and breastfeeding isn't well established. If you have concerns about how it works with your specific medications or health situation, check with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Big Noise Unflavored label
Go deeper

The Full Monographs Behind Big Noise Unflavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glycerol

Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well established as a laxative and a skin and eye moi...

Read the full Glycerol monograph → Herb & supplement monograph

Agmatine

Interacts with 258 drugs

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most of its claimed benefits is limited and...

Read the full Agmatine monograph → Herb & supplement monograph

Rhodiola

Interacts with 1,271 drugs

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue and improve mood, but the evidence is li...

Read the full Rhodiola monograph → Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph → Herb & supplement monograph

Beet

Interacts with 861 drugs

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some people. It is generally safe as a food, but s...

Read the full Beet monograph → Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph → Herb & supplement monograph

Huperzine A

Interacts with 219 drugs

Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription Alzheimer's drugs. Some small studies sug...

Read the full Huperzine A monograph → Herb & supplement monograph

Betaine Anhydrous

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and as a prescription medicine for a rare gen...

Read the full Betaine Anhydrous monograph →
Sources

Sources & How We Checked

Big Noise Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 80 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycerol 8 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Wagner DR. Hyperhydrating with glycerol: implications for athletic performance. J Am Diet Assoc 1999;99:207-12. PubMed
  3. Yu YL, Kumana CR, Lauder IJ, et al. Treatment of acute cortical infarct with intravenous glycerol. A double-blind, placebo-controlled randomized trial. Stroke 1993;24:1119-24. PubMed
  4. Frei A, Cottier C, Wunderlich P, Ludin E. Glycerol and dextran combined in the therapy of acute stroke. A placebo-controlled, double-blind trial with a planned interim analysis. Stroke 1987;18:373-9. PubMed
  5. Balaskas E, Szepietowski JC, Bessis D, Ioannides D, Ponticelli C, Ghienne C, Taberly A, Dupuy P. Randomized, double-blind study with glycerol and paraffin in uremic xerosis. Clin J Am Soc Nephrol. 2011 Apr;6(4):748-52. PubMed
  6. Blanchet-Bardon C, Tadini G, Machado Matos M, Delarue A. Association of glycerol and paraffin in the treatment of ichthyosis in children: an international, multicentric, randomized, controlled, double-blind study. J Eur Acad Dermatol Venereol. 2012 Aug;26 PubMed
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Agmatine 3 references
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Rhodiola 13 references
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Alpha-gpc 4 references
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Beet 14 references
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Choline 14 references
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  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
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See these in context on the Choline monograph →

Huperzine A 13 references
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  2. Ye JW, Cai JX, Wang LM, Tang XC. Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment. J Pharmacol Exp Ther 1999;288:814-9.. DOI
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Betaine Anhydrous 11 references
  1. Cystadane (betaine anhydrous for oral solution) Package insert. Orphan Medical, Inc. Minnetonka, MN. November 2005.
  2. Abdelmalek MF, Angulo P, Jorgensen RA, et al. Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Am J Gastroenterol 2001;96:2711-7.. PubMed
  3. Schwab U, Torronen A, Toppinen L, et al. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr 2002;76:961-7. PubMed
  4. McGregor DO, Dellow WJ, Robson RA, et al. Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure. Kidney Int 2002;61:1040-6. PubMed
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  7. Moat, S. J., Madhavan, A., Taylor, S. Y., Payne, N., Allen, R. H., Stabler, S. P., Goodfellow, J., McDowell, I. F., Lewis, M. J., and Lang, D. High- but not low-dose folic acid improves endothelial function in coronary artery disease. Eur J Clin Invest 2 PubMed
  8. Abdelmalek, M. F., Sanderson, S. O., Angulo, P., Soldevila-Pico, C., Liu, C., Peter, J., Keach, J., Cave, M., Chen, T., McClain, C. J., and Lindor, K. D. Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial. Hepa PubMed
  9. Ashtary-Larky D, Bagheri R, Ghanavati M, et al. Effects of betaine supplementation on cardiovascular markers: a systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2021 Mar 25:1-18. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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