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Dietary supplement

Calendula 250 mg Ingredients & Drug Interactions

by Eclectic Herb

Calendula 250 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Calendula 250 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Calendula 250 mg is a dietary supplement by Eclectic Herb with 1 active ingredient. Its ingredients are commonly taken for minor wounds and skin healing, skin inflammation and irritation, diaper rash.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Calendula, Freeze-Dried. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Calendula 250 mg by Eclectic Herb

Ask about any prescription or over-the-counter medication and we check it for interactions with Calendula 250 mg by Eclectic Herb — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Calendula 250 mg by Eclectic Herb

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: freeze-dried calendula at 250 mg per capsule. Calendula is a traditional herb used in natural medicine, though the evidence for its specific health effects isn't well established.

The capsule also contains hypromellose, an inactive ingredient that holds it together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Calendula product and its label doesn't state a use — see Calendula's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for calendula's effectiveness isn't established in the data we hold. It's been studied for acne, bacterial vaginosis, burns, COPD, liver disease, and radiation dermatitis, but in each case we don't have reliable evidence to rate how well it works.

That doesn't mean it doesn't help—just that the research backing it up isn't solid enough yet for us to say.

The evidence, ingredient by ingredient Calendula

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calendula is generally well tolerated, but allergic reactions are possible both when taken by mouth and when applied to skin. If you're sensitive to ragweed, chrysanthemums, marigolds, or daisies, you may react to calendula too—they're in the same plant family.

Patch testing before use is recommended to check your skin's response. The safety data for taking calendula by mouth during pregnancy isn't strong enough, so it's best avoided then.

Since reliable safety information is also lacking for oral use overall, talk with your doctor or pharmacist before starting it.

Side effects, ingredient by ingredient Calendula

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Calendula.
  • The most serious interaction on file is rated Minor.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take CNS depressants—sedatives, sleep aids, or certain pain relievers that slow your nervous system—check your exact medications before adding this product, although the risk appears minor. Altogether, these interactions span 248 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Calendula is a traditional herbal option for people exploring natural remedies, but the evidence for what it actually does isn't well established. If you're pregnant or breastfeeding, or if you take CNS depressants (sleep aids, sedatives, certain pain relievers), check with your pharmacist first.

A skin patch test is smart if you have plant allergies, especially to ragweed or related flowers.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Calendula 250 mg, straight from the product label.

Brand Eclectic Herb
Barcode (UPC) 023363309047
Net contents 90 Veg Cap(s)
Market status On market
Date entered into DSLD Aug 22, 2024
DSLD ID 316751
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Calendula 250 mg by Eclectic Herb, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veg Cap(s)
Maximum serving Sizes:
3 Veg Cap(s)
Servings per container
90
UPC/BARCODE
023363309047
IngredientAmount% DV
Calendula, Freeze-Dried250 mg--

Other ingredients: Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Concentrated 9x through freeze-drying Freeze dried fresh for peak plant power

No fillers Non GMO Gluten free

Whole herb Raw food

Vegan

Grown in the United States Naturally concentrated

Nothing artificial - no fillers or additives.

Freeze-drying is the best method of preservation as it naturally concentrates the nutrients in the plant by removing only the water. Digestive support

Small batch freeze dried

Formula

100% Kosher

Our calendula flowers are locally grown and fresh freeze-dried in-house in small batches.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. this product is not intended to diagnose, treat, cure or prevent disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Take 1-3 capsules per day.

Precautions

Keep away from children. Consult your doctor about herbs with pregnancy, infants or prescription drugs.

Consult your doctor about herbs with pregnancy, infants or prescription drugs.

General Statements

@eclecticherb

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Calendula 250 mg by Eclectic Herb label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Calendula 250 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Calendula 250 mg by Eclectic Herb

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veg Cap(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Calendula, Freeze-Dried

Interacts with
248 drugs
250 mg per serving Form: Calendula officinalis, Freeze-Dried

Calendula is a flowering plant whose petals are used mainly in skin creams, oils, and ointments to soothe minor irritation and support wound healing....

