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Dietary supplement

Calcium D-Glucarate 1500 mg Ingredients & Drug Interactions

by SuperSmart

Calcium D-Glucarate 1500 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Calcium D-Glucarate 1500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Calcium D-Glucarate 1500 mg is a dietary supplement by SuperSmart with 1 active ingredient. Its ingredients are commonly taken for detoxification support, hormone balance, estrogen metabolism.Based on those ingredients, 126 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Calcium D-Glucarate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Calcium D-Glucarate 1500 mg by SuperSmart

Ask about any prescription or over-the-counter medication and we check it for interactions with Calcium D-Glucarate 1500 mg by SuperSmart — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Calcium D-Glucarate 1500 mg by SuperSmart

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: calcium D-glucarate at 1500 mg per capsule. It also includes two inactive ingredients — acacia gum and white rice flour — which help form and fill the capsule.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Calcium D-glucarate product and its label doesn't state a use — see Calcium D-glucarate's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for calcium D-glucarate isn't established in our data. For breast cancer, prostate cancer, and colorectal cancer — the conditions it's commonly marketed for — the rating is insufficient reliable evidence to rate.

That means there simply isn't enough solid research yet to say whether it works or how well.

The evidence, ingredient by ingredient Calcium D-glucarate

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium D-glucarate appears generally well tolerated in the small studies available, but long-term safety in humans isn't well established. There isn't enough safety information to recommend it during pregnancy, so it's best avoided.

Safety while breastfeeding is also unknown, so it's best avoided at that time too. No adverse effects are documented in our data.

Side effects, ingredient by ingredient Calcium D-glucarate

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Calcium D-glucarate.
  • The most serious interaction on file is rated Moderate.
  • For scale: 126 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist about any medications you take that undergo glucuronidation (a liver and kidney process that breaks down many drugs) — calcium D-glucarate may speed up how your body clears them, which could make them less effective. Also mention if you drink alcohol regularly, as it may reduce how this supplement works.

Kanamycin, an antibiotic, may also see lower levels in your blood.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

This is a single-ingredient supplement marketed for cancer prevention, but the evidence for its effectiveness isn't established. If you're considering it, talk with your doctor or pharmacist first — especially if you take medications that undergo glucuronidation or drink alcohol regularly.

They can weigh whether it's right for you and help you monitor any effects.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Calcium D-Glucarate 1500 mg, straight from the product label.

Brand SuperSmart
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD May 22, 2021
DSLD ID 250205
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Calcium D-Glucarate 1500 mg by SuperSmart, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
IngredientAmount% DV
Calcium D-Glucarate1500 mg23%

Other ingredients: Acacia Gum, White Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Detox

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommended use: Adults. Take 3 capsules per day.

Formula

Each capsule contains 500 mg of calcium D-glucarate.

Precautions

Precautions: Do not exceed the recommended daily dose. This product is a nutritional supplement and should not replace a varied, balanced diet.

Keep out of childrens' reach.

As with any nutritional supplement, you should consult a health professional before taking this product if you are pregnant, breastfeeding or have a health problem.

Storage

Store away from direct light, heat and humidity.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Calcium D-Glucarate 1500 mg by SuperSmart label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Calcium D-Glucarate 1500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Calcium D-Glucarate 1500 mg by SuperSmart

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Calcium D-Glucarate

Interacts with
126 drugs
1500 mg per serving

Calcium D-glucarate is a supplement form of a natural compound found in fruits and vegetables that is promoted for 'detoxification' and helping the bo...

Calcium D-Glucarate monograph & interactions

Other (inactive) ingredients: Acacia Gum, White Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Calcium D-Glucarate 1500 mg by SuperSmart Drug Interactions

Want to check YOUR meds against Calcium D-Glucarate 1500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
126Drugs
125 Moderate 1 Minor

Ingredients driving the most interactions

Calcium D-Glucarate 126

Individual Drug Interactions

The ingredients in Calcium D-Glucarate 1500 mg interact with 126 drugs. Click any drug to see the details.

1 of the 1 ingredient in Calcium D-Glucarate 1500 mg interact with drugs. Each result below shows which ingredient is responsible. Calcium D-Glucarate

Each ingredient & the kinds of drugs it affects

For each ingredient in Calcium D-Glucarate 1500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Calcium D-Glucarate3 drug types · 126 drugs

Alcohol (Ethanol)

Theoretically, concomitant use with alcohol might decrease calcium D-glucarate activity.
There is some evidence that urinary excretion of calcium D-glucarate metabolites increases in people consuming alcohol.

Likelihood Possible Evidence B
Glucuronidated Drugs

Theoretically, calcium D-glucarate might increase the clearance of drugs that undergo glucuronidation.
The calcium D-glucarate metabolite, D-glucaro-1,4-lactone, inhibits the enzyme beta-glucuronidase, reducing deconjugation of glucuronides in the intestine and thereby reducing reabsorption of the drugs.

Likelihood Possible Evidence B
Kanamycin

Theoretically, calcium D-glucarate may reduce plasma levels of kanamycin.
Calcium D-glucarate may increase the rate of kanamycin elimination, which may decrease its clinical and adverse effects.

Likelihood Possible Evidence D
Calcium D-Glucarate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Calcium D-Glucarate 1500 mg, from the product label.

SuperSmart

See all SuperSmart products
Name
SN Worldwide Unipessoal, Lda
Street Address
Avenida Do Infante 66, Edificio Quinta Avenida 1 C
City
Funchal
ZipCode
9000-015
Pharmacist Counseling Corner

Calcium D-Glucarate 1500 mg by SuperSmart: Common Questions

Does Calcium D-Glucarate 1500 mg by SuperSmart interact with any medications?
Yes. Based on its ingredients, Calcium D-Glucarate 1500 mg has a known interaction with 126 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Calcium D-Glucarate 1500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is calcium D-glucarate safe during pregnancy?
No, there isn't enough safety information, so it's best avoided during pregnancy. Talk with your doctor or pharmacist about whether it's right for you.
Can I take this while breastfeeding?
Safety while breastfeeding is unknown, so it's best avoided. Check with your doctor or pharmacist before taking it if you're nursing.
Does calcium D-glucarate actually work for cancer prevention?
The evidence isn't established in our data. For breast, prostate, and colorectal cancer, there's insufficient reliable evidence to rate whether it works.
What side effects does calcium D-glucarate have?
No adverse effects are documented in our data. It appears generally well tolerated in the small studies available, but long-term safety in humans isn't well established.
Why might it interact with so many medications?
Calcium D-glucarate can theoretically speed up how your body breaks down drugs that use glucuronidation — a key pathway for eliminating many medications. That's why it affects a broad number of different drugs, even though the interactions are documented as moderate or minor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Calcium D-Glucarate 1500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Calcium D-Glucarate 1500 mg label
Go deeper

The Full Monographs Behind Calcium D-Glucarate 1500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calcium D-glucarate

Interacts with 126 drugs

Calcium D-glucarate is a supplement form of a natural compound found in fruits and vegetables that is promoted for 'detoxification' and helping the body clear excess hormones. Human evidence...

Read the full Calcium D-glucarate monograph →
Sources

Sources & How We Checked

Calcium D-Glucarate 1500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calcium D-glucarate 5 references
  1. Dwivedi C, Heck WJ, Downie AA, et al. Effect of calcium glucarate on B-glucuronidase activity and glucarate content on certain vegetables and fruits. Biochem Med Metab Bio 1990;43:83-92.
  2. Furuno K, Matsubara S, Ando K, Suzuki S. Preventive effect of D-glucarate against renal damage induced by kanamycin. J Antibiot (Tokyo) 1976;29:950-3. PubMed
  3. Mezey E. Increased urinary excretion of D-glucarate acid in alcoholism. Res Commun Chem Pathol Pharmacol 1976;15:735-42.
  4. Pantuck EJ, Pantuck CB, Anderson KE, et al. Effect of brussels sprouts and cabbage on drug conjugation. Clin Pharmacol Ther 1984;35:161-9. PubMed
  5. Anon. Calcium-D-Glucarate. Altern Med Review 2002;7(4):336-9.

See these in context on the Calcium D-glucarate monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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