Chamomile 2,000 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Chamomile 2,000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Chamomile 2,000 mg is a dietary supplement by Nature's Answer with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, sleep and relaxation, digestive upset.Based on those ingredients, 960 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chamomile (Matricaria recutita) flower extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Chamomile 2,000 mg by Nature's Answer
Ask about any prescription or over-the-counter medication and we check it for interactions with Chamomile 2,000 mg by Nature's Answer — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Chamomile 2,000 mg by Nature's Answer
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: German chamomile (Matricaria recutita) flower extract at 2,000 mg per serving. Chamomile is a traditional herb used to promote relaxation and ease minor discomfort.
The liquid form also includes purified water, vegetable glycerin, and 12–15% certified organic alcohol as inactive ingredients.
Does it work?
Couldn't assess
The evidence we hold does not establish that chamomile works for anxiety, hay fever, ADHD, sexual dysfunction, or lack of appetite—the data rates all of these as having insufficient reliable evidence. If you're considering it for one of these reasons, talk with your doctor about what the current research actually supports and what other options might help.
How safe is it?
Well-documented data
Chamomile is generally well tolerated by most adults. However, it can trigger allergic reactions in people sensitive to ragweed and related plants, and in rare cases has caused severe reactions including anaphylaxis.
Topically, it may cause allergic skin reactions, dermatitis, or eczema. When used as an oral rinse, it has been reported to cause mouth burning and nausea in some people.
The safety data during pregnancy advises against use unless your doctor approves; for breastfeeding, limited data exist, so check with your doctor or pharmacist before starting.
Meds to double-check
Moderate interaction found
Before you take this product, double-check with your doctor or pharmacist if you use warfarin or other blood thinners (moderate risk of bleeding), CNS depressants like benzodiazepines or sleep aids (moderate risk of added drowsiness), oral contraceptives or hormone replacement therapy (moderate risk of reduced effectiveness), tamoxifen or other cancer drugs (moderate risk of reduced effectiveness), or any medication metabolized by your liver's CYP2D6, CYP2C9, or CYP3A4 enzymes (moderate risk of higher drug levels).
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Chamomile may be worth considering if you're looking for a traditional relaxation aid and have no drug interactions or allergies to ragweed plants. However, if you take blood thinners, sedating medications, hormone therapies, or many other drugs processed by your liver, you'll need to check first.
Talk with your doctor or pharmacist about whether it's right for you and your current medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2016.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Chamomile 2,000 mg, straight from the product label.
| Brand | Nature's Answer |
|---|---|
| Barcode (UPC) | 083000002021 |
| Net contents | 2 fl. Oz.; 60 mL |
| Market status | On market |
| Date entered into DSLD | Jun 24, 2016 |
| DSLD ID | 60506 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Kosher, Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Chamomile 2,000 mg by Nature's Answer, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Chamomile (Matricaria recutita) flower extract | 2000 mg | -- |
Other ingredients: purified Water, Vegetable Glycerin, 12-15% certified organic Alcohol
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols
K Parve
Bio-chelated Cold Extraction Process
Gluten Free
Formula
K Parve
Low Alcohol
Matricaria recutita
General
9218A Rev. 515 1034
General Statements
Super concentrated 2,000 mg
Our facility is cGMP certified, organic and kosher certified.
Since 1972
Brand IP Statement(s)
Discover Nature's Answer
Our organic alcohol extracts are produced using our cold Bio-Chelated proprietary extraction process, yielding a Holistically Balanced Advanced Botanical Fingerprint extract in the same synergistic ratios as in the plant.
2015 Nature's Answer
Advanced Botanical Fingerprint
Formulation
Gluten-Free
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take 1-2 mL (28-56 drops) three (3) times a day in a small amount of water. Shake well.
Precautions
Keep out of reach of children.
Warning: Do not use if pregnant or nursing.
Do not use if safety seal is damaged or missing.
FDA Disclaimer Statement
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Chamomile 2,000 mg by Nature's Answer label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Chamomile 2,000 mg by Nature's Answer
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.
Chamomile (Matricaria recutita) flower extract
Interacts with960 drugs
German chamomile is a widely used herbal remedy taken mainly as a tea for calming, sleep, and digestive complaints. Early research suggests possible b...
Chamomile (Matricaria recutita) flower extract monograph & interactionsOther (inactive) ingredients: Purified Water, Vegetable Glycerin, 12-15% certified organic Alcohol. These complete the product’s ingredient list but are not active constituents.
Chamomile 2,000 mg by Nature's Answer Drug Interactions
HelloPharmacist Interaction Report
Chamomile 2,000 mg by Nature's Answer contains German chamomile flower extract, which has documented interactions with several medication types.
The most serious concern is with warfarin (a blood thinner), where chamomile may increase bleeding risk—in fact, one case reported a patient on warfarin who developed life-threatening bleeding after drinking 4–5 cups of chamomile tea daily alongside topical chamomile use.
Read the full breakdown — every affected drug type, severity by severity
Chamomile may also interact with CNS depressants (sedating drugs like benzodiazepines and sleep aids) by adding to their drowsy effects. It can theoretically slow how your body clears certain medications metabolized by your liver's CYP2D6, CYP2C9, and CYP3A4 enzymes—a broad group that includes many common drugs—and potentially raise their levels in your blood.
Additionally, in theory, large amounts of chamomile might weaken oral contraceptives and hormone replacement therapy by blocking estrogen activity; it may also interfere with tamoxifen (a cancer drug) in the same way.
Altogether, these interactions span 961 individual medications. Because chamomile's effects on liver enzymes haven't been proven in humans yet, the real-world risk is unclear—but it's real enough to warrant caution.
Before you start this product, run your exact medications through the checker on this page, and talk with your doctor or pharmacist about any blood thinners, sedating drugs, hormone therapies, or cancer medications you take.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Chamomile 2,000 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Chamomile 2,000 mg interact with 960 drugs. Click any drug to see the details.
1 of the 1 ingredient in Chamomile 2,000 mg interact with drugs. Each result below shows which ingredient is responsible. Chamomile (Matricaria recutita) flower extract
Atazanavir, CobicistatEvotaz
How Atazanavir, Cobicistat interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile (matricaria Recutita) Flower Extract + Atazanavir, Cobicistat interactionAtogepantQulipta
How Atogepant interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile (matricaria Recutita) Flower Extract + Atogepant interactionAtomoxetineStrattera
How Atomoxetine interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP2D6 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile (matricaria Recutita) Flower Extract + Atomoxetine interactionAtorvastatinAtorvaliq
How Atorvastatin interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile (matricaria Recutita) Flower Extract + Atorvastatin interactionAtorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile (matricaria Recutita) Flower Extract + Atorvastatin Calcium interactionAtropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, ScopolamineAtrohist Plus, Pro Tuss, Ru-tuss, Stahist
How Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile (matricaria Recutita) Flower Extract + Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interactionAtropine, Hyoscyamine, PhenobarbitalHypnaldyne
How Atropine, Hyoscyamine, Phenobarbital interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCns Depressants Moderate
Interaction Summary
Theoretically, German chamomile might have additive effects when used with CNS depressants.
Read the full Chamomile (matricaria Recutita) Flower Extract + Atropine, Hyoscyamine, Phenobarbital interactionAtropine, Hyoscyamine, Phenobarbital, ScopolamineBarbidonna No. 2, Belladonna Phenobarbital
How Atropine, Hyoscyamine, Phenobarbital, Scopolamine interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCns Depressants Moderate
Interaction Summary
Theoretically, German chamomile might have additive effects when used with CNS depressants.
Read the full Chamomile (matricaria Recutita) Flower Extract + Atropine, Hyoscyamine, Phenobarbital, Scopolamine interactionAtropine, Hyoscyamine, Scopolamine, PhenobarbitalBarbeloid, Donnatal #2, Donphen
How Atropine, Hyoscyamine, Scopolamine, Phenobarbital interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCns Depressants Moderate
Interaction Summary
Theoretically, German chamomile might have additive effects when used with CNS depressants.
Read the full Chamomile (matricaria Recutita) Flower Extract + Atropine, Hyoscyamine, Scopolamine, Phenobarbital interactionAtropine, PhenobarbitalAnthrocol
How Atropine, Phenobarbital interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCns Depressants Moderate
Interaction Summary
Theoretically, German chamomile might have additive effects when used with CNS depressants.
Read the full Chamomile (matricaria Recutita) Flower Extract + Atropine, Phenobarbital interactionAtropine, MeperidineAtropine, Meperidine
How Atropine, Meperidine interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might have additive effects when used with CNS depressants.
