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Dietary supplement

Chewable Papaya Papain Ingredients & Drug Interactions

by Puritan's Pride

Chewable Papaya Papain label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Chewable Papaya Papain against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Chewable Papaya Papain is a dietary supplement by Puritan's Pride with 1 active ingredient. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Chewable Papaya Papain by Puritan's Pride

Ask about any prescription or over-the-counter medication and we check it for interactions with Chewable Papaya Papain by Puritan's Pride — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Chewable Papaya Papain by Puritan's Pride

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This chewable tablet contains one active ingredient: papain, a protein-digesting enzyme derived from papaya. Papain is intended to help break down proteins in food.

The product also includes inactive ingredients — sucrose, dextrates, stearic acid, colorants, and flavorings — that serve as sweeteners, binders, and taste enhancers.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Papain product and its label doesn't state a use — see Papain's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we have on file does not establish that papain works for the conditions it's marketed for. Insufficient reliable evidence exists for cancer, dental caries, radiation dermatitis, exercise-induced muscle soreness, herpes zoster (shingles), and intestinal parasites.

If you're considering this product for any of those uses, talk with your pharmacist or doctor about what the science actually supports.

The evidence, ingredient by ingredient Papain

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papain from food is generally well tolerated, but supplements may irritate your digestive tract or cause allergic reactions in sensitive people. Short-term use at normal doses appears safe.

High oral doses may be unsafe and can cause rare but serious problems like severe inflammation of the stomach lining or even perforation of the esophagus. Some people experience itchy watery eyes, runny nose, sneezing, stomach cramps, sweating, or diarrhea if they're sensitive to papain.

Concentrated papain and unripe papaya products are not recommended in pregnancy because of safety concerns. There isn't enough reliable safety data to recommend papain supplements while breastfeeding — talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Papain

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Papain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take warfarin (Coumadin) or any blood thinner, stop and talk to your pharmacist or doctor before taking this product — papain may increase bleeding risk. Check your exact medications on this page before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is intended as a digestive aid, but we don't have solid evidence it works for any specific health condition. The main concern is people taking warfarin or other blood thinners — papain may increase the drug's effects and risk of bleeding.

If you're on any blood thinner, check with your pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Chewable Papaya Papain, straight from the product label.

Brand Puritan's Pride
Barcode (UPC) 025077120314
Net contents 100 Delicious Chewable Tablet(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 286079
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Chewable Papaya Papain by Puritan's Pride, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Tablet(s)
Maximum serving Sizes:
3 Tablet(s)
Servings per container
33
UPC/BARCODE
025077120314
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
Added Sugars1 Gram(s)2%
Total Sugars1 Gram(s)--
Papain3.99 mg--

Other ingredients: Sucrose, Dextrates, Stearic Acid, FD&C Yellow # 6 Lake, Magnesium Silicate, Maltodextrin, Natural and Artificial flavors

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Puritan's Pride supplements are produced from the finest raw materials under stringent quality control standards. State-of-the-art manufacturing and packaging facilities ensure you the highest quality nutritional supplements money can buy. When it comes to your health...choose the best.

To reorder item # 12031 www.puritan.com 1-800-645-1030

Precautions

WARNING: If you are pregnant, nursing, taking any medications or have any medical condition, including a known sensitivity to latex, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Contains bioengineered food ingredients.

Storage

Store at room temperature

Brand IP Statement(s)

Copyright 2021 Puritan's Pride, Inc.

The After Meal Supplement

Seals/Symbols

QA Quality Assured

Formulation

Digestive Enzyme

Vegetarian Dietary Supplement

No artificial sweetener, No milk, No lactose, No soy, No gluten, No wheat, No yeast, No fish. Sodium free.

FDA Statement of Identity

Vegetarian Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, chew three (3) tablets one to three times daily with a meal.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Chewable Papaya Papain by Puritan's Pride label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Chewable Papaya Papain label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Chewable Papaya Papain by Puritan's Pride

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Tablet(s) Dosage formTablet Or Pill Servings per container33 Amounts shown are per serving.

Papain

Interacts with
2 drugs
3.99 mg per serving Form: Papaya

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Other (inactive) ingredients: Sucrose, Dextrates, Stearic Acid, FD&C Yellow # 6 Lake, Magnesium Silicate, Maltodextrin, Natural and Artificial flavors. These complete the product’s ingredient list but are not active constituents.

Interaction report

Chewable Papaya Papain by Puritan's Pride Drug Interactions

Want to check YOUR meds against Chewable Papaya Papain?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

Papain 2

Individual Drug Interactions

The ingredients in Chewable Papaya Papain interact with 2 drugs. Click any drug to see the details.

1 of the 1 ingredient in Chewable Papaya Papain interact with drugs. Each result below shows which ingredient is responsible. Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Chewable Papaya Papain with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Chewable Papaya Papain, from the product label.

Puritan's Pride

See all Puritan's Pride products
Name
Puritan's Pride, Inc.
City
Ronkonkoma
State
NY
ZipCode
11779
Phone Number
1-800-645-1030
Web Address
www.puritan.com
Pharmacist Counseling Corner

Chewable Papaya Papain by Puritan's Pride: Common Questions

Does Chewable Papaya Papain by Puritan's Pride interact with any medications?
Yes. Based on its ingredients, Chewable Papaya Papain has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Chewable Papaya Papain contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Concentrated papain and unripe papaya products are not recommended in pregnancy. For breastfeeding, there isn't enough safety data — talk with your doctor or pharmacist about what's right for you.
What's papain and what does it do?
Papain is an enzyme from papaya that breaks down proteins in food. It's sold as a digestive aid, though we don't have solid evidence it works for specific health conditions.
Are there any side effects I should watch for?
Most people tolerate papain well at normal doses. Some sensitive people experience allergic reactions — itchy watery eyes, runny nose, sneezing, stomach cramps, or diarrhea. High doses may cause serious stomach irritation. If you have a papain allergy, skip this product.
Does this really help with digestion or muscle soreness?
We don't have reliable evidence that papain works for digestive issues, muscle soreness after exercise, or the other conditions marketed. The evidence is insufficient to rate it.
Is there anything in this besides papain?
The chewable also contains inactive ingredients like sucrose (sugar), stearic acid (a binder), and flavorings to make it taste better. Papain is the only active ingredient.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Chewable Papaya Papain is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Chewable Papaya Papain label
Go deeper

The Full Monographs Behind Chewable Papaya Papain’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph →
Sources

Sources & How We Checked

Chewable Papaya Papain's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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