Chi Shao Alcohol Free Ingredients & Drug Interactions
by Herbal Terra
What is this page for?
First and foremost: checking Chi Shao Alcohol Free against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Chi Shao Alcohol Free is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for menstrual cramps and irregular periods, muscle cramps and spasms, anxiety and stress.Based on those ingredients, 811 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Paeonia rubra Root Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Chi Shao Alcohol Free by Herbal Terra
Ask about any prescription or over-the-counter medication and we check it for interactions with Chi Shao Alcohol Free by Herbal Terra — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Chi Shao Alcohol Free by Herbal Terra
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Chi Shao Alcohol Free contains one active ingredient: Paeonia rubra (red peony) root extract in dried form. Red peony is used in traditional Chinese medicine, though the evidence supporting its use for specific conditions like aging skin, migraines, and fatigue is not established in the data we hold.
The product also contains glycerin and water as inactive ingredients.
Does it work?
Couldn't assess
The data we hold does not establish reliable evidence for red peony's effectiveness for any of the conditions listed — aging skin, anal fissures, atherosclerosis, chronic fatigue, cirrhosis, or migraines all fall into the "insufficient evidence" category. That doesn't mean it doesn't work; it means the quality of research so far isn't strong enough to confirm a real benefit.
How safe is it?
Well-documented data
Red peony is generally well tolerated when used short-term, though high-quality safety data are limited. The most common side effects when taken by mouth are gastrointestinal — abdominal bloating, loss of appetite, diarrhea, nausea, and general stomach discomfort.
One clinical trial found diarrhea in about 5% of people taking a peony extract at 600 mg three times daily for 24 weeks. There's also one case report of bleeding problems (easy gum bleeding, nosebleeds, and bruising) in a person on warfarin who switched to a Chinese herbal blend containing red peony — though that product had other ingredients too.
Do not use during pregnancy; there isn't enough safety data. Similarly, don't use while breastfeeding unless you talk with your doctor or pharmacist first.
Meds to double-check
Moderate interaction found
Before taking this product, check your medications against these types: blood thinners and antiplatelet drugs (moderate concern for increased bleeding), drugs broken down by CYP1A2 and CYP3A4 enzymes (moderate risk of increased drug levels), estrogen-based hormones and birth control pills (moderate risk of interference or added estrogen effects), clozapine (antipsychotic), and phenytoin (seizure medication). If you take any of these, verify with the tool or your pharmacist.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Chi Shao Alcohol Free is a single-ingredient red peony product. If you're on blood thinners, certain psychiatric or seizure medications, or hormone therapy, you need to check this against your exact medications before starting — the interaction potential is real, even if not proven in humans yet.
Talk with your pharmacist to decide if it's right for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Chi Shao Alcohol Free, straight from the product label.
| Brand | Herbal Terra |
|---|---|
| Barcode (UPC) | 7386004956974 |
| Net contents | 2 Fluid Ounce(s); 60 mL |
| Market status | On market |
| Date entered into DSLD | Nov 22, 2024 |
| DSLD ID | 324068 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Chi Shao Alcohol Free by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Paeonia rubra Root Extract, Dry | 1156 mg | -- |
Other ingredients: Glycerin, Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz. of juice or water up to 4 times a day.
Precautions
We recommend to seek expert medical advice before taking. May have contraindications and cause adverse reaction.
Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications.
Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications. Keep out of the reach of children!
Do not use if you are allergic to any ingredients.
Storage
Store in a cool, dry, dark place.
FDA Disclaimer Statement
This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.
Formulation
cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.
Sugar free
Expertly extracted 100% natural Premium product
No alcohol (ethyl), artificial ingredients, color additives, fillers or binders.
Natural Gluten free
Formula
Paeonia rubra
FDA Statement of Identity
Herbal Supplement
Seals/Symbols
Made in USA
General Statements
organic raw material
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Chi Shao Alcohol Free by Herbal Terra label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Chi Shao Alcohol Free by Herbal Terra
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.
Paeonia rubra Root Extract, Dry
Interacts with811 drugs
Peony root is a traditional Chinese medicine herb often used for menstrual problems, cramps, and inflammation, frequently as part of combination formu...
Paeonia rubra Root Extract, Dry monograph & interactionsOther (inactive) ingredients: Glycerin, Water. These complete the product’s ingredient list but are not active constituents.
Chi Shao Alcohol Free by Herbal Terra Drug Interactions
HelloPharmacist Interaction Report
Chi Shao Alcohol Free by Herbal Terra contains red peony root extract, which has documented interactions with several medication types.
The most serious concern is with blood thinners (anticoagulants) and antiplatelet drugs — peony may increase bleeding risk based on lab research suggesting it has blood-thinning properties, though this hasn't been confirmed in humans.
Read the full breakdown — every affected drug type, severity by severity
The ingredient also affects how your liver processes certain medications. It may slow the breakdown of drugs metabolized by CYP1A2 and CYP3A4 enzymes, potentially raising their levels in your body — including the antipsychotic clozapine specifically.
Additionally, peony has estrogenic activity in lab studies, so it theoretically could interfere with hormone replacement therapy and birth control pills by competing for estrogen receptors. There's also a theoretical concern with the seizure medication phenytoin, where animal research suggests peony might lower its effectiveness, though human studies haven't confirmed this.
Altogether, these interactions span 801 individual medications. Use the medication checker on this page to verify your specific drugs before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Chi Shao Alcohol Free?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Chi Shao Alcohol Free interact with 811 drugs. Click any drug to see the details.
1 of the 1 ingredient in Chi Shao Alcohol Free interact with drugs. Each result below shows which ingredient is responsible. Paeonia rubra Root Extract, Dry
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Paeonia Rubra Root Extract, Dry + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, combining peony with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Paeonia Rubra Root Extract, Dry + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Paeonia Rubra Root Extract, Dry + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Paeonia Rubra Root Extract, Dry + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Paeonia Rubra Root Extract, Dry + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, combining peony with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Paeonia Rubra Root Extract, Dry + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Paeonia Rubra Root Extract, Dry + Acalabrutinib interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, combining peony with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Paeonia Rubra Root Extract, Dry + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Paeonia Rubra Root Extract, Dry + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Paeonia Rubra Root Extract, Dry + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Paeonia Rubra Root Extract, Dry + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Paeonia Rubra Root Extract, Dry + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Paeonia Rubra Root Extract, Dry + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Paeonia Rubra Root Extract, Dry + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Paeonia Rubra Root Extract, Dry + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Paeonia Rubra Root Extract, Dry + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Paeonia Rubra Root Extract, Dry + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Paeonia Rubra Root Extract, Dry + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Paeonia Rubra Root Extract, Dry + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Paeonia Rubra Root Extract, Dry + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Paeonia Rubra Root Extract, Dry + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Paeonia Rubra Root Extract, Dry + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Paeonia Rubra Root Extract, Dry + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Paeonia Rubra Root Extract, Dry + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Paeonia Rubra Root Extract, Dry + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Paeonia Rubra Root Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Paeonia Rubra Root Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Paeonia Rubra Root Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Paeonia Rubra Root Extract, Dry + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Chi Shao Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Paeonia Rubra Root Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Paeonia Rubra Root Extract, Dry + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Chi Shao Alcohol Free with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Paeonia rubra Root Extract, Dry
Anticoagulant/Antiplatelet Drugs
Theoretically, combining peony with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research suggests that peony might have antiplatelet, anticoagulant, and antithrombotic effects.
Clozapine (Clozaril)
Theoretically, peony might increase the levels and clinical effects of clozapine.
In vitro research shows that peony suppresses the metabolism of clozapine via weak-to-moderate inhibitory effects on cytochromes P450 (CYP) 1A2 and CYP3A4. This effect has not been reported in humans.
Contraceptive Drugs
Theoretically, peony might interfere with contraceptive drugs due to competition for estrogen receptors.
In vitro and animal research shows that peony extract has estrogenic activity. Concomitant use might also increase the risk for estrogen-related adverse effects.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research shows that peony suppresses the metabolism of clozapine via weak-to-moderate inhibitory effects on CYP1A2 and CYP3A4. This effect has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.
In vitro research shows that peony suppresses the metabolism of clozapine via weak-to-moderate inhibitory effects on CYP1A2 and CYP3A4. This effect has not been reported in humans.
Estrogens
Theoretically, concomitant use of large amounts of peony might interfere with hormone replacement therapy and/or increase the risk for estrogen-related adverse effects.
In vitro and animal research shows that peony extract has estrogenic activity. Theoretically, peony might compete for estrogen receptors and/or cause additive estrogenic effects.
Phenytoin (Dilantin)
Theoretically, peony might reduce the levels and clinical effects of phenytoin.
Animal research shows that taking peony root reduces levels of phenytoin. Some researchers suggest that peony root might affect cytochrome P450 (CYP) 2C9, which metabolizes phenytoin. However, preliminary research in humans shows that peony root does not alter levels of losartan (Cozaar), which is also metabolized by CYP2C9.
Brand information
Manufacturer and brand details for Chi Shao Alcohol Free, from the product label.
Herbal Terra
See all Herbal Terra products- Name
- Herbal Terra LLC
- Phone Number
- +18083857868
- Web Address
- herbalterra.com
Chi Shao Alcohol Free by Herbal Terra: Common Questions
Does Chi Shao Alcohol Free by Herbal Terra interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm on birth control?
What side effects should I expect?
Is it safe during pregnancy?
Can I use this while breastfeeding?
Does it actually work for what it claims?
What happens if I take it with a blood thinner like warfarin?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Chi Shao Alcohol Free’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Chi Shao Alcohol Free's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 15 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Peony 15 references
- Chen LC, Chou MH, Lin MF, Yang LL. Effects of Paeoniae Radix, a traditional Chinese medicine, on the pharmacokinetics of phenytoin. J Clin Pharm Ther 2001;26:271-8. PubMed
- Guo TL, Zhou XW. [Clinical observations on the treatment of the gestational hypertension syndrome with Angelica and Paeonia powder]. Zhong Xi Yi Jie He Za Zhi 1986;6:714-6, 707.
- Xie HJ, Yasar U, Sandberg M, Rane A. Paeoniae Radix, a traditional Chinese medicine, and CYP2C9 activity. J Clin Pharm Ther 2002;27:229-30. . PubMed
- Harada M, Suzuki M, Ozaki Y. Effect of Japanese Angelica root and peony root on uterine contraction in the rabbit in situ. J Pharmacobiodyn 1984;7:304-11. PubMed
- Anon. Monograph. Peony (Paeonia spp). Alt Med Rev 2001;6:495-9.
- Bruynzeel DP. Contact Dermatitis Due to Paeonia (Peony). Contact Dermatitis 1989; 20:152-3..
- Bian, X., Xu, Y., Zhu, L., Gao, P., Liu, X., Liu, S., Qian, M., Gai, M., Yang, J., and Wu, Y. Prevention of maternal-fetal blood group incompatibility with traditional Chinese herbal medicine. Chin Med J (Engl.) 1998;111(7):585-587.
- Wong, A. L. and Chan, T. Y. Interaction between warfarin and the herbal product quilinggao. Ann Pharmacother 2003;37(6):836-838.
- Cai Y, Yuan Q, Xu K, et al. Assessment of the therapeutic effect of total glycosides of peony for juvenile idiopathic arthritis: a systematic review and meta-analysis. Evid Based Complement Alternat Med 2016;2016:8292486.
- Koo YK, Kim JM, Koo JY, et al. Platelet anti-aggregatory and blood anti-coagulant effects of compounds isolated from Paeonia lactiflora and Paeonia suffruticosa. Pharmazie 2010;65(8):624-8.
- Wang W, Tian DD, Zheng B, et al. Peony-glycyrrhiza decoction, an herbal preparation, inhibits clozapine metabolism via cytochrome P450s, but not flavin-containing monooxygenase in in vitro models. Drug Metab Dispos 2015;43(7):1147-53. PubMed
- Zhou Y, Jin L, Kong F, et al. Clinical and immunological consequences of total glucosides of paeony treatment in Sjögren's syndrome: A randomized controlled pilot trial. Int Immunopharmacol. 2016 Oct;39:314-319. doi: 10.1016/j.intimp.2016.08.006. PubMed
- Zhu Q, Qi X, Wu Y, Wang K. Clinical study of total glucosides of paeony for the treatment of diabetic kidney disease in patients with diabetes mellitus. Int Urol Nephrol. 2016 Nov;48(11):1873-1880. doi: 10.1007/s11255-016-1345-5. PubMed
- Xu Y, Li X, Chen T, et al. Radix Paeoniae Alba increases serum estrogen level and up-regulates estrogen receptor expression in uterus and vagina of immature/ovariectomized mice. Phytother Res. 2019;33(1):117-29. [RETRACTED].
- Liu X, Li X, Li X, et al. The efficacy and safety of total glucosides of peony in the treatment of primary Sjögren's syndrome: a multi-center, randomized, double-blinded, placebo-controlled clinical trial. Clin Rheumatol. 2019;38(3):657-64. Erratum i
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC