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Dietary supplement

Calcium D-Glucarate Ingredients & Drug Interactions

by Designs for Health

Calcium D-Glucarate label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Calcium D-Glucarate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Calcium D-Glucarate is a dietary supplement by Designs for Health with 1 active ingredient. Its ingredients are commonly taken for detoxification support, hormone balance, estrogen metabolism.Based on those ingredients, 126 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Calcium D-Glucarate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Calcium D-Glucarate by Designs for Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Calcium D-Glucarate by Designs for Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Calcium D-Glucarate by Designs for Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: calcium D-glucarate, a compound formed naturally in small amounts in the body and present in some fruits and vegetables. The supplement is delivered in a capsule with microcrystalline cellulose and vegetable stearate as inactive ingredients (standard capsule materials and binders).

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Calcium D-glucarate product and its label doesn't state a use — see Calcium D-glucarate's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for calcium D-glucarate isn't established in our data. We hold insufficient reliable evidence to rate it for breast cancer, prostate cancer, or colorectal cancer — the main conditions people typically consider it for.

If you're thinking about it for one of these uses, that's something worth discussing with your doctor, since the science isn't settled yet.

The evidence, ingredient by ingredient Calcium D-glucarate

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium D-glucarate appears generally well tolerated in the small studies available, but long-term safety in humans hasn't been well studied, so we don't know how it behaves with years of use. There isn't enough safety information to recommend it during pregnancy, so the safety data advises against use then.

Safety while breastfeeding is unknown as well, so it's best avoided unless you've talked it through with your doctor or pharmacist.

Side effects, ingredient by ingredient Calcium D-glucarate

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Calcium D-glucarate.
  • The most serious interaction on file is rated Moderate.
  • For scale: 126 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this supplement, have your doctor or pharmacist check any medications you're on that undergo glucuronidation (a common liver process) — the supplement may make them less effective. Also flag any regular alcohol use and any antibiotic use, particularly kanamycin.

If you're unsure whether a drug is affected, use the medication search tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Calcium D-glucarate may be worth considering if you're interested in its potential role in cancer prevention, but the evidence isn't solid yet. The big thing to know is that it can interact with a large number of medications by speeding up how your body eliminates them — so if you take any prescription drugs, check your exact medications with our tool before starting.

Talk it over with your own doctor or pharmacist, especially if you're pregnant, breastfeeding, or taking anything regularly.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Calcium D-Glucarate, straight from the product label.

Brand Designs for Health
Barcode (UPC) 879452003859
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Apr 25, 2014
DSLD ID 31975
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Calcium D-Glucarate by Designs for Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
879452003859
IngredientAmount% DV
Calcium D-Glucarate1.2 Gram(s)--

Other ingredients: Microcrystalline Cellulose, Vegetable Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

STORE IN A COOL, DRY PLACE.

Precautions

KEEP OUT OF REACH OF CHILDREN.

General Statements

Notice: Color, size or shape may appear different between lots.

For Professional Use Only

Manufactured in a GMP Audited Facility in Arlee, MT, USA

Formulation

Does not contain gluten.

General

CDG060

Seals/Symbols

Guaranteed GMP COMPLIANT Products

MADE WITH NON-GMO INGREDIENTS

Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement, take two capsule per day with meals, or as directed by your health care practitioner.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Calcium D-Glucarate by Designs for Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Calcium D-Glucarate label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Calcium D-Glucarate by Designs for Health

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Calcium D-Glucarate

Interacts with
126 drugs
1.2 Gram(s) per serving

Calcium D-glucarate is a supplement form of a natural compound found in fruits and vegetables that is promoted for 'detoxification' and helping the bo...

Calcium D-Glucarate monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Calcium D-Glucarate by Designs for Health Drug Interactions

Want to check YOUR meds against Calcium D-Glucarate?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
126Drugs
125 Moderate 1 Minor

Ingredients driving the most interactions

Calcium D-Glucarate 126

Individual Drug Interactions

The ingredients in Calcium D-Glucarate interact with 126 drugs. Click any drug to see the details.

1 of the 1 ingredient in Calcium D-Glucarate interact with drugs. Each result below shows which ingredient is responsible. Calcium D-Glucarate

Each ingredient & the kinds of drugs it affects

For each ingredient in Calcium D-Glucarate with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Calcium D-Glucarate3 drug types · 126 drugs

Alcohol (Ethanol)

Theoretically, concomitant use with alcohol might decrease calcium D-glucarate activity.
There is some evidence that urinary excretion of calcium D-glucarate metabolites increases in people consuming alcohol.

Likelihood Possible Evidence B
Glucuronidated Drugs

Theoretically, calcium D-glucarate might increase the clearance of drugs that undergo glucuronidation.
The calcium D-glucarate metabolite, D-glucaro-1,4-lactone, inhibits the enzyme beta-glucuronidase, reducing deconjugation of glucuronides in the intestine and thereby reducing reabsorption of the drugs.

Likelihood Possible Evidence B
Kanamycin

Theoretically, calcium D-glucarate may reduce plasma levels of kanamycin.
Calcium D-glucarate may increase the rate of kanamycin elimination, which may decrease its clinical and adverse effects.

Likelihood Possible Evidence D
Calcium D-Glucarate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Calcium D-Glucarate, from the product label.

Designs for Health

See all Designs for Health products
Name
Designs for Health, Inc.
Street Address
980 South Street
City
Suffield
State
CT
ZipCode
06078
Web Address
www.designsforhealth.com
Pharmacist Counseling Corner

Calcium D-Glucarate by Designs for Health: Common Questions

Does Calcium D-Glucarate by Designs for Health interact with any medications?
Yes. Based on its ingredients, Calcium D-Glucarate has a known interaction with 126 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Calcium D-Glucarate contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No. There isn't enough safety information during pregnancy, so the data advises against it then. Safety while breastfeeding is unknown as well, so it's best avoided. Talk with your doctor or pharmacist about whether it's right for you in these situations.
Does it really work for cancer prevention?
The evidence isn't there yet. We hold insufficient reliable evidence to rate it for breast, prostate, or colorectal cancer. That doesn't mean it won't work — just that the studies haven't established it so far. Your doctor is the best person to discuss whether it makes sense for you.
What happens if I drink alcohol while taking this?
Theoretically, alcohol may reduce how well this supplement works in your body by speeding up how quickly your body gets rid of it. It's a Moderate-severity interaction, so it's worth avoiding or at least talking through with your pharmacist if alcohol is a regular part of your routine.
How long has it been studied in humans?
Long-term safety in humans isn't well established yet. Small studies suggest it's generally well tolerated, but we don't have a lot of data on how it performs or behaves over years of use.
What exactly does this supplement do?
Calcium D-glucarate is a compound your body makes naturally in small amounts and that's found in some fruits and vegetables. It's being studied for potential effects related to how your liver and intestines process and eliminate certain substances, but the clinical evidence is still incomplete.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Calcium D-Glucarate is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Calcium D-Glucarate label
Go deeper

The Full Monographs Behind Calcium D-Glucarate’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calcium D-glucarate

Interacts with 126 drugs

Calcium D-glucarate is a supplement form of a natural compound found in fruits and vegetables that is promoted for 'detoxification' and helping the body clear excess hormones. Human evidence...

Read the full Calcium D-glucarate monograph →
Sources

Sources & How We Checked

Calcium D-Glucarate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calcium D-glucarate 5 references
  1. Dwivedi C, Heck WJ, Downie AA, et al. Effect of calcium glucarate on B-glucuronidase activity and glucarate content on certain vegetables and fruits. Biochem Med Metab Bio 1990;43:83-92.
  2. Furuno K, Matsubara S, Ando K, Suzuki S. Preventive effect of D-glucarate against renal damage induced by kanamycin. J Antibiot (Tokyo) 1976;29:950-3. PubMed
  3. Mezey E. Increased urinary excretion of D-glucarate acid in alcoholism. Res Commun Chem Pathol Pharmacol 1976;15:735-42.
  4. Pantuck EJ, Pantuck CB, Anderson KE, et al. Effect of brussels sprouts and cabbage on drug conjugation. Clin Pharmacol Ther 1984;35:161-9. PubMed
  5. Anon. Calcium-D-Glucarate. Altern Med Review 2002;7(4):336-9.

See these in context on the Calcium D-glucarate monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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