Citrulline Unflavored Ingredients & Drug Interactions
by Kaged
What is this page for?
First and foremost: checking Citrulline Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Citrulline Unflavored is a dietary supplement by Kaged with 1 active ingredient. Its ingredients are commonly taken for exercise performance, muscle soreness and fatigue, blood flow and circulation.Based on those ingredients, 178 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Citrulline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Citrulline Unflavored by Kaged
Ask about any prescription or over-the-counter medication and we check it for interactions with Citrulline Unflavored by Kaged — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Citrulline Unflavored by Kaged
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-citrulline, an amino acid your body naturally makes and uses to help relax blood vessels and improve blood flow. There are no other active ingredients, and no inactive fillers are included.
Does it work?
Moderate evidence
L-citrulline is possibly effective for athletic performance — some evidence supports its use for that purpose. For sarcopenia (age-related muscle loss), the data suggests it's possibly ineffective.
For heart disease, heart failure, Reye syndrome, and diabetes, we don't have enough reliable evidence to know whether it works. Talk with your doctor about whether this ingredient matches what you're trying to achieve.
How safe is it?
Well-documented data
L-citrulline is generally well tolerated in healthy adults, though long-term safety hasn't been fully studied. The most common side effects are gastrointestinal: heartburn, stomach discomfort, and general digestive upset.
A small number of people with pulmonary hypertension reported cough. There isn't enough safety data to know whether it's okay during pregnancy, so the recommendation is to avoid it then.
Safety while breastfeeding is also unknown, so supplemental use isn't advised. Talk with your doctor or pharmacist before taking this if you're pregnant, planning pregnancy, or breastfeeding.
Meds to double-check
Moderate interaction found
Before taking this product, double-check with your doctor or pharmacist if you take blood pressure medications or erectile dysfunction drugs — both have Moderate interactions with L-citrulline and could amplify each other's blood-pressure-lowering effects.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Citrulline Unflavored is a single-ingredient supplement aimed mostly at athletic performance. If you take blood pressure medication or erectile dysfunction medication, check with your doctor or pharmacist before starting — both can interact with L-citrulline.
If you're pregnant, breastfeeding, or planning pregnancy, this isn't the right choice. For other questions about whether it fits your goals, talk it over with your own healthcare provider.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Citrulline Unflavored, straight from the product label.
| Brand | Kaged |
|---|---|
| Barcode (UPC) | 013189942122 |
| Net contents | 7.05 Ounce(s); 200 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Sep 25, 2023 |
| DSLD ID | 298710 |
| Product type | Amino Acid/protein |
| Supplement form | Powder |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Citrulline Unflavored by Kaged, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Bloodflow Athletic endurance Cardiovascular support
Kaged L-Citrulline is 100% plant-based, non-GMO, gluten-free, and third-party tested.
This product is certified and 3rd party tested to be safer for athletes.
Vegan Friendly
Non GMO Gluten Free
Pump
Formula
Clean Pumps L-Citrulline is an amino acid that raises nitric oxide levels and vasodilation in the body, helping you increase blood flow and muscle pumps during exercise. Kaged L-Citrulline is 100% plant-based, non-GMO, gluten-free, and third-party tested. Mix Kaged L-Citrulline with BCAAs, Glutamine, Creatine, and Hydra-Charge for a muscle-building performance matrix.
General Statements
We Are Kaged We are Kaged, the elite supplement brand. We provide you with the highest quality formulas in the world to help you lift heavier, be healthier, and evolve into the strongest version of yourself.
Contents may settle during shipping. Sold by weight, not volume. 33 659485 117 998802
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Seals/Symbols
Informed Sport We Test You Trust Banned Substance Tested Every Batch
Micropure Quality Guarantee
Brand IP Statement(s)
Never Stop Evolving
Copyright 2022 Kaged Muscle LLC.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Third-party tested for purity and potency.
Directions: Mix one rounded scoop in your favorite beverage or protein shake twice a day. Mix Your Own System Mix Citrulline with BCAAs, Glutamine, and Hydra-Charge to create your own pre and post-workout drinks.
Precautions
Consult your physician prior to using this product if you are pregnant, nursing, under 18 years of age, take medication or have a medical condition.
Consult your physician prior to using this product if you are pregnant, nursing, under 18 years of age, take medication or have a medical condition. Keep out of reach of children.
Immediately discontinue use and contact your physician if any adverse reactions occur.
This product contains a silica gel pack. Do not eat.
Storage
Store in a cool, dry place away from excessive heat.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Citrulline Unflavored by Kaged label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Citrulline Unflavored by Kaged
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Gram(s) Dosage formPowder Servings per container100 Amounts shown are per serving.
L-Citrulline
Interacts with178 drugs
L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...
L-Citrulline monograph & interactionsOther (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
Citrulline Unflavored by Kaged Drug Interactions
HelloPharmacist Interaction Report
Citrulline Unflavored by Kaged contains L-citrulline, which has documented interactions with two major drug categories.
The most serious concern is with blood pressure–lowering drugs (antihypertensive drugs). L-citrulline converts to L-arginine in your body, which can relax blood vessels and lower pressure; taking it alongside blood pressure medications could add up and drop your pressure too far.
The evidence here is theoretical — a review of small studies suggests the effect may be modest with typical doses — but it's a Moderate-severity interaction that deserves attention.
Read the full breakdown — every affected drug type, severity by severity
L-citrulline also interacts with erectile dysfunction medications (phosphodiesterase-5 inhibitors, like sildenafil or tadalafil). Again, both work by relaxing blood vessels; combined, they might lower your blood pressure more than either alone.
This is also rated Moderate. Both interactions are based on how the ingredient works rather than large human trials, but the mechanism is real.
Additionally, both of these interactions are theoretical based on L-citrulline's known effects in the body. Before you start this product alongside blood pressure medication or ED drugs, check your exact medications with the tool on this page or with your own doctor or pharmacist.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Citrulline Unflavored?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Citrulline Unflavored interact with 178 drugs. Click any drug to see the details.
1 of the 1 ingredient in Citrulline Unflavored interact with drugs. Each result below shows which ingredient is responsible. L-Citrulline
EpoprostenolFlolan
How Epoprostenol interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Epoprostenol interactionEprosartanTeveten
How Eprosartan interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Eprosartan interactionEsmololBrevibloc
How Esmolol interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Esmolol interactionEthacrynic AcidEdecrin
How Ethacrynic Acid interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Ethacrynic Acid interactionFelodipinePlendil, Renedil
How Felodipine interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Felodipine interactionFenoldopamCorlopam
How Fenoldopam interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Fenoldopam interactionFinasteride, TadalafilEntadfi
How Finasteride, Tadalafil interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullinePhosphodiesterase-5 Inhibitors Moderate
Interaction Summary
Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
Read the full L-citrulline + Finasteride, Tadalafil interactionFosinoprilMonopril
How Fosinopril interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Fosinopril interactionFosinopril, HydrochlorothiazideMonopril HCT
How Fosinopril, Hydrochlorothiazide interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Fosinopril, Hydrochlorothiazide interactionFurosemideLasix
How Furosemide interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Furosemide interactionGuanabenz AcetateWytensin
How Guanabenz Acetate interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Guanabenz Acetate interactionGuanadrel SulfateHylorel
How Guanadrel Sulfate interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Guanadrel Sulfate interactionGuanethidine MonosulfateIsimil, Ismelin
How Guanethidine Monosulfate interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Guanethidine Monosulfate interactionGuanethidine, HydrochlorothiazideEsimil
How Guanethidine, Hydrochlorothiazide interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Guanethidine, Hydrochlorothiazide interactionGuanfacineTenex
How Guanfacine interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Guanfacine interactionHydralazineApresoline, Apresoline Injection, Dralzine, Hydralazine, Hylazin
How Hydