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Dietary supplement

Choline Bitartrate 260 mg Ingredients & Drug Interactions

by Advance Physician Formulas

Choline Bitartrate 260 mg label
See full label image
Capsule Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Choline Bitartrate 260 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Choline Bitartrate 260 mg is a dietary supplement by Advance Physician Formulas with 1 active ingredient. Its ingredients are commonly taken for liver health and fatty liver, brain and memory support, prenatal nutrition and fetal development.Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Choline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Choline Bitartrate 260 mg by Advance Physician Formulas

Ask about any prescription or over-the-counter medication and we check it for interactions with Choline Bitartrate 260 mg by Advance Physician Formulas — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Choline Bitartrate 260 mg by Advance Physician Formulas

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: choline (260 mg per capsule as choline bitartrate). Choline is a nutrient your body uses for brain function, cell structure, and nerve signaling.

The capsule also contains cellulose and rice flour as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Choline's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: increase acetylcholine levels.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Cognitive function, Dementia, Infant development, Neural tube birth defects — and 3 related terms.
  • The closest evidence on file: Choline is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Choline is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease, Cognitive function, Dementia, Neural tube birth defects, and more.

The evidence we hold on choline for specific uses is mixed. For athletic performance, the data suggests it's possibly ineffective.

For bronchitis, age-related cognitive decline, liver disease related to intravenous nutrition (TPN-associated hepatic steatosis), hay fever, and Alzheimer disease, there isn't enough reliable evidence yet to make a rating. If you're considering choline for one of these purposes, talk with your pharmacist about what the current research shows.

The evidence, ingredient by ingredient Choline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Choline is well tolerated at normal doses. High-dose supplements—particularly doses exceeding 3.5 grams daily—can cause side effects.

At doses of 9 grams or more daily, some people have reported fishy body odor, diarrhea, nausea, vomiting, and sweating. Much higher doses (32 grams daily) have been linked to more severe gastrointestinal upset.

During pregnancy and breastfeeding, choline is considered likely safe, though your needs are higher while nursing. Use prenatal vitamins or supplements only as your doctor advises rather than on your own.

Side effects, ingredient by ingredient Choline

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Choline.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take atropine or other anticholinergic drugs (medications that block acetylcholine activity), check your specific medication on this page before starting choline, as it may reduce how well the drug works.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Choline Bitartrate is a straightforward single-ingredient supplement well tolerated at the dose in this product. It's worth considering if you're pregnant, nursing, or looking to support brain function—but the evidence for specific conditions isn't established yet.

If you take atropine or anticholinergic medications, check first with your pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Choline Bitartrate 260 mg, straight from the product label.

Brand Advance Physician Formulas
Barcode (UPC) 896996000083
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2025
DSLD ID 337923
Product type Vitamin
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Choline Bitartrate 260 mg by Advance Physician Formulas, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
896996000083
IngredientAmount% DV
Choline260 mg47%

Other ingredients: Cellulose, Modified, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Choline Bitartrate is a supplemental source of the essential nutrient choline which when taken regularly may help increase acetylcholine levels.

260 mg Choline per serving

Precautions

Warnings: For adults only. Keep out of reach of children.

Consult with a qualified healthcare professional prior to taking this product especially if you are pregnant, nursing, have a diagnosed medical condition, or are taking a prescription medication.

Sealed for your protection. Do not use if seal is missing or broken.

This product is not manufactured with milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soy, sesame, or gluten. Produced in an FDA-registered, third-party audited, and cGMP-compliant facility that may process other products that contain these allergens or ingredients.

Storage

Store at room temperature, in a dry place. Protect product from excessive heat, freezing, humidity, and light.

Formulation

This product is not manufactured with milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soy, sesame, or gluten.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, healthy adults take 1 capsule daily in the morning with or without food or as recommended by a qualified healthcare professional.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Choline Bitartrate 260 mg by Advance Physician Formulas label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Choline Bitartrate 260 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Choline Bitartrate 260 mg by Advance Physician Formulas

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Choline

Interacts with
16 drugs
260 mg per serving Form: Choline Bitartrate

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline monograph & interactions

Other (inactive) ingredients: Cellulose, Modified, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Choline Bitartrate 260 mg by Advance Physician Formulas Drug Interactions

Want to check YOUR meds against Choline Bitartrate 260 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Choline 16

Individual Drug Interactions

The ingredients in Choline Bitartrate 260 mg interact with 16 drugs. Click any drug to see the details.

1 of the 1 ingredient in Choline Bitartrate 260 mg interact with drugs. Each result below shows which ingredient is responsible. Choline

Each ingredient & the kinds of drugs it affects

For each ingredient in Choline Bitartrate 260 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Choline1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Choline Bitartrate 260 mg, from the product label.

Advance Physician Formulas

See all Advance Physician Formulas products
Name
Advance Physician Formulas Inc.
Street Address
17165 Von Karman Avenue, Suite 109
City
Irvine
State
California
ZipCode
92614
Web Address
physicianformulas.com
Pharmacist Counseling Corner

Choline Bitartrate 260 mg by Advance Physician Formulas: Common Questions

Does Choline Bitartrate 260 mg by Advance Physician Formulas interact with any medications?
Yes. Based on its ingredients, Choline Bitartrate 260 mg has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Choline Bitartrate 260 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is 260 mg of choline a high dose?
No. The tolerable upper limit for choline is 3.5 grams (3,500 mg) daily—the dose at which side effects become more likely. This product provides 260 mg per capsule, which is well below that threshold. Most people won't experience side effects at this dose.
Can I take this while pregnant or breastfeeding?
Choline is rated likely safe during pregnancy and lactation, and your body actually needs more of it while nursing. However, any supplement in pregnancy or while breastfeeding should be discussed with your doctor first to make sure it's right for your situation.
What's the fishy smell some people report?
At high doses, choline can be broken down by gut bacteria into a compound called trimethylamine, which creates a fishy body odor. This happens mainly at doses well above what's in this single capsule.
Does choline actually improve memory or brain function?
The evidence we have isn't strong enough to rate choline as effective for age-related cognitive decline or Alzheimer disease. If brain support is your goal, talk with your pharmacist about what the research actually shows for this and other supplements.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Choline Bitartrate 260 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Choline Bitartrate 260 mg label
Go deeper

The Full Monographs Behind Choline Bitartrate 260 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph →
Sources

Sources & How We Checked

Choline Bitartrate 260 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
  3. Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
  4. Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M. Depression associated with oral choline. Lancet 10-23-1976;2(7991):905. PubMed
  5. Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
  8. Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
  9. Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
  10. Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
  11. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
  13. Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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