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Dietary supplement

Calendula Ingredients & Drug Interactions

by Tonic Tinctures

Liquid Category: Botanical
Most serious interaction: Minor
The interaction bottom line Most serious interaction: Minor

Calendula is a dietary supplement by Tonic Tinctures with 1 active ingredient. Its ingredients are commonly taken for minor wounds and skin healing, skin inflammation and irritation, diaper rash.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Calendula flowers. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Calendula by Tonic Tinctures

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: calendula flowers. Calendula is a traditional botanical used in herbal preparations, typically taken in liquid form as a tincture.

The inactive ingredients are water, distilled water, and alcohol — the alcohol is there as a preservative and to extract the plant compounds.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Calendula product and its label doesn't state a use — see Calendula's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold doesn't establish that calendula works for acne, bacterial vaginosis, burns, COPD, liver disease, or radiation dermatitis — the data for all of these conditions is rated as insufficient reliable evidence. That doesn't mean it doesn't work; it means the research so far isn't strong enough to say one way or the other.

If you're considering calendula for a specific health goal, talk with us about what the science actually shows.

The evidence, ingredient by ingredient Calendula

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calendula is generally well tolerated when applied to the skin, but it can trigger allergic reactions in people who are sensitive to it or to plants in the ragweed and daisy family (Asteraceae/Compositae). Because you're taking this as an oral tincture, allergic reactions are possible — and the safety data for taking calendula by mouth is limited.

Reported side effects when applied topically include hives, burning, itching, redness, and scaling, though these are rare. There isn't enough safety information to recommend taking this by mouth during pregnancy, so it's best avoided then unless your doctor approves.

Side effects, ingredient by ingredient Calendula

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Calendula.
  • The most serious interaction on file is rated Minor.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with us before combining this with CNS depressants (sedatives, sleep aids, and some pain or anxiety medications) — calendula might theoretically add to their drowsy effects, though this is considered minor. If you take any other medications, use the interaction checker on this page to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Calendula tincture is generally well tolerated, but allergic reactions are possible — especially if you're sensitive to ragweed or daisy-family plants. Because you're taking it orally rather than applying it topically, safety data is thinner and pregnancy safety isn't established.

Talk with your pharmacist before starting, particularly if you take any sedating medications or are pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Calendula, straight from the product label.

Brand Tonic Tinctures
Net contents 1 Fluid Ounce(s); 30 Milliliter(s)
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 317928
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Calendula by Tonic Tinctures, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Dropper(s)
Maximum serving Sizes:
3 Dropper(s)
Servings per container
30
IngredientAmount% DV
Calendula flowers0 NP--

Other ingredients: Water, Distilled, Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Artisan liquid extract Single-step tincture Ratio 1:9 Herb: Menstruum

Formulation

Gluten free, no hidden additives

Suggested/Recommended/Usage/Directions

Shake gently before use

Directions: Use as directed, 1-3 droppers 1-3 times a day. Expires 2 years from batch date.

Precautions

Keep out of reach of children.

Discontinue use if unusual symptoms occur.

FDA Disclaimer Statement

Caution: These products are not intended to diagnose, treat, cure or prevent any disease. These statement have not been evaluated by the FDA

FDA Statement of Identity

Dietary Supplement

See for yourself

Calendula by Tonic Tinctures label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Calendula by Tonic Tinctures

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Dropper(s) Dosage formLiquid Servings per container30 Amounts shown are per serving.

Calendula flowers

Interacts with
248 drugs
0 NP per serving

Calendula is a flowering plant whose petals are used mainly in skin creams, oils, and ointments to soothe minor irritation and support wound healing....

Calendula flowers monograph & interactions

Other (inactive) ingredients: Water, Distilled, Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Calendula by Tonic Tinctures Drug Interactions

Want to check YOUR meds against Calendula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
248Drugs
248 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Calendula with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Calendula flowers1 drug type · 248 drugs

Cns Depressants

Theoretically, calendula might have additive effects when used with CNS depressants, although this appears to be unlikely.
Although some animal research has suggested that a saponoside constituent in calendula may have sedative effects, calendula has been used for over 30 years without reports of sedation in humans.

Likelihood Unlikely Evidence D
The maker

Brand information

Manufacturer and brand details for Calendula, from the product label.

Tonic Tinctures

See all Tonic Tinctures products
Name
Tonic Apothecary
Web Address
www.tonictinctures.com
Pharmacist Counseling Corner

Calendula by Tonic Tinctures: Common Questions

Does Calendula by Tonic Tinctures interact with any medications?
Yes. Based on its ingredients, Calendula has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Calendula contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is calendula safe if I'm pregnant or breastfeeding?
For pregnancy, there isn't enough safety data, so taking calendula by mouth is best avoided unless your doctor says otherwise. We don't have safety information on file for breastfeeding — talk with your doctor or pharmacist about whether it's right for you.
What should I watch for if I take this?
Allergic reactions are possible, especially if you're sensitive to ragweed or related plants (daisies, marigolds, chrysanthemums). If you notice hives, itching, burning, redness, or scaling, stop and let us know. If you take sleep aids or sedating medications, ask us first — calendula might add to their effects.
Can I use this if I have a ragweed allergy?
You should be cautious. Calendula belongs to the same plant family as ragweed, so cross-sensitivity is possible. Patch testing (applying a small amount to your skin first) is recommended to check whether you'll react before you take or use it regularly.
Does this tincture contain alcohol?
Yes — it's made with alcohol and distilled water. The alcohol extracts the plant compounds and preserves the product. If you need to avoid alcohol, this form isn't for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Calendula is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Calendula label
Sources

Sources & How We Checked

Calendula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calendula 9 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Reider N, Komericki P, Hausen BM, et al. The seamy side of natural medicines: contact sensitization to arnica (Arnica montana L.) and marigold (Calendula officinalis L.). Contact Dermatitis 2001;45:269-72..
  3. Gol'dman II. [Anaphylactic shock after gargling with an infusion of Calendula]. Klin Med (Mosk) 1974;52:142-3.
  4. Paulsen E. Contact sensitization from Compositae-containing herbal remedies and cosmetics. Contact Dermatitis 2002;47:189-98. PubMed
  5. Bojadjiev C. On the sedative and hypotensive effect of preparations from the plant Calendula officinalis. Nauch Trud Visshi Med Inst Sof 1964;43:15-20.
  6. Samochowiec L. Pharmacological study of saponosides from Aralia mandshurica Rupr. et Maxim and Calendula officinalis L. Herba Pol. 1983;29:151-155.
  7. Madisetti M, Kelechi TJ, Mueller M, Amella EJ, Prentice MA. Feasibility, acceptability, and tolerability of RGN107 in the palliative wound care management of chronic wound symptoms. J Wound Care. 2017;26(Sup1):S25-S34. PubMed
  8. Final Assessment report on Calendula officinalis L., flos. European Medicines Agency: Committee on Herbal Medicinal Products (HMPC). 2018. EMA/HMPC/603409/2017. Available at: https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-cal
  9. Puaratanaarunkon T, Washrawirul C, Chuenboonngarm N, Noppakun N, Asawanonda P, Kumtornrut C. Efficacy and safety of a facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glaba root extract in the treatment of maskne: A

See these in context on the Calendula monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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