Chamomile Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Chamomile against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Chamomile is a dietary supplement by L.A. Naturals with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, sleep and relaxation, digestive upset.Based on those ingredients, 960 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are certified organic Chamomile. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Chamomile by L.A. Naturals
Ask about any prescription or over-the-counter medication and we check it for interactions with Chamomile by L.A. Naturals — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Chamomile by L.A. Naturals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This liquid contains one active ingredient: certified organic German chamomile, a flowering plant used traditionally for relaxation and digestive support. The product also includes grain alcohol and deionized water as inactive ingredients that keep the remedy in liquid form.
Does it work?
Couldn't assess
The evidence we hold on chamomile doesn't establish that it works for the conditions it's often used for. Studies show insufficient reliable evidence to rate it for anxiety, hay fever, ADHD, sexual dysfunction, or cancer-related loss of appetite.
If you're considering it for one of these purposes, talk with your doctor about what the research actually supports for your situation.
How safe is it?
Well-documented data
German chamomile is generally well tolerated in most adults but can trigger allergic reactions in people who are sensitive to ragweed and related plants—ragweed allergies are a red flag here. When taken by mouth, it may cause nausea and burning sensations in the mouth in some people.
Topically, it can cause allergic skin reactions or eczema. Rare but serious reactions including severe allergic reactions and anaphylaxis have been reported.
The safety data during pregnancy advise against use unless your doctor approves it. Limited safety information exists for breastfeeding, so check with your doctor or pharmacist before using it while nursing.
Meds to double-check
Moderate interaction found
Before taking this chamomile product, check with your doctor or pharmacist if you take warfarin or any blood thinner, CNS depressants (sleep aids, anxiety medications, opioids), birth control pills, hormone replacement therapy, tamoxifen, or any medications processed by your liver through the CYP2D6, CYP2C9, or CYP3A4 enzyme systems. All of these carry Moderate risk of interaction.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Chamomile liquid may be worth considering if you're looking for a traditional relaxation aid, but it's not proven effective for the conditions listed on many product labels. If you take warfarin, any sedating medication, birth control, hormone therapy, or cancer medications like tamoxifen, you'll need to clear this with your doctor or pharmacist first—the interactions are real and can be serious.
Anyone allergic to ragweed should avoid it, and pregnant people should get their doctor's approval.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2014.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Chamomile, straight from the product label.
| Brand | L.A. Naturals |
|---|---|
| Barcode (UPC) | 641356039117 |
| Net contents | 1 fl. Oz.; 30 mL |
| Market status | On market |
| Date entered into DSLD | Jul 25, 2014 |
| DSLD ID | 35016 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Kosher |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Chamomile by L.A. Naturals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| certified organic Chamomile | 0 NP | -- |
Other ingredients: Grain Alcohol, deionized Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
SUGGESTED USE: 30-60 drops in water or juice, 2-3 times daily, or as needed.
Shake well before using.
Precautions
WARNING: Keep out of the reach of children.
General Statements
Plant # K-0001604
MADE IN THE USA
FAST ABSORPTION MEDICINAL BOTANICALS
Amount Per Serving 333 mg Herb Weight Equivalence
Herb Strength Ratio 1:3
Seals/Symbols
L.a.(TM)
K PARVE
FDA Statement of Identity
DIETARY SUPPLEMENT
Formula
SINGLE HERB IN ALCOHOL
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Chamomile by L.A. Naturals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Chamomile by L.A. Naturals
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.
Certified organic Chamomile
Interacts with960 drugs
German chamomile is a widely used herbal remedy taken mainly as a tea for calming, sleep, and digestive complaints. Early research suggests possible b...
Certified organic Chamomile monograph & interactionsOther (inactive) ingredients: Grain Alcohol, Deionized Water. These complete the product’s ingredient list but are not active constituents.
Chamomile by L.A. Naturals Drug Interactions
HelloPharmacist Interaction Report
Chamomile by L.A.
Naturals is a single-ingredient liquid supplement, and its active component, German chamomile, does interact with a number of medications. The most serious concern is warfarin (Coumadin), a blood thinner: chamomile may increase warfarin's effects and raise your bleeding risk.
One documented case involved a patient who developed serious internal bleeding after drinking chamomile tea daily while on warfarin.
Read the full breakdown — every affected drug type, severity by severity
German chamomile can also cause additive sedative effects when combined with CNS depressants—medications that slow your brain and nervous system, like sleep aids, anxiety drugs, and opioids. Additionally, chamomile may slow how your liver clears certain medications by interfering with three major enzyme systems (CYP2D6, CYP2C9, and CYP3A4), which could raise levels of drugs metabolized this way and cause side effects.
These interactions are rated Moderate.
Large amounts of chamomile may also interfere with birth control pills and hormone replacement therapy through an antiestrogenic effect, and might reduce tamoxifen's (Nolvadex) effectiveness in cancer treatment—all Moderate concerns.
Altogether, these interactions span 961 individual medications. Before you start this product, run your exact medications through the checker on this page or talk them over with your doctor or pharmacist.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Chamomile?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Chamomile interact with 960 drugs. Click any drug to see the details.
1 of the 1 ingredient in Chamomile interact with drugs. Each result below shows which ingredient is responsible. certified organic Chamomile
Acetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Certified Organic Chamomile + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
How Acetaminophen, Chlorzoxazone, Codeine interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP2D6 and increase levels of drugs metabolized by these enzymes.
Read the full Certified Organic Chamomile + Acetaminophen, Chlorzoxazone, Codeine interactionAcetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine
How Acetaminophen, Codeine interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, German chamomile might have additive effects when used with CNS depressants.
Read the full Certified Organic Chamomile + Acetaminophen, Codeine interactionAcetaminophen, Codeine, DoxylamineMersyndol
How Acetaminophen, Codeine, Doxylamine interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP1A2 and increase levels of drugs metabolized by these enzymes.
Read the full Certified Organic Chamomile + Acetaminophen, Codeine, Doxylamine interactionAcetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP2D6 and increase levels of drugs metabolized by these enzymes.
Read the full Certified Organic Chamomile + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, DextromethorphanTylenol Cough Ex Strength
How Acetaminophen, Dextromethorphan interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP1A2 and increase levels of drugs metabolized by these enzymes.
Read the full Certified Organic Chamomile + Acetaminophen, Dextromethorphan interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP2D6 and increase levels of drugs metabolized by these enzymes.
Read the full Certified Organic Chamomile + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Certified Organic Chamomile + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP2D6 and increase levels of drugs metabolized by these enzymes.
Read the full Certified Organic Chamomile + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough
How Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Certified Organic Chamomile + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
How Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Certified Organic Chamomile + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAcetaminophen, Dextromethorphan, PseudoephedrineAlka-Seltzer PLUS Flu Liquid Gels, Non Aspirin Cold Caps, Tylenol Cold, Tylenol Flu Daytime Ex Strength, Tylenol Flu Ex Strength
How Acetaminophen, Dextromethorphan, Pseudoephedrine interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP2D6 and increase levels of drugs metabolized by these enzymes.
Read the full Certified Organic Chamomile + Acetaminophen, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Dichloralantipyrine, IsomethepteneAmidrine, Midchlor, Migquin, Migratine
How Acetaminophen, Dichloralantipyrine, Isometheptene interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP1A2 and increase levels of drugs metabolized by these enzymes.
Read the full Certified Organic Chamomile + Acetaminophen, Dichloralantipyrine, Isometheptene interactionAcetaminophen, Dichloralphenazone, IsomethepteneMidrin
How Acetaminophen, Dichloralphenazone, Isometheptene interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might have additive effects when used with CNS depressants.
Read the full Certified Organic Chamomile + Acetaminophen, Dichloralphenazone, Isometheptene interactionAcetaminophen, Dichlorophenazone, IsometheptaneIsocom
How Acetaminophen, Dichlorophenazone, Isometheptane interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP1A2 and increase levels of drugs metabolized by these enzymes.
Read the full Certified Organic Chamomile + Acetaminophen, Dichlorophenazone, Isometheptane interactionAcetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
How Acetaminophen, Diphenhydramine interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might have additive effects when used with CNS depressants.
Read the full Certified Organic Chamomile + Acetaminophen, Diphenhydramine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might have additive effects when used with CNS depressants.
Read the full Certified Organic Chamomile + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionAcetaminophen, HydrocodoneAnexsia, Anodynos DHC, Azdone, Co-Gesic, Doucet, Lorcet +9 more
How Acetaminophen, Hydrocodone interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP2D6 and increase levels of drugs metabolized by these enzymes.
Read the full Certified Organic Chamomile + Acetaminophen, Hydrocodone interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP2C9 and increase levels of drugs metabolized by these enzymes.
Read the full Certified Organic Chamomile + Acetaminophen, Ibuprofen interactionAcetaminophen, MeperidineDemerol APAP
How Acetaminophen, Meperidine interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP1A2 and increase levels of drugs metabolized by these enzymes.
Read the full Certified Organic Chamomile + Acetaminophen, Meperidine interactionAcetaminophen, OxycodonePercocet, Roxicet, Tylox, Xartemis XR
How Acetaminophen, Oxycodone interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP1A2 and increase levels of drugs metabolized by these enzymes.
Read the full Certified Organic Chamomile + Acetaminophen, Oxycodone interactionAcetaminophen, PentazocineTalacen
How Acetaminophen, Pentazocine interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP1A2 and increase levels of drugs metabolized by these enzymes.
Read the full Certified Organic Chamomile + Acetaminophen, Pentazocine interactionAcetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
How Acetaminophen, Phenylephrine, Chlorpheniramine interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Certified Organic Chamomile + Acetaminophen, Phenylephrine, Chlorpheniramine interactionAcetaminophen, PropoxypheneDarvocet-N 100, Darvocet-N 50, E-Lor, Wygesic
How Acetaminophen, Propoxyphene interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, German chamomile might have additive effects when used with CNS depressants.
Read the full Certified Organic Chamomile + Acetaminophen, Propoxyphene interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCns Depressants Moderate
Interaction Summary
Theoretically, German chamomile might have additive effects when used with CNS depressants.
Read the full Certified Organic Chamomile + Acetazolamide interactionAdagrasibKrazati
How Adagrasib interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Certified Organic Chamomile + Adagrasib interactionAerosphere Budesonide, Formoterol Fumarate, GlycopyrrolateBreztri
How Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP2D6 and increase levels of drugs metabolized by these enzymes.
Read the full Certified Organic Chamomile + Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interactionAgomelatineValdoxan
How Agomelatine interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP2C9 and increase levels of drugs metabolized by these enzymes.
Read the full Certified Organic Chamomile + Agomelatine interactionAlfentanilAlfenta
How Alfentanil interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might have additive effects when used with CNS depressants.
Read the full Certified Organic Chamomile + Alfentanil interactionAlfuzosinUroxatral
How Alfuzosin interacts with Chamomile — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic ChamomileCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Certified Organic Chamomile + Alfuzosin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Chamomile with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
certified organic Chamomile
Cns Depressants
Theoretically, German chamomile might have additive effects when used with CNS depressants.
German chamomile has mild sedative effects. Theoretically, concomitant use with drugs with sedative properties can cause additive effects and side effects.
Contraceptive Drugs
Theoretically, large amounts of German chamomile might reduce the effectiveness of oral contraceptives.
In vitro, German chamomile has demonstrated antiestrogenic activity. Theoretically, concomitant use of large amounts of German chamomile might interfere with contraceptive drugs through competition for estrogen receptors.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, German chamomile might inhibit CYP2C9 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP2C9. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP2C9 in patients taking German chamomile.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, German chamomile might inhibit CYP2D6 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP2D6. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP2D6 in patients taking German chamomile.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP3A4. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP3A4 in patients taking German chamomile.
Estrogens
Theoretically, large amounts of German chamomile might reduce the effectiveness of estrogens.
In vitro, German chamomile has demonstrated antiestrogenic activity. Theoretically, large amounts of German chamomile might interfere with hormone replacement therapy through competition for estrogen receptors.
Tamoxifen (Nolvadex)
Theoretically, large amounts of German chamomile might interfere with the activity of tamoxifen.
In vitro, German chamomile has demonstrated antiestrogenic activity.
Warfarin (Coumadin)
German chamomile might increase the effects of warfarin and increase the risk of bleeding.
In one case, a 70-year-old female taking warfarin developed retroperitoneal hematoma and bilateral recti muscle bleeding along with an INR of 7.9 following ingestion of German chamomile tea 4-5 cups daily and use of a topical chamomile-based lotion applied 4-5 times daily.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, German chamomile might inhibit CYP1A2 and increase levels of drugs metabolized by these enzymes.
In vitro and animal research shows that German chamomile might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP1A2 in patients taking German chamomile.
Brand information
Manufacturer and brand details for Chamomile, from the product label.
L.A. Naturals
See all L.A. Naturals products- Name
- Palko Services
- Street Address
- 4991 W. US Hwy 20
- City
- Michigan City
- State
- IN
- ZipCode
- 46360
Chamomile by L.A. Naturals: Common Questions
Does Chamomile by L.A. Naturals interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm allergic to ragweed?
What side effects might I experience?
Is this safe during pregnancy?
Can I use this while breastfeeding?
Does chamomile actually work for anxiety?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Chamomile’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Chamomile's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 15 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
German Chamomile 15 references
- Subiza J, Subiza JL, Hinojosa M, et al. Anaphylactic reaction after the ingestion of chamomile tea; a study of cross-reactivity with other composite pollens. J Allergy Clin Immunol 1989;84:353-8. PubMed
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- Viola H, Wasowski C, Levi de Stein M, et al. Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. Planta Med 1995;61:213-6.
- van Ketel WG. Allergy to Matricaria chamomilla. Contact Dermatitis 1982;8:143. PubMed
- van Ketel WG. Allergy to Matricaria chamomilla. Contact Dermatitis 1987;16:50-1. PubMed
- Hormann HP, Korting HC. Evidence for the efficacy and safety of topical herbal drugs in dermatology: part I: anti-inflammatory agents. Phytomedicine 1994;1:161-71. PubMed
- Avallone R, Zanoli P, Puia G, et al. Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. Biochem Pharmacol 2000;59:1387-94. PubMed
- Kassi E, Papoutsi Z, Fokialakis N, et al. Greek plant extracts exhibit selective estrogen receptor modulator (SERM)-like properties. J Agric Food Chem 2004;52:6956-61. PubMed
- Maliakal PP, Wanwimolruk S. Effect of herbal teas on hepatic drug metabolizing enzymes in rats. J Pharm Pharmacol 2001;53:1323-9. PubMed
- Segal R, Pilote L. Warfarin interaction with Matricaria chamomilla. CMAJ 2006;174:1281-2. PubMed
- Loggia RD, Traversa U, Scarcia V, et al. Depressive effects of Chamomilla recutita (L.) Rausch, tubular flowers, on central nervous system in mice. Pharmacol Res Commun 1982;14(2):153-162. PubMed
- Ganzera M, Schneider P, Stuppner H. Inhibitory effects of the essential oil of chamomile (Matricaria recutita L.) and its major constituents on human cytochrome P450 enzymes. Life Sci 2006;78(8):856-861. PubMed
- Benito P, Rodríguez-Perez R, García F, Juste S, Moneo I, Caballero ML. Occupational allergic rhinoconjunctivitis induced by Matricaria chamomilla with tolerance of chamomile tea. J Investig Allergol Clin Immunol. 2014;24(5):369-70. No abstract available.
- Braga FT, Santos AC, Bueno PC, et al. Use of Chamomilla recutita in the prevention and treatment of oral mucositis in patients undergoing hematopoietic stem cell transplantation: a randomized, controlled, phase II clinical trial. Cancer Nurs 2015;38(4):32 PubMed
- Sarris J, Ravindran A, Yatham LN, et al. Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety T
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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