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Dietary supplement

Chaga Mushroom Complex Capsule Ingredients & Drug Interactions

by Esmond Natural

Chaga Mushroom Complex Capsule label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Chaga Mushroom Complex Capsule against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Chaga Mushroom Complex Capsule is a dietary supplement by Esmond Natural with 5 active ingredients. Its ingredients are commonly taken for fatigue and low energy, physical and athletic performance, stress resistance (adaptogen).Based on those ingredients, 1,259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Siberian Ginseng extract, Reishi Mushroom extract, Chaga Mushroom. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Chaga Mushroom Complex Capsule by Esmond Natural

Ask about any prescription or over-the-counter medication and we check it for interactions with Chaga Mushroom Complex Capsule by Esmond Natural — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Chaga Mushroom Complex Capsule by Esmond Natural

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 5 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (200 mg) without saying how much of each component you get.

This capsule contains five active ingredients: Siberian Ginseng extract, Bilberry extract, Reishi Mushroom extract, Chaga Mushroom, and Cordyceps sinensis. Each plays a different role — ginseng and cordyceps are traditionally used for stamina and energy, bilberry for eye health, reishi for relaxation and immune support, and chaga for general wellness.

The capsule itself is made from gelatin with inactive ingredients (dicalcium phosphate, silica, and vegetable magnesium stearate) as binders and fillers.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Support immune system and digestion.
  • We looked for evidence on: Common cold, Influenza, Upper respiratory tract infection (URTI), Coronavirus disease 2019 (COVID-19), Pneumonia, Bronchitis — and 4 related terms.
  • The closest evidence on file: Bilberry is rated "Insufficient Reliable Evidence To Rate" for Ulcerative colitis (Natural Medicines).
  • Also on file: Bilberry is rated "Insufficient Reliable Evidence To Rate" for Irritable bowel syndrome (IBS).
  • Also on file: Cordyceps is rated "Insufficient Reliable Evidence To Rate" for Asthma, Cough.

The evidence for what these ingredients actually do is thin. Siberian Ginseng is possibly effective for genital herpes, but for everything else we tested — chronic fatigue, bipolar disorder, osteoporosis, and familial Mediterranean fever — the evidence isn't established.

Bilberry is possibly ineffective for night vision, and we don't have solid evidence for it on cognitive decline, macular degeneration, or heart and cholesterol issues. Reishi appears possibly ineffective for high cholesterol, and evidence is insufficient for altitude sickness, Alzheimer disease, and athletic performance.

Chaga and Cordyceps lack sufficient evidence across the conditions we evaluated, including diabetes, heart disease, and athletic performance. In short, none of these ingredients have strong proof they work for their traditional uses.

The evidence, ingredient by ingredient Eleuthero Bilberry Reishi Mushroom Cordyceps Chaga

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term use of these ingredients is generally well tolerated, but long-term safety isn't well studied for any of them. Siberian Ginseng may cause diarrhea, nausea, headache, or stomach upset; nervousness occurred in about 7% of people in one study, and it can raise blood pressure — a concern if you already have high blood pressure.

Bilberry often causes dark-colored stools and gas but is otherwise gentle. Reishi may cause dizziness, dry mouth, nausea, rash, or stomach upset, and respiratory allergy to reishi spores can occur.

Chaga has caused kidney failure and kidney damage in rare cases from very high doses due to its oxalate content. Cordyceps can cause stomach discomfort, constipation, or diarrhea; one case of liver inflammation was reported, though it's unclear if cordyceps was responsible.

The safety data for pregnancy and breastfeeding is insufficient for Siberian Ginseng, Reishi Mushroom, Chaga, and Cordyceps — the facts advise against their use in these situations. Bilberry is likely safe in pregnancy and lactation.

Side effects, ingredient by ingredient Eleuthero Bilberry Reishi Mushroom Cordyceps Chaga

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Bilberry, Cordyceps, Reishi Mushroom, Eleuthero, Chaga.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications.
  • For scale: 1,260 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you're on any of these: blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel), since multiple ingredients increase bleeding risk moderately; diabetes medications, because several ingredients may lower blood sugar; digoxin (Lanoxin) for heart rhythm, since Siberian Ginseng may raise its levels; blood pressure medications, since Reishi may lower blood pressure further; immunosuppressants like cyclosporine, since Siberian Ginseng and Chaga may interfere; or erlotinib (Tarceva) for cancer, since bilberry may reduce how well it works. These are moderate interactions documented in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines five mushroom and plant extracts with documented interactions—most notably with blood thinners, diabetes drugs, and the heart medication digoxin. It's also unproven for the conditions it may be marketed for.

