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Dietary supplement

Boldo and Fringe Non-Alcohol Ingredients & Drug Interactions

by Hawaii Pharm

Boldo and Fringe Non-Alcohol label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Boldo and Fringe Non-Alcohol against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Boldo and Fringe Non-Alcohol is a dietary supplement by Hawaii Pharm with 2 active ingredients. Its ingredients are commonly taken for indigestion and bloating, mild constipation, liver and gallbladder support.Based on those ingredients, 482 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are wildcrafted Boldo extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Boldo and Fringe Non-Alcohol by Hawaii Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Boldo and Fringe Non-Alcohol by Hawaii Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Boldo and Fringe Non-Alcohol by Hawaii Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.

This product contains 2 active ingredients: wildcrafted boldo extract and wildcrafted fringe tree extract, delivered in a non-alcohol liquid form. Boldo is traditionally used to support gallbladder and digestive function, though evidence for these uses is insufficient to confirm.

Fringe tree has very limited human safety data on file. The product also contains vegetable palm glycerin and artesian Hawaiian water as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The label doesn't state a purpose we can grade — see each ingredient's own graded uses on its monograph instead.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold doesn't establish that boldo is effective for any of its traditional uses—benign prostate enlargement, gallbladder disease, kidney stones, or joint pain all carry ratings of insufficient reliable evidence. Fringe tree has no effectiveness data on file.

If you're considering this product for a specific condition, talk with your doctor or pharmacist about whether the evidence supports its use for your needs.

The evidence, ingredient by ingredient Boldo Fringetree

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, boldo in food amounts is generally well tolerated, but medicinal doses can cause significant harm—most commonly abdominal pain, nausea, and vomiting. The real concern is hepatotoxicity: boldo's ascaridole content can injure your liver, and multiple cases of elevated liver enzymes have been reported.

Short-term use in low doses is sometimes cautioned, but the liver risk is real and documented. Boldo is considered unsafe in pregnancy because it may stimulate the uterus, and there isn't enough safety information to use it while breastfeeding.

Fringe tree has very limited safety data; use it cautiously and under professional guidance, and avoid it in pregnancy and while breastfeeding.

Side effects, ingredient by ingredient Boldo Fringetree

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Boldo.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; lithium.
  • For scale: 483 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist or doctor if you take drugs that can injure the liver, blood thinners (especially warfarin), lithium, or tacrolimus. These are Moderate-severity interactions, and your doses or product use may need to change.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product carries real risks—especially if you take blood thinners, liver-metabolized drugs, lithium, or tacrolimus—and boldo itself can injure your liver over time. If you're considering it, check your medications and any liver or bleeding conditions with your own doctor or pharmacist first.

Pregnant or breastfeeding individuals should avoid it entirely.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Boldo and Fringe Non-Alcohol, straight from the product label.

Brand Hawaii Pharm
Barcode (UPC) 6339127899094
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Dec 26, 2020
DSLD ID 238621
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Boldo and Fringe Non-Alcohol by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
20 Drop(s)
Maximum serving Sizes:
30 Drop(s)
UPC/BARCODE
6339127899094
IngredientAmount% DV
wildcrafted Boldo extract0 NP--
wildcrafted Fringe Tree extract0 NP--

Other ingredients: Vegetable Palm Glycerin, crystal clear artesian Hawaiian Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Hawaii Pharm Non-Alcohol Herbal Extract Highest quality since 2008

Made with Aloha! 120 servings

Formulation

Contains no gluten, artificial colors, pesticides, preservatives, heavy metals. Non GMO.

Super concentrated liquid herbal extract Dry herb/menstruum ratio: 1:3

Contains no alcohol

Description: We produced this extract according to precise standards where each herbs are individually extracted according to their distinct characteristic. We use a cold maceration extraction method, so that the active constituents of the herbs are extracted and maintained.

Non GMO Gluten free

Manufactured in an FDA registered facility. Ultra Sonic

Made in USA, Hawaii

Suggested/Recommended/Usage/Directions

Directions for use: Shake well before using. Take 1 mL (about 20-30) drops in juice, water, tea or as desired up to four times per day.

Precautions

Warnings: Keep out of the reach of children.

Not to be used during pregnancy.

Do not use if you are allergic to any ingredients.

Consult a physician before using if nursing or taking any medications.

Do not use if seal is broken or missing.

Storage

Refrigerate after opening.

FDA Statement of Identity

Herbal Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

FDA Registered Facility Made in United States of America USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Boldo and Fringe Non-Alcohol by Hawaii Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Boldo and Fringe Non-Alcohol label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Boldo and Fringe Non-Alcohol by Hawaii Pharm

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size20 Drop(s) Dosage formLiquid Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Wildcrafted Boldo extract

Interacts with
482 drugs
0 NP per serving

Boldo is a South American shrub whose leaves are traditionally used for digestive and gallbladder complaints, but good human evidence is very limited....

Wildcrafted Boldo extract monograph & interactions

Wildcrafted Fringe Tree extract

No known
interactions
0 NP per serving

Fringetree is a North American shrub whose root and stem bark have long been used in traditional herbal medicine, mainly for liver, gallbladder, and d...

Wildcrafted Fringe Tree extract monograph & interactions

Other (inactive) ingredients: Vegetable Palm Glycerin, Crystal clear artesian Hawaiian Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Boldo and Fringe Non-Alcohol by Hawaii Pharm Drug Interactions

Want to check YOUR meds against Boldo and Fringe Non-Alcohol?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
482Drugs
482 Moderate

Ingredients driving the most interactions

wildcrafted Boldo extract 482

Individual Drug Interactions

The ingredients in Boldo and Fringe Non-Alcohol interact with 482 drugs. Click any drug to see the details.

1 of the 2 ingredients in Boldo and Fringe Non-Alcohol interact with drugs. Each result below shows which ingredient is responsible. wildcrafted Boldo extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Boldo and Fringe Non-Alcohol with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

wildcrafted Boldo extract5 drug types · 482 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking boldo with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Animal and in vitro research shows that boldine, a constituent of boldo, has antiplatelet activity. In one case report, an adult taking a combination of boldo and fenugreek with warfarin experienced an increase in international normalized ratio (INR); however, it is unclear if this effect was due to boldo, fenugreek, the combination, or another factor.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.
Boldo leaf contains ascaridole, a known liver toxin. Many cases of hepatotoxicity, including elevated liver transaminase levels and jaundice, have been reported in patients taking boldo.

Likelihood Possible Evidence D
Lithium

Theoretically, taking boldo with lithium might increase the levels and clinical effects of lithium.
Boldo is believed to have diuretic effects. Theoretically, these diuretic effects might reduce the excretion of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tacrolimus (Prograf)

Taking boldo with tacrolimus may decrease the levels and clinical effects of tacrolimus, potentially increasing the risk of transplant rejection.
In one case report, a patient with a long-term history of stable tacrolimus levels developed subtherapeutic levels after taking boldo 300 mg twice daily orally for several weeks. Tacrolimus levels returned to normal after discontinuing boldo. However, the mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Warfarin (Coumadin)

A combination of boldo and fenugreek was thought to be associated with an increased international normalized ratio (INR) in a female on warfarin. It is not clear if boldo, fenugreek, or the combination played a role in this interaction. Therefore, boldo may have additive effects with warfarin.

Likelihood Possible Evidence D
wildcrafted Boldo extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Boldo and Fringe Non-Alcohol, from the product label.

Hawaii Pharm

See all Hawaii Pharm products
Name
Hawaii Pharm LLC
City
Honolulu
State
HI
ZipCode
96815
Pharmacist Counseling Corner

