Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Cartilage Collagen Ingredients & Drug Interactions

by Enviromedica

Cartilage Collagen label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cartilage Collagen against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cartilage Collagen is a dietary supplement by Enviromedica with 2 active ingredients. Its ingredients are commonly taken for osteoarthritis joint pain, joint stiffness, cartilage support.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chondroitin Sulfate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cartilage Collagen by Enviromedica

Ask about any prescription or over-the-counter medication and we check it for interactions with Cartilage Collagen by Enviromedica — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cartilage Collagen by Enviromedica

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “Collagen Type II” is listed as a grouped ingredient — the label gives one combined amount (1,200 mg) without saying how much of each component you get.
  • “Bovine Tracheal Cartilage, Freeze-Dried” is listed as a grouped ingredient — the label gives one combined amount (3,000 mg) without saying how much of each component you get.

This product has 2 active ingredients. Chondroitin sulfate is a naturally occurring compound found in cartilage; it's used to support joint health.

Collagen Type II, specifically undenatured (meaning it hasn't been broken down by heat), is a structural protein that makes up cartilage tissue. The capsule itself is gelatin.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: joint, cartilage, and immune health.
  • We looked for evidence on: Osteoarthritis, Aromatase inhibitor-induced arthralgia, Kashin-Beck disease, Temporomandibular disorders (TMD), joint pain, cartilage degeneration — and 1 related terms.
  • The strongest evidence on file: Chondroitin Sulfate is rated "Possibly Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Chondroitin Sulfate is rated "Insufficient Reliable Evidence To Rate" for Temporomandibular disorders (TMD), Kashin-Beck disease, Aromatase inhibitor-induced arthralgia.

Chondroitin sulfate is possibly effective for cataracts and osteoarthritis (wear-and-tear joint damage), meaning there's some evidence, but it's not conclusive. For aging skin, osteoporosis, high cholesterol, and colorectal polyps, the evidence we have isn't strong enough to rate how well it works.

Collagen Type II's effectiveness rating is not included in our data.

The evidence, ingredient by ingredient Chondroitin Sulfate

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chondroitin sulfate is generally well tolerated for short-term use, though the quality of supplements varies and long-term benefit isn't certain. The most common side effects taken by mouth are abdominal pain, bloating, constipation, diarrhea, heartburn, and nausea.

Skin symptoms like swelling around the eyes, swelling in the lower legs, hair loss, and rash have been reported, as have rare cases of liver damage. One case of asthma getting worse was reported with a glucosamine-chondroitin combination product.

The safety data advises against use during pregnancy and while breastfeeding.

Side effects, ingredient by ingredient Chondroitin Sulfate

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Chondroitin Sulfate.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take warfarin (Coumadin) or other blood thinners, double-check this product with your pharmacist or doctor before starting. The combination of chondroitin with warfarin carries a Moderate risk of increased bleeding.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you have osteoarthritis or cataracts and want to try a chondroitin product, this one is worth discussing with your pharmacist. If you take warfarin or other blood thinners, talk to us first—we'll need to make sure this is okay with your other medications.

Anyone who's pregnant, breastfeeding, or has a history of liver problems should check in before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cartilage Collagen, straight from the product label.

Brand Enviromedica
Barcode (UPC) 853956003096
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD May 23, 2024
DSLD ID 308925
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cartilage Collagen by Enviromedica, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
30
UPC/BARCODE
853956003096
IngredientAmount% DV
Chondroitin Sulfate525 mg--
Collagen Type II1200 mg--
Collagen Type II, Undenatured50 mg--
Bovine Tracheal Cartilage, Freeze-Dried3000 mg--

Other ingredients: Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Throughout most of recorded history, our ancestors utilized whole-animal nutrition, where the cartilaginous tissue of grass-fed pastured animals was frequently consumed in traditional diets. Rich in bioactive compounds including Undenatured Type II Collagen and chondroitin sulfate. Enviromedica Cartilage Collagen provides a concentrated matrix of naturally occurring nutrients in their correct physiological ratios.

Enviromedica Cartilage Collagen is sourced exclusively from grass-fed livestock raised on the rich open pastures of New Zealand, where animal husbandry practices are globally considered as second to none. Fresh tracheal cartilage is gently freeze-dried to preserve biological activity and nutrient content.

Cartilage Collagen 750mg

Formulation

This ancient nutritional powerhouse place a fundamental role in supporting healthy joints, cartilage, and immune function.

New Zealand- The premier source

Grass-fed, New Zealand pasture-raised Whole Food nutritional support For cartilage, joint, and immune health

Contains no dairy, wheat, yeast, gluten, corn, sugar, soy, shellfish, tree nuts, or preservatives. Made without stearates, fillers, binders, flow agents, or additives of any kind.

Product of New Zealand Manufactured in a cGMP facility

General Statements

Our promise Premium foundational products to support the body's ancestral biology.

Verum Paterna Nutrtionis Subsidium

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Take 4 capsules per day with or without food, or as recommended by your healthcare professional.

Precautions

If you are pregnant, nursing, or have a medical condition, consult your healthcare practitioner before use.

Use only if safety seal is intact.

Storage

Store tightly sealed in a cool dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cartilage Collagen by Enviromedica label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cartilage Collagen label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cartilage Collagen by Enviromedica

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bovine Tracheal Cartilage, Freeze-Dried

3000 mg per serving

Other (inactive) ingredients: Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cartilage Collagen by Enviromedica Drug Interactions

Want to check YOUR meds against Cartilage Collagen?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

Chondroitin Sulfate 2

Individual Drug Interactions

The ingredients in Cartilage Collagen interact with 2 drugs. Click any drug to see the details.

1 of the 2 ingredients in Cartilage Collagen interact with drugs. Each result below shows which ingredient is responsible. Chondroitin Sulfate

Each ingredient & the kinds of drugs it affects

For each ingredient in Cartilage Collagen with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Chondroitin Sulfate1 drug type · 2 drugs

Warfarin (Coumadin)

Taking chondroitin in combination with glucosamine might increase the anticoagulant effects of warfarin. However, the effect of chondroitin alone is unclear.
There have been multiple reports of increased international normalized ratio (INR) in patients taking warfarin with glucosamine, with or without chondroitin. The lack of reports with chondroitin alone seem to suggest that the interactions occurring in these reports may have been due to glucosamine. In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in INR in patients previously stabilized on warfarin. Additionally, 20 voluntary case reports to the US Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone, without chondroitin, to increased INR in patients taking warfarin.

Likelihood Unlikely Evidence D
Chondroitin Sulfate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cartilage Collagen, from the product label.

Enviromedica

See all Enviromedica products
Name
Enviromedica
City
Austin
State
Texas
ZipCode
78728
Web Address
www.enviromedica.com
Pharmacist Counseling Corner

Cartilage Collagen by Enviromedica: Common Questions

Does Cartilage Collagen by Enviromedica interact with any medications?
Yes. Based on its ingredients, Cartilage Collagen has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cartilage Collagen contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is chondroitin sulfate, and what's it supposed to do?
Chondroitin sulfate is a compound that naturally occurs in cartilage. The data shows it's possibly effective for osteoarthritis (wear-and-tear joint damage) and cataracts, though the evidence isn't definitive. It's included in joint-support supplements because cartilage is made partly of it.
Can I take this while I'm pregnant or breastfeeding?
The safety data advises against use during pregnancy and while breastfeeding. There isn't enough information to know it's safe in those situations, so you should talk with your doctor or pharmacist about what's right for you.
What side effects might I experience?
The most common ones are digestive: abdominal pain, bloating, constipation, diarrhea, heartburn, and nausea. Skin symptoms like rash, swelling around the eyes, and hair loss have also been reported. Serious side effects like liver damage are rare. If you have asthma, note that one case of asthma getting worse was reported with a chondroitin-glucosamine product.
Does this product have any fillers?
The capsule itself is made of gelatin. That's the only other ingredient listed, so there are no added fillers beyond that.
How long does it take to work?
Our data doesn't say how quickly you'd notice results. Chondroitin is generally considered a short-term supplement, but the exact timeline depends on your body and what you're taking it for—ask your pharmacist what to expect.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cartilage Collagen label
Go deeper

The Full Monographs Behind Cartilage Collagen’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chondroitin Sulfate

Interacts with 2 drugs

Chondroitin sulfate is a naturally occurring building block of cartilage that is widely taken, often with glucosamine, for osteoarthritis joint pain. The evidence is mixed—some people report...

Read the full Chondroitin Sulfate monograph →
Sources

Sources & How We Checked

Cartilage Collagen's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chondroitin Sulfate 22 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Tallia AF, Cardone DA. Asthma exacerbation associated with glucosamine-chondroitin supplement. J Am Board Fam Pract 2002;15:481-4..
  3. Danao-Camara T. Potential side effects of treatment with glucosamine and chondroitin. Arthritis Rheum 2000;43:2853. PubMed
  4. Rozenfeld V, Crain JL, Callahan AK. Possible augmentation of warfarin effect by glucosamine-chondroitin. Am J Health Syst Pharm 2004;61:306-307. PubMed
  5. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;354:795-808. DOI
  6. Knudsen J, Sokol GH. Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: Case report and review of the literature and MedWatch database. Pharmacotherapy 2008;28:540-8. PubMed
  7. Yue QY, Strandell J, Myrberg O. Concomitant use of glucosamine potentiates the effect of warfarin. Jan 2006. Drug Safety 29(10):911-1010. DOI
  8. Nordling, J. and van, Ophoven A. Intravesical glycosaminoglycan replenishment with chondroitin sulphate in chronic forms of cystitis. A multi-national, multi-centre, prospective observational clinical trial. Arzneimittelforschung. 2008;58(7):328-335. PubMed
  9. Nickel, J. C., Egerdie, B., Downey, J., Singh, R., Skehan, A., Carr, L., and Irvine-Bird, K. A real-life multicentre clinical practice study to evaluate the efficacy and safety of intravesical chondroitin sulphate for the treatment of interstitial cystit
  10. Oliviero, U., Sorrentino, G. P., De Paola, P., Tranfaglia, E., D'Alessandro, A., Carifi, S., Porfido, F. A., Cerio, R., Grasso, A. M., Policicchio, D., and . Effects of the treatment with matrix on elderly people with chronic articular degeneration. Drug
  11. Crowley, D. C., Lau, F. C., Sharma, P., Evans, M., Guthrie, N., Bagchi, M., Bagchi, D., Dey, D. K., and Raychaudhuri, S. P. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int.J.Med.Sc PubMed
  12. Nickel, J. C., Egerdie, R. B., Steinhoff, G., Palmer, B., and Hanno, P. A multicenter, randomized, double-blind, parallel group pilot evaluation of the efficacy and safety of intravesical sodium chondroitin sulfate versus vehicle control in patients with
  13. Sawitzke, A. D., Shi, H., Finco, M. F., Dunlop, D. D., Harris, C. L., Singer, N. G., Bradley, J. D., Silver, D., Jackson, C. G., Lane, N. E., Oddis, C. V., Wolfe, F., Lisse, J., Furst, D. E., Bingham, C. O., Reda, D. J., Moskowitz, R. W., Williams, H. J.
  14. Wildi, L. M., Raynauld, J. P., Martel-Pelletier, J., Beaulieu, A., Bessette, L., Morin, F., Abram, F., Dorais, M., and Pelletier, J. P. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starti
  15. Pavelka and et al. Double-blind, dose effect study of oral cs 4 & 6 1200mg, 800mg, 200mg against placebo in the treatment of femorotibial osteoarthritis. Wular Rheumatol Liter 1998;27(suppl 2):63.
  16. Cerda C, Bruguera M, Parés A. Hepatotoxicity associated with glucosamine and chondroitin sulfate in patients with chronic liver disease. World J Gastroenterol 2013;19(32):5381-4. PubMed
  17. von Felden J, Montani M, Kessebohm K, Stickel F. Drug-induced acute liver injury mimicking autoimmune hepatitis after intake of dietary supplements containing glucosamine and chondroitin sulfate. Int J Clin Pharmacol Ther 2013;51(3):219-23. PubMed
  18. Provenza JR, Shinjo SK, Silva JM, Peron CR, Rocha FA. Combined glucosamine and chondroitin sulfate, once or three times daily, provides clinically relevant analgesia in knee osteoarthritis. Clin Rheumatol 2015;34:1455-62. PubMed
  19. Ossendza RA, Grandval P, Chinoune F, Rocher F, Chapel F, Bernardini D. [Acute cholestatic hepatitis due to glucosamine forte]. Gastroenterol Clin Biol. 2007 Apr;31(4):449-50.
  20. Greenlee H, Crew KD, Shao T, Kranwinkel G, Kalinsky K, Maurer M, Brafman L, Insel B, Tsai WY, Hershman DL. Phase II study of glucosamine with chondroitin on aromatase inhibitor-associated joint symptoms in women with breast cancer. Support Care Cancer 201 PubMed
  21. Chu EC, Huang KHK, Cheung G, Ng G, Lin A. Delayed Skin Allergy to Glucosamine Chondroitin Supplement. Cureus 2023;15(3):e36310. PubMed
  22. Lila AM, Alekseeva LI, Baranov AA, et al. Chondroitin sulfate and glucosamine combination in patients with knee and hip osteoarthritis: A long-term observational study in Russia. World J Orthop 2023;14(6):443-457. PubMed

See these in context on the Chondroitin Sulfate monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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