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Dietary supplement

Baby Calm + Comfort Ingredients & Drug Interactions

by Culturelle Baby

Baby Calm + Comfort label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Baby Calm + Comfort against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Baby Calm + Comfort is a dietary supplement by Culturelle Baby with 2 active ingredients. Its ingredients are commonly taken for anxiety and stress, sleep and relaxation, digestive upset.Based on those ingredients, 960 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are German Chamomile flower extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Baby Calm + Comfort by Culturelle Baby

Ask about any prescription or over-the-counter medication and we check it for interactions with Baby Calm + Comfort by Culturelle Baby — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Baby Calm + Comfort by Culturelle Baby

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Culturelle Baby's Baby Calm + Comfort has 2 active ingredients. Lactobacillus rhamnosus GG is a beneficial live bacteria (probiotic) intended to support digestive health.

German chamomile flower extract is an herbal ingredient often used for its calming properties. The product also contains rice bran oil and carnauba wax as inactive ingredients (binders and carriers).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see German Chamomile's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: reduce fussiness and occasional digestive upset.
  • We looked for evidence on: Colic, Diarrhea, Dyspepsia, Flatulence, infant digestive discomfort, gastrointestinal distress.
  • The closest evidence on file: German Chamomile is rated "Insufficient Reliable Evidence To Rate" for Diarrhea (Natural Medicines).
  • Also on file: German Chamomile is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia, Flatulence, Colic.

The effectiveness of German chamomile in this product hasn't been firmly established for most of its marketed uses. Our data shows insufficient reliable evidence to rate it for anxiety, ADHD, hay fever, or anorexia.

The probiotics in this product are not rated in the evidence we hold. Talk with your child's pediatrician about whether this product is right for your baby's specific needs.

The evidence, ingredient by ingredient German Chamomile

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

German chamomile is generally well tolerated but can trigger allergic reactions in people sensitive to ragweed and related plants, including severe reactions like anaphylaxis in rare cases. Some people have reported nausea or mouth burning when using chamomile as an oral rinse.

The safety data for German chamomile during pregnancy advise against use unless your doctor approves. If you're breastfeeding, the data are limited — check with your doctor or pharmacist before using this product.

For Lactobacillus rhamnosus GG, we hold no pregnancy or breastfeeding safety information.

Side effects, ingredient by ingredient German Chamomile

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — German Chamomile.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 961 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before giving this product, double-check if anyone in the home takes warfarin (a blood thinner) — German chamomile may increase bleeding risk. Also check for CNS depressants (sedating medications), birth control pills, hormone replacement therapy, tamoxifen, or any drugs metabolized by CYP2D6, CYP2C9, or CYP3A4 enzymes.

Altogether, these interactions span 961 individual medications. Run your household medications through the search tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is marketed for infant comfort and may appeal to parents looking for a gentle option with probiotics and herbal support. However, because German chamomile interacts with warfarin and several other medication types, families with caregivers taking those drugs should check first.

If anyone in the household takes sedating medications or a blood thinner, or if your child has a history of allergies to ragweed or related plants, talk it over with your pediatrician or pharmacist before using it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Baby Calm + Comfort, straight from the product label.

Brand Culturelle Baby
Barcode (UPC) 049100400525
Net contents 0.29 fl. Oz.; 8.5 mL
Market status On market
Date entered into DSLD Apr 22, 2021
DSLD ID 246009
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Infants/Baby (0 - 1 Year), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Baby Calm + Comfort by Culturelle Baby, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Drop(s)
Maximum serving Sizes:
5 Drop(s)
Servings per container
30
UPC/BARCODE
049100400525
IngredientAmount% DV
Calories0 Calorie(s)--
Total Carbohydrates0 Gram(s)--
Added Sugars0 Gram(s)--
Total Sugars0 Gram(s)--
Lactobacillus rhamnosus GG16 mg--
German Chamomile flower extract1 mg--

Other ingredients: Rice bran oil, Carnauba Wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Allergy friendly Free from Milk Wheat Eggs Tree nuts Peanuts

Guaranteed purity & potency Guaranteed potency through date on box when stored as directed.

Dairy Gluten Soy free Meets the FDA's guidelines for gluten free. Not a reduced calorie food

Helps reduce fussiness and crying Due to occasional digestive upset. Reduces occasional digestive upset

Culturelle Baby Calm + Comfort helps you soothe your baby & helps their digestive system work better. This product contains safe & gentle ingredients that work naturally with your baby's body to help reduce fussiness & crying & helps keep your baby's gut microbiome balanced & healthy.

Precautions

For questions, concerns or to report an adverse event, please call (800) 722-3476 www.Culturelle.com

Please consult your healthcare professional prior to use.

Warning: Keep out of reach of children. When first taking a probiotic, your baby's gut microbiome adjusts. Your baby may experience minor bloating, gas or intestinal gurgling which should subside with continued use. Consult your healthcare professional if symptoms continue after two weeks.

Tamper Evident: Do not use if bottle or dropper appears to be opened.

Formula

Naturally sourced LGG Most researched strain in children Based on the number of Lactobacillus rhamnosus GG studies, as of January 2019

Probiotic + Chamomile drops

Probiotic Supplement with Chamomile

0-12 months

General Statements

The Culturelle Difference Excludes gummy formulas. #1 Pediatrician recommended brand Based on a 2018 survey among pediatricians recommending a probiotic brand.

Yellow color and creamy consistency are normal.

FDA Statement of Identity

Probiotic Supplement with Chamomile

Suggested/Recommended/Usage/Directions

Directions for 0-12 months: Shake before use. Use 5 drops once a day. Dispense onto a spoon, directly into baby's mouth, bottle or while breastfeeding. Replace cap with dropper. Once opened, use within 60 days.

Storage

Storage Instructions: Store Culturelle in a cool, dry place away from direct sunlight.

Brand IP Statement(s)

Patent pending. Culturelle is a trademark of DSM. LGG, & LGG logo are trademarks of Chr. Hansen A/S.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Baby Calm + Comfort by Culturelle Baby label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Baby Calm + Comfort label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Baby Calm + Comfort by Culturelle Baby

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size5 Drop(s) Dosage formLiquid Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lactobacillus rhamnosus GG

16 mg per serving

German Chamomile flower extract

Interacts with
960 drugs
1 mg per serving

German chamomile is a widely used herbal remedy taken mainly as a tea for calming, sleep, and digestive complaints. Early research suggests possible b...

German Chamomile flower extract monograph & interactions

Other (inactive) ingredients: Rice bran oil, Carnauba Wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Baby Calm + Comfort by Culturelle Baby Drug Interactions

Want to check YOUR meds against Baby Calm + Comfort?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
960Drugs
925 Moderate 35 Minor

Ingredients driving the most interactions

German Chamomile flower extract 960

Individual Drug Interactions

The ingredients in Baby Calm + Comfort interact with 960 drugs. Click any drug to see the details.

1 of the 2 ingredients in Baby Calm + Comfort interact with drugs. Each result below shows which ingredient is responsible. German Chamomile flower extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Baby Calm + Comfort with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

German Chamomile flower extract9 drug types · 960 drugs

Cns Depressants

Theoretically, German chamomile might have additive effects when used with CNS depressants.
German chamomile has mild sedative effects. Theoretically, concomitant use with drugs with sedative properties can cause additive effects and side effects.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, large amounts of German chamomile might reduce the effectiveness of oral contraceptives.
In vitro, German chamomile has demonstrated antiestrogenic activity. Theoretically, concomitant use of large amounts of German chamomile might interfere with contraceptive drugs through competition for estrogen receptors.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, German chamomile might inhibit CYP2C9 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP2C9. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP2C9 in patients taking German chamomile.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, German chamomile might inhibit CYP2D6 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP2D6. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP2D6 in patients taking German chamomile.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP3A4. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP3A4 in patients taking German chamomile.

Likelihood Possible Evidence D
Estrogens

Theoretically, large amounts of German chamomile might reduce the effectiveness of estrogens.
In vitro, German chamomile has demonstrated antiestrogenic activity. Theoretically, large amounts of German chamomile might interfere with hormone replacement therapy through competition for estrogen receptors.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, large amounts of German chamomile might interfere with the activity of tamoxifen.
In vitro, German chamomile has demonstrated antiestrogenic activity.

Likelihood Possible Evidence D
Warfarin (Coumadin)

German chamomile might increase the effects of warfarin and increase the risk of bleeding.
In one case, a 70-year-old female taking warfarin developed retroperitoneal hematoma and bilateral recti muscle bleeding along with an INR of 7.9 following ingestion of German chamomile tea 4-5 cups daily and use of a topical chamomile-based lotion applied 4-5 times daily.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, German chamomile might inhibit CYP1A2 and increase levels of drugs metabolized by these enzymes.
In vitro and animal research shows that German chamomile might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP1A2 in patients taking German chamomile.

Likelihood Possible Evidence D
German Chamomile flower extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Baby Calm + Comfort, from the product label.

