Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Calendula Oil Ingredients & Drug Interactions

by Herb Pharm

Liquid Category: Botanical With Nutrients
Most serious interaction: Minor
The interaction bottom line Most serious interaction: Minor

Calendula Oil is a dietary supplement by Herb Pharm with 2 active ingredients. Its ingredients are commonly taken for heart health, high blood pressure, high cholesterol.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Calendula Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Calendula Oil by Herb Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.

Herb Pharm's Calendula Oil is a 2-ingredient blend: calendula extract (the active component) and olive oil (the carrier). The calendula extract is the working ingredient — it's been used topically for skin care for decades.

Olive oil serves as the base that carries the calendula into the product.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Minor wounds and skin healing support.
  • We looked for evidence on: Burns, Diaper rash, Pressure ulcers, Radiation dermatitis, Venous leg ulcers, Wound healing — and 3 related terms.
  • The closest evidence on file: Calendula is rated "Insufficient Reliable Evidence To Rate" for Burns (Natural Medicines).
  • Also on file: Calendula is rated "Insufficient Reliable Evidence To Rate" for Radiation dermatitis, Diaper rash, Wound healing, Venous leg ulcers, and more.

The evidence on calendula for specific conditions — acne, burns, radiation skin damage, and others — is rated insufficient in our data, meaning we don't have strong clinical proof it works for those uses. That doesn't mean it doesn't; it means the studies aren't solid enough yet to say one way or the other.

It's been used traditionally for skin care, but we can't point to reliable trial data backing those claims.

The evidence, ingredient by ingredient Olive Calendula

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calendula is generally well tolerated on the skin, but allergic reactions do happen, especially in people sensitive to ragweed, chrysanthemums, or other plants in the daisy family — you might want to patch-test a small amount first. Taken by mouth, calendula can cause allergic reactions; the safety data for oral use in pregnancy is too thin to recommend it.

Olive oil as food is very safe, but concentrated supplements are less studied, so talk with your doctor before using a supplement form if you're not sure it's right for you. Rare side effects with topical calendula include burning, itching, redness, and scaling, though these were reported in combination products, so calendula's specific role is unclear.

Side effects, ingredient by ingredient Olive Calendula

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Calendula.
  • The most serious interaction on file is rated Minor.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check any CNS depressants (sedating medications like benzodiazepines or sleep aids) with the tool below — calendula may add to their sedating effects, though the risk is Minor and human cases are rare.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

This oil is a traditional skin-care product; if you're using it on your skin and you're not allergic to ragweed or related plants, it's generally well tolerated. If you take any sedating medication, check it below before starting.

If you're pregnant or thinking of taking calendula by mouth, talk with your pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Calendula Oil, straight from the product label.

Brand Herb Pharm
Barcode (UPC) 090900000811
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Sep 25, 2025
DSLD ID 334511
Product type Botanical With Nutrients
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Calendula Oil by Herb Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0 Not Present
Maximum serving Sizes:
0 Not Present
UPC/BARCODE
090900000811
IngredientAmount% DV
Olive Oil0 NP--
Calendula Extract0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use Shake well before using Apply to skin with cotton gauze, or massage into skin until well absorbed.

Precautions

For external use only May stain clothing.

Keep out of the reach of children.

Storage

Store away from heat & light

Formula

Calendula oil Whole flower

Seals/Symbols

USDA Organic

Formulation

USDA Organic

We prepare our Calendula Oil from the whole flower of Calendula officinalis plants which are certified organically grown. To assure optimal extraction of Calendula's bioactive compounds, the flower is harvested while in full bloom, and is carefully shade dried to retain its full color & aroma. The flower is then thoroughly extracted and concentrated into cold-pressed, certified organic olive oil.

Certified organic by Organic Certifiers

See for yourself

Calendula Oil by Herb Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Calendula Oil by Herb Pharm

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size0 Not Present Dosage formLiquid Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Olive Oil

No known
interactions
0 NP per serving

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyr...

Olive Oil monograph & interactions

Calendula Extract

Interacts with
248 drugs
0 NP per serving

Calendula is a flowering plant whose petals are used mainly in skin creams, oils, and ointments to soothe minor irritation and support wound healing....

Calendula Extract monograph & interactions
Interaction report

Calendula Oil by Herb Pharm Drug Interactions

Want to check YOUR meds against Calendula Oil?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
248Drugs
248 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Calendula Oil with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Calendula Extract1 drug type · 248 drugs

Cns Depressants

Theoretically, calendula might have additive effects when used with CNS depressants, although this appears to be unlikely.
Although some animal research has suggested that a saponoside constituent in calendula may have sedative effects, calendula has been used for over 30 years without reports of sedation in humans.

Likelihood Unlikely Evidence D
The maker

Brand information

Manufacturer and brand details for Calendula Oil, from the product label.

Herb Pharm

See all Herb Pharm products
Name
Herb Pharm
City
Williams
State
OR
ZipCode
97544
Phone Number
800-348-4372
Web Address
www.herb-pharm.com
Pharmacist Counseling Corner

Calendula Oil by Herb Pharm: Common Questions

Does Calendula Oil by Herb Pharm interact with any medications?
Yes. Based on its ingredients, Calendula Oil has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Calendula Oil contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I use this if I'm allergic to ragweed?
You should be cautious. Calendula can trigger allergic reactions in people sensitive to ragweed, chrysanthemums, and related plants. A patch test on a small area of skin first is a smart idea to see if you react.
Is this safe during pregnancy?
The safety data for taking calendula by mouth during pregnancy isn't strong enough to recommend it. If you're pregnant and want to use it, talk with your doctor or pharmacist first. We don't have safety information on file for topical use in pregnancy either.
What is calendula extract, and what's it supposed to do?
Calendula extract comes from the calendula flower (also called marigold). It's been used in traditional skin care for over 30 years, but the clinical evidence for specific skin conditions — like acne or burns — is still insufficient to say definitively that it works.
Can I get a rash from this?
Yes. Allergic skin reactions are possible, especially if you're sensitive to plants in the daisy family. Rare reactions have included burning, itching, redness, and scaling when calendula was applied topically. Patch-testing first is a good precaution.
Does this have any fillers?
No — the product contains only calendula extract and olive oil, with no other inactive ingredients listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Calendula Oil is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Calendula Oil label
Sources

Sources & How We Checked

Calendula Oil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Olive 2 references
  1. Liccardi G, D'Amato M, D'Amato G. Oleaceae pollinosis: a review. Int Arch Allergy Immunol 1996;111:210-7. PubMed
  2. Somerville V, Moore R, Braakhuis A. The effect of olive leaf extract on upper respiratory illness in high school athletes: A randomised control trial. Nutrients. 2019;11(2). pii: E358. PubMed

See these in context on the Olive monograph →

Calendula 9 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Reider N, Komericki P, Hausen BM, et al. The seamy side of natural medicines: contact sensitization to arnica (Arnica montana L.) and marigold (Calendula officinalis L.). Contact Dermatitis 2001;45:269-72..
  3. Gol'dman II. [Anaphylactic shock after gargling with an infusion of Calendula]. Klin Med (Mosk) 1974;52:142-3.
  4. Paulsen E. Contact sensitization from Compositae-containing herbal remedies and cosmetics. Contact Dermatitis 2002;47:189-98. PubMed
  5. Bojadjiev C. On the sedative and hypotensive effect of preparations from the plant Calendula officinalis. Nauch Trud Visshi Med Inst Sof 1964;43:15-20.
  6. Samochowiec L. Pharmacological study of saponosides from Aralia mandshurica Rupr. et Maxim and Calendula officinalis L. Herba Pol. 1983;29:151-155.
  7. Madisetti M, Kelechi TJ, Mueller M, Amella EJ, Prentice MA. Feasibility, acceptability, and tolerability of RGN107 in the palliative wound care management of chronic wound symptoms. J Wound Care. 2017;26(Sup1):S25-S34. PubMed
  8. Final Assessment report on Calendula officinalis L., flos. European Medicines Agency: Committee on Herbal Medicinal Products (HMPC). 2018. EMA/HMPC/603409/2017. Available at: https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-cal
  9. Puaratanaarunkon T, Washrawirul C, Chuenboonngarm N, Noppakun N, Asawanonda P, Kumtornrut C. Efficacy and safety of a facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glaba root extract in the treatment of maskne: A

See these in context on the Calendula monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring