Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

CholestOff Complete Ingredients & Drug Interactions

by Nature Made

CholestOff Complete label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking CholestOff Complete against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

CholestOff Complete is a dietary supplement by Nature Made with 3 active ingredients. Its ingredients are commonly taken for high cholesterol, high triglycerides, heart health support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pantethine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against CholestOff Complete by Nature Made

Ask about any prescription or over-the-counter medication and we check it for interactions with CholestOff Complete by Nature Made — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of CholestOff Complete by Nature Made

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 3 active ingredients.
  • “Plant Sterols and Plant Stanols” is listed as a grouped ingredient — the label gives one combined amount (900 mg) without saying how much of each component you get.

CholestOff Complete has three active ingredients. Pantethine is a form of pantothenic acid (vitamin B5) that may help with cholesterol and fat levels in the blood.

Plant sterols and plant stanols are compounds naturally found in plants that help block cholesterol absorption in your gut. The product also contains several inactive ingredients—gelatin capsule, oils, glycerin, and other excipients—to hold everything together.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: lowers dietary cholesterol and reduces liver cholesterol production.
  • We looked for evidence on: Hypercholesterolemia, Familial hypercholesterolemia, Hyperlipidemia, Hyperlipoproteinemia, Coronary heart disease (CHD), Myocardial infarction (MI) — and 2 related terms.
  • The strongest evidence on file: Plant Sterols is rated "Likely Effective" for Familial hypercholesterolemia (Natural Medicines).
  • Also on file: Plant Sterols is rated "Likely Effective" for Hypercholesterolemia.
  • Also on file: Pantethine is rated "Possibly Effective" for Hyperlipoproteinemia.

Plant sterols are likely effective for high cholesterol and possibly effective for heart disease. Pantethine is possibly effective for a blood-fat disorder called hyperlipoproteinemia, but the evidence for its use in general high cholesterol isn't strong enough to rate.

Plant stanols are listed as an ingredient but we hold no effectiveness data for them on file.

The evidence, ingredient by ingredient Pantethine Plant Sterols

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 1 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pantethine is generally well tolerated in studies, though long-term safety data are limited—gastrointestinal side effects like nausea, diarrhea, bloating, and flatulence are the most common complaints, and mild itching has been reported rarely. Plant sterols are generally well tolerated at typical amounts for most adults.

A case of widespread rash was reported in one person using a plant sterol supplement, and one child experienced abdominal discomfort in a trial, though gastrointestinal symptoms haven't been widespread in research. There's theoretical concern that plant sterols could cause diarrhea or fatty stools because of how they work in the gut, but this hasn't been documented in clinical studies.

Side effects, ingredient by ingredient Pantethine Plant Sterols

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Pantethine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your blood thinners and antiplatelet medications—pantethine may increase bleeding risk with anticoagulants like warfarin or dabigatran and with drugs like aspirin or clopidogrel (Plavix). This is a Moderate-severity concern.

For plant sterols and plant stanols, no interactions are documented in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may be worth considering if you're working on cholesterol and don't take blood thinners. If you use any anticoagulant or antiplatelet drug, talk with your doctor or pharmacist before adding it—pantethine's effect on bleeding risk needs to be weighed for your specific situation.

The evidence for pantethine's cholesterol benefit is modest, whereas plant sterols have solid support. Either way, run your medications through the interaction checker and have a conversation with your own healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 21, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about CholestOff Complete, straight from the product label.

Brand Nature Made
Net contents 120 Softgel(s)
Market status On market
Date entered into DSLD Apr 21, 2023
DSLD ID 271299
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Approved Health, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for CholestOff Complete by Nature Made, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Softgel(s)
Maximum serving Sizes:
3 Softgel(s)
Servings per container
40
IngredientAmount% DV
Calories15 Calorie(s)--
Total Fat1 Gram(s)1%
Protein1 Gram(s)--
Pantethine300 mg--
Plant Sterols and Plant Stanols900 mg--
Plant Sterols0 NP--
Plant Stanols0 NP--

Other ingredients: Plant Sterols, Plant Stanols, Gelatin, Sunflower Oil Esters, Pantethine, Glycerin, Medium Chain Triglycerides, Soy Lecithin, Water, Colors added

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Lowers dietary cholesterol & reduces cholesterol production in the liver

Colors derived from natural sources - No synthetic dyes No artificial flavors No preservatives No yeast or starch Gluten free

Products containing at least 400 mg per serving of plant sterols and stanols, eaten twice a day with meals for a daily intake of at least 800 mg as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease. One serving of Nature Made CholestOff Complete supplies 900 mg of plant sterols and stanols for a daily intake of 1800 mg.

Sterols/stanols are esterified with sunflower oil fatty acids.

USP has tested and verified ingredients, potency, and manufacturing process. USP sets official standard for dietary supplements. www.uspverified.org

Formula

With plant sterols and stanols

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Suggested use: Take three softgels two times daily with your two largest meals. For easier swallowing, take with water before and during ingestion.

Precautions

Caution: Not for use by children or pregnant or lactating women.

Caution: Not for use by children or pregnant or lactating women. Check with your physician before using CholestOff Complete if you are currently using any cholesterol-lowering or blood thinning medications, facing surgery, have bleeding problems, or undergoing any treatment that may affect the ability of blood to clot.

Store in a cool, dry place, out of reach of children.

Do not use if imprinted seal under cap is broken or missing.

Contains: Soy.

Storage

Keep bottle tightly closed. Store in a cool, dry place, out of reach of children.

Brand IP Statement(s)

Reducol Reducol is a trademark of Pharmachem Laboratories Inc.

Pantesin is a trademark of Daiichi F.C.Co., Ltd of Tokyo, Japan

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

CholestOff Complete by Nature Made label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

CholestOff Complete label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in CholestOff Complete by Nature Made

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Softgel(s) Dosage formSoftgel Capsule Servings per container40 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protein

1 Gram(s) per serving

Pantethine

Interacts with
122 drugs
300 mg per serving

Pantethine is a derivative of vitamin B5 (pantothenic acid) that some studies suggest may modestly lower cholesterol and triglycerides. The evidence i...

Pantethine monograph & interactions

Plant Sterols and Plant Stanols

No known
interactions
900 mg per serving Form: Esters

Plant sterols (and their close relatives, plant stanols) are natural compounds found in plants that can modestly lower LDL ('bad') cholesterol when ta...

Plant Sterols and Plant Stanols monograph & interactions

Other (inactive) ingredients: Plant Sterols, Plant Stanols, Gelatin, Sunflower Oil Esters, Pantethine, Glycerin, Medium Chain Triglycerides, Soy Lecithin, Water, Colors added. These complete the product’s ingredient list but are not active constituents.

Interaction report

CholestOff Complete by Nature Made Drug Interactions

Want to check YOUR meds against CholestOff Complete?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Pantethine 122

Individual Drug Interactions

The ingredients in CholestOff Complete interact with 122 drugs. Click any drug to see the details.

1 of the 3 ingredients in CholestOff Complete interact with drugs. Each result below shows which ingredient is responsible. Pantethine

Each ingredient & the kinds of drugs it affects

For each ingredient in CholestOff Complete with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pantethine1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, pantethine might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Some evidence suggests that pantethine reduces platelet aggregation.

Likelihood Possible Evidence B
Pantethine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for CholestOff Complete, from the product label.

Nature Made

See all Nature Made products
Name
Nature Made Nutritional Products
City
Mission Hills
State
CA
ZipCode
91346-9606
Phone Number
1-800-276-2878
Web Address
www.NatureMade.com
Pharmacist Counseling Corner

CholestOff Complete by Nature Made: Common Questions

Does CholestOff Complete by Nature Made interact with any medications?
Yes. Based on its ingredients, CholestOff Complete has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
CholestOff Complete contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my cholesterol?
Plant sterols in this product are likely effective for high cholesterol. Pantethine is possibly effective for a specific blood-fat disorder but hasn't been proven for typical high cholesterol. Results vary person to person—talk with your doctor about whether it fits your goals.
What side effects might I have?
The most common are mild—nausea, diarrhea, bloating, flatulence, and stomach discomfort from pantethine. Mild itching has been reported rarely. Plant sterols typically cause no problems, though there's a theoretical risk of diarrhea or fatty stools because of how they block cholesterol absorption in your gut, though this hasn't shown up in studies.
Is it safe during pregnancy or breastfeeding?
Safety data for pantethine in pregnancy and breastfeeding aren't strong enough to know either way—talk with your doctor before using it. Plant sterols have similar gaps in safety information for concentrated supplements during pregnancy and breastfeeding, so caution and a conversation with your healthcare provider are advised.
Can I take this long-term?
Pantethine is generally well tolerated in studies, but long-term safety data are limited. Plant sterols are generally well tolerated at typical amounts. For reassurance about using it over months or years, check with your doctor.
What exactly is pantethine?
Pantethine is a form of pantothenic acid, also called B5, that your body uses for energy and fat metabolism. It's been studied to see if it can help lower certain blood fats.
Does this product have any fillers or additives?
Yes—it contains gelatin, oils (sunflower oil esters and medium chain triglycerides), soy lecithin, glycerin, water, and added colors to make the softgel capsule. If you have soy allergies, the soy lecithin is worth noting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

CholestOff Complete label
Go deeper

The Full Monographs Behind CholestOff Complete’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pantethine

Interacts with 122 drugs

Pantethine is a derivative of vitamin B5 (pantothenic acid) that some studies suggest may modestly lower cholesterol and triglycerides. The evidence is limited and not strong enough to repla...

Read the full Pantethine monograph → Herb & supplement monograph

Plant Sterols

Plant sterols (and their close relatives, plant stanols) are natural compounds found in plants that can modestly lower LDL ('bad') cholesterol when taken regularly in adequate amounts, usual...

Read the full Plant Sterols monograph →
Sources

Sources & How We Checked

CholestOff Complete's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pantethine 9 references
  1. Da Col PG, Cattin L, Fonda M, et al. Pantethine in the treatment of hypercholesterolemia: a randomized double-blind trial versus tiadenol. Curr Ther Res 1984;36:314-22.
  2. Rubba P, Postaiglione B, De Simone F, et al. Comparative evaluation of the lipid-lowering effects of fenofibrate and pantethine in type II hyperlipoproteinemia. Curr Ther Res 1985;38:719-27.
  3. Coronel F, Tornero F, Torrente J, et al. Treatment of hyperlipemia in diabetic patients on dialysis with a physiological substance. Am J Nephrol 1991;11:32-6.. PubMed
  4. Agrati AM, Ambrosi G, Ferraro G, Palmieri. Gemfibrozil efficacy vs pantethine in dyslipoproteinemic patients: a controlled study. Curr Ther Res 1989;45:650-63.
  5. Rumberger, J. A., Napolitano, J., Azumano, I., Kamiya, T., and Evans, M. Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk No
  6. Hiramatsu, K., Nozaki, H., and Arimori, S. Influence of pantethine on platelet volume, microviscosity, lipid composition and functions in diabetes mellitus with hyperlipidemia. Tokai J.Exp.Clin.Med. 1981;6(1):49-57.
  7. McRae MP. Treatment of hyperlipoproteinemia with pantethine: A review and analysis of efficacy and tolerability. Nutrition Res 2005;25:319-333. DOI
  8. Cattin, L., Da Col, P. G., Fonda, M., Mameli, M. G., and Fergulio, G. A. Treatment of hypercholesterolemia with pantethine and fenofibrate; open randomized study on 43 subjects. Current Therapeutic Research 1985;38(Sep):386-395.
  9. Evans M, Rumberger JA, Azumano I, Napolitano JJ, Citrolo D, Kamiya T. Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded

See these in context on the Pantethine monograph →

Plant Sterols 3 references
  1. Guardamagna, O., Abello, F., Baracco, V., Federici, G., Bertucci, P., Mozzi, A., Mannucci, L., Gnasso, A., and Cortese, C. Primary hyperlipidemias in children: effect of plant sterol supplementation on plasma lipids and markers of cholesterol synthesis a
  2. Haque Hussain SS, Weir J, Roberts N. Severe dermatitis secondary to plant sterol supplements. Clin Exp Dermatol. 2009 Oct;34(7):e276-7. PubMed
  3. Xue P, Wang Y, Chen Y, et al. A Case of Peripheral Precocious Puberty May Be Caused by a Diet Containing Phytosterols in a 20-Month-Old Boy. Horm Res Paediatr 2022;95(5):484-491. PubMed

See these in context on the Plant Sterols monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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