If you take any prescription medication, especially for blood clotting, blood sugar, blood pressure, or heart rhythm, or if you're pregnant or breastfeeding, check with your pharmacist before using it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Chaga Mushroom Complex Capsule, straight from the product label.

Brand Esmond Natural
Barcode (UPC) 641399088455
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 315873
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Chaga Mushroom Complex Capsule by Esmond Natural, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
641399088455
IngredientAmount% DV
Proprietary Blend200 mg--
Siberian Ginseng extract0 NP--
Bilberry extract0 NP--
Reishi Mushroom extract0 NP--
Chaga Mushroom300 mg--
Cordyceps sinensis0 NP--

Other ingredients: Gelatin, Dicalcium Phosphate, Silica, Vegetable Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

May support immune and digestion.

GMP

Maintain health Regulate physical function

Precautions

Warning: If you are pregnant, nursing or taking any medications, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur. Tamper resistant: Do not use if imprinted seal under cap is broken or missing.

Keep out of reach of children.

Store in a dry place and avoid excessive heat.

Storage

Store in a dry place and avoid excessive heat.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Herbal health Since 1994

Esmondnatural Integrated health

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) capsule daily, preferably with meals. As a reminder, discuss the supplements and medications you take with your health care providers.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Chaga Mushroom Complex Capsule by Esmond Natural label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Chaga Mushroom Complex Capsule label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Chaga Mushroom Complex Capsule by Esmond Natural

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

200 mg per serving

Chaga Mushroom

Interacts with
327 drugs
300 mg per serving

Chaga is a fungus that grows mostly on birch trees and is used as a tea or supplement, mainly for immune and antioxidant support. Human evidence for i...

Chaga Mushroom monograph & interactions

Other (inactive) ingredients: Gelatin, Dicalcium Phosphate, Silica, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Chaga Mushroom Complex Capsule by Esmond Natural Drug Interactions

Want to check YOUR meds against Chaga Mushroom Complex Capsule?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,259Drugs
824 Moderate 435 Minor

Ingredients driving the most interactions

Siberian Ginseng extract 1,140
Reishi Mushroom extract 375
Chaga Mushroom 327
Bilberry extract 275
Cordyceps sinensis 249

Individual Drug Interactions

The ingredients in Chaga Mushroom Complex Capsule interact with 1,259 drugs. Click any drug to see the details.

5 of the 5 ingredients in Chaga Mushroom Complex Capsule interact with drugs. Each result below shows which ingredient is responsible. Siberian Ginseng extract Reishi Mushroom extract Chaga Mushroom Bilberry extract Cordyceps sinensis

Each ingredient & the kinds of drugs it affects

For each ingredient in Chaga Mushroom Complex Capsule with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Siberian Ginseng extract10 drug types · 1,140 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research shows that a constituent of eleuthero, dihydroxybenzoic acid, appears to inhibit platelet aggregation. Concomitant use with anticoagulant or antiplatelet drugs might increase the risk of bleeding. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Animal research suggests that certain constituents of eleuthero have hypoglycemic activity in both healthy and diabetic animals. A small study in adults with type 2 diabetes also shows that taking eleuthero for 3 months can lower blood glucose levels. However, one very small study in healthy individuals shows that taking powdered eleuthero 3 grams, 40 minutes prior to a 75-gram oral glucose tolerance test, significantly increases postprandial blood glucose levels when compared with placebo. These contradictory findings might be due to patient-specific variability and variability in active ingredient ratios.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
In vitro and animal research suggest that standardized extracts of eleuthero inhibit CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP2C9.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP2C9. This effect has not been reported in humans.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Eleuthero might increase serum digoxin levels and increase the risk of side effects.
In one case report, a 74-year-old male who was stabilized on digoxin presented with an elevated serum digoxin level after starting an eleuthero supplement, without symptoms of toxicity. After stopping the supplement, serum digoxin levels returned to normal. It is not clear whether this was due to a pharmacokinetic interaction or to interference with the digoxin assay. Although the product was found to be free of digoxin and digitoxin, it was not tested for other contaminants.

Likelihood Unlikely Evidence D
Immunosuppressants

Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Animal and in vitro research shows that eleuthero extracts have immunomodulatory effects, including increasing cellular and humoral activity.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
In vitro research suggests that eleuthero can inhibit the multi-drug transporter protein, P-glycoprotein. However, it is too soon to tell if this is clinically important. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP2D6. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP2D6 drug metabolism.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP3A4. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP3A4 drug metabolism.

Likelihood Unlikely Evidence B
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, eleuthero might decrease levels of drugs metabolized by OATP.
In vitro research suggests that eleuthero inhibits OATP2B1, which might reduce the bioavailability of oral drugs that are substrates of OATP2B1. Due to the weak inhibitory effect identified in this study, this interaction is not likely to be clinically significant.

Likelihood Possible Evidence D
Siberian Ginseng extract full monograph & interactions

Reishi Mushroom extract3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Reishi Mushroom extract full monograph & interactions

Chaga Mushroom3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that chaga extract can inhibit platelet aggregation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking chaga with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that chaga might decrease blood glucose levels and increase insulin levels. This has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, chaga might interfere with immunosuppressive therapy.
In vitro research suggests that certain constituents of chaga stimulate immune function. This has not been reported in humans.

Likelihood Possible Evidence D
Chaga Mushroom full monograph & interactions

Bilberry extract4 drug types · 275 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro, animal, and clinical research suggest that anthocyanidin extracts from bilberry can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that bilberry leaf extract might have blood glucose-lowering activity. Also, one small clinical trial in patients with type 2 diabetes shows that taking bilberry fruit extract 470 mg as a single dose prior to an oral glucose tolerance test lowers plasma glucose levels when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Animal research shows that exposure to small concentrations of bilberry extract in drinking water for around one month increased CYP2E1 activity by 31%. However, exposure over a 2-month period did not increase CYP2E1 activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Erlotinib (Tarceva)

Theoretically, bilberry fruit extract might reduce the efficacy of erlotinib.
In vitro research suggests that bilberry fruit extract and its constituents, delphinidin and delphinidin-3-O-glucoside, inhibit the activity of erlotinib. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Bilberry extract full monograph & interactions

Cordyceps sinensis3 drug types · 249 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.

Likelihood Possible Evidence B
Testosterone

Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
Cordyceps sinensis full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Chaga Mushroom Complex Capsule, from the product label.

Esmond Natural

See all Esmond Natural products
Name
Esmond Natural Inc.
City
Irwindale
State
CA
ZipCode
91706
Web Address
www.esmondnatural.com
Pharmacist Counseling Corner

Chaga Mushroom Complex Capsule by Esmond Natural: Common Questions

Does Chaga Mushroom Complex Capsule by Esmond Natural interact with any medications?
Yes. Based on its ingredients, Chaga Mushroom Complex Capsule has a known interaction with 1,259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Chaga Mushroom Complex Capsule contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe if I'm pregnant or breastfeeding?
Not enough safety data exists for four of the five active ingredients—Siberian Ginseng, Reishi, Chaga, and Cordyceps—so the facts advise against using them during pregnancy or lactation. Bilberry is likely safe, but since this is a blend product, talk with your doctor or pharmacist before starting it.
What are the most common side effects?
Siberian Ginseng most often causes diarrhea, nausea, headache, or stomach upset; nervousness occurred in about 7% of users. Bilberry can cause dark stools and gas. Reishi may bring dizziness, dry mouth, nausea, or rash. Cordyceps may cause stomach discomfort or changes in bowel habits. Most people tolerate these ingredients short-term without trouble.
Does this product actually work for anything?
The evidence is very limited. Siberian Ginseng is possibly effective only for genital herpes. The other ingredients lack solid proof they work for the conditions tested—cognitive health, eye health, cholesterol, athletic performance, and diabetes. Don't expect strong results based on what we know.
Can I take this long-term?
The safety data for long-term use is not well studied for any of these ingredients. They're generally tolerated short-term, but we don't have strong evidence they're safe or effective over months or years. Talk to your pharmacist about your specific timeline.
What is Chaga and why is it in this product?
Chaga is a fungus that grows on birch trees, traditionally used in teas for wellness. It's included in this blend for general immune and antioxidant support, though proof it works is lacking. One caution: very high doses can cause kidney problems because chaga is high in oxalate, a substance that builds up in the kidneys.
Does this interact with blood pressure or heart medications?
Yes. Reishi may lower blood pressure further, creating a risk of dangerously low blood pressure if you're already on blood pressure drugs. Siberian Ginseng may raise blood pressure and can increase digoxin levels—a heart medication—so either way, check with your pharmacist before adding this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Chaga Mushroom Complex Capsule label
Go deeper

The Full Monographs Behind Chaga Mushroom Complex Capsule’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Eleuthero

Interacts with 1,140 drugs

Eleuthero is an herb traditionally used as an 'adaptogen' to fight fatigue, boost energy, and help the body handle stress. The scientific evidence behind these uses is limited and mixed, so...

Read the full Eleuthero monograph → Herb & supplement monograph

Bilberry

Interacts with 275 drugs

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye health, circulation, and mild diarrhea. While...

Read the full Bilberry monograph → Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph → Herb & supplement monograph

Cordyceps

Interacts with 249 drugs

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...

Read the full Cordyceps monograph → Herb & supplement monograph

Chaga

Interacts with 327 drugs

Chaga is a fungus that grows mostly on birch trees and is used as a tea or supplement, mainly for immune and antioxidant support. Human evidence for its benefits is very limited, and it may...

Read the full Chaga monograph →
Sources

Sources & How We Checked

Chaga Mushroom Complex Capsule's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 78 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Eleuthero 24 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. McRae S. Elevated serum digoxin levels in a patient taking digoxin and Siberian ginseng. CMAJ 1996;155:293-5.
  3. Awang DVC. Siberian ginseng toxicity may be case of mistaken identity (letter). CMAJ 1996;155:1237.
  4. Mills S, Bone K. Principles and Practice of Phytotherapy. London: Churchill Livingstone, 2000.
  5. Harkey MR, Henderson GL, Zhou L, et al. Effects of Siberian ginseng (Eleutherococcus senticosus) on c-DNA-expressed P450 drug metabolizing enzymes. Alt Ther 2001;7:S14.
  6. Hikino H, Takahashi M, Otake K, Konno C. Isolation and hypoglycemic activity of eleutherans A, B, C, D, E, F, and G: glycans of Eleutherococcus senticosus roots. J Nat Prod 1986;49:293-7. PubMed
  7. Yun-Choi HS, Kim JH, Lee JR. Potential inhibitors of platelet aggregation from plant sources, III. J Nat Prod 1987;50:1059-64. PubMed
  8. Donovan JL, DeVane CL, Chavin KD, et al. Siberian Ginseng (Eleutheroccus senticosus) Effects on CYP2D6 and CYP3A4 Activity in Normal Volunteers. Drug Metab Dispos 2003;31:519-22.. PubMed
  9. Hartz AJ, Bentler S, Noyes R et al. Randomized controlled trial of Siberian ginseng for chronic fatigue. Psychol Med 2004;34:51-61. PubMed
  10. Sievenpiper JL, Arnason JT, Leiter LA, Vuksan V. Decreasing, null and increasing effects of eight popular types of ginseng on acute postprandial glycemic indices in healthy humans: the role of ginsenosides. J Am Coll Nutr 2004;23:248-58. PubMed
  11. Dasgupta A, Wu S, Actor J, et al. Effect of Asian and Siberian ginseng on serum digoxin measurement by five digoxin immunoassays. Significant variation in digoxin-like immunoreactivity among commercial ginsengs. Am J Clin Pathol 2003;119:298-303. DOI
  12. Takahashi T, Kaku T, Sato T, et al. Effects of Acanthopanax senticosus HARMS extract on drug transport in human intestinal cell line Caco-2. J Nat Med. 2010;64(1):55-62. PubMed
  13. Fuchikami H, Satoh H, Tsujimoto M, Ohdo S, Ohtani H, Sawada Y. Effects of herbal extracts on the function of human organic anion-transporting polypeptide OATP-B. Drug Metab Dispos 2006;34:577-82. PubMed
  14. Friedman, J. A., Taylor, S. A., McDermott, W., and Alikhani, P. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins. Neurocrit.Care 2007;7(1):76-80. PubMed
  15. Molokovskii, D. S., Davydov, V. V., and Tiulenev, V. V. [The action of adaptogenic plant preparations in experimental alloxan diabetes]. Probl.Endokrinol.(Mosk) 1989;35(6):82-87.
  16. Schmolz, M. W., Sacher, F., and Aicher, B. The synthesis of Rantes, G-CSF, IL-4, IL-5, IL-6, IL-12 and IL-13 in human whole-blood cultures is modulated by an extract from Eleutherococcus senticosus L. roots. Phytother.Res 2001;15(3):268-270.
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Bilberry 14 references
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Reishi Mushroom 17 references
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Chaga 9 references
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Cordyceps 14 references
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