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Dietary supplement

Calcium D-Glucarate 500 mg Ingredients & Drug Interactions

by Martin Avenue Pharmacy

Calcium D-Glucarate 500 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Calcium D-Glucarate 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Calcium D-Glucarate 500 mg is a dietary supplement by Martin Avenue Pharmacy with 1 active ingredient. Its ingredients are commonly taken for detoxification support, hormone balance, estrogen metabolism.Based on those ingredients, 126 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Calcium D-Glucarate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Calcium D-Glucarate 500 mg by Martin Avenue Pharmacy

Ask about any prescription or over-the-counter medication and we check it for interactions with Calcium D-Glucarate 500 mg by Martin Avenue Pharmacy — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Calcium D-Glucarate 500 mg by Martin Avenue Pharmacy

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: calcium D-glucarate 500 mg per capsule. Calcium D-glucarate is a naturally occurring compound found in some fruits and vegetables; the supplement form is derived from glucaric acid.

The capsule also contains inactive ingredients — gelatin, cellulose, water, and magnesium stearate — which serve as the capsule shell and binding agents.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Calcium D-glucarate product and its label doesn't state a use — see Calcium D-glucarate's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence supporting calcium D-glucarate for breast, prostate, and colorectal cancer is insufficient to rate. Our data does not establish whether this supplement is effective for these or any other conditions at this time.

If you're considering it for a specific health goal, talk it over with your doctor about what the current research shows.

The evidence, ingredient by ingredient Calcium D-glucarate

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium D-glucarate appears generally well tolerated in small studies, but long-term safety in humans hasn't been established, so we don't have a complete picture of how it might affect you over months or years. There is not enough safety information to recommend it during pregnancy or while breastfeeding — the data advises against use in both situations.

If you're pregnant, planning pregnancy, or breastfeeding, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Calcium D-glucarate

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Calcium D-glucarate.
  • The most serious interaction on file is rated Moderate.
  • For scale: 126 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist or doctor if you take any glucuronidated drugs — a wide group that includes many common medications — or if you drink alcohol regularly. You should also let them know if you take kanamycin or any antibiotic in that class.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Calcium D-glucarate may interact with a large number of medications, especially those processed by your liver in a specific way. If you take any prescription drugs or drink alcohol regularly, check with your pharmacist or doctor before starting this supplement.

The evidence for its effectiveness isn't established yet, and long-term safety data is limited.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Calcium D-Glucarate 500 mg, straight from the product label.

Brand Martin Avenue Pharmacy
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2013
DSLD ID 18836
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Calcium D-Glucarate 500 mg by Martin Avenue Pharmacy, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
IngredientAmount% DV
Calcium D-Glucarate500 mg--

Other ingredients: Gelatin, Cellulose, Water, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Supports Phase 2 Detoxification

QUALITY AND POTENCY GUARANTEED

CALCIUM D-GLUCARATE supplies D-glucaric acid bound to calcium which serves as a bioavailable precursor to D-glucaro-1,4-lactone.

"We Make It Better..."

FDA Statement of Identity

Dietary Supplement

General

#10025

Suggested/Recommended/Usage/Directions

Suggested Use: 1 - 2 capsules daily.

Storage

Store in a cool, dry place and away from direct light.

Precautions

Keep out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Calcium D-Glucarate 500 mg by Martin Avenue Pharmacy label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Calcium D-Glucarate 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Calcium D-Glucarate 500 mg by Martin Avenue Pharmacy

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Calcium D-Glucarate

Interacts with
126 drugs
500 mg per serving

Calcium D-glucarate is a supplement form of a natural compound found in fruits and vegetables that is promoted for 'detoxification' and helping the bo...

Calcium D-Glucarate monograph & interactions

Other (inactive) ingredients: Gelatin, Cellulose, Water, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Calcium D-Glucarate 500 mg by Martin Avenue Pharmacy Drug Interactions

Want to check YOUR meds against Calcium D-Glucarate 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
126Drugs
125 Moderate 1 Minor

Ingredients driving the most interactions

Calcium D-Glucarate 126

Individual Drug Interactions

The ingredients in Calcium D-Glucarate 500 mg interact with 126 drugs. Click any drug to see the details.

1 of the 1 ingredient in Calcium D-Glucarate 500 mg interact with drugs. Each result below shows which ingredient is responsible. Calcium D-Glucarate

Each ingredient & the kinds of drugs it affects

For each ingredient in Calcium D-Glucarate 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Calcium D-Glucarate3 drug types · 126 drugs

Alcohol (Ethanol)

Theoretically, concomitant use with alcohol might decrease calcium D-glucarate activity.
There is some evidence that urinary excretion of calcium D-glucarate metabolites increases in people consuming alcohol.

Likelihood Possible Evidence B
Glucuronidated Drugs

Theoretically, calcium D-glucarate might increase the clearance of drugs that undergo glucuronidation.
The calcium D-glucarate metabolite, D-glucaro-1,4-lactone, inhibits the enzyme beta-glucuronidase, reducing deconjugation of glucuronides in the intestine and thereby reducing reabsorption of the drugs.

Likelihood Possible Evidence B
Kanamycin

Theoretically, calcium D-glucarate may reduce plasma levels of kanamycin.
Calcium D-glucarate may increase the rate of kanamycin elimination, which may decrease its clinical and adverse effects.

Likelihood Possible Evidence D
Calcium D-Glucarate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Calcium D-Glucarate 500 mg, from the product label.

Martin Avenue Pharmacy

See all Martin Avenue Pharmacy products
Name
Martin Avenue Pharmacy, Inc.
City
Naperville
State
IL
ZipCode
60540
Phone Number
(630) 355-6400
Pharmacist Counseling Corner

Calcium D-Glucarate 500 mg by Martin Avenue Pharmacy: Common Questions

Does Calcium D-Glucarate 500 mg by Martin Avenue Pharmacy interact with any medications?
Yes. Based on its ingredients, Calcium D-Glucarate 500 mg has a known interaction with 126 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Calcium D-Glucarate 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take calcium D-glucarate if I'm pregnant or breastfeeding?
No — there isn't enough safety information, so it's advised against during pregnancy and while breastfeeding. Talk with your doctor or pharmacist for personalized guidance if you're in either situation.
Does calcium D-glucarate actually work?
The evidence isn't established yet. The data we hold rates it as having insufficient reliable evidence for breast cancer, prostate cancer, and colorectal cancer. If you're considering it for a specific reason, ask your doctor what the current research supports.
Will alcohol affect how this supplement works?
Yes — drinking alcohol may reduce calcium D-glucarate's activity. If you drink regularly, mention that to your pharmacist or doctor before starting.
What is calcium D-glucarate?
It's a naturally occurring compound found in some fruits and vegetables. The supplement form is derived from glucaric acid and is thought to support certain detoxification pathways in your body, though the evidence for health benefits isn't yet established.
Why does this product interact with so many medications?
Calcium D-glucarate affects how your body processes and reabsorbs drugs that undergo a specific liver pathway called glucuronidation — which is how your body clears many common medications. That's why it potentially touches a large number of drugs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Calcium D-Glucarate 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Calcium D-Glucarate 500 mg label
Go deeper

The Full Monographs Behind Calcium D-Glucarate 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calcium D-glucarate

Interacts with 126 drugs

Calcium D-glucarate is a supplement form of a natural compound found in fruits and vegetables that is promoted for 'detoxification' and helping the body clear excess hormones. Human evidence...

Read the full Calcium D-glucarate monograph →
Sources

Sources & How We Checked

Calcium D-Glucarate 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calcium D-glucarate 5 references
  1. Dwivedi C, Heck WJ, Downie AA, et al. Effect of calcium glucarate on B-glucuronidase activity and glucarate content on certain vegetables and fruits. Biochem Med Metab Bio 1990;43:83-92.
  2. Furuno K, Matsubara S, Ando K, Suzuki S. Preventive effect of D-glucarate against renal damage induced by kanamycin. J Antibiot (Tokyo) 1976;29:950-3. PubMed
  3. Mezey E. Increased urinary excretion of D-glucarate acid in alcoholism. Res Commun Chem Pathol Pharmacol 1976;15:735-42.
  4. Pantuck EJ, Pantuck CB, Anderson KE, et al. Effect of brussels sprouts and cabbage on drug conjugation. Clin Pharmacol Ther 1984;35:161-9. PubMed
  5. Anon. Calcium-D-Glucarate. Altern Med Review 2002;7(4):336-9.

See these in context on the Calcium D-glucarate monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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