Boldo and Fringe Non-Alcohol by Hawaii Pharm: Common Questions

Does Boldo and Fringe Non-Alcohol by Hawaii Pharm interact with any medications?
Yes. Based on its ingredients, Boldo and Fringe Non-Alcohol has a known interaction with 482 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Boldo and Fringe Non-Alcohol contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on warfarin or another blood thinner?
No — boldo in this product can increase bleeding risk when combined with blood thinners like warfarin. A case report documented this risk. Talk to your doctor or pharmacist before using it if you take any blood thinner or antiplatelet drug.
What are the most common side effects?
When boldo is used in medicinal amounts, the most common side effects are abdominal pain, nausea, and vomiting. More serious (though rare) is hepatotoxicity—liver injury from boldo's ascaridole content.
Is it safe to use while pregnant or breastfeeding?
No. Boldo is considered unsafe in pregnancy because it may stimulate the uterus. There isn't enough safety data to use it while breastfeeding either. Avoid it during both.
Does boldo actually work for gallbladder problems or joint pain?
The evidence we hold doesn't confirm that boldo is effective for gallbladder disease, kidney stones, joint pain, or prostate issues—all are rated as having insufficient reliable evidence. If you're considering it for one of these, ask your doctor whether the science supports it for you.
What is fringe tree supposed to do?
Fringe tree has no established effectiveness claims on file, and human safety data for it are very limited. It should be used only under professional guidance.
Can I take this if I'm on lithium or tacrolimus?
No — boldo may raise lithium levels in your blood and lower tacrolimus levels, potentially reducing the drug's effectiveness and increasing transplant rejection risk. Check with your doctor or pharmacist before using this product if you take either.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Boldo and Fringe Non-Alcohol is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Boldo and Fringe Non-Alcohol label
Go deeper

The Full Monographs Behind Boldo and Fringe Non-Alcohol’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Boldo

Interacts with 482 drugs

Boldo is a South American shrub whose leaves are traditionally used for digestive and gallbladder complaints, but good human evidence is very limited. The leaves and oil contain ascaridole,...

Read the full Boldo monograph → Herb & supplement monograph

Fringetree

Fringetree is a North American shrub whose root and stem bark have long been used in traditional herbal medicine, mainly for liver, gallbladder, and digestive complaints. There is very littl...

Read the full Fringetree monograph →
Sources

Sources & How We Checked

Boldo and Fringe Non-Alcohol's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Boldo 10 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Lambert J, Cormier J. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy 2001;21:509-12. PubMed
  3. Piscaglia F, Leoni S, Venturi A, et al. Caution in the use of boldo in herbal laxatives: a case of hepatotoxicity. Scand J Gastroenterol 2005;40:236-9. PubMed
  4. Agarwal SC, Crook JR, Pepper CB. Herbal remedies -- how safe are they? A case report of polymorphic ventricular tachycardia/ventricular fibrillation induced by herbal medication used for obesity. Int J Cardiol 2006;106:260-1. PubMed
  5. Teng, C. M., Hsueh, C. M., Chang, Y. L., Ko, F. N., Lee, S. S., and Liu, K. C. Antiplatelet effects of some aporphine and phenanthrene alkaloids in rabbits and man. J Pharm Pharmacol 1997;49(7):706-711. PubMed
  6. Carbajal R, Yisfalem A, Pradhan N, et al. Case report: Boldo (Peumus boldus) and tacrolimus interaction in a renal transplant patient. Transplant Proc 2014;46(7):2400-2. PubMed
  7. Almeida ER, Melo AM, Xavier H. Toxicological evaluation of the hydro-alcohol extract of the dry leaves of Peumus boldus and boldine in rats. Phytother Res 2000;14(2):99-102. DOI
  8. Ribeiro RJ, Silvestre C, Duarte C. Hidden risks of alternative medicines: a case of boldo-induced hepatotoxicity. J Diet Suppl 2017;14(2):186-90. PubMed
  9. Oliveira Sá A, Pimentel T, Oliveira N. Boldo-Induced Hepatotoxicity: A Case of Unexplained Jaundice. Eur J Case Rep Intern Med 2020;7(12):002116. PubMed
  10. Valdes R, Feuereisen A, Bellinghausen M. Allergic Contact Dermatitis to Boldo. Dermatitis 2021;32(2):e31-e32. PubMed

See these in context on the Boldo monograph →

Fringetree 2 references
  1. Herbs at a Glance — NIH NCCIH Source
  2. Herbs and Supplements — MedlinePlus Source

See these in context on the Fringetree monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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