Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Circulation & Metabolism Support Ingredients & Drug Interactions

by GNC Women's Ultra Mega

Circulation & Metabolism Support label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Circulation & Metabolism Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Circulation & Metabolism Support is a dietary supplement by GNC Women's Ultra Mega with 3 active ingredients. Its ingredients are commonly taken for diabetic nerve pain (neuropathy), blood sugar support in diabetes, antioxidant support.Based on those ingredients, 944 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are resVida Trans-Resveratrol, Alpha-Lipoic Acid, L-Carnitine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Circulation & Metabolism Support by GNC Women's Ultra Mega

Ask about any prescription or over-the-counter medication and we check it for interactions with Circulation & Metabolism Support by GNC Women's Ultra Mega — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Circulation & Metabolism Support by GNC Women's Ultra Mega

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has 3 active ingredients: alpha-lipoic acid, L-carnitine, and resVida trans-resveratrol. Alpha-lipoic acid is an antioxidant compound studied for its effects on blood sugar and cholesterol.

L-carnitine is an amino acid that helps your body produce energy and may support heart and metabolic function. Resveratrol is a plant compound from grapes and berries that's been studied for cardiovascular and metabolic health.

The capsules also contain inactive ingredients — cellulose, gelatin, corn starch, and titanium dioxide — which are fillers, binders, and the capsule material itself.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: circulation and metabolism support.
  • We looked for evidence on: Cardiovascular disease (CVD), Coronary heart disease (CHD), Angina, Arrhythmia, Atrial fibrillation, Heart failure — and 4 related terms.
  • The strongest evidence on file: Alpha-lipoic Acid is rated "Possibly Effective" for Hyperlipidemia (Natural Medicines).
  • Also on file: L-carnitine is rated "Possibly Effective" for Angina, Congestive heart failure (CHF), Hyperlipidemia.
  • Also on file: Resveratrol is rated "Possibly Ineffective" for Cardiovascular disease (CVD), Hypercholesterolemia.

According to the research we hold, alpha-lipoic acid is possibly effective for diabetic nerve damage (neuropathy) and possibly effective for high cholesterol and obesity. L-carnitine is effective for L-carnitine deficiency and possibly effective for high cholesterol, heart failure, and angina.

Resveratrol is possibly effective for obesity and hay fever, though the data suggests it is possibly ineffective for heart disease and high cholesterol. The strength of the evidence varies — some claims rest on smaller or limited studies, so talk with your doctor about what to expect.

The evidence, ingredient by ingredient Alpha-lipoic Acid L-carnitine Resveratrol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Alpha-lipoic acid is generally well tolerated but can lower blood sugar, so it's best used under medical guidance if you have diabetes. The most common side effects are headache, heartburn, nausea, and vomiting.

Rare cases have raised concerns about a specific type of autoimmune insulin disorder. There is not enough reliable safety data to use alpha-lipoic acid during pregnancy or while breastfeeding — avoid it in both cases.

L-carnitine is generally well tolerated at typical doses, though high doses can cause stomach upset and a fish-like body odor. Common side effects include abdominal cramps, diarrhea, heartburn, nausea, and reduced appetite.

Safety during pregnancy is not well studied — use only under medical supervision. It is possibly safe while breastfeeding.

Resveratrol is generally well tolerated, but high doses may cause diarrhea and digestive discomfort, and long-term safety at high doses isn't fully known. There is not enough safety information to use resveratrol supplements during pregnancy or while breastfeeding.

Side effects, ingredient by ingredient Alpha-lipoic Acid L-carnitine Resveratrol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Resveratrol, Alpha-lipoic Acid, L-carnitine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments; diabetes medications.
  • For scale: 945 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product if you take blood thinners (anticoagulants) or antiplatelet drugs like warfarin, acenocoumarol, or aspirin — all three ingredients may increase bleeding risk. If you're on chemotherapy, especially alkylating agents or antitumor antibiotics, talk to your oncologist because alpha-lipoic acid may reduce their effectiveness.

Anyone on thyroid hormone replacement should verify the interaction with their doctor. Also flag any diabetes medications, and any drugs your liver processes heavily — resveratrol may raise their blood levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is designed to support circulation and metabolism through three studied ingredients. If you take blood thinners, thyroid medication, diabetes drugs, or chemotherapy, you need to check with your pharmacist before starting it — the interactions are real and could affect how your drugs work.

Anyone with diabetes should use it only under medical guidance because of blood sugar effects. Talk to your pharmacist or doctor about whether it fits your health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Circulation & Metabolism Support, straight from the product label.

