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Dietary supplement

Organic Calendula Ingredients & Drug Interactions

by Ra Herbals

Organic Calendula label
See full label image
Liquid Category: Botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Organic Calendula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Organic Calendula is a dietary supplement by Ra Herbals with 1 active ingredient. Its ingredients are commonly taken for minor wounds and skin healing, skin inflammation and irritation, diaper rash.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Calendula. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Organic Calendula by Ra Herbals

Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Calendula by Ra Herbals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Organic Calendula by Ra Herbals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This liquid supplement contains one active ingredient: calendula, a flowering plant used traditionally to support skin health and healing. The product is made with cane alcohol and distilled water.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Calendula product and its label doesn't state a use — see Calendula's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold for calendula doesn't establish reliable effectiveness for any of the conditions tested — acne, bacterial vaginosis, burns, COPD, liver disease, and radiation dermatitis all carry a rating of Insufficient Reliable Evidence. That doesn't mean calendula doesn't work; it means the clinical trials to prove it haven't been done or aren't strong enough yet.

If you're considering it for a specific health concern, talk it over with your doctor or pharmacist to weigh what limited evidence exists against other options.

The evidence, ingredient by ingredient Calendula

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Applied to skin, calendula is generally well tolerated but can trigger allergic reactions in sensitive people, especially those allergic to plants in the ragweed family (like chrysanthemums, marigolds, and daisies). Patch testing with calendula is recommended before you use it if you have known plant allergies.

Taken by mouth, calendula can also cause allergic reactions, and there isn't enough safety data to recommend oral use during pregnancy — the safety data rates it Likely Unsafe in that setting. If you're pregnant, nursing, or considering oral use, check with your doctor or pharmacist first.

Side effects, ingredient by ingredient Calendula

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Calendula.
  • The most serious interaction on file is rated Minor.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take CNS depressants — such as benzodiazepines, sleep aids, or opioids — check your exact medications with the tool on this page before using this product by mouth. The interaction is rated Minor and appears unlikely in practice, but it's worth confirming your specific drugs aren't affected.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Calendula is generally well tolerated on skin and has a long history of use, but the clinical evidence for its effectiveness isn't established in the data we hold. It does interact with CNS depressants (a Minor concern), so check your medications before taking it by mouth.

Allergic reactions are possible, particularly if you're sensitive to the ragweed family of plants. Talk to your doctor or pharmacist before starting, especially if you're pregnant, nursing, or taking sedating medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Organic Calendula, straight from the product label.

Brand Ra Herbals
Barcode (UPC) 767787973162
Net contents 1 Fluid Ounce; 30 Milliliter(s)
Market status On market
Date entered into DSLD Jan 24, 2024
DSLD ID 305478
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Organic Calendula by Ra Herbals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
30
UPC/BARCODE
767787973162
IngredientAmount% DV
Calendula0 NP--

Other ingredients: Cane Alcohol, Water, Distilled

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Bioregional Herbal Company

Instagram Facebook Twitter @sungodmeds

Seals/Symbols

OTCO (Oregon Tilth Certified Organic)

USDA Organic

Formulation

Certified organic by: Oregon Tilth

USDA Organic

Oregon made I (Immunity aid) M (Mental ease) P (Pain relief)

Non-GMO Gluten free

Precautions

Do not exceed. Caution: Do not use if safety seal is missing or broken.

If pregnant, nursing, or on medication, consult with your health care practitioner before use.

Keep out of reach of children.

Brand IP Statement(s)

Ra Herbals Herbs enlightened

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Shake well before use

See website for recommended dosage.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Organic Calendula by Ra Herbals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Organic Calendula label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Organic Calendula by Ra Herbals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.

Calendula

Interacts with
248 drugs
0 NP per serving Form: Calendula officinalis

Calendula is a flowering plant whose petals are used mainly in skin creams, oils, and ointments to soothe minor irritation and support wound healing....

Calendula monograph & interactions

Other (inactive) ingredients: Cane Alcohol, Water, Distilled. These complete the product’s ingredient list but are not active constituents.

Interaction report

Organic Calendula by Ra Herbals Drug Interactions

Want to check YOUR meds against Organic Calendula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Minor

Ingredients driving the most interactions

Calendula 248

Individual Drug Interactions

The ingredients in Organic Calendula interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Organic Calendula interact with drugs. Each result below shows which ingredient is responsible. Calendula

Each ingredient & the kinds of drugs it affects

For each ingredient in Organic Calendula with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Calendula1 drug type · 248 drugs

Cns Depressants

Theoretically, calendula might have additive effects when used with CNS depressants, although this appears to be unlikely.
Although some animal research has suggested that a saponoside constituent in calendula may have sedative effects, calendula has been used for over 30 years without reports of sedation in humans.

Likelihood Unlikely Evidence D
Calendula full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Organic Calendula, from the product label.

Ra Herbals

See all Ra Herbals products
Name
Sun God Medicinals
Street Address
540 E Vilas Rd Ste C
City
Central Point
State
OR
ZipCode
97502
Phone Number
888-470-7394
Web Address
www.sungodmedicinals.com
Pharmacist Counseling Corner

Organic Calendula by Ra Herbals: Common Questions

Does Organic Calendula by Ra Herbals interact with any medications?
Yes. Based on its ingredients, Organic Calendula has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Organic Calendula contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I use this if I'm pregnant?
The safety data advises against taking calendula by mouth during pregnancy — it's rated Likely Unsafe. If you're pregnant and interested in calendula, talk with your doctor or pharmacist about whether topical use (on the skin) might be an option for you.
Is calendula safe if I'm breastfeeding?
We don't have safety data on file for calendula during breastfeeding. Check with your doctor or pharmacist before using this product while nursing to make sure it's right for you.
Can calendula cause allergic reactions?
Yes. When taken by mouth, calendula can trigger allergic reactions. On skin, it can cause eczematous allergic reactions (itching, redness, scaling, or inflammation), especially in people sensitive to the ragweed family of plants — which includes chrysanthemums, marigolds, and daisies. Patch testing is recommended before use if you have plant allergies.
What is calendula used for?
Calendula has been used traditionally to support skin healing and health, but the clinical evidence in our data doesn't establish reliable effectiveness for acne, burns, bacterial vaginosis, COPD, liver disease, or radiation dermatitis. If you're considering it for a specific concern, ask your doctor or pharmacist what the current evidence suggests.
Is this product safe to take by mouth?
Calendula is generally well tolerated when taken by mouth, but there isn't enough safety data to recommend oral use without a doctor's approval. Allergic reactions are possible. If you want to take it orally, check with your doctor or pharmacist first.
Does it matter that this liquid contains alcohol?
The product contains cane alcohol as a preservative. If you avoid alcohol or have a condition where alcohol intake matters, you may want to confirm the alcohol concentration with the brand or consider a different calendula form.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Organic Calendula is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Organic Calendula label
Go deeper

The Full Monographs Behind Organic Calendula’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calendula

Interacts with 248 drugs

Calendula is a flowering plant whose petals are used mainly in skin creams, oils, and ointments to soothe minor irritation and support wound healing. Some early research is promising for ski...

Read the full Calendula monograph →
Sources

Sources & How We Checked

Organic Calendula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calendula 9 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Reider N, Komericki P, Hausen BM, et al. The seamy side of natural medicines: contact sensitization to arnica (Arnica montana L.) and marigold (Calendula officinalis L.). Contact Dermatitis 2001;45:269-72..
  3. Gol'dman II. [Anaphylactic shock after gargling with an infusion of Calendula]. Klin Med (Mosk) 1974;52:142-3.
  4. Paulsen E. Contact sensitization from Compositae-containing herbal remedies and cosmetics. Contact Dermatitis 2002;47:189-98. PubMed
  5. Bojadjiev C. On the sedative and hypotensive effect of preparations from the plant Calendula officinalis. Nauch Trud Visshi Med Inst Sof 1964;43:15-20.
  6. Samochowiec L. Pharmacological study of saponosides from Aralia mandshurica Rupr. et Maxim and Calendula officinalis L. Herba Pol. 1983;29:151-155.
  7. Madisetti M, Kelechi TJ, Mueller M, Amella EJ, Prentice MA. Feasibility, acceptability, and tolerability of RGN107 in the palliative wound care management of chronic wound symptoms. J Wound Care. 2017;26(Sup1):S25-S34. PubMed
  8. Final Assessment report on Calendula officinalis L., flos. European Medicines Agency: Committee on Herbal Medicinal Products (HMPC). 2018. EMA/HMPC/603409/2017. Available at: https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-cal
  9. Puaratanaarunkon T, Washrawirul C, Chuenboonngarm N, Noppakun N, Asawanonda P, Kumtornrut C. Efficacy and safety of a facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glaba root extract in the treatment of maskne: A

See these in context on the Calendula monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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