Culturelle Baby

See all Culturelle Baby products
Name
i-Health, Inc.
Street Address
55 Sebethe Dr.
City
Cromwell
State
CT
ZipCode
06416
Phone Number
800-722-3476
Web Address
www.Culturelle.com
Pharmacist Counseling Corner

Baby Calm + Comfort by Culturelle Baby: Common Questions

Does Baby Calm + Comfort by Culturelle Baby interact with any medications?
Yes. Based on its ingredients, Baby Calm + Comfort has a known interaction with 960 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Baby Calm + Comfort contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe for babies allergic to ragweed?
No. German chamomile can trigger allergic reactions in people sensitive to ragweed and related plants. If your baby or anyone in your household has a ragweed allergy, skip this product and talk with your pediatrician about alternatives.
What is Lactobacillus rhamnosus GG?
It's a beneficial live bacteria (a probiotic) meant to support digestive health. We don't hold effectiveness data on it, so ask your pediatrician whether it's right for your baby.
Can I use this while breastfeeding?
There isn't enough safety data on German chamomile to know for certain. Check with your doctor or pharmacist before using it while breastfeeding — they can weigh the benefits and risks for your situation.
Does German chamomile actually calm babies?
The evidence isn't strong enough to say for sure. Our data show insufficient reliable evidence for German chamomile's use in anxiety and similar conditions. Your pediatrician can help you decide if it's worth trying.
What are the side effects?
Allergic reactions are the main concern, especially in people sensitive to ragweed. Some people have reported nausea or burning in the mouth. In rare cases, severe reactions like anaphylaxis have occurred.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Baby Calm + Comfort is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Baby Calm + Comfort label
Go deeper

The Full Monographs Behind Baby Calm + Comfort’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

German Chamomile

Interacts with 960 drugs

German chamomile is a widely used herbal remedy taken mainly as a tea for calming, sleep, and digestive complaints. Early research suggests possible benefits for mild anxiety and some skin o...

Read the full German Chamomile monograph →
Sources

Sources & How We Checked

Baby Calm + Comfort's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

German Chamomile 15 references
  1. Subiza J, Subiza JL, Hinojosa M, et al. Anaphylactic reaction after the ingestion of chamomile tea; a study of cross-reactivity with other composite pollens. J Allergy Clin Immunol 1989;84:353-8. PubMed
  2. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  3. Viola H, Wasowski C, Levi de Stein M, et al. Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. Planta Med 1995;61:213-6.
  4. van Ketel WG. Allergy to Matricaria chamomilla. Contact Dermatitis 1982;8:143. PubMed
  5. van Ketel WG. Allergy to Matricaria chamomilla. Contact Dermatitis 1987;16:50-1. PubMed
  6. Hormann HP, Korting HC. Evidence for the efficacy and safety of topical herbal drugs in dermatology: part I: anti-inflammatory agents. Phytomedicine 1994;1:161-71. PubMed
  7. Avallone R, Zanoli P, Puia G, et al. Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. Biochem Pharmacol 2000;59:1387-94. PubMed
  8. Kassi E, Papoutsi Z, Fokialakis N, et al. Greek plant extracts exhibit selective estrogen receptor modulator (SERM)-like properties. J Agric Food Chem 2004;52:6956-61. PubMed
  9. Maliakal PP, Wanwimolruk S. Effect of herbal teas on hepatic drug metabolizing enzymes in rats. J Pharm Pharmacol 2001;53:1323-9. PubMed
  10. Segal R, Pilote L. Warfarin interaction with Matricaria chamomilla. CMAJ 2006;174:1281-2. PubMed
  11. Loggia RD, Traversa U, Scarcia V, et al. Depressive effects of Chamomilla recutita (L.) Rausch, tubular flowers, on central nervous system in mice. Pharmacol Res Commun 1982;14(2):153-162. PubMed
  12. Ganzera M, Schneider P, Stuppner H. Inhibitory effects of the essential oil of chamomile (Matricaria recutita L.) and its major constituents on human cytochrome P450 enzymes. Life Sci 2006;78(8):856-861. PubMed
  13. Benito P, Rodríguez-Perez R, García F, Juste S, Moneo I, Caballero ML. Occupational allergic rhinoconjunctivitis induced by Matricaria chamomilla with tolerance of chamomile tea. J Investig Allergol Clin Immunol. 2014;24(5):369-70. No abstract available.
  14. Braga FT, Santos AC, Bueno PC, et al. Use of Chamomilla recutita in the prevention and treatment of oral mucositis in patients undergoing hematopoietic stem cell transplantation: a randomized, controlled, phase II clinical trial. Cancer Nurs 2015;38(4):32 PubMed
  15. Sarris J, Ravindran A, Yatham LN, et al. Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety T

See these in context on the German Chamomile monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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