Brand GNC Women's Ultra Mega
Net contents 30 Pack(s)
Market status On market
Date entered into DSLD May 23, 2014
DSLD ID 33543
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Female (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Circulation & Metabolism Support by GNC Women's Ultra Mega, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 White Capsule(s)
Maximum serving Sizes:
1 White Capsule(s)
IngredientAmount% DV
Alpha-Lipoic Acid150 mg--
L-Carnitine100 mg--
resVida Trans-Resveratrol30 mg--

Other ingredients: Cellulose, Gelatin, Corn Starch, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, for optimal health benefits take contents of one packet daily with food.

To ensure a complete nutritional program, take daily with these GNC products: - Ultra Probiotic Complex 25 - Calcimate Plus(TM) - Triple Strength Fish Oil - SuperFoods Whole Foods Blend

Brand IP Statement(s)

resVida(R) is a trademark of DSM

VITAPAK(R) PROGRAM NUTRITION PLAN

Use Women's Ultra Mega(R) Diabetic Support Vitapak(R) Program in conjunction with a nutritionally balanced diet suitable for persons with diabetes to help maintain healthy blood sugar levels and improve circulation and eye health.

General Statements

GNC QUALITY COMMITMENT For more than 77 years, GNC has been the leader in the development of superior nutritional supplements. Our products are produced using only fresh, high-quality ingredients and are manufactured under the strictest quality controls. GNC GUARANTEE If you are not 100% completely satisfied, return the unused portion of the product with your receipt to a GNC store within 30 days. Our trained sales staff will either refund your purchase price or, if you prefer, assist you in finding a replacement product to help you LIVE WELL.

Each pack contains: Circulation & Metabolism Support

{White Capsule} ACTUAL SIZE

This product is endorsed by the GNC Medical Advisory Board. This team of esteemed physicians utilizes their extensive medical knowledge and experience to aid in the creation of GNC premium products, helping you to achieve optimal health through comprehensive nutritional support so you can live you best life!

{QR Code} SCAN & LEARN MORE

- Multivitamin enhanced with key ingredients to support normal blood sugar utilization* - Premium ingredients that support glucose metabolism, circulatory health & optimal eye health* - Supports heart health & a healthy anti-inflammatory response with resveratrol & triple strength fish oil*

NEW

It contains nutrients that address the primary health concerns of people with diabetes: blood glucose metabolism support, eye health and circulatory health.

FDA Statement of Identity

Dietary Supplement

Formula

Circulation & Metabolism Support - Provides premium resVida(R) Resveratrol, clinically shown to significantly enhance blood vessel dilation.* Also delivers L-carnitine, which facilitates the metabolism of long chain fatty acids, and alpha-lipoic acid, which plays an important role in cellular energy metabolism.*

GNC Women's Ultra Mega(R) Diabetic Support Vitapak(R) Program is scientifically designed for the special dietary needs of people with diabetes and is formulated to provide optimal health benefits when taken as directed every day.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General

CODE 345922 KNG

Precautions

WARNING: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use two weeks prior to surgery.

KEEP OUT OF REACH OF CHILDREN.

Storage

Store in a cool, dry place.

Formulation

No Artificial Colors, No Wheat, No Gluten, No Dairy, Yeast Free.

Seals/Symbols

resVida(R)

PHYSICIAN ENDORSED

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Circulation & Metabolism Support by GNC Women's Ultra Mega label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Circulation & Metabolism Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Circulation & Metabolism Support by GNC Women's Ultra Mega

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 White Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Alpha-Lipoic Acid

Interacts with
263 drugs
150 mg per serving

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain,...

Alpha-Lipoic Acid monograph & interactions

L-Carnitine

Interacts with
19 drugs
100 mg per serving

L-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most...

L-Carnitine monograph & interactions

ResVida Trans-Resveratrol

Interacts with
822 drugs
30 mg per serving

Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While...

ResVida Trans-Resveratrol monograph & interactions

Other (inactive) ingredients: Cellulose, Gelatin, Corn Starch, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Circulation & Metabolism Support by GNC Women's Ultra Mega Drug Interactions

Want to check YOUR meds against Circulation & Metabolism Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
944Drugs
865 Moderate 79 Minor

Ingredients driving the most interactions

resVida Trans-Resveratrol 822
Alpha-Lipoic Acid 263
L-Carnitine 19

Individual Drug Interactions

The ingredients in Circulation & Metabolism Support interact with 944 drugs. Click any drug to see the details.

