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Dietary supplement

Biotin Advanced Ingredients & Drug Interactions

by MyTrition

Biotin Advanced label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Biotin Advanced against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Biotin Advanced is a dietary supplement by MyTrition with 2 active ingredients. Its ingredients are commonly taken for antioxidant support, skin health and aging, eye health.Based on those ingredients, 671 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Biotin Advanced by MyTrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Biotin Advanced by MyTrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Biotin Advanced by MyTrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has 2 active ingredients. Biotin is a B vitamin your body uses to process fats, carbohydrates, and amino acids; your body can't store it, so it relies on daily intake.

Astaxanthin is a carotenoid — a pigment found in certain seafood and algae — that acts as an antioxidant. The tablet also contains inactive ingredients (microcrystalline cellulose, croscarmellose sodium, silica, and stearic acid) that help hold it together and make it easier to swallow.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Healthy hair, nails, and skin appearance.
  • We looked for evidence on: Alopecia areata, Biotin deficiency, Brittle nails, Aging skin, Seborrheic dermatitis, Hair loss — and 2 related terms.
  • The strongest evidence on file: Biotin is rated "Likely Effective" for Biotin deficiency (Natural Medicines).
  • Also on file: Biotin is rated "Possibly Ineffective" for Seborrheic dermatitis.
  • Also on file: Biotin is rated "Insufficient Reliable Evidence To Rate" for Alopecia areata, Brittle nails.

Biotin is likely effective for biotin deficiency — if you're actually deficient, supplementing will help. For other uses listed here, the evidence in our data shows insufficient or possibly ineffective ratings: age-related cognitive decline, macular degeneration, aging skin, Alzheimer disease, athletic performance, and carpal tunnel syndrome don't have reliable evidence supporting biotin yet.

Astaxanthin has insufficient reliable evidence for all the conditions we track — age-related cognitive decline, macular degeneration, aging skin, Alzheimer disease, athletic performance, and carpal tunnel syndrome. That means the research isn't settled on whether it works for these uses.

The evidence, ingredient by ingredient Astaxanthin Biotin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Biotin is generally well tolerated, even at fairly high doses, because your body excretes excess in urine. High-dose biotin has rarely caused mild diarrhea; one case report linked high-dose biotin combined with pantothenic acid to a serious inflammatory condition, but it's unclear whether biotin was responsible.

Astaxanthin is also generally well tolerated, though long-term safety data are limited. The most common side effects from astaxanthin are abdominal pain, diarrhea, and red-colored stool; at very high doses (40 mg daily), severe stomach pain has been reported in a small number of trial participants.

For pregnancy: the safety data advise against astaxanthin during pregnancy and breastfeeding — there isn't enough information to know it's safe. Biotin is likely safe during pregnancy and breastfeeding at normal dietary and supplement amounts, though you should check with your doctor before taking high-dose biotin supplements.

Side effects, ingredient by ingredient Astaxanthin Biotin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Astaxanthin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 672 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start Biotin Advanced, check with your doctor or pharmacist about any medications you take that are metabolized by your liver — especially drugs broken down by the CYP3A4 or CYP2B6 enzymes (Moderate severity for both). These include certain statins, blood pressure medications, and immunosuppressants.

Biotin has no documented interactions with medications we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product makes sense if you're deficient in biotin and want an antioxidant supplement, but the evidence for astaxanthin's effectiveness on aging, cognition, or skin isn't strong yet. The main caution is astaxanthin's potential to speed up how your liver breaks down certain medications — if you take prescription drugs, especially ones metabolized by your liver, run them through the checker below with your doctor or pharmacist before starting.

Pregnancy and breastfeeding: talk with your doctor or pharmacist about whether this is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 7, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Biotin Advanced, straight from the product label.

Brand MyTrition
Barcode (UPC) 766536036134
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Jan 7, 2019
DSLD ID 180794
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Biotin Advanced by MyTrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
766536036134
IngredientAmount% DV
Astaxanthin6 mg--
Biotin5000 mcg16670%

Other ingredients: Microcrystalline Cellulose, Croscarmellose Sodium, Silica, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Beauty

For beauty from within

Healthy hair & nails support Improves appearance of skin & elasticity

Visit www.vitaminshoppe.com or call 1-800-223-1216 for more information and to reorder.

FDA Statement of Identity

Dietary supplement

Formulation

Does Not Contain: Gluten, Sugar, Salt, Fish, Preservatives, Artificial Colors or Flavors

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Directions: Take one (1) tablet daily with or without food.

Precautions

Warning: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions.

Keep out of reach of children.

Tamper evident Do not use if outer seal is broken or missing.

Storage

Store in a cool, dry place.

General

Item No. VS-3613 2153179 CS 64

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Biotin Advanced by MyTrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Biotin Advanced label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Biotin Advanced by MyTrition

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Astaxanthin

Interacts with
671 drugs
6 mg per serving

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin monograph & interactions

Biotin

No known
interactions
5000 mcg per serving

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get...

Biotin monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Croscarmellose Sodium, Silica, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Biotin Advanced by MyTrition Drug Interactions

Want to check YOUR meds against Biotin Advanced?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
671Drugs
671 Moderate

Ingredients driving the most interactions

Astaxanthin 671

Individual Drug Interactions

The ingredients in Biotin Advanced interact with 671 drugs. Click any drug to see the details.

1 of the 2 ingredients in Biotin Advanced interact with drugs. Each result below shows which ingredient is responsible. Astaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Biotin Advanced with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Biotin Advanced, from the product label.

MyTrition

See all MyTrition products
Name
Vitamin Shoppe, Inc.
City
Secaucus
State
NJ
ZipCode
07094
Phone Number
1-800-223-1216
Web Address
www.vitaminshoppe.com
Pharmacist Counseling Corner

Biotin Advanced by MyTrition: Common Questions

Does Biotin Advanced by MyTrition interact with any medications?
Yes. Based on its ingredients, Biotin Advanced has a known interaction with 671 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Biotin Advanced contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is biotin safe in high doses?
Biotin is generally well tolerated at high doses because your body excretes excess in urine. However, safety data are limited, and high-dose biotin has rarely caused mild diarrhea. Talk with your doctor or pharmacist before taking high-dose biotin supplements to make sure it's right for you.
Can I take this while pregnant or breastfeeding?
Biotin at normal dietary and supplement amounts is likely safe during pregnancy and breastfeeding, but astaxanthin isn't — there isn't enough safety data for astaxanthin in either condition. Discuss this product with your doctor or pharmacist before using it if you're pregnant or nursing.
What does astaxanthin do?
Astaxanthin is a carotenoid that acts as an antioxidant in your body. The evidence for its effectiveness on aging skin, cognitive decline, and other conditions listed here is insufficient — the research isn't settled yet on whether it works for these uses.
Does biotin work for hair loss or skin?
Biotin is likely effective for biotin deficiency. For other uses like alopecia (hair loss) or aging skin, the evidence we hold is insufficient or possibly ineffective, meaning we don't have strong proof it works yet.
What are the most common side effects?
Biotin rarely causes mild diarrhea at very high doses. Astaxanthin may cause abdominal pain, diarrhea, or red-colored stool; severe stomach pain has been reported at very high doses (40 mg daily). Both ingredients are generally well tolerated at typical doses.
Will this speed up how my liver processes medications?
Astaxanthin may theoretically decrease blood levels of drugs metabolized by your liver's CYP3A4 and CYP2B6 enzymes, though this hasn't been reported in humans yet. Use the interaction checker on this page to look up your exact medications, and talk with your doctor or pharmacist before starting if you take prescription drugs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Biotin Advanced label
Go deeper

The Full Monographs Behind Biotin Advanced’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph → Herb & supplement monograph

Biotin

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get plenty from a normal diet, and true defi...

Read the full Biotin monograph →
Sources

Sources & How We Checked

Biotin Advanced's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Biotin 4 references
  1. Debourdeau PM, Djezzar S, Estival JL, et al. Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann Pharmacother 2001;35:424-6. DOI
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. Mock DM, Quirk JG, Mock NI. Marginal biotin deficiency during normal pregnancy. Am J Clin Nutr 2002;75:295-9. PubMed
  4. Sedel F, Papeix C, Bellanger A, Touitou V, Lebrun-Frenay C, Galanaud D, et al. High doses of biotin in chronic progressive multiple sclerosis: a pilot study.Mult Scler Relat Disord. 2015;4(2):159-69. doi: 10.1016/j.msard.2015.01.005. PubMed

See these in context on the Biotin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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