Read the full Chamomile (matricaria Recutita) Flower Extract + Atropine, Meperidine interactionAtropine, Morphine SulfateAtropine, Morphine Sulfate
How Atropine, Morphine Sulfate interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP2D6 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile (matricaria Recutita) Flower Extract + Atropine, Morphine Sulfate interactionAvacopanTavneos
How Avacopan interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile (matricaria Recutita) Flower Extract + Avacopan interactionAvanafilStendra
How Avanafil interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile (matricaria Recutita) Flower Extract + Avanafil interactionAvapritinibAyvakit
How Avapritinib interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile (matricaria Recutita) Flower Extract + Avapritinib interactionAxitinibInlyta
How Axitinib interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile (matricaria Recutita) Flower Extract + Axitinib interactionAzelastine Hydrochloride, Fluticasone PropionateDymista
How Azelastine Hydrochloride, Fluticasone Propionate interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile (matricaria Recutita) Flower Extract + Azelastine Hydrochloride, Fluticasone Propionate interactionAzilsartanEdarbi
How Azilsartan interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP2C9 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile (matricaria Recutita) Flower Extract + Azilsartan interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP2C9 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile (matricaria Recutita) Flower Extract + Azilsartan, Chlorthalidone interactionBazedoxifene Acetate, Conjugated EstrogensDuavee
How Bazedoxifene Acetate, Conjugated Estrogens interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile (matricaria Recutita) Flower Extract + Bazedoxifene Acetate, Conjugated Estrogens interactionBeclometasone DipropionateBecotide
How Beclometasone Dipropionate interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile (matricaria Recutita) Flower Extract + Beclometasone Dipropionate interactionBeclomethasoneBeclovent, Vanceril
How Beclomethasone interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile (matricaria Recutita) Flower Extract + Beclomethasone interactionBeclomethasone DipropionateQNASL, Qvar
How Beclomethasone Dipropionate interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile (matricaria Recutita) Flower Extract + Beclomethasone Dipropionate interactionBedaquilineSirturo
How Bedaquiline interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile (matricaria Recutita) Flower Extract + Bedaquiline interactionBelladona Extract, PhenobarbitalChardonna-2
How Belladona Extract, Phenobarbital interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCns Depressants Moderate
Interaction Summary
Theoretically, German chamomile might have additive effects when used with CNS depressants.
Read the full Chamomile (matricaria Recutita) Flower Extract + Belladona Extract, Phenobarbital interactionBelladonna Alkaloids, Chlorpheniramine, Phenylephrine, PhenylpropanolamineRespa ARM
How Belladonna Alkaloids, Chlorpheniramine, Phenylephrine, Phenylpropanolamine interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile (matricaria Recutita) Flower Extract + Belladonna Alkaloids, Chlorpheniramine, Phenylephrine, Phenylpropanolamine interactionBelladonna Alkaloids, Ergotamine Tartrate, PhenobarbitalBel Tabs, Bellamine-S, Bellaphen-S, Duragal S, Phenarbal S, Spastrin
How Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile (matricaria Recutita) Flower Extract + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interactionBelladonna Alkaloids, PhenobarbitalBarbidonna, Donnatal
How Belladonna Alkaloids, Phenobarbital interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCns Depressants Moderate
Interaction Summary
Theoretically, German chamomile might have additive effects when used with CNS depressants.
Read the full Chamomile (matricaria Recutita) Flower Extract + Belladonna Alkaloids, Phenobarbital interactionBelladonna Extract, PhenobarbitalBelap
How Belladonna Extract, Phenobarbital interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCns Depressants Moderate
Interaction Summary
Theoretically, German chamomile might have additive effects when used with CNS depressants.
Read the full Chamomile (matricaria Recutita) Flower Extract + Belladonna Extract, Phenobarbital interactionBelladonna, Caffeine, Ergotamine, PentobarbitalMicomp PB
How Belladonna, Caffeine, Ergotamine, Pentobarbital interacts with Chamomile 2,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Chamomile (matricaria Recutita) Flower ExtractCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, German chamomile might have additive effects when used with CNS depressants.
Read the full Chamomile (matricaria Recutita) Flower Extract + Belladonna, Caffeine, Ergotamine, Pentobarbital interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Chamomile 2,000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Chamomile (Matricaria recutita) flower extract
Cns Depressants
Theoretically, German chamomile might have additive effects when used with CNS depressants.
German chamomile has mild sedative effects. Theoretically, concomitant use with drugs with sedative properties can cause additive effects and side effects.
Contraceptive Drugs
Theoretically, large amounts of German chamomile might reduce the effectiveness of oral contraceptives.
In vitro, German chamomile has demonstrated antiestrogenic activity. Theoretically, concomitant use of large amounts of German chamomile might interfere with contraceptive drugs through competition for estrogen receptors.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, German chamomile might inhibit CYP2C9 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP2C9. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP2C9 in patients taking German chamomile.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, German chamomile might inhibit CYP2D6 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP2D6. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP2D6 in patients taking German chamomile.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP3A4. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP3A4 in patients taking German chamomile.
Estrogens
Theoretically, large amounts of German chamomile might reduce the effectiveness of estrogens.
In vitro, German chamomile has demonstrated antiestrogenic activity. Theoretically, large amounts of German chamomile might interfere with hormone replacement therapy through competition for estrogen receptors.
Tamoxifen (Nolvadex)
Theoretically, large amounts of German chamomile might interfere with the activity of tamoxifen.
In vitro, German chamomile has demonstrated antiestrogenic activity.
Warfarin (Coumadin)
German chamomile might increase the effects of warfarin and increase the risk of bleeding.
In one case, a 70-year-old female taking warfarin developed retroperitoneal hematoma and bilateral recti muscle bleeding along with an INR of 7.9 following ingestion of German chamomile tea 4-5 cups daily and use of a topical chamomile-based lotion applied 4-5 times daily.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, German chamomile might inhibit CYP1A2 and increase levels of drugs metabolized by these enzymes.
In vitro and animal research shows that German chamomile might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP1A2 in patients taking German chamomile.
Brand information
Manufacturer and brand details for Chamomile 2,000 mg, from the product label.
Nature's Answer
See all Nature's Answer products- Name
- Nature's Answer
- City
- Hauppauge
- State
- NY
- ZipCode
- 11788-3943
- Phone Number
- (800) 439-2324
- Web Address
- www.naturesanswer.com
Chamomile 2,000 mg by Nature's Answer: Common Questions
Does Chamomile 2,000 mg by Nature's Answer interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm allergic to ragweed?
Will this make me drowsy?
Is it safe to take while pregnant?
Can I use this while breastfeeding?
What is this product actually proven to help with?
Can I take this with my birth control?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Chamomile 2,000 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Chamomile 2,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 15 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
German Chamomile 15 references
- Subiza J, Subiza JL, Hinojosa M, et al. Anaphylactic reaction after the ingestion of chamomile tea; a study of cross-reactivity with other composite pollens. J Allergy Clin Immunol 1989;84:353-8. PubMed
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- Viola H, Wasowski C, Levi de Stein M, et al. Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. Planta Med 1995;61:213-6.
- van Ketel WG. Allergy to Matricaria chamomilla. Contact Dermatitis 1982;8:143. PubMed
- van Ketel WG. Allergy to Matricaria chamomilla. Contact Dermatitis 1987;16:50-1. PubMed
- Hormann HP, Korting HC. Evidence for the efficacy and safety of topical herbal drugs in dermatology: part I: anti-inflammatory agents. Phytomedicine 1994;1:161-71. PubMed
- Avallone R, Zanoli P, Puia G, et al. Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. Biochem Pharmacol 2000;59:1387-94. PubMed
- Kassi E, Papoutsi Z, Fokialakis N, et al. Greek plant extracts exhibit selective estrogen receptor modulator (SERM)-like properties. J Agric Food Chem 2004;52:6956-61. PubMed
- Maliakal PP, Wanwimolruk S. Effect of herbal teas on hepatic drug metabolizing enzymes in rats. J Pharm Pharmacol 2001;53:1323-9. PubMed
- Segal R, Pilote L. Warfarin interaction with Matricaria chamomilla. CMAJ 2006;174:1281-2. PubMed
- Loggia RD, Traversa U, Scarcia V, et al. Depressive effects of Chamomilla recutita (L.) Rausch, tubular flowers, on central nervous system in mice. Pharmacol Res Commun 1982;14(2):153-162. PubMed
- Ganzera M, Schneider P, Stuppner H. Inhibitory effects of the essential oil of chamomile (Matricaria recutita L.) and its major constituents on human cytochrome P450 enzymes. Life Sci 2006;78(8):856-861. PubMed
- Benito P, Rodríguez-Perez R, García F, Juste S, Moneo I, Caballero ML. Occupational allergic rhinoconjunctivitis induced by Matricaria chamomilla with tolerance of chamomile tea. J Investig Allergol Clin Immunol. 2014;24(5):369-70. No abstract available.
- Braga FT, Santos AC, Bueno PC, et al. Use of Chamomilla recutita in the prevention and treatment of oral mucositis in patients undergoing hematopoietic stem cell transplantation: a randomized, controlled, phase II clinical trial. Cancer Nurs 2015;38(4):32 PubMed
- Sarris J, Ravindran A, Yatham LN, et al. Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety T
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC