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Dietary supplement

CalmAid Ingredients & Drug Interactions

by Nature's Way

CalmAid label
See full label image
Softgel Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking CalmAid against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

CalmAid is a dietary supplement by Nature's Way with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, sleep problems, relaxation and calming.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Silexan. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against CalmAid by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with CalmAid by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of CalmAid by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

CalmAid contains one active ingredient: Silexan, a lavender oil extract. Lavender has been studied for anxiety, period pain, and a few other uses.

The softgel also holds canola oil, gelatin, glycerin, sorbitol, and annatto extract as inactive ingredients to hold everything together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Lavender's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: feel relaxed and support restful sleep.
  • We looked for evidence on: Insomnia, Perioperative anxiety, Pre-procedural anxiety, Stress, Psychological well-being, Nervousness — and 2 related terms.
  • The closest evidence on file: Lavender is rated "Insufficient Reliable Evidence To Rate" for Pre-procedural anxiety (Natural Medicines).
  • Also on file: Lavender is rated "Insufficient Reliable Evidence To Rate" for Insomnia, Stress, Psychological well-being, Perioperative anxiety.

The evidence for lavender in CalmAid is mixed. It's rated possibly effective for period pain (dysmenorrhea).

For cancer-related pain it's possibly ineffective. For alopecia areata, cancer-related fatigue, and pre-procedural anxiety, there isn't enough reliable evidence yet to know whether it works.

The evidence, ingredient by ingredient Lavender

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Silexan is generally well tolerated when taken by mouth. The most common side effects reported in studies are breath odor, constipation, diarrhea, indigestion, burping, headache, and nausea—most people don't experience these.

One rare serious effect reported with lavender oil use in young boys is gynecomastia (breast tissue growth). Because safety data are limited, the facts advise you to use lavender only with your doctor's approval and guidance.

Side effects, ingredient by ingredient Lavender

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lavender.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking CalmAid, check whether you use any CNS depressants—sedatives, sleep aids, anti-anxiety drugs, or pain medications that cause drowsiness. Silexan may increase their effects.

Use the interaction checker below with your exact medication names.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

CalmAid may help with period pain, but evidence is limited for other uses. The main caution is if you take sedatives or other CNS depressants—lavender might make them stronger.

Talk to your pharmacist before starting, especially if you're on any medication that makes you drowsy.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about CalmAid, straight from the product label.

Brand Nature's Way
Barcode (UPC) 033674147139
Net contents 90 Softgel(s)
Market status On market
Date entered into DSLD Sep 25, 2025
DSLD ID 333708
Product type Botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for CalmAid by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
90
UPC/BARCODE
033674147139
IngredientAmount% DV
Silexan80 mg--

Other ingredients: Canola Oil, Gelatin, Glycerin, Sorbitol, Annatto Extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Feel more relaxed Reduces occasional nervousness Supports restful sleep when disrupted by stress Non-habit forming

Gluten free. No salt, wheat, or dairy.

Product of Germany

Helps manage stress & tension Plant powered Non-drowsy

Formula

CalmAid With clinically studied Silexan lavender oil

Clinically studied lavender

General Statements

Explore more products at naturesway.com

Precautions

Contains soy.

Warning: Do not use if you are pregnant, nursing, or under 12 years of age. If you are taking any medications, consult a healthcare professional before use.

Warning: Do not use if you are pregnant, nursing, or under 12 years of age. Keep out of reach of children.

This product has a tamper-evident foil pouch. Do not use if foil or plastic is punctured.

Brand IP Statement(s)

Copyright 2023 Nature's Way Brands, LLC

Suggested/Recommended/Usage/Directions

Recommendation: Adults swallow 1 softgel once or twice daily with a full glass of water, or as recommended by a healthcare professional. Do not chew. A small number of individuals may experience mild aromatic burps, in this case, swallow softgel with a full glass of water and food.

Once daily

Storage

Store at room temperature. Avoid excessive heat and direct sunlight.

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

CalmAid by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

CalmAid label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in CalmAid by Nature's Way

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container90 Amounts shown are per serving.

Silexan

Interacts with
248 drugs
80 mg per serving Form: English Lavender Flower Essential Oil

Lavender is a fragrant herb most popular for promoting relaxation, easing anxiety, and supporting sleep, with some encouraging evidence for a standard...

Silexan monograph & interactions

Other (inactive) ingredients: Canola Oil, Gelatin, Glycerin, Sorbitol, Annatto Extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

CalmAid by Nature's Way Drug Interactions

Want to check YOUR meds against CalmAid?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Silexan 248

Individual Drug Interactions

The ingredients in CalmAid interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in CalmAid interact with drugs. Each result below shows which ingredient is responsible. Silexan

Each ingredient & the kinds of drugs it affects

For each ingredient in CalmAid with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Silexan1 drug type · 248 drugs

Cns Depressants

Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Laboratory research suggests that lavender has sedative effects. However, clinical studies in patients taking oral lavender oil (Silexan) 160 mg for 10 weeks or taking lavender flower powder 1 gram daily for 2 months have not reported side effects of drowsiness, sedation, or sleepiness. There is still some concern that higher doses or different preparations of lavender might have additive effects with CNS depressant medications.

Likelihood Unlikely Evidence D
Silexan full monograph & interactions
The maker

Brand information

Manufacturer and brand details for CalmAid, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

CalmAid by Nature's Way: Common Questions

Does CalmAid by Nature's Way interact with any medications?
Yes. Based on its ingredients, CalmAid has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
CalmAid contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Silexan?
Silexan is a lavender oil extract. It's the active ingredient in CalmAid and has been studied for anxiety, period pain, and a few other conditions.
Will CalmAid help my period pain?
Lavender is rated possibly effective for period pain, so it may help some people. The evidence isn't strong enough to guarantee it will work for you, though—that's worth discussing with your doctor or pharmacist.
What are the most common side effects?
Breath odor, constipation, diarrhea, indigestion, burping, headache, and nausea are the most commonly reported. Most people tolerate lavender well and don't experience these.
Is CalmAid safe to take long-term?
Safety data for lavender are limited, especially over long periods. The facts advise using it only with your doctor's approval and guidance rather than on your own for extended time.
Can I take CalmAid while pregnant or breastfeeding?
The safety data on file don't give us enough information to say either way. Talk with your doctor or pharmacist for personalized advice.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if CalmAid is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

CalmAid label
Go deeper

The Full Monographs Behind CalmAid’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lavender

Interacts with 248 drugs

Lavender is a fragrant herb most popular for promoting relaxation, easing anxiety, and supporting sleep, with some encouraging evidence for a standardized oral lavender oil product for anxie...

Read the full Lavender monograph →
Sources

Sources & How We Checked

CalmAid's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lavender 20 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  3. Akhondzadeh S, Kashani L, Fotouhi A, et al. Comparison of Lavandula angustifolia Mill. tincture and imipramine in the treatment of mild to moderate depression: a double-blind, randomized trial. Prog Neuropsychopharmacol Biol Psychiatry 2003;27:123-7. PubMed
  4. Varma S, Blackford S, Statham BN, Blackwell A. Combined contact allergy to tea tree oil and lavender oil complicating chronic vulvovaginitis. Contact Dermatitis 2000;42:309-10.
  5. Coulson IH and Khan AS. Facial 'pillow' dermatitis due to lavender oil allergy. Contact Dermatitis 1999;41(2):111. PubMed
  6. Woelk, H. and Schlafke, S. A multi-center, double-blind, randomised study of the Lavender oil preparation Silexan in comparison to Lorazepam for generalized anxiety disorder. Phytomedicine. 2010;17(2):94-99. PubMed
  7. Kasper, S., Gastpar, M., Muller, W. E., Volz, H. P., Moller, H. J., Dienel, A., and Schlafke, S. Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of 'subsyndromal' anxiety disorder: a randomized, double-blind, plac
  8. Uehleke, B., Schaper, S., Dienel, A., Schlaefke, S., and Stange, R. Phase II trial on the effects of Silexan in patients with neurasthenia, post-traumatic stress disorder or somatization disorder. Phytomedicine. 6-15-2012;19(8-9):665-671. PubMed
  9. Brandao FM. Occupational allergy to lavender oil. Contact Dermatitis 1986;15(4):249-250. PubMed
  10. Rademaker M. Allergic contact dermatitis from lavender fragrance in Difflam gel. Contact Dermatitis 1994;31(1):58-59. PubMed
  11. Kasper S, Gastpar M, Müller WE, et al. Lavender oil preparation Silexan is effective in generalized anxiety disorder--a randomized, double-blind comparison to placebo and paroxetine. Int J Neuropsychopharmacol. 2014 Jun;17(6):859-69. PubMed
  12. Farshbaf-Khalili A, Kamalifard M, Namadian M. Comparison of the effect of lavender and bitter orange on anxiety in postmenopausal women: A triple-blind, randomized, controlled clinical trial. Complement Ther Clin Pract 2018;31:132-8. PubMed
  13. Bingham LJ, Tam MM, Palmer AM, Cahill JL, Nixon RL. Contact allergy and allergic contact dermatitis caused by lavender: A retrospective study from an Australian clinic. Contact Dermatitis. 2019;81(1):37-42. PubMed
  14. Donelli D, Antonelli M, Bellinazzi C, Gensini GF, Firenzuoli F. Effects of lavender on anxiety: A systematic review and meta-analysis. Phytomedicine. 2019;65:153099. PubMed
  15. Firoozeei TS, Feizi A, Rezaeizadeh H, Zargaran A, Roohafza HR, Karimi M. The antidepressant effects of lavender (Lavandula angustifolia Mill.): A systematic review and meta-analysis of randomized controlled clinical trials. Complement Ther Med 2021;59:102 PubMed
  16. Kodama T, Watanabe T, Mataki N, Kanoh S, Kichikawa Y. Acute eosinophilic pneumonia following aromatherapy with essential oil. Respir Med Case Rep 2022;37:101657. PubMed
  17. Barbaud A, Kurihara F, Raison-Peyron N, et al. Allergic contact dermatitis from essential oil in consumer products: Mode of uses and value of patch-tests with an essential oil series. Results of a French study of the DAG (dermato-allergy group of the Fren
  18. Ozer H, Sayan ZA, Baloglu I, Ozturk Y, Yonet F, Turkmen K. Unknown criminals for kidney: Acute interstitial nephritis due to lavender tea. Explore (NY) 2023. PubMed
  19. Kasper S, Volz HP, Möller HJ, et al. Lavender oil preparation Silexan is effective in mild-to-moderate major depression: a randomized, placebo- and reference-controlled trial. Eur Arch Psychiatry Clin Neurosci 2024. PubMed
  20. Simaei SR, Askari VR, Rostami M, et al. Lavender and metformin effectively propagate progesterone levels in patients with polycystic ovary syndrome: A randomized, double-blind clinical trial. Fitoterapia 2023;172:105720. PubMed

See these in context on the Lavender monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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