Bitter Melon Extract, 500 mg Ingredients & Drug Interactions
by Solaray
What is this page for?
First and foremost: checking Bitter Melon Extract, 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Bitter Melon Extract, 500 mg is a dietary supplement by Solaray with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, diabetes, digestive complaints.Based on those ingredients, 282 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bitter Melon. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Bitter Melon Extract, 500 mg by Solaray
Ask about any prescription or over-the-counter medication and we check it for interactions with Bitter Melon Extract, 500 mg by Solaray — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Bitter Melon Extract, 500 mg by Solaray
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: bitter melon, a vine fruit used in traditional medicine and cooking. It's a single-ingredient supplement with no added actives — just the extract itself.
The capsule is made from vegetable cellulose, and the formula includes cellulose, silica, and magnesium stearate as inactive ingredients to hold everything together.
Does it work?
Not established
The evidence for bitter melon isn't established in our data. We hold no reliable evidence to rate its use for amenorrhea, athletic performance, liver disease, constipation, diabetes, or indigestion.
That doesn't mean it doesn't work — it means the studies we have aren't strong enough to say for certain.
How safe is it?
Well-documented data
Bitter melon taken by mouth is generally well tolerated as a food. When you take it as a supplement at higher doses, though, it may lower your blood sugar and cause stomach upset.
The most common side effects in studies were gastrointestinal — things like heartburn, nausea, vomiting, diarrhea, constipation, and abdominal discomfort, reported in about 3% to 16% of people. Rare serious effects include very low blood sugar (hypoglycemic coma) and seizures in children.
One case linked long-term use of bitter melon extract to kidney inflammation, which reversed once the supplement was stopped. Traditionally, bitter melon has been avoided in pregnancy because seeds and high doses may cause uterine effects or other harm.
While breastfeeding, there isn't enough reliable safety information, so it's best to avoid it or talk with your pharmacist or doctor for personalized advice.
Meds to double-check
Moderate interaction found
Check your medications if you take any P-glycoprotein substrate drugs (Moderate severity), antidiabetes medications (Moderate), or pazopanib/Votrient (Moderate). These interactions could raise drug levels or lower blood sugar too far.
Use the medication checker below to see if any of yours are listed.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
If you take diabetes drugs or cancer medications — especially those that use the P-glycoprotein pump — check your exact medications on this page before starting. The gastrointestinal side effects are usually mild, but they're worth knowing about.
Talk to your pharmacist about whether this supplement fits with your current medications and health.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2015.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Bitter Melon Extract, 500 mg, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Bitter Melon Extract, 500 mg by Solaray, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Bitter Melon | 500 mg | -- |
Other ingredients: Vegetable Cellulose Capsule, Cellulose, Silica, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Dietary Supplement
General Statements
Guaranteed Potency
Precautions
Keep out of reach of children.
Warning: Do not use if safety seal is broken or missing.
Keep your licensed health care practitioner informed when using this product, especially if you are taking prescription medication. Do not use if you are pregnant.
Suggested/Recommended/Usage/Directions
Directions: Use only as directed. Take one vegetarian capsule daily with a meal or glass of water.
Storage
Store in a cool, dry place.
Formulation
SOLARAY GUARANTEES that NO ingredient other than those listed on this label have been added to this product.
Formula
5% Bitter Principles
Seals/Symbols
Green Screened(R)
General
8405676 0415
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Bitter Melon Extract, 500 mg by Solaray label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Bitter Melon Extract, 500 mg by Solaray
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.
Bitter Melon
Interacts with282 drugs
Bitter melon is a tropical fruit eaten as food and used in traditional medicine, most often for blood sugar control. While some small studies hint it...
Bitter Melon monograph & interactionsOther (inactive) ingredients: Vegetable Cellulose Capsule, Cellulose, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Bitter Melon Extract, 500 mg by Solaray Drug Interactions
HelloPharmacist Interaction Report
Bitter Melon Extract by Solaray does interact with several medication types, and the most serious concern is with cancer drugs that rely on a cellular pump called P-glycoprotein (a protein transporter) to work.
Bitter melon may block this pump and raise levels of those drugs in your bloodstream, which could increase the risk of side effects. This is a Moderate severity interaction.
Read the full breakdown — every affected drug type, severity by severity
You'll also want to be careful if you take diabetes medications. Bitter melon can lower your blood sugar on its own, so combining it with drugs that do the same thing might push your levels too low (low blood sugar, or hypoglycemia).
Monitor your blood glucose closely if you use both. There's also a specific alert: bitter melon has been reported to potentially raise levels of pazopanib (Votrient), a cancer drug, and one case linked bitter melon juice to severe pancreas inflammation in a patient taking pazopanib.
Additionally, bitter melon has no other ingredient, so any interaction is from the plant itself. Run your exact medications through the checker on this page to see if you're affected.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Bitter Melon Extract, 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Bitter Melon Extract, 500 mg interact with 282 drugs. Click any drug to see the details.
1 of the 1 ingredient in Bitter Melon Extract, 500 mg interact with drugs. Each result below shows which ingredient is responsible. Bitter Melon
BetrixabanBevyxxa
How Betrixaban interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon + Betrixaban interactionBictegravir, Emtricitabine, Tenofovir AlafenamideBiktarvy
How Bictegravir, Emtricitabine, Tenofovir Alafenamide interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon + Bictegravir, Emtricitabine, Tenofovir Alafenamide interactionBoceprevirVictrelis
How Boceprevir interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon + Boceprevir interactionCanagliflozinInvokana
How Canagliflozin interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon + Canagliflozin interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon + Canagliflozin, Metformin Hydrochloride interactionCeliprololCelicard
How Celiprolol interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon + Celiprolol interactionChlorpropamideChlorpropam, Diabinese
How Chlorpropamide interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon + Chlorpropamide interactionChlortetracyclineAureomycin
How Chlortetracycline interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon + Chlortetracycline interactionCimetidineCimetidine Injection, Tagamet, Tagamet HB
How Cimetidine interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon + Cimetidine interactionCisapridePropulsid
How Cisapride interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon + Cisapride interactionClobetasolClobex, Temovate
How Clobetasol interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon + Clobetasol interactionCobicistat, Elvitegravir, Emtricitabine, Tenofovir Alafenamide FumarateGenvoya
How Cobicistat, Elvitegravir, Emtricitabine, Tenofovir Alafenamide Fumarate interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon + Cobicistat, Elvitegravir, Emtricitabine, Tenofovir Alafenamide Fumarate interactionColchicineColchicine, Colcrys, Colsalide Improved, Gloperba, Lodoco, Mitigare
How Colchicine interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon + Colchicine interactionColchicine, ProbenecidColBenemid
How Colchicine, Probenecid interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon + Colchicine, Probenecid interactionConjugated EstrogensCenestin, Enjuvia, Premarin, Premarin Vaginal Cream
How Conjugated Estrogens interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon + Conjugated Estrogens interactionConjugated Estrogens, Medroxyprogesterone AcetatePremplus, Prempro
How Conjugated Estrogens, Medroxyprogesterone Acetate interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon + Conjugated Estrogens, Medroxyprogesterone Acetate interactionConjugated Estrogens, MeprobamatePMB 200, PMB 400
How Conjugated Estrogens, Meprobamate interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon + Conjugated Estrogens, Meprobamate interactionConjugated Estrogens, MethyltestosteronePremarin with Methyltestosterone
How Conjugated Estrogens, Methyltestosterone interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon + Conjugated Estrogens, Methyltestosterone interactionCortisone AcetateCortisone Tablets, Cortone
How Cortisone Acetate interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon + Cortisone Acetate interactionCrizotinibXalkori
How Crizotinib interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon + Crizotinib interactionCyclosporineCequa, Ciclosporine, Gengraf, Neoral, Sandimmune, Verkazia +1 more
How Cyclosporine interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon + Cyclosporine interactionCyproterone Acetate, Ethinyl EstradiolDiane-35, Dianette
How Cyproterone Acetate, Ethinyl Estradiol interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon + Cyproterone Acetate, Ethinyl Estradiol interactionDapagliflozinFarxiga
How Dapagliflozin interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon + Dapagliflozin interactionDapagliflozin Propanediol, MetforminXigduo XR
How Dapagliflozin Propanediol, Metformin interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon + Dapagliflozin Propanediol, Metformin interactionDapagliflozin Propanediol, Saxagliptin HydrochlorideQtern
How Dapagliflozin Propanediol, Saxagliptin Hydrochloride interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon + Dapagliflozin Propanediol, Saxagliptin Hydrochloride interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDarolutamideNubeqa
How Darolutamide interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon + Darolutamide interactionDarunavir, Cobicistat, Emtricitabine, Tenofovir AlafenamideSymtuza
How Darunavir, Cobicistat, Emtricitabine, Tenofovir Alafenamide interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon + Darunavir, Cobicistat, Emtricitabine, Tenofovir Alafenamide interactionDarunavir, RitonavirDarunavir, Ritonavir
How Darunavir, Ritonavir interacts with Bitter Melon Extract, 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter MelonP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon + Darunavir, Ritonavir interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Bitter Melon Extract, 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Bitter Melon
Antidiabetes Drugs
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Bitter melon can lower blood glucose levels and might have additive effects when used with antidiabetes drugs. This might increase the risk of hypoglycemia in some patients. Monitor blood glucose levels closely.
P-Glycoprotein Substrates
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Bitter melon might inhibit the p-glycoprotein (P-gp) intestinal pump and increase intracellular levels of P-gp substrates. In vitro research in intestinal cells shows that 1-monopalmitin, a constituent of bitter melon, increases levels of daunomycin, a P-gp substrate. Additionally, drinking bitter melon juice has been associated with a case of acute pancreatitis in a patient who had been taking pazopanib, a P-gp substrate, for 8 years. Researchers theorize that inhibition of P-gp led to increased levels of pazopanib, resulting in pazopanib-induced pancreatitis.
Pazopanib (Votrient)
Theoretically, bitter melon might increase levels of pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 8 years for renal cell carcinoma experienced signs and symptoms consistent with acute pancreatitis 4 days after drinking bitter melon juice at a dose of 100-150 mL daily. The patient's symptoms, amylase levels, and lipase levels improved upon discontinuation of bitter melon and pazopanib. Pazopanib treatment was re-initiated with no further evidence of pancreatitis. Researchers theorize that inhibition of P-glycoprotein by bitter melon led to increased levels of pazopanib, a P-glycoprotein substrate, resulting in pazopanib-induced pancreatitis.
Brand information
Manufacturer and brand details for Bitter Melon Extract, 500 mg, from the product label.
Bitter Melon Extract, 500 mg by Solaray: Common Questions
Does Bitter Melon Extract, 500 mg by Solaray interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will bitter melon lower my blood sugar?
What side effects should I expect?
Is it safe to take during pregnancy?
Can I take this while breastfeeding?
Does bitter melon actually work for diabetes?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Bitter Melon Extract, 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Bitter Melon Extract, 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Bitter Melon Extract, 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 18 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Bitter Melon 18 references
- Leatherdale B, Panesar RK, Singh G, et al. Improvement in glucose tolerance due to Momordica charantia. Br Med J (Clin Res Ed) 1981;282:1823-4.
- Welihinda J, et al. Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. J Ethnopharmacol 1986;17:277-82. PubMed
- Srivastava Y, Venkatakrishna-Bhatt H, Verma Y, et al. Antidiabetic and adaptogenic properties of Momordica charantia extract: An experimental and clinical evaluation. Phytother Res 1993;7:285-9.
- Baldwa VS, Bhandari CM, Pangaria A, Goyal RK. Clinical trial in patients with diabetes mellitus of an insulin-like compound obtained from plant sources. Ups J Med Sci 1977;82:39-41. PubMed
- Aslam M, Stockley IH. Interaction between curry ingredient (karela) and drug (chlorpropamide). Lancet 1979:1:607. PubMed
- Ahmad N, Hassan MR, Halder H, Bennoor KS. Effect of Momordica charantia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM patients (abstract). Bangladesh Med Res Counc Bull 1999;25:11-3.
- Basch E, Gabardi S, Ulbricht C. Bitter melon (Momordica charantia): a review of efficacy and safety. Am J Health Syst Pharm 2003;60:356-9. PubMed
- Yin RV, Lee NC, Hirpara H, Phung OJ. T. The effect of bitter melon (Mormordica charantia) in patients with diabetes mellitus: s systematic review and meta-analysis. Nutr Diabetes. 2014;4:e145.
- Rahman IU, Khan RU, Rahman KU, Bashir M. Lower hypoglycemic but higher antiatherogenic effects of bitter melon than glibenclamide in type 2 diabetic patients. Nutr J. 2015;14:13. PubMed
- Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids. 2015;2015:496169. PubMed
- Konishi T, Satsu H, Hatsugai Y, et al. Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells. Br J Pharmacol. 2004;143(3):379-87. PubMed
- Peter EL, Kasali FM, Deyno S, et al. Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: Systematic review and meta-analysis. J Ethnopharmacol. 2019;231:311-24. doi: 10.1016/j.jep.2018.10.033. PubMed
- Cortez-Navarrete M, Martínez-Abundis E, Pérez-Rubio KG, González-Ortiz M, Méndez-Del Villar M. Momordica charantia administration improves insulin secretion in type 2 diabetes mellitus. J Med Food. 2018;21(7):672-7. doi: 10.108
- Kim SK, Jung J, Jung JH, et al. Hypoglycemic efficacy and safety of Momordica charantia (bitter melon) in patients with type 2 diabetes mellitus. Complement Ther Med. 2020 Aug;52:102524. doi: 10.1016/j.ctim.2020.102524. PubMed
- Unsal O, Sütcüoglu O, Yazici O. Dangerous interaction of bitter melon (Momordica charantia) with pazopanib: a case of acute pancreatitis. J Oncol Pharm Pract 2022;28(2):486-8.
- Bae W, Kim S, Choi J, et al. Acute interstitial nephritis associated with ingesting a Momordica charantia extract: a case report. Medicine (Baltimore) 2021;100(27):e26606. PubMed
- Chattopadhyay K, Wang H, Kaur J, et al. Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis. Front Pharmacol. 2022;13:821810. Published 2022 Jun 8. PubMed
- Kim B, Lee HS, Kim HJ, et al. Momordica charantia (bitter melon) efficacy and safety on glucose metabolism in Korean prediabetes participants: a 12-week, randomized clinical study. Food Sci Biotechnol 2022;32(5):697-704. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC