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Dietary supplement

Chocamine Extract 2580 Grams Ingredients & Drug Interactions

by Nootropics Depot

Chocamine Extract 2580 Grams label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Chocamine Extract 2580 Grams against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Chocamine Extract 2580 Grams is a dietary supplement by Nootropics Depot with 1 active ingredient. Its ingredients are commonly taken for heart and blood vessel health, high blood pressure, high cholesterol.Based on those ingredients, 1,394 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chocamine Proprietary Cocoa extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Chocamine Extract 2580 Grams by Nootropics Depot

Ask about any prescription or over-the-counter medication and we check it for interactions with Chocamine Extract 2580 Grams by Nootropics Depot — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Chocamine Extract 2580 Grams by Nootropics Depot

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 7 active ingredients.
  • “Spices” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Chocamine Proprietary Cocoa extract” is a proprietary blend — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

Chocamine Extract 2580 Grams contains seven ingredients. The active ones are natural vanilla flavor, theobromine (from cocoa), ginger, cinnamon, tapioca starch, allspice, and lowfat cocoa extract.

Two ingredients listed—Spices and Chocamine Proprietary Cocoa extract—are blend containers whose components are listed individually above. The product contains no inactive other ingredients listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Cardiovascular disease (CVD) — rated "Possibly Effective" (Cocoa) (Natural Medicines).
  • On file: Osteoarthritis — rated "Possibly Effective" (Ginger) (Natural Medicines).
  • On file: Pregnancy-induced nausea and vomiting — rated "Possibly Effective" (Ginger) (Natural Medicines).
  • On file: Dysmenorrhea — rated "Possibly Effective" (Ginger) (Natural Medicines).

Theobromine (cocoa) is possibly effective for cardiovascular disease but possibly ineffective for stretch marks; evidence is insufficient for several other uses including HIV-related cholesterol problems, aging skin, and asthma. Ginger is possibly effective for pregnancy-related nausea and vomiting and for period pain (dysmenorrhea), and possibly effective for osteoarthritis, but possibly ineffective for exercise-related muscle soreness and chemotherapy-related nausea.

Cinnamon, vanilla, tapioca starch, and allspice have insufficient evidence or no established ratings in our data for their potential benefits.

The evidence, ingredient by ingredient Cocoa Vanilla Tapioca

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cocoa is generally well tolerated but contains caffeine and stimulants; common side effects include stomach upset, constipation, headache, nausea, and gas. In rare cases, it may cause fast heart rate (tachycardia).

Ginger is generally well tolerated at typical amounts but can cause heartburn, stomach discomfort, diarrhea, belching, and a peppery mouth sensation — higher doses increase the risk of side effects. Cinnamon in food amounts is likely safe, but large doses over time carry theoretical concern for liver harm due to its coumarin content.

Vanilla at food amounts is generally recognized as safe, but concentrated supplement doses aren't well studied; allergic reactions including contact dermatitis have been reported in sensitive people. Tapioca is well tolerated; gastrointestinal side effects like bloating and flatulence are possible.

Allspice can cause allergic skin reactions in sensitive individuals. All ingredients listed are likely safe in pregnancy and lactation, though cocoa's caffeine does pass into breast milk — keep intake modest and watch your baby for fussiness.

Side effects, ingredient by ingredient Cocoa Vanilla Tapioca

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 6 matched ingredients can interact with medications — Allspice, Cocoa, Ginger, Cassia Cinnamon.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,395 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check with your pharmacist if you take any stimulants (ephedrine), blood thinners or antiplatelet drugs (warfarin, aspirin, others), diabetes medications, blood pressure drugs, heart medications (beta-agonists, nifedipine, dipyridamole), sleep aids (pentobarbital), antibiotics (quinolones), cancer medications, or any drug metabolized by the liver. The cocoa and ginger in this product interact with all of these.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product may appeal to you if you're looking for cocoa and ginger benefits for heart health or nausea. But if you take blood thinners, diabetes medications, heart drugs, antidepressants, or stimulants, you need to check with your pharmacist first — the interactions are real.

Pregnant or nursing? The ingredients are generally considered safe in food amounts, but talk to your doctor about supplement-strength doses.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Chocamine Extract 2580 Grams, straight from the product label.

Brand Nootropics Depot
Net contents 8.8 Ounce(s); 250 Gram(s)
Market status On market
Date entered into DSLD Jun 23, 2021
DSLD ID 251094
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Chocamine Extract 2580 Grams by Nootropics Depot, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1000 mg
Maximum serving Sizes:
1000 mg
Servings per container
250
IngredientAmount% DV
natural Vanilla flavor0 NP--
Theobromine0 NP--
Ginger0 NP--
Cinnamon0 NP--
Tapioca Starch0 NP--
Allspice0 NP--
Spices0 NP--
Chocamine Proprietary Cocoa extract1000 mg--
lowfat Cocoa extract0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Precautions

Disclaimer: Always consult with a qualified health physician before taking any new dietary supplement.

Warning: Keep out of reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drug(s) or OTC medication(s).

Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drug(s) or OTC medication(s).

FDA Disclaimer Statement

This product is not intended to diagnose, treat, cure or prevent any diseases. These statements have not been evaluated by the Food and Drug Administration.

Brand IP Statement(s)

Chocamine is exclusively licensed by RFI, LLC.

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 1,000 mg once daily.

General Statements

Transfer scoops are not accurate forms of measurement. A milligram scale is needed to accurately measure dosages.

Storage

Storage: Store in a cool and dry place. Keep away from direct sunlight and heat.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Chocamine Extract 2580 Grams by Nootropics Depot label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Chocamine Extract 2580 Grams label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Chocamine Extract 2580 Grams by Nootropics Depot

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1000 mg Dosage formPowder Servings per container250 Amounts shown are per serving.

Chocamine Proprietary Cocoa extract

Interacts with
661 drugs
1000 mg per serving

Cocoa is rich in plant compounds called flavanols that may modestly support blood vessel function and blood pressure, but most chocolate products are...

Chocamine Proprietary Cocoa extract monograph & interactions
Interaction report

Chocamine Extract 2580 Grams by Nootropics Depot Drug Interactions

Want to check YOUR meds against Chocamine Extract 2580 Grams?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,394Drugs
1,332 Moderate 62 Minor

Ingredients driving the most interactions

Chocamine Proprietary Cocoa extract 661

Individual Drug Interactions

The ingredients in Chocamine Extract 2580 Grams interact with 1,394 drugs. Click any drug to see the details.

1 of the 1 ingredient in Chocamine Extract 2580 Grams interact with drugs. Each result below shows which ingredient is responsible. Chocamine Proprietary Cocoa extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Chocamine Extract 2580 Grams with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Chocamine Proprietary Cocoa extract37 drug types · 661 drugs

Ace Inhibitors (Aceis)

Theoretically, taking cocoa with ACEIs might increase the risk of adverse effects.
Human research shows that dark chocolate can inhibit ACE. Additionally, prolonged angioedema in an elderly patient on an ACE inhibitor was precipitated with intake of diabetic chocolate.

Likelihood Possible Evidence D
Adenosine (Adenocard)

Theoretically, cocoa might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Cocoa contains caffeine. Caffeine is a competitive inhibitor of adenosine at the cellular level. However, caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole than adenosine-induced stress testing.

Likelihood Possible Evidence B
Alcohol (Ethanol)

Theoretically, concomitant use might increase levels and adverse effects of caffeine.
Cocoa contains caffeine. Alcohol reduces caffeine metabolism. Concomitant use of alcohol can increase caffeine serum concentrations and the risk of caffeine adverse effects.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, cocoa may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Clinical research shows that intake of cocoa can inhibit platelet adhesion, aggregation, and activity and increase aspirin-induced bleeding time. For patients on dual antiplatelet therapy, cocoa may enhance the inhibitory effect of clopidogrel, but not aspirin, on platelet aggregation.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking cocoa with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that cocoa can modestly decrease blood pressure in hypertensive and normotensive patients.

Likelihood Possible Evidence D
Beta-Adrenergic Agonists

Theoretically, large amounts of cocoa might increase the cardiac inotropic effects of beta-agonists.
Cocoa contains caffeine. Theoretically, large amounts of caffeine might increase cardiac inotropic effects of beta-agonists. A case of atrial fibrillation associated with consumption of large quantities of chocolate in a patient with chronic albuterol inhalation abuse has also been reported.

Likelihood Probable Evidence D
Cytochrome P450 1A2 (Cyp1A2) Inhibitors

Theoretically, concomitant use might increase the levels and adverse effects of caffeine.
Cocoa contains caffeine. Caffeine is metabolized by cytochrome P450 1A2 (CYP1A2),. Theoretically, drugs that inhibit CYP1A2 may decrease the clearance rate of caffeine from cocoa and increase caffeine levels.

Likelihood Possible Evidence D
Dipyridamole (Persantine)

Theoretically, cocoa might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Cocoa contains caffeine. Caffeine may inhibit dipyridamole-induced vasodilation. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole than adenosine-induced stress testing.

Likelihood Probable Evidence B
Disulfiram (Antabuse)

Theoretically, disulfiram might increase the risk of adverse effects from caffeine.
Cocoa contains caffeine. In human research, disulfiram decreases the rate of caffeine clearance.

Likelihood Probable Evidence B
Diuretic Drugs

Theoretically, using cocoa with diuretic drugs might increase the risk of hypokalemia.
Cocoa contains caffeine. In excessive amounts, caffeine can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.

Likelihood Possible Evidence D
Ephedrine

Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Cocoa contains caffeine. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.

Likelihood Possible Evidence D
Estrogens

Theoretically, estrogens might increase the levels and adverse effects of caffeine.
Cocoa contains caffeine. Estrogen inhibits caffeine metabolism.

Likelihood Probable Evidence B
Flutamide (Eulexin)

Theoretically, cocoa might increase the levels and adverse effects of flutamide.
Cocoa contains caffeine. In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide.

Likelihood Possible Evidence D
Fluvoxamine (Luvox)

Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine.
Cocoa contains caffeine. Fluvoxamine reduces caffeine metabolism.

Likelihood Probable Evidence D
Lithium

Theoretically, abrupt cocoa withdrawal might increase the levels and adverse effects of lithium.
Cocoa contains caffeine. There are two case reports of lithium tremor that worsened upon abrupt coffee withdrawal.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Cocoa contains caffeine. Large amounts of caffeine with MAOIs might precipitate a hypertensive crisis.

Likelihood Possible Evidence D
Nicotine

Theoretically, concomitant use might increase the risk of hypertension.
Cocoa contains caffeine. Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.

Likelihood Probable Evidence B
Pentobarbital (Nembutal)

Theoretically, cocoa might decrease the effects of pentobarbital.
Cocoa contains caffeine. Caffeine might negate the hypnotic effects of pentobarbital.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

Theoretically, cocoa might reduce the effects of phenobarbital and increase the risk for convulsions.
Cocoa contains caffeine. Animal research suggests that caffeine can decrease the anticonvulsant activity of phenobarbital. The exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Phenylpropanolamine

Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Cocoa contains caffeine. Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, cocoa might reduce the effects of phenytoin and increase the risk for convulsions.
Cocoa contains caffeine. Animal research suggests that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.
Cocoa contains caffeine. Quinolones (also referred to as fluoroquinolones) decrease caffeine clearance.

Likelihood Probable Evidence B
Riluzole (Rilutek)

Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Cocoa contains caffeine. Caffeine and riluzole are both metabolized by cytochrome P450 1A2, and concomitant use might reduce metabolism of one or both agents.

Likelihood Possible Evidence D
Stimulant Drugs

Theoretically, concomitant use might increase stimulant adverse effects.
Cocoa contains caffeine. Concomitant use might increase the risk of stimulant adverse effects.

Likelihood Probable Evidence C
Theophylline

Theoretically, cocoa might increase the levels and adverse effects of theophylline.
Cocoa contains caffeine. Large amounts of caffeine might inhibit theophylline metabolism. Caffeine decreases theophylline clearance 23% to 29%.

Likelihood Probable Evidence B
Chocamine Proprietary Cocoa extract full monograph & all 37 interactions
The maker

Brand information

Manufacturer and brand details for Chocamine Extract 2580 Grams, from the product label.

Nootropics Depot

See all Nootropics Depot products
Name
Nootropics Depot
Street Address
8380 S. Kyrene Rd. Ste. 110
City
Tempe
State
AZ
ZipCode
85284
Web Address
nootropicsdepot.com
Pharmacist Counseling Corner

Chocamine Extract 2580 Grams by Nootropics Depot: Common Questions

Does Chocamine Extract 2580 Grams by Nootropics Depot interact with any medications?
Yes. Based on its ingredients, Chocamine Extract 2580 Grams has a known interaction with 1,394 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Chocamine Extract 2580 Grams contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product have any ingredients checked for interactions?
Yes. We checked theobromine (from cocoa), ginger, cinnamon, allspice, and lowfat cocoa extract. Natural vanilla flavor and tapioca starch were also checked and have no documented interactions. Two ingredients—Spices and Chocamine Proprietary Cocoa extract—are blends; their components are listed separately.
What is theobromine and why is it in here?
Theobromine is a stimulant naturally found in cocoa. It's in this product because the formula centers on cocoa extract, which contains theobromine and caffeine. Cocoa is possibly effective for heart health.
Why is ginger in Chocamine Extract?
Ginger is possibly effective for pregnancy-related nausea, period pain, and osteoarthritis, so it complements the other active ingredients. It does carry Moderate interactions with blood thinners and diabetes drugs, so check with your pharmacist if you take those.
Is vanilla safe to eat in this product?
Yes, vanilla is generally recognized as safe in food amounts. This product uses natural vanilla flavor. However, concentrated supplement doses of vanilla aren't well studied, so use it as directed and watch for any allergic skin reactions.
What side effects might I notice?
The most common are stomach upset, nausea, gas, constipation, heartburn, or headache from the cocoa and ginger. Ginger may also cause a peppery taste in your mouth. Rare cases of fast heart rate have been reported with cocoa. Allergic skin reactions are possible in sensitive people.
Is this safe during pregnancy or while breastfeeding?
The ingredients are rated likely safe or possibly safe for pregnancy and lactation, but cocoa's caffeine does pass into breast milk. Keep your intake modest and watch your baby for fussiness. Talk to your doctor or pharmacist about the right amount for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Chocamine Extract 2580 Grams label
Go deeper

The Full Monographs Behind Chocamine Extract 2580 Grams’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cocoa

Interacts with 661 drugs

Cocoa is rich in plant compounds called flavanols that may modestly support blood vessel function and blood pressure, but most chocolate products are high in sugar, fat, and calories, which...

Read the full Cocoa monograph → Herb & supplement monograph

Vanilla

Vanilla is best known and very safe as a food flavoring, and small amounts used in cooking are not a concern for most people. As a health supplement, evidence for any specific medical benefi...

Read the full Vanilla monograph → Herb & supplement monograph

Tapioca

Tapioca is a starch made from the root of the cassava plant and is mainly used as a food ingredient and gluten-free thickener, not as a medicinal supplement. It is generally safe to eat in n...

Read the full Tapioca monograph →
Sources

Sources & How We Checked

Chocamine Extract 2580 Grams's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 217 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vanilla 5 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Kanny, G., Hatahet, R., Moneret-Vautrin, D. A., Kohler, C., and Bellut, A. Allergy and intolerance to flavouring agents in atopic dermatitis in young children. Allerg.Immunol (Paris) 1994;26(6):204-210.
  3. Ferguson, J. E. and Beck, M. H. Contact sensitivity to vanilla in a lip salve. Contact Dermatitis 1995;33(5):352. PubMed
  4. The National Institute for Occupational Safety and Health (NIOSH). Registry of Toxic Effects of Chemical Substances (RTECS): Vanillin (CAS #121-33-5). Available at: https://www.cdc.gov/niosh-rtecs/YW581E98.html. Updated November 16,2018. Accessed October
  5. Bacqueville D, Maret A, Noizet M, et al. Efficacy of a dermocosmetic serum combining bakuchiol and vanilla tahitensis extract to prevent skin photoaging in vitro and to improve clinical outcomes for naturally aged skin. Clin Cosmet Investig Dermatol. 2020

See these in context on the Vanilla monograph →

Cocoa 119 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  4. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
  5. Harder S, Fuhr U, Staib AH, Wolff T. Ciprofloxacin-caffeine: a drug interaction established using in vivo and in vitro investigations. Am J Med 1989;87:89S-91S. PubMed
  6. Carbo M, Segura J, De la Torre R, et al. Effect of quinolones on caffeine disposition. Clin Pharmacol Ther 1989;45:234-40. PubMed
  7. Healy DP, Polk RE, Kanawati L, et al. Interaction between oral ciprofloxacin and caffeine in normal volunteers. Antimicrob Agents Chemother 1989;33:474-8. PubMed
  8. Mester R, Toren P, Mizrachi I, et al. Caffeine withdrawal increases lithium blood levels. Biol Psychiatry 1995;37:348-50. PubMed
  9. Jefferson JW. Lithium tremor and caffeine intake: two cases of drinking less and shaking more. J Clin Psychiatry 1988;49:72-3.
  10. Joeres R, Klinker H, Heusler H, et al. Influence of mexiletine on caffeine elimination. Pharmacol Ther 1987;33:163-9. PubMed
  11. Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3.
  12. Baron AM, Donnerstein RL, Samson RA, et al. Hemodynamic and electrophysiologic effects of acute chocolate ingestion in young adults. Am J Cardiol 1999;84:370-3. PubMed
  13. Friedman G. Diet and the irritable bowel syndrome. Gastroenterol Clin North Am 1991;20:313-24. DOI
  14. The National Toxicology Program (NTP). Caffeine. Center for the Evaluation of Risks to Human Reproduction (CERHR). Available at: http://cerhr.niehs.nih.gov/common/caffeine.html.
  15. Pollock BG, Wylie M, Stack JA, et al. Inhibition of caffeine metabolism by estrogen replacement therapy in postmenopausal women. J Clin Pharmacol 1999;39:936-40. PubMed
  16. Peirce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York, NY: William Morrow and Co., 1999.
  17. Weisburger JH. Tea and health: the underlying mechanisms. Proc Soc Exp Biol Med 1999;220:271-5. PubMed
  18. Briggs GB, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1998.
  19. Hagg S, Spigset O, Mjorndal T, Dahlqvist R. Effect of caffeine on clozapine pharmacokinetics in healthy volunteers. Br J Clin Pharmacol 2000;49:59-63. PubMed
  20. American Academy of Pediatrics. The transfer of drugs and other chemicals into human milk. Pediatrics 2001;108:776-89. PubMed
  21. Dietrich R, Paglieroni TG, Wun T, et al. Cocoa inhibits platelet activation and function. Am J Clin Nutr 2000;72:30-5. PubMed
  22. Sinclair CJ, Geiger JD. Caffeine use in sports. A pharmacological review. J Sports Med Phys Fitness 2000;40:71-9.
  23. Haller CA, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 2000;343:1833-8. PubMed
  24. Kockler DR, McCarthy MW, Lawson CL. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy 2001;21:647-51.. PubMed
  25. Nix D, Zelenitsky S, Symonds W, et al. The effect of fluconazole on the pharmacokinetics of caffeine in young and elderly subjects. Clin Pharmacol Ther 1992;51:183. DOI
  26. Nawrot P, Jordan S, Eastwood J, et al. Effects of caffeine on human health. Food Addit Contam 2003;20:1-30. PubMed
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See these in context on the Cocoa monograph →

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See these in context on the Ginger monograph →

Cassia Cinnamon 20 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
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  5. Press release. Cinnamon capsules to reduce blood sugar are medicinal products! Efficacy has not been scientifically proven - some products contain high levels of coumarin. Federal Institute of Risk Assessment (BfM), Germany, November 11, 2006. Available a
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  11. Altschuler JA, Casella SJ, MacKenzie TA, Curtis KM. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diabetes Care 2007;30(4):813-6. PubMed
  12. Stoecker BR, Zhan Z, Luo R, et al. Cinnamon extract lowers blood glucose in hyperglycemic subjects. FASEB J. 2010;22:722.1 (Abstract only). DOI
  13. Admani S, Hill H, Jacob SE. Cinnamon Sugar Scrub Dermatitis: "Natural" Is Not Always Best. Pediatr Dermatol. 2017;34(1):e42-e43. PubMed
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  16. Wickenberg J, Lindstedt S, Nilsson J, Hlebowicz J. Cassia cinnamon does not change the insulin sensitivity or the liver enzymes in subjects with impaired glucose tolerance. Nutr J 2014 Sep 24;13:96. PubMed
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  19. Bernaola J, Valverde-Monge M, Otal-Buesa M, Cullen D, Heras-Mendaza F. Cinnamon allergic contact cheilitis. Contact Dermatitis 2023;88(5):418-419. PubMed
  20. Patel K, Howard M, Tate B. Cheilitis caused by allergic contact dermatitis to cinnamon in chai tea: A case report. Contact Dermatitis 2023;88(3):239-240. PubMed

See these in context on the Cassia Cinnamon monograph →

Tapioca 4 references
  1. Kehoe SH, Chopra H, Sahariah SA, et al. Effects of a food-based intervention on markers of micronutrient status among Indian women of low socio-economic status. Br J Nutr. 2015;113(5):813-21. PubMed
  2. Yamada Y, Hosoya S, Nishimura S, et al. Effect of bread containing resistant starch on postprandial blood glucose levels in humans. Biosci Biotechnol Biochem. 2005;69(3):559-66. PubMed
  3. Astina J, Sapwarobol S. Attenuation of glycaemic and insulin responses following tapioca resistant maltodextrin consumption in healthy subjects: a randomised cross-over controlled trial. J Nutr Sci 2020;9:e29. PubMed
  4. Astina J, Saphyakhajorn W, Borompichaichartkul C, Sapwarobol S. Tapioca resistant maltodextrin as a carbohydrate source of oral nutrition supplement (ONS) on metabolic indicators: a clinical trial. Nutrients 2022;14(5):916. PubMed

See these in context on the Tapioca monograph →

Allspice 5 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Kanerva L, Estlander T, Jolanki R. Occupational allergic contact dermatitis from spices. Contact Dermatitis 1996;35:157-62. PubMed
  3. Chen SJ, Wang MH, Chen IJ. Antiplatelet and calcium inhibitory properties of eugenol and sodium eugenol acetate. Gen Pharmacol 1996;27:629-33. PubMed
  4. Niinimaki, A. Delayed-type allergy to spices. Contact Dermatitis 1984;11(1):34-40. PubMed
  5. Regula P, Edelman D, Ferastraoaru D, Ramesh M, Hudes G. Severe allergic reaction to allspice, a hidden food allergen. Ann Allergy Asthma Immunol. 2022;129(2):241-2. PubMed

See these in context on the Allspice monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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