Calendula, Freeze-Dried monograph & interactions

Other (inactive) ingredients: Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Calendula 250 mg by Eclectic Herb Drug Interactions

Want to check YOUR meds against Calendula 250 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Minor

Ingredients driving the most interactions

Calendula, Freeze-Dried 248

Individual Drug Interactions

The ingredients in Calendula 250 mg interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Calendula 250 mg interact with drugs. Each result below shows which ingredient is responsible. Calendula, Freeze-Dried

Each ingredient & the kinds of drugs it affects

For each ingredient in Calendula 250 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Calendula, Freeze-Dried1 drug type · 248 drugs

Cns Depressants

Theoretically, calendula might have additive effects when used with CNS depressants, although this appears to be unlikely.
Although some animal research has suggested that a saponoside constituent in calendula may have sedative effects, calendula has been used for over 30 years without reports of sedation in humans.

Likelihood Unlikely Evidence D
Calendula, Freeze-Dried full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Calendula 250 mg, from the product label.

Eclectic Herb

See all Eclectic Herb products
Name
Eclectic Herb
Street Address
755 NE 6th St.
City
Gresham
State
Oregon
ZipCode
97030
Phone Number
503.668.4120
Web Address
www.eclecticherb.com
Pharmacist Counseling Corner

Calendula 250 mg by Eclectic Herb: Common Questions

Does Calendula 250 mg by Eclectic Herb interact with any medications?
Yes. Based on its ingredients, Calendula 250 mg has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Calendula 250 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Calendula if I'm pregnant?
The safety data for taking calendula by mouth during pregnancy isn't strong enough, so it's best avoided. Talk with your doctor or pharmacist about whether it's right for you.
What should I watch for if I take this with my sleep medication?
Calendula might theoretically add to the drowsy effect of sleep aids, though this appears unlikely since calendula hasn't caused sedation in people over 30 years of use. Still, mention it to your pharmacist so they can review your specific medication.
Will I have an allergic reaction to this?
Most people tolerate it well, but allergic reactions are possible when taken by mouth or applied to skin. If you're allergic to ragweed or related plants like daisies and marigolds, you're at higher risk. A patch test before use can help you know.
Does calendula actually work for burns or acne?
Calendula has been studied for both, but we don't have reliable evidence yet that it works for either one. It's a traditional remedy, but the research backing it up isn't solid enough for us to say how well it helps.
Are there any fillers or other ingredients I should know about?
The capsule contains hypromellose, an inactive ingredient that holds it together. The active ingredient is freeze-dried calendula at 250 mg.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Calendula 250 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Calendula 250 mg label
Go deeper

The Full Monographs Behind Calendula 250 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calendula

Interacts with 248 drugs

Calendula is a flowering plant whose petals are used mainly in skin creams, oils, and ointments to soothe minor irritation and support wound healing. Some early research is promising for ski...

Read the full Calendula monograph →
Sources

Sources & How We Checked

Calendula 250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calendula 9 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Reider N, Komericki P, Hausen BM, et al. The seamy side of natural medicines: contact sensitization to arnica (Arnica montana L.) and marigold (Calendula officinalis L.). Contact Dermatitis 2001;45:269-72..
  3. Gol'dman II. [Anaphylactic shock after gargling with an infusion of Calendula]. Klin Med (Mosk) 1974;52:142-3.
  4. Paulsen E. Contact sensitization from Compositae-containing herbal remedies and cosmetics. Contact Dermatitis 2002;47:189-98. PubMed
  5. Bojadjiev C. On the sedative and hypotensive effect of preparations from the plant Calendula officinalis. Nauch Trud Visshi Med Inst Sof 1964;43:15-20.
  6. Samochowiec L. Pharmacological study of saponosides from Aralia mandshurica Rupr. et Maxim and Calendula officinalis L. Herba Pol. 1983;29:151-155.
  7. Madisetti M, Kelechi TJ, Mueller M, Amella EJ, Prentice MA. Feasibility, acceptability, and tolerability of RGN107 in the palliative wound care management of chronic wound symptoms. J Wound Care. 2017;26(Sup1):S25-S34. PubMed
  8. Final Assessment report on Calendula officinalis L., flos. European Medicines Agency: Committee on Herbal Medicinal Products (HMPC). 2018. EMA/HMPC/603409/2017. Available at: https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-cal
  9. Puaratanaarunkon T, Washrawirul C, Chuenboonngarm N, Noppakun N, Asawanonda P, Kumtornrut C. Efficacy and safety of a facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glaba root extract in the treatment of maskne: A

See these in context on the Calendula monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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