Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Brain Nourish 500 mg Ingredients & Drug Interactions

by Optimal Carnivore

Brain Nourish 500 mg label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Brain Nourish 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Brain Nourish 500 mg is a dietary supplement by Optimal Carnivore with 2 active ingredients. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lion's Mane Fruiting Body Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Brain Nourish 500 mg by Optimal Carnivore

Ask about any prescription or over-the-counter medication and we check it for interactions with Brain Nourish 500 mg by Optimal Carnivore — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Brain Nourish 500 mg by Optimal Carnivore

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Brain Nourish has 2 active ingredients. Lion's Mane Fruiting Body Extract is a mushroom known in traditional use for brain health — though evidence for specific benefits in people isn't yet established in our data.

The product also contains New Zealand Bovine Brain; we don't have detailed interaction or safety data for this ingredient on file. The capsules themselves are gelatin, an inactive ingredient that holds everything together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Lion's Mane Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Mood, memory, and focus support.
  • We looked for evidence on: Memory, Cognitive function, Anxiety, Depression, Mental clarity, Cognitive performance — and 2 related terms.
  • The closest evidence on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Depression, Memory.

The evidence for lion's mane on Alzheimer's disease, anxiety, cognitive function, cognitive impairment, athletic performance, or cancer is insufficient in the data we hold — meaning studies haven't been rigorous enough or large enough to say whether it works for those purposes. We have no effectiveness ratings for the bovine brain ingredient.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lion's mane is generally well tolerated when eaten as food, but long-term safety as a supplement hasn't been thoroughly studied. The most common side effects reported orally are gastrointestinal discomfort, nausea, and skin rash — though a small number of trial participants experienced these.

Pregnancy and breastfeeding: There isn't enough safety data for lion's mane during pregnancy or while nursing, so the safety data advises against use in both situations. We have no pregnancy or breastfeeding information on file for the bovine brain ingredient.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking this if you're on blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel) — lion's mane may increase bleeding risk. Also flag diabetes medications and any immune-suppressing drugs with your pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

If you take blood thinners, diabetes medication, or immune-suppressing drugs, talk to your pharmacist before starting this product — the interactions are real. If you're pregnant or breastfeeding, skip it for now based on the data we have.

For everyone else, use the medication checker below with your exact prescriptions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Brain Nourish 500 mg, straight from the product label.

Brand Optimal Carnivore
Barcode (UPC) X0035OE1Y5
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2025
DSLD ID 323268
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Brain Nourish 500 mg by Optimal Carnivore, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6 Capsule(s)
Maximum serving Sizes:
6 Capsule(s)
Servings per container
30
UPC/BARCODE
X0035OE1Y5
IngredientAmount% DV
Lion's Mane Fruiting Body Extract1500 mg--
New Zealand Bovine Brain1500 mg--

Other ingredients: Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Helping you thrive with the most nutrient dense foods on the planet We believe that everyone deserves access to the most nutrient-dense food on the planet in a convenient, easy to take form. We only source from 100% grass-fed animals in New Zealand-one of the cleanest purest environments on earth. The cattle are reared as nature intended, without the use of growth-promoting hormones, free to roam grass pastures.

Nothing but nutrients Hormone-free & Non-GMO. 100% additive-free. No stearates, lubricants, binders, fillers or flow agents

Mood Memory Focus

Formula

Brain Nourish is a mixture of Grassfed Brain and Organic Lion's Mane mushroom (fruiting body). Nothing but nutrients

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: 6 capsules daily or as directed by a healthcare professional

Seals/Symbols

GMP Quality Good Manufacturing Practice Certification Made in USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Brain Nourish 500 mg by Optimal Carnivore label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Brain Nourish 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Brain Nourish 500 mg by Optimal Carnivore

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size6 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lion's Mane Fruiting Body Extract

Interacts with
327 drugs
1500 mg per serving Form: Hericium erinaceus Fruiting Body Extract

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lion's Mane Fruiting Body Extract monograph & interactions

New Zealand Bovine Brain

1500 mg per serving

Other (inactive) ingredients: Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Brain Nourish 500 mg by Optimal Carnivore Drug Interactions

Want to check YOUR meds against Brain Nourish 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Lion's Mane Fruiting Body Extract 327

Individual Drug Interactions

The ingredients in Brain Nourish 500 mg interact with 327 drugs. Click any drug to see the details.

1 of the 2 ingredients in Brain Nourish 500 mg interact with drugs. Each result below shows which ingredient is responsible. Lion's Mane Fruiting Body Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Brain Nourish 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lion's Mane Fruiting Body Extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane Fruiting Body Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Brain Nourish 500 mg, from the product label.

Optimal Carnivore

See all Optimal Carnivore products
Name
Optimal Carnivore, LLC
Street Address
13359 N Hwy 183, Ste 406.
City
Austin
State
TX
ZipCode
78750
Web Address
www.optimalcarnivore.com
Pharmacist Counseling Corner

Brain Nourish 500 mg by Optimal Carnivore: Common Questions

Does Brain Nourish 500 mg by Optimal Carnivore interact with any medications?
Yes. Based on its ingredients, Brain Nourish 500 mg has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Brain Nourish 500 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is lion's mane mushroom supposed to do?
Lion's mane has been used traditionally for brain health, but we don't yet have strong evidence it works for Alzheimer's disease, anxiety, cognitive impairment, or other brain-related conditions. The research so far hasn't been rigorous enough to say either way.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against it. There isn't enough information to know whether lion's mane is safe for your baby during pregnancy or while nursing, so it's best to skip it until after. Talk to your OB or pharmacist.
What side effects might I notice?
Gastrointestinal discomfort, nausea, and skin rash are the most common ones reported — though most people tolerate it fine orally. If you notice anything concerning, stop and let us know.
Why can't you check the bovine brain ingredient for interactions?
We simply don't have interaction or safety data on file for New Zealand Bovine Brain. That doesn't mean it's unsafe — it means we can't advise on it one way or the other from our data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Brain Nourish 500 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Brain Nourish 500 mg label
Go deeper

The Full Monographs Behind Brain Nourish 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Brain Nourish 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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