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Dietary supplement

Bone, Flesh & Cartilage 440 mg Ingredients & Drug Interactions

by Nature's Way

Bone, Flesh & Cartilage 440 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bone, Flesh & Cartilage 440 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bone, Flesh & Cartilage 440 mg is a dietary supplement by Nature's Way with 6 active ingredients. Its ingredients are commonly taken for cough and chest congestion, sore throat, bronchitis and respiratory irritation.Based on those ingredients, 2,055 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Marshmallow, Slippery Elm, Calendula. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bone, Flesh & Cartilage 440 mg by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Bone, Flesh & Cartilage 440 mg by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Bone, Flesh & Cartilage 440 mg by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.
  • “Bone, Flesh & Cartilage Blend” is a proprietary blend — the label gives one combined amount (880 mg) without saying how much of each component you get.

This product contains six active ingredients: Mullein, Black Walnut, Marshmallow, Slippery Elm, White Oak, and Calendula, combined in a 440 mg capsule. Each is a plant-based extract chosen traditionally to support joint and connective tissue health, though the evidence for most is not yet established.

The capsule itself is plant-derived.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The label doesn't state a purpose we can grade — see each ingredient's own graded uses on its monograph instead.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence on these ingredients is limited. For Mullein, Black Walnut, Marshmallow, Slippery Elm, and Calendula, we don't have enough reliable data to rate whether they work for their intended uses—the facts show insufficient evidence for conditions ranging from respiratory health to wound healing and skin concerns.

White Oak has no effectiveness ratings on file. This doesn't mean they don't work; it means large, well-designed human studies are lacking.

The evidence, ingredient by ingredient Mullein Black Walnut Marshmallow Slippery Elm White Oak Calendula

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated for short-term use, but human safety data are limited for all of them. Mullein, Black Walnut, and Marshmallow should be avoided during pregnancy and breastfeeding due to insufficient safety information.

Slippery Elm requires caution in pregnancy and while breastfeeding because safety data are sparse. White Oak and Calendula also lack adequate safety data for pregnancy and breastfeeding.

Black Walnut may cause stomach upset due to its tannin content, and both Black Walnut and Calendula can trigger allergic reactions in sensitive people, particularly those allergic to tree nuts or ragweed-family plants. Rare cases of skin irritation (dermatitis, contact rash) have been reported with Mullein and Slippery Elm.

Side effects, ingredient by ingredient Mullein Black Walnut Marshmallow Slippery Elm White Oak Calendula

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 6 matched ingredients can interact with medications — Calendula, Mullein, Marshmallow, Slippery Elm.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; lithium.
  • For scale: 2,056 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check with your pharmacist if you take lithium—Marshmallow may raise its levels and risk toxicity. Also double-check any oral medications you take regularly, since both Marshmallow and Slippery Elm may slow how your body absorbs them.

If you're on blood thinners like warfarin, be aware that Mullein and Marshmallow carry a minor blood-thinning effect. And if you take CNS depressants such as sedatives or anti-anxiety drugs, flag this product with your pharmacist, though the risk appears small.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is best suited for adults with no pregnancy or breastfeeding plans who want to explore traditional herbal support for bone and joint health—though evidence of benefit isn't established in our data. If you take lithium, blood thinners, or any regular oral medications, talk with your pharmacist before starting it.

Anyone with a tree nut or ragweed allergy should be cautious.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bone, Flesh & Cartilage 440 mg, straight from the product label.

Brand Nature's Way
Barcode (UPC) 033674000267
Net contents 100 Veg. Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2019
DSLD ID 184493
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bone, Flesh & Cartilage 440 mg by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
50
UPC/BARCODE
033674000267
IngredientAmount% DV
Mullein0 NP--
Black Walnut0 NP--
Marshmallow0 NP--
Slippery Elm0 NP--
White Oak0 NP--
Calendula0 NP--
Bone, Flesh & Cartilage Blend880 mg--

Other ingredients: plant-derived Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Warning: This product contains Slippery Elm.

Bone, Flesh & Cartilage 440 mg per cap

Contains tree nuts (walnuts).

Precautions

Warning: This product contains Slippery Elm.

Slippery Elm should not be taken together with any medication as it may interfere with their absorption.

This product is intended for short-term use only, not to exceed 6 weeks of use unless directed by a healthcare professional.

Persons with allergies to plants of the Asteraceae (Compositae) family, including ragweed, should use this product with caution.

If pregnant, nursing or taking any medications, consult a healthcare professional before use.

Keep out of reach of children.

Safety sealed with printed inner seal. Do not use if seal is broken or missing.

For occasional use only.

Contains tree nuts (walnuts).

Formulation

Gluten free. No sugar, salt, yeast, wheat, corn, soy, dairy products, artificial colors, flavors or preservatives.

Vegetarian

Non GMO

Seals/Symbols

Vegetarian

Non GMO Project Verified Nongmoproject.org

Certified Authentic Tru-ID

General

LN26.D01 BLK8268D

General Statements

Premium formula

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Take 2 capsules daily, preferably with food. For occasional use only.

Brand IP Statement(s)

2018 Nature's Way Brands, LLC

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bone, Flesh & Cartilage 440 mg by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bone, Flesh & Cartilage 440 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bone, Flesh & Cartilage 440 mg by Nature's Way

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bone, Flesh & Cartilage Blend

880 mg per serving

Other (inactive) ingredients: Plant-derived Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bone, Flesh & Cartilage 440 mg by Nature's Way Drug Interactions

Want to check YOUR meds against Bone, Flesh & Cartilage 440 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,055Drugs
2,022 Moderate 33 Minor

Ingredients driving the most interactions

Marshmallow 2,040
Slippery Elm 2,022
Calendula 248
Mullein 122

Individual Drug Interactions

The ingredients in Bone, Flesh & Cartilage 440 mg interact with 2,055 drugs. Click any drug to see the details.

4 of the 6 ingredients in Bone, Flesh & Cartilage 440 mg interact with drugs. Each result below shows which ingredient is responsible. Marshmallow Slippery Elm Calendula Mullein

Each ingredient & the kinds of drugs it affects

For each ingredient in Bone, Flesh & Cartilage 440 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Marshmallow3 drug types · 2,040 drugs

Lithium

Theoretically, due to potential diuretic effects, marshmallow might reduce excretion and increase levels of lithium.
Marshmallow is thought to have diuretic properties. To avoid lithium toxicity, the dose of lithium might need to be decreased when used with marshmallow.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, marshmallow flower might have antiplatelet effects.
Animal research suggests that marshmallow flower extract has antiplatelet effects. However, the root and leaf of marshmallow, not the flower, are the plant parts most commonly found in dietary supplements. Theoretically, use of marshmallow flower with anticoagulant/antiplatelet drugs can have additive effects, and might increase the risk for bleeding in some patients.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Marshmallow contains mucilage which can affect oral drug absorption. To avoid changes in absorption, take marshmallow 30-60 minutes after oral medications.

Likelihood Possible Evidence D
Marshmallow full monograph & interactions

Slippery Elm1 drug type · 2,022 drugs

Oral Drugs

Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Slippery elm inner bark contains mucilage, which may interfere with the absorption of orally administered drugs.

Likelihood Possible Evidence D
Slippery Elm full monograph & interactions

Calendula1 drug type · 248 drugs

Cns Depressants

Theoretically, calendula might have additive effects when used with CNS depressants, although this appears to be unlikely.
Although some animal research has suggested that a saponoside constituent in calendula may have sedative effects, calendula has been used for over 30 years without reports of sedation in humans.

Likelihood Unlikely Evidence D
Calendula full monograph & interactions

Mullein1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot. This is likely due to at least one of the known constituents of muellein, triterpenoid saponins. However, the effects appear to be mild and results have been inconsistent. Extracts from different plant parts have been show to have varying anticoagulant strengths, with water-based ones being more potent than alcohol-based extracts.

Likelihood Unlikely Evidence A
Mullein full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bone, Flesh & Cartilage 440 mg, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Bone, Flesh & Cartilage 440 mg by Nature's Way: Common Questions

Does Bone, Flesh & Cartilage 440 mg by Nature's Way interact with any medications?
Yes. Based on its ingredients, Bone, Flesh & Cartilage 440 mg has a known interaction with 2,055 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bone, Flesh & Cartilage 440 mg contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant or breastfeeding?
The safety data for these herbs during pregnancy and breastfeeding are not strong enough. Mullein, Black Walnut, Marshmallow, and Calendula should be avoided in pregnancy; Slippery Elm and White Oak require caution. For breastfeeding, the picture is similar—safety isn't clear enough. Talk with your doctor or pharmacist for personalized advice if you're planning pregnancy or nursing.
Will this help with joint or bone health?
That's what these herbs are traditionally used for, but we don't have enough reliable evidence to say whether they work for bone, cartilage, or joint conditions. The ingredients are generally well tolerated, but you're not getting proven benefit from the science we hold.
What's the difference between the Mullein in this and Mullein supplements sold on their own?
The facts on file don't compare this blend to standalone Mullein supplements. What I can tell you is that the Mullein in this product carries the same interactions—minor blood-thinning effects if you're on anticoagulants—and the same limited safety data as any other Mullein.
Can I take this with my other supplements or vitamins?
The interaction data we have cover medications, not other supplements. If you're taking multiple supplements or herbal products, it's a good idea to check with your pharmacist about potential overlap or conflicts—especially if you take blood thinners or lithium.
Is there a risk of allergic reaction?
Yes. Black Walnut is a tree nut and can trigger nut allergies. Calendula can cause allergic skin reactions, especially in people sensitive to ragweed or related plants like marigolds and daisies. If you have known allergies to tree nuts or the ragweed family, tell your pharmacist before using this product.
How long can I safely use this?
Human safety data are limited for all the herbs in this blend. They're described as generally well tolerated for short-term use, but long-term safety isn't well studied. Check with your pharmacist about how long is right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bone, Flesh & Cartilage 440 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bone, Flesh & Cartilage 440 mg label
Go deeper

The Full Monographs Behind Bone, Flesh & Cartilage 440 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Mullein

Interacts with 122 drugs

Mullein is a traditional herbal remedy most often used as a tea or syrup to soothe coughs, sore throats, and respiratory irritation. High-quality human studies are lacking, so its benefits a...

Read the full Mullein monograph → Herb & supplement monograph

Black Walnut

Black walnut is a tree whose green hulls are traditionally used as a natural antiparasitic and digestive remedy, but solid human evidence for these uses is lacking. It contains a compound ca...

Read the full Black Walnut monograph → Herb & supplement monograph

Marshmallow

Interacts with 2,040 drugs

Marshmallow root is a traditional herb rich in soothing, gel-like fibers called mucilage, which is why it has long been used for coughs, sore throats, and stomach irritation. Evidence for th...

Read the full Marshmallow monograph → Herb & supplement monograph

Slippery Elm

Interacts with 2,022 drugs

Slippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated digestive tracts. Its mucilage can coat an...

Read the full Slippery Elm monograph → Herb & supplement monograph

White Oak

White oak bark is a traditional herbal remedy rich in tannins, used mostly as a tea or skin wash for diarrhea, sore throat, and minor skin problems. Solid human evidence is very limited, and...

Read the full White Oak monograph → Herb & supplement monograph

Calendula

Interacts with 248 drugs

Calendula is a flowering plant whose petals are used mainly in skin creams, oils, and ointments to soothe minor irritation and support wound healing. Some early research is promising for ski...

Read the full Calendula monograph →
Sources

Sources & How We Checked

Bone, Flesh & Cartilage 440 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 24 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Mullein 2 references
  1. Castro AI, Carmona JB, Gonzales FG, Nestar OB. Occupational airborne dermatitis from gordolobo (Verbascum densiflorum). Contact Dermatitis 2006;55(5):301.
  2. Flores Echaiz C, Al Ali A, Cao AQ, Sasseville D. Simultaneous contact dermatitis caused by Asteraceae and Verbascum thapsus. Contact Dermatitis 2017;76(5):316-8.

See these in context on the Mullein monograph →

Black Walnut 3 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Food and Drug Administration. Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA); Public Law 108-282, Title II. Accessed on May 19, 2021. Available at: https://www.fda.gov/food/food-allergensgluten-free-guidance-documents-regulatory-infor

See these in context on the Black Walnut monograph →

Marshmallow 5 references
  1. Monographs on the medicinal uses of plant drugs. Exeter, UK: European Scientific Co-op Phytother, 1997.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  5. Hage-Sleiman R, Mroueh M, Daher CF. Pharmacological evaluation of aqueous extract of Althaea officinalis flower grown in Lebanon. Pharm Biol 2011;49(3):327-33.

See these in context on the Marshmallow monograph →

Slippery Elm 3 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Czarnecki D, Nixon R, Bekhor P, and et al. Delayed prolonged contact urticaria from the elm tree. Contact Dermatitis 1993;28:196-197. PubMed

See these in context on the Slippery Elm monograph →

White Oak 2 references
  1. Herbs at a Glance — NIH NCCIH Source
  2. Herbs and Supplements — MedlinePlus Source

See these in context on the White Oak monograph →

Calendula 9 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Reider N, Komericki P, Hausen BM, et al. The seamy side of natural medicines: contact sensitization to arnica (Arnica montana L.) and marigold (Calendula officinalis L.). Contact Dermatitis 2001;45:269-72..
  3. Gol'dman II. [Anaphylactic shock after gargling with an infusion of Calendula]. Klin Med (Mosk) 1974;52:142-3.
  4. Paulsen E. Contact sensitization from Compositae-containing herbal remedies and cosmetics. Contact Dermatitis 2002;47:189-98. PubMed
  5. Bojadjiev C. On the sedative and hypotensive effect of preparations from the plant Calendula officinalis. Nauch Trud Visshi Med Inst Sof 1964;43:15-20.
  6. Samochowiec L. Pharmacological study of saponosides from Aralia mandshurica Rupr. et Maxim and Calendula officinalis L. Herba Pol. 1983;29:151-155.
  7. Madisetti M, Kelechi TJ, Mueller M, Amella EJ, Prentice MA. Feasibility, acceptability, and tolerability of RGN107 in the palliative wound care management of chronic wound symptoms. J Wound Care. 2017;26(Sup1):S25-S34. PubMed
  8. Final Assessment report on Calendula officinalis L., flos. European Medicines Agency: Committee on Herbal Medicinal Products (HMPC). 2018. EMA/HMPC/603409/2017. Available at: https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-cal
  9. Puaratanaarunkon T, Washrawirul C, Chuenboonngarm N, Noppakun N, Asawanonda P, Kumtornrut C. Efficacy and safety of a facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glaba root extract in the treatment of maskne: A

See these in context on the Calendula monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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