3 of the 3 ingredients in Circulation & Metabolism Support interact with drugs. Each result below shows which ingredient is responsible. resVida Trans-Resveratrol Alpha-Lipoic Acid L-Carnitine

Each ingredient & the kinds of drugs it affects

For each ingredient in Circulation & Metabolism Support with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

resVida Trans-Resveratrol5 drug types · 822 drugs

Anticoagulant/Antiplatelet Drugs

Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Resveratrol seems to have antiplatelet effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that resveratrol can inhibit CYP1A2 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that resveratrol can inhibit CYP2C19 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Resveratrol might increase levels of drugs metabolized by CYP2E1.
In vitro research suggests that resveratrol inhibits CYP2E1 isoenzyme. Also, a pharmacokinetic study shows that taking resveratrol 500 mg daily for 10 days prior to taking a single dose of chlorzoxazone 250 mg increases the maximum concentration of chlorzoxazone by about 54%, the area under the curve of chlorzoxazone by about 72%, and the half-life of chlorzoxazone by about 35%. Chlorzoxazone is used as a probe drug for CYP2E1.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that resveratrol can inhibit the CYP3A4 enzyme. However, clinical research shows that taking resveratrol 3000 mg daily for 8 weeks does not necessitate dose adjustments to medications metabolized by CYP3A4.

Likelihood Possible Evidence D
resVida Trans-Resveratrol full monograph & interactions

Alpha-Lipoic Acid5 drug types · 263 drugs

Alkylating Agents

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro, alpha-lipoic acid inhibits platelet aggregation.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of antitumor antibiotic drugs, which work by generating free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.
Animal research suggests that co-administration of thyroxine with alpha-lipoic acid reduces conversion into the active T3 form.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Although some small clinical studies have suggested that alpha-lipoic acid can lower blood glucose levels, larger clinical studies in patients with diabetes have shown no clinically meaningful effect. Additionally, co-administration of single doses of alpha-lipoic acid and glyburide or acarbose did not cause detectable drug interactions in healthy volunteers.

Likelihood Unlikely Evidence B
Alpha-Lipoic Acid full monograph & interactions

L-Carnitine3 drug types · 19 drugs

Acenocoumarol (Sintrom)

Theoretically, L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation with concomitant use. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism.

Likelihood Probable Evidence B
Warfarin (Coumadin)

Theoretically, L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with L-carnitine and warfarin.

Likelihood Possible Evidence D
L-Carnitine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Circulation & Metabolism Support, from the product label.

GNC Women's Ultra Mega

See all GNC Women's Ultra Mega products
Phone Number
1-888-462-2548
Pharmacist Counseling Corner

Circulation & Metabolism Support by GNC Women's Ultra Mega: Common Questions

Does Circulation & Metabolism Support by GNC Women's Ultra Mega interact with any medications?
Yes. Based on its ingredients, Circulation & Metabolism Support has a known interaction with 944 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Circulation & Metabolism Support contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Alpha-lipoic acid should be avoided — there isn't enough safety data. L-carnitine is not well studied in pregnancy, so use only under medical supervision; it is possibly safe while breastfeeding. Resveratrol is not well studied in either, so avoid concentrated supplements. Talk with your doctor about what's right for your situation.
Will this help with my cholesterol?
Alpha-lipoic acid and L-carnitine are both possibly effective for high cholesterol. Resveratrol, however, is possibly ineffective for cholesterol, so don't count on it for that purpose. Work with your doctor on whether this product is a reasonable add-on to your routine.
What are the most common side effects?
Alpha-lipoic acid most commonly causes headache, heartburn, nausea, and vomiting. L-carnitine can cause abdominal cramps, diarrhea, heartburn, nausea, and a fish-like body odor, especially at higher doses. Resveratrol may cause diarrhea and loose stools. These are generally mild and often settle down.
Does this work for weight management?
Both alpha-lipoic acid and resveratrol are possibly effective for obesity, and L-carnitine is not listed for weight loss specifically. The evidence isn't strong for any of them as a standalone treatment, so they'd be best used alongside diet and exercise under your doctor's guidance.
Is L-carnitine safe for the heart?
L-carnitine is possibly effective for heart failure and angina. However, the data show that high L-carnitine levels in the blood are linked to heart disease risk — though taking the supplement itself has not been shown to increase that risk. If you have heart disease, check with your cardiologist before starting.
Can I take this with my diabetes medication?
Alpha-lipoic acid has a Minor interaction with diabetes drugs and may theoretically increase low blood sugar risk, so use this product only under medical guidance if you're on diabetes medication. Your doctor or pharmacist should review your exact dosages and blood sugar pattern.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Circulation & Metabolism Support label
Go deeper

The Full Monographs Behind Circulation & Metabolism Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Alpha-lipoic Acid

Interacts with 263 drugs

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help...

Read the full Alpha-lipoic Acid monograph → Herb & supplement monograph

L-carnitine

Interacts with 19 drugs

L-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most clearly useful for people with a true ca...

Read the full L-carnitine monograph → Herb & supplement monograph

Resveratrol

Interacts with 822 drugs

Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While lab and animal studies are promising, s...

Read the full Resveratrol monograph →
Sources

Sources & How We Checked

Circulation & Metabolism Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 113 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Alpha-lipoic Acid 48 references
  1. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  2. Anon. Alpha-lipoic acid. Altern Med Rev 1998;3:308-10.
  3. Konrad T, Vicini P, Kusterer K, et al. Alpha-lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with Type 2 diabetes. Diabetes Care 1999;22:280-7. PubMed
  4. Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid: A 3-week, multicentre randomized controlled trial (ALADIN Study). Diabetologia 1995;38:1425-33.
  5. Gleiter CH, Schreeb KH, Freudenthaler S, et al. Lack of interaction between thioctic acid, glibenclamide and acarbose. Br J Clin Pharmacol 1999;48:819-25. PubMed
  6. Jacob S, Henriksen EJ, Tritschler HJ, et al. Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. Exp Clin Endocrinol Diabet 1996;104:284-8. PubMed
  7. Jacob S, Henriksen EJ, Schiemann AL, et al. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittelforschung 1995;45:872-4.
  8. Jacob S, Ruus P, Hermann R, et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled, pilot trial. Free Rad Biol Med 1999;27:309-14.
  9. Segermann J, Hotze A, Ulrich H, Rao GS. Effect of alpha-lipoic acid on the peripheral conversion of thyroxine to triiodothyronine and on serum lipid-, protein- and glucose levels. Arzneimittelforschung 1991;41:1294-8.
  10. Beitner H. Randomized, placebo controlled, double-blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoaging of facial skin. Br J Dermatol 2003;149:841-9.
  11. Ziegler D, Nowak H, Kempler P, et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A meta-analysis. Diabet Med 2004;21:114-21.
  12. Prasad KN. Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy. J Nutr 2004;134:3182S-3S. PubMed
  13. Conklin KA. Cancer chemotherapy and antioxidants. J Nutr 2004;134:3201S-3204S. PubMed
  14. Vincent HK, Bourguignon CM, Vincent KR, Taylor AG. Effects of alpha-lipoic acid supplementation in peripheral arterial disease: a pilot study. J Alt Complement Med 2007;13:577-84. PubMed
  15. Furukawa N, Miyamura N, Nishida K, et al. Possible relevance of alpha lipoic acid contained in a health supplement in a case of insulin autoimmune syndrome. Diabetes Res Clin Pract 2007;75:366-7. PubMed
  16. Ziegler D., Ametov A., Barinov A., Dyck P. J., Gurieva I., Low P. A., Munzel U., Yakhno N., Raz I., Novosadova M., Maus J., Samigullin, R. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Car
  17. Gu X. M., Zhang S. S., Wu J. C., Tang Z. Y., Lu Z. Q., Li H., Liu C., Chen L., Ning, G. [Efficacy and safety of high-dose a-lipoic acid in the treatment of diabetic polyneuropathy]. Zhonghua Yi Xue Za Zhi 2010;90(35):2473-2476.
  18. Porasuphatana S., Suddee S., Nartnampong A., Konsil J., Harnwong B., Santaweesuk A. Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alpha-lipoic acid: a randomized double-blinded placebo-controlled
  19. Ansar H., Mazloom Z., Kazemi F., Hejazi N. Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients. Saudi Med J 2011;32(6):584-588. DOI
  20. de Oliveira A. M., Rondó P. H., Luzia L. A., D'Abronzo F. H., Illison V. K. The effects of lipoic acid and a-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: a randomized, double-blind, pla
  21. Mazloom Z., Ansar H. The Effect of Alpha-Lipoic Acid on Blood Pressure in Type 2 Diabetics. Iranian Journal of Endocrinology and Metabolism 2009;11(3):245-250.
  22. Volchegorskii I. A., Rassokhina L. M., Koliadich M. I., Alekseev M. I. [Comparative study of alpha-lipoic acid and mexidol effects on affective status, cognitive functions and quality of life in diabetes mellitus patients]. Eksp Klin Farmakol 2011;74(11):
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Resveratrol 24 references
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