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Dietary supplement

Broccoli Sulforaphane Glucosinolate Ingredients & Drug Interactions

by SuperSmart

Broccoli Sulforaphane Glucosinolate label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Broccoli Sulforaphane Glucosinolate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Broccoli Sulforaphane Glucosinolate is a dietary supplement by SuperSmart with 1 active ingredient. Its ingredients are commonly taken for general nutrition and antioxidant support, heart and digestive health, detoxification support.Based on those ingredients, 187 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Broccoli extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Broccoli Sulforaphane Glucosinolate by SuperSmart

Ask about any prescription or over-the-counter medication and we check it for interactions with Broccoli Sulforaphane Glucosinolate by SuperSmart — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Broccoli Sulforaphane Glucosinolate by SuperSmart

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: broccoli extract, a concentrated form of the glucosinolates found naturally in broccoli. It also includes acacia gum and rice flour as inactive ingredients to hold the capsule together and improve handling.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Broccoli's overall clinical evidence instead.

Moderate

Some clinical evidence supports Broccoli for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Colorectal cancer — rated "Possibly Effective" (Natural Medicines).

The evidence shows broccoli extract may be possibly effective for colorectal cancer prevention. For bladder cancer, breast cancer, fibromyalgia, and gastric cancer, the available evidence isn't reliable or complete enough to rate it — we simply don't have solid research yet on whether it helps with those conditions.

The evidence, ingredient by ingredient Broccoli

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Broccoli as a food is well tolerated by most people, but concentrated supplements are less studied. The safety data we have advises caution with concentrated extracts unless your doctor approves.

Side effects reported from broccoli seed and sprout extracts include loose stools, diarrhea, abdominal pain, and cramping, especially at higher doses. Topically, allergic contact reactions to broccoli have occurred in some people.

Side effects, ingredient by ingredient Broccoli

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Broccoli.
  • The most serious interaction on file is rated Moderate.
  • For scale: 187 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take any medications broken down by CYP1A2 or CYP2A6 enzymes in your liver. Broccoli extract can reduce blood levels of these drugs and make them less effective.

The search tool on this page will let you verify your exact medications against this product's interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product might interest someone looking to add a broccoli concentrate to their diet, particularly if they're curious about colorectal cancer prevention support. However, if you take any regular medications — especially those processed through the liver — you'll want to check your specific drugs before starting because broccoli can speed up how your body clears a large group of them.

Talk with your doctor or pharmacist about whether this supplement makes sense for you and your medication routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Broccoli Sulforaphane Glucosinolate, straight from the product label.

Brand SuperSmart
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD May 22, 2021
DSLD ID 250194
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Broccoli Sulforaphane Glucosinolate by SuperSmart, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
Broccoli extract600 mg--

Other ingredients: Acacia Gum, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Phytonutrient

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommended Use: Adults. Take one to two vegetarian capsules a day.

Formula

Each vegetarian capsule contains 300 mg of standardised broccoli extract.

Precautions

Precautions: Do not exceed the recommended daily dose. This product is a nutritional supplement and should not replace a varied, balanced diet.

Keep out of childrens' reach.

As with any nutritional supplement, you should consult a health professional before taking this product if you are pregnant, breastfeeding or have a health problem.

Storage

Store away from direct light, heat and humidity.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Broccoli Sulforaphane Glucosinolate by SuperSmart label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Broccoli Sulforaphane Glucosinolate label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Broccoli Sulforaphane Glucosinolate by SuperSmart

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Broccoli extract

Interacts with
187 drugs
600 mg per serving Form: Sulforaphane Glucosinolate

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...

Broccoli extract monograph & interactions

Other (inactive) ingredients: Acacia Gum, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Broccoli Sulforaphane Glucosinolate by SuperSmart Drug Interactions

Want to check YOUR meds against Broccoli Sulforaphane Glucosinolate?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
187Drugs
187 Moderate

Ingredients driving the most interactions

Broccoli extract 187

Individual Drug Interactions

The ingredients in Broccoli Sulforaphane Glucosinolate interact with 187 drugs. Click any drug to see the details.

1 of the 1 ingredient in Broccoli Sulforaphane Glucosinolate interact with drugs. Each result below shows which ingredient is responsible. Broccoli extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Broccoli Sulforaphane Glucosinolate with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Broccoli extract2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Broccoli extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Broccoli Sulforaphane Glucosinolate, from the product label.

SuperSmart

See all SuperSmart products
Name
SN Worldwide Unipessoal, Lda
Street Address
Avenida Do Infante 66, Edificio Quinta Avenida 1 C
City
Funchal
ZipCode
9000-015
Pharmacist Counseling Corner

Broccoli Sulforaphane Glucosinolate by SuperSmart: Common Questions

Does Broccoli Sulforaphane Glucosinolate by SuperSmart interact with any medications?
Yes. Based on its ingredients, Broccoli Sulforaphane Glucosinolate has a known interaction with 187 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Broccoli Sulforaphane Glucosinolate contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while I'm pregnant or breastfeeding?
The data rates broccoli extract as likely safe during pregnancy and lactation. That said, since this is a concentrated supplement rather than whole food broccoli, it's a good idea to check with your own doctor or pharmacist for personalized advice before taking it.
What does sulforaphane do?
Sulforaphane is one of the active compounds in broccoli — a glucosinolate — that gives broccoli many of its health properties. In this product, it's the ingredient responsible for the interactions with your liver's drug-processing system.
Can this help prevent cancer?
The evidence shows broccoli extract may be possibly effective for colorectal cancer. For other cancers like breast, bladder, and gastric cancer, we don't have enough reliable research to say whether it helps.
What side effects might I get from this supplement?
The most common effects reported are loose stools, diarrhea, abdominal pain, and cramping — especially at higher doses. These tend to come from broccoli seed and sprout extracts. A small number of people have had allergic skin reactions to broccoli.
Why is concentrated broccoli extract less studied than eating broccoli as food?
Broccoli as a vegetable has been eaten safely for centuries and is well tolerated in normal amounts. Concentrated supplements are much newer and much more potent, so we simply haven't gathered as much safety data on long-term or regular use.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Broccoli Sulforaphane Glucosinolate is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Broccoli Sulforaphane Glucosinolate label
Go deeper

The Full Monographs Behind Broccoli Sulforaphane Glucosinolate’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Broccoli

Interacts with 187 drugs

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for health benefits. Eating broccoli as food...

Read the full Broccoli monograph →
Sources

Sources & How We Checked

Broccoli Sulforaphane Glucosinolate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Broccoli 5 references
  1. Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 2002;42:1-9. PubMed
  2. Chakrabarti A, Prais L, Foulds IS. Allergic contact dermatitis to broccoli. Br J Dermatol 2003;148:172-3. PubMed
  3. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  4. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed
  5. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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