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Dietary supplement

Jiaogulan Ingredients & Drug Interactions

by Tonic Tinctures

Jiaogulan label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Jiaogulan against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Jiaogulan is a dietary supplement by Tonic Tinctures with 1 active ingredient. Its ingredients are commonly taken for fatigue and stress (adaptogen), blood sugar support, high blood pressure.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Jiaogulan. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Jiaogulan by Tonic Tinctures

Ask about any prescription or over-the-counter medication and we check it for interactions with Jiaogulan by Tonic Tinctures — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Jiaogulan by Tonic Tinctures

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: jiaogulan, a vine used in traditional Asian medicine. It comes as a liquid tincture with water and alcohol as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Jiaogulan's overall clinical evidence instead.

Moderate

Some clinical evidence supports Jiaogulan for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Diabetes — rated "Possibly Effective" (Natural Medicines).

Jiaogulan is possibly effective for diabetes based on clinical research showing it can lower blood glucose. For athletic performance, cancer, heart disease, fatty liver disease, and respiratory infections, the evidence isn't established in the data we hold — there isn't enough reliable research to rate it one way or the other.

The evidence, ingredient by ingredient Jiaogulan

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Jiaogulan is generally well tolerated when used in tea or supplement form for short periods, though long-term safety hasn't been well studied. The most common side effects are diarrhea and nausea; some people also report dry mouth, dizziness, or trouble sleeping.

Safety during pregnancy has not been established — the data advises against use because it may affect the developing baby. There isn't enough safety information to use this while breastfeeding either.

Side effects, ingredient by ingredient Jiaogulan

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Jiaogulan.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting this product, double-check if you take blood thinners or antiplatelet drugs (like warfarin or aspirin), immunosuppressants, or diabetes medications. Jiaogulan may affect how all three work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

If you're managing blood sugar and interested in botanical support, jiaogulan may be worth discussing with your doctor or pharmacist. If you take blood thinners, immunosuppressants, or diabetes medications, check with us first — the interaction potential is real.

Avoid during pregnancy and while nursing.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Jiaogulan, straight from the product label.

Brand Tonic Tinctures
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 317934
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Jiaogulan by Tonic Tinctures, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Dropper(s)
Maximum serving Sizes:
3 Dropper(s)
Servings per container
60
IngredientAmount% DV
Jiaogulan500 mg--

Other ingredients: Water, Distilled, Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Artisan liquid extract Jiaogulan 1 dropper is approximately equal to 500mgs

Formulation

Gluten free, no hidden additives

Suggested/Recommended/Usage/Directions

Shake gently before use

Directions: Use as directed, 1-3 droppers 1-3 times a day.

Precautions

Keep out of reach of children.

Discontinue use if unusual symptoms occur.

FDA Disclaimer Statement

Caution: These products are not intended to diagnose, treat, cure or prevent any disease. These statement have not been evaluated by the FDA

FDA Statement of Identity

Dietary Supplement

Storage

Use within 45 days of opening

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Jiaogulan by Tonic Tinctures label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Jiaogulan label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Jiaogulan by Tonic Tinctures

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Dropper(s) Dosage formLiquid Servings per container60 Amounts shown are per serving.

Jiaogulan

Interacts with
327 drugs
500 mg per serving

Jiaogulan is a climbing vine used in traditional Chinese medicine as an adaptogen and for heart, blood sugar, and cholesterol support. Early human and...

Jiaogulan monograph & interactions

Other (inactive) ingredients: Water, Distilled, Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Jiaogulan by Tonic Tinctures Drug Interactions

Want to check YOUR meds against Jiaogulan?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Jiaogulan 327

Individual Drug Interactions

The ingredients in Jiaogulan interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Jiaogulan interact with drugs. Each result below shows which ingredient is responsible. Jiaogulan

Each ingredient & the kinds of drugs it affects

For each ingredient in Jiaogulan with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Jiaogulan3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, jiaogulan might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research suggests that jiaogulan has antiplatelet effects.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, jiaogulan might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research shows that jiaogulan can lower blood glucose levels.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, jiaogulan might decrease the effectiveness of immunosuppressive therapy.
Clinical and animal studies suggest that jiaogulan can stimulate the immune system.

Likelihood Possible Evidence D
Jiaogulan full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Jiaogulan, from the product label.

Tonic Tinctures

See all Tonic Tinctures products
Name
Tonic Apothecary
Web Address
www.tonictinctures.com
Pharmacist Counseling Corner

Jiaogulan by Tonic Tinctures: Common Questions

Does Jiaogulan by Tonic Tinctures interact with any medications?
Yes. Based on its ingredients, Jiaogulan has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Jiaogulan contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No — safety hasn't been established during pregnancy and it may affect the baby, and there isn't enough safety data for breastfeeding. Talk with your doctor or midwife before considering it.
What are the side effects?
The most common ones are diarrhea and nausea. Some people also experience dry mouth, dizziness, or insomnia. It's been well tolerated in studies lasting up to 4 months.
Does jiaogulan actually work for diabetes?
Clinical research shows it can lower blood glucose, so it's rated possibly effective for diabetes. That said, if you take diabetes medication, combining them could lower your blood sugar too much — check with your pharmacist first.
Can I use this long-term?
Long-term safety hasn't been well studied. Most of the safety data comes from short-term use — up to 4 months — so talk with your pharmacist about your timeline.
What's in this product besides jiaogulan?
It's a liquid tincture, so it also contains water and alcohol as inactive ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Jiaogulan is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Jiaogulan label
Go deeper

The Full Monographs Behind Jiaogulan’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Jiaogulan

Interacts with 327 drugs

Jiaogulan is a climbing vine used in traditional Chinese medicine as an adaptogen and for heart, blood sugar, and cholesterol support. Early human and animal studies are promising for some u...

Read the full Jiaogulan monograph →
Sources

Sources & How We Checked

Jiaogulan's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Jiaogulan 8 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Tan H, Liu ZL, Liu MJ. [Antithrombotic effect of Gynostemma pentaphyllum]. Zhingguo Zhong Xi Yi Jie He Za Zhi 1993;13:278-80.
  3. Chan LY, Chiu PY, Lau TK. An in-vitro study of ginsenoside Rb(1)-induced teratogenicity using a whole rat embryo culture model. Hum Reprod 2003;18:2166-8..
  4. Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Gynostemma pentaphyllum Tea Improves Insulin Sensitivity in Type 2 Diabetic Patients. J Nutr Metab. 2013;2013:765383. doi: 10.1155/2013/765383.
  5. Li Y, Lin W, Huang J, Xie Y, Ma W. Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan). Chin Med. 2016 Sep 27;11:43. Review. PubMed
  6. Huyen VT, Phan DV, Thang P, Ky PT, Hoa NK, Ostenson CG. Antidiabetic effect of add-on Gynostemma pentaphyllum extract therapy with sulfonylureas in type 2 diabetic patients. Evid Based Complement Alternat Med 2012; 452313.
  7. Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Antidiabetic effect of Gynostemma pentaphyllum tea in randomly assigned type 2 diabetic patients. Horm Metab Res. 2010;42(5):353-7.
  8. Rao A, Clayton P, Briskey D. The effect of an orally-dosed Gynostemma pentaphyllum extract (ActivAMP®) on body composition in overweight, adult men and women: a double-blind, randomised, placebo-controlled study. J Hum Nutr Diet 2021.

See these in context on the Jiaogulan monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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