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Dietary supplement

Mangosteen 500 mg Ingredients & Drug Interactions

by Advance Physician Formulas

Mangosteen 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mangosteen 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Mangosteen 500 mg is a dietary supplement by Advance Physician Formulas with 1 active ingredient. Its ingredients are commonly taken for antioxidant support, anti-inflammatory support, immune support.Based on those ingredients, 125 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Mangosteen Pericarp Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Mangosteen 500 mg by Advance Physician Formulas

Ask about any prescription or over-the-counter medication and we check it for interactions with Mangosteen 500 mg by Advance Physician Formulas — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Mangosteen 500 mg by Advance Physician Formulas

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: mangosteen pericarp extract at 500 mg per capsule. The pericarp is the outer rind of the mangosteen fruit, where most of its active compounds live.

The capsule itself is vegetable-based.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Mangosteen's overall clinical evidence instead.

Moderate

Some clinical evidence supports Mangosteen for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Periodontitis — rated "Possibly Effective" (Natural Medicines).

Mangosteen shows possibly effective evidence for periodontitis (gum disease). For androgenic alopecia (male pattern baldness), Alzheimer disease, and atopic dermatitis (eczema), the evidence is too limited for us to rate it either way.

The evidence, ingredient by ingredient Mangosteen

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Mangosteen is generally well tolerated as a food, but long-term safety of concentrated supplement doses hasn't been thoroughly studied. At doses up to 560 mg daily, some people have reported mild tiredness, headache, dizziness, upset stomach, constipation, diarrhea, dry throat, cough, and cold-like symptoms — though it's unclear whether mangosteen itself caused them.

The safety data advises against using supplement amounts of mangosteen during pregnancy or while breastfeeding. There isn't enough information to know it's safe in those situations, so talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Mangosteen

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Mangosteen.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 125 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product before you start if you take blood thinners or antiplatelet drugs — there's a moderate risk of increased bleeding. If you take donepezil (Aricept), it may boost the drug's effects, so your doctor should know you're considering this supplement.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

If you have gum disease, this may be worth considering — the evidence for that use is reasonably solid. If you take blood thinners, antiplatelet drugs, or donepezil, you'll want to check with your doctor or pharmacist first.

Pregnant or breastfeeding? Skip it until you've talked it over with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mangosteen 500 mg, straight from the product label.

Brand Advance Physician Formulas
Barcode (UPC) 896996000366
Net contents 60 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Sep 22, 2022
DSLD ID 270315
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mangosteen 500 mg by Advance Physician Formulas, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
Servings per container
60
UPC/BARCODE
896996000366
IngredientAmount% DV
Mangosteen Pericarp Extract500 mg--

Other ingredients: Vegetable Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Mangosteen (Garcina mangostana) is an edible tropical fruit native to Southeast Asia. Its rind (pericarp) is a source of a class of polyphenols known as xanthones.

10% mangostin Mangosteen 500 mg per serving

Precautions

Warnings: Keep out of reach of children.

Consult with a qualified healthcare professional prior to using this product. Sealed for your protection. Do not use if seal is missing or broken.

This product is not manufactured with milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soy or gluten. Produced in a third-party registered cGMP compliant facility that may process other products containing these allergens or ingredients.

Storage

Store at room temperature, in a dry place. Protect product from excessive heat, freezing, humidity, and light.

Formulation

This product is not manufactured with milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soy or gluten.

Doctor formulated

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, healthy adults take one capsule in the morning with or without food, or as recommended by a qualified healthcare professional.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mangosteen 500 mg by Advance Physician Formulas label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mangosteen 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mangosteen 500 mg by Advance Physician Formulas

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Mangosteen Pericarp Extract

Interacts with
125 drugs
500 mg per serving Form: Mangostin

Mangosteen is a tropical fruit whose rind is rich in plant compounds called xanthones that act as antioxidants. While it is popular in juices and supp...

Mangosteen Pericarp Extract monograph & interactions

Other (inactive) ingredients: Vegetable Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mangosteen 500 mg by Advance Physician Formulas Drug Interactions

Want to check YOUR meds against Mangosteen 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
125Drugs
122 Moderate 3 Minor

Ingredients driving the most interactions

Mangosteen Pericarp Extract 125

Individual Drug Interactions

The ingredients in Mangosteen 500 mg interact with 125 drugs. Click any drug to see the details.

1 of the 1 ingredient in Mangosteen 500 mg interact with drugs. Each result below shows which ingredient is responsible. Mangosteen Pericarp Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Mangosteen 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Mangosteen Pericarp Extract2 drug types · 125 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of mangosteen with anticoagulant or antiplatelet drugs may increase the risk of bleeding.
In vitro and animal research shows that gamma-mangostin, a constituent of mangosteen, is a potent and competitive antagonist of the serotonin 2A (5-HT2A) receptor. Antagonism of the 5-HT2A receptor is believed to reduce platelet aggregation.

Likelihood Possible Evidence D
Donepezil (Aricept)

Theoretically, concomitant use of mangosteen with donepezil might increase the effects of donepezil.
Animal research shows that concomitant use of an aqueous extract of mangosteen pericarp with donepezil increases brain concentrations of donepezil at 4 hours by 64% without associated effects on systemic exposure.

Likelihood Possible Evidence D
Mangosteen Pericarp Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mangosteen 500 mg, from the product label.

Advance Physician Formulas

See all Advance Physician Formulas products
Name
Advance Physician Formulas, Inc.
Street Address
17165 Von Karman Ave. Suite 109
City
Irvine
State
CA
ZipCode
92614
Web Address
physicianformulas.com
Pharmacist Counseling Corner

Mangosteen 500 mg by Advance Physician Formulas: Common Questions

Does Mangosteen 500 mg by Advance Physician Formulas interact with any medications?
Yes. Based on its ingredients, Mangosteen 500 mg has a known interaction with 125 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mangosteen 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's mangosteen pericarp, and why is it in this supplement?
Pericarp is the outer rind of the mangosteen fruit. It's the part where the active compounds concentrate, so that's what supplement makers extract and use.
Can I take this if I'm pregnant or breastfeeding?
No — there isn't enough safety data. The facts advise against supplement amounts during pregnancy and breastfeeding. Talk with your doctor or pharmacist for personalized guidance.
Does mangosteen actually work for gum disease?
The evidence suggests it possibly does for periodontitis (gum disease). For baldness, Alzheimer disease, and eczema, we don't have enough reliable data to say either way.
What side effects have been reported?
At doses up to 560 mg daily, some people reported mild tiredness, headache, dizziness, upset stomach (constipation, diarrhea, nausea), dry throat, cough, and cold-like symptoms — but it's not clear mangosteen caused them.
Is this safe to take long-term?
Mangosteen is generally considered safe as a food, but long-term safety of concentrated supplements hasn't been well studied. If you're thinking of taking it regularly, check in with your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Mangosteen 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mangosteen 500 mg label
Go deeper

The Full Monographs Behind Mangosteen 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Mangosteen

Interacts with 125 drugs

Mangosteen is a tropical fruit whose rind is rich in plant compounds called xanthones that act as antioxidants. While it is popular in juices and supplements for inflammation, immune support...

Read the full Mangosteen monograph →
Sources

Sources & How We Checked

Mangosteen 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Mangosteen 6 references
  1. Chairungsrilerd N, Furukawa K, Ohta T, et al. Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana. Planta Med 1996;62:471-2.
  2. Wong LP, Klemmer PJ. Severe lactic acidosis associated with juice of the mangosteen fruit Garcinia mangostana. Am J Kidney Dis 2008;51:829-33. PubMed
  3. Furukawa, K., Chairungsrilerd, N., Ohta, T., Nozoe, S., and Ohizumi, Y. [Novel types of receptor antagonists from the medicinal plant Garcinia mangostana]. Nippon Yakurigaku Zasshi 1997;110 Suppl 1:153P-158P. PubMed
  4. Chairungsrilerd, N., Furukawa, K., Tadano, T., Kisara, K., and Ohizumi, Y. Effect of gamma-mangostin through the inhibition of 5-hydroxy-tryptamine2A receptors in 5-fluoro-alpha-methyltryptamine-induced head-twitch responses of mice. Br J Pharmacol. 1998
  5. Suthammarak W, Numpraphrut P, Charoensakdi R, et al. Antioxidant-enhancing property of the polar fraction of mangosteen pericarp extract and evaluation of its safety in humans. Oxid Med Cell Longev 2016;2016:1293036. PubMed
  6. Bae M, Han SY, Kim ES, et al. Effect of Water Extract of Mangosteen Pericarp on Donepezil Pharmacokinetics in Mice. Molecules 2021;26(17):5246. PubMed

See these in context on the Mangosteen monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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