Citicoline CDP Choline 250 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Citicoline CDP Choline 250 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Citicoline CDP Choline 250 mg is a dietary supplement by Jarrow Formulas with 1 active ingredient. Its ingredients are commonly taken for memory and thinking, brain health and aging, stroke recovery support.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Citicoline CDP Choline 250 mg by Jarrow Formulas
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: citicoline, a compound your body can produce naturally and that plays a role in brain cell function and protection. The capsule itself is made from bovine gelatin, and the remaining ingredients — silicon dioxide, magnesium stearate, and microcrystalline cellulose — are inactive fillers and binders that help hold the capsule together.
Does it work?
Moderate evidence
The evidence for citicoline is mixed. It's rated possibly effective for age-related cognitive decline and glaucoma based on available research.
For stroke, the data suggests it's probably not effective. For Alzheimer disease, traumatic brain injury, and cardiac arrest, we don't yet have enough reliable evidence to say whether it works or doesn't.
If you're considering it for a specific reason, talk it over with your doctor about what the research actually supports for your situation.
How safe is it?
Well-documented data
Citicoline is generally well tolerated in studies, though long-term safety data isn't fully established yet. The most common side effects reported with oral use are abdominal pain, back pain, blurred vision, constipation, diarrhea, swelling, headache, trouble sleeping, nausea, and rash — though a small number of trial participants experienced these.
Because there isn't enough safety data, the evidence advises against use during pregnancy and while breastfeeding; talk with your doctor or pharmacist for personalized guidance if you're pregnant, planning to become pregnant, or nursing.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients in this product.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
Citicoline may be worth considering if you're interested in supporting cognitive function or eye health, and the safety data we have suggests it's generally well tolerated. The evidence for some uses is stronger than others, so knowing what you're taking it for matters.
Before you start — especially if you're pregnant, breastfeeding, or taking other medications — check in with your own doctor or pharmacist to make sure it fits your situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Citicoline CDP Choline 250 mg, straight from the product label.
| Brand | Jarrow Formulas |
|---|---|
| Barcode (UPC) | 790011200123 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 22, 2024 |
| DSLD ID | 307571 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Citicoline CDP Choline 250 mg by Jarrow Formulas, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Citicoline | 250 mg | -- |
Other ingredients: Bovine Gelatin, Silicon Dioxide, Magnesium Stearate, Microcrystalline Cellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use: Adults take 1 capsule 1-2 times a day with food or as directed by your qualified healthcare professional.
Formula
Citicoline (stabilized CDP Choline) is a naturally-occurring intermediate involved in the synthesis of phosphatidylcholine, a major constituent of the grey matter of brain tissue. Citicoline supplementation supports brain energy metabolism, and has been shown in clinical research to support attention performance in healthy adults and adolescents.
Precautions
Warning: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, are taking medication or have a medical condition; if adverse reactions occur, discontinue use.
Warning: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, are taking medication or have a medical condition; if adverse reactions occur, discontinue use. Keep out of the reach of children.
Do not use if safety seal is damaged or missing.
Seals/Symbols
IGEN Non-GMO tested
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formulation
Brain function Supports brain health, performance, and memory
Non-GMO Gluten free
No wheat, gluten, soybeans, dairy, egg, fish/shellfish, peanuts/tree nuts or sesame.
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
Cognizin Citicoline Cognizin is a registered trademark of Kyowa Hakko Bio Co., Ltd. Copyright 2023 Jarrow Formulas
General Statements
Mental wellness
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Citicoline CDP Choline 250 mg by Jarrow Formulas label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Citicoline CDP Choline 250 mg by Jarrow Formulas
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Citicoline
No knowninteractions
Citicoline is a naturally occurring compound involved in making brain cell membranes and the messenger chemical acetylcholine. It is popularly taken f...
Citicoline monograph & interactionsOther (inactive) ingredients: Bovine Gelatin, Silicon Dioxide, Magnesium Stearate, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.
Citicoline CDP Choline 250 mg by Jarrow Formulas Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Citicoline CDP Choline 250 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Citicoline CDP Choline 250 mg, from the product label.
Jarrow Formulas
See all Jarrow Formulas products- Name
- Jarrow Formulas, Inc.
- City
- Sherman Oaks
- State
- CA
- ZipCode
- 91403
- Phone Number
- 1-866-459-4154
- Web Address
- www.Jarrow.com
Citicoline CDP Choline 250 mg by Jarrow Formulas: Common Questions
Does Citicoline CDP Choline 250 mg by Jarrow Formulas interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is citicoline and what does it do in the body?
Can I take this if I'm pregnant or breastfeeding?
Does this actually work for memory or brain health?
What side effects might I experience?
How long until I notice results?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Citicoline CDP Choline 250 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Citicoline CDP Choline 250 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Citicoline CDP Choline 250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 11 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Citicoline 11 references
- Spiers PA, Myers D, Hochanadel GS, et al. Citicoline improves verbal memory in aging. Arch Neurol 1996;53:441-8. PubMed
- Fioravanti M, Yanagi M. Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly. Cochrane Database Syst Rev 2005;(2):CD000269. PubMed
- Conant R, Schauss AG. Therapeutic applications of citicoline for stroke and cognitive function in the elderly: A review of the literature. Altern Med Rev 2004;9:17-31.
- Warach, S., Pettigrew, L. C., Dashe, J. F., Pullicino, P., Lefkowitz, D. M., Sabounjian, L., Harnett, K., Schwiderski, U., and Gammans, R. Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Citicoline 0 DOI
- Lukas, S. E., Kouri, E. M., Rhee, C., Madrid, A., and Renshaw, P. F. Effects of short-term citicoline treatment on acute cocaine intoxication and cardiovascular effects. Psychopharmacology.(Berl.) 2001;157(2):163-167. PubMed
- Dinsdale, J. R., Griffiths, G. K., Castello, J., Maddock, J., Ortiz, J. A., and Aylward, M. CDP-choline: repeated oral dose tolerance studies in adult healthy volunteers. Arzneimittelforschung. 1983;33(7A):1061-1065.
- Clark BC, Georgekutty J, Berul CI. Myocardial ischemia secondary to synthetic cannabinoid (K2) use in pediatric patients. J Pediatr 2015;167(3):757-61.e1. PubMed
- Ghajar A, Gholamian F, Tabatabei-Motlagh M, et al. Citicoline (CDP-choline) add-on therapy to risperidone for treatment of negative symptoms in patients with stable schizophrenia: a double-blind, randomized placebo-controlled trial. Hum Psychopharmacol. 2
- Castagna A, Manzo C, Fabbo A, Lacava R, Ruberto C, Ruotolo G. The CITIMERIVA Study: CITIcoline plus MEmantina plus RIVAstigmine in Older Patients Affected with Alzheimer's Disease. Clin Drug Investig. 2021 Feb;41(2):177-182. PubMed
- Jeong H, Yoon S, Sung YH, et al. Effects of cytidine-5'-diphosphate choline on gray matter volumes in methamphetamine-dependent patients: A randomized, double-blind, placebo-controlled study. J Psychiatr Res 2021;143:215-221. PubMed
- Nakazaki E, Mah E, Sanoshy K, Citrolo D, Watanabe F. Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Nutr 2021;151(8):2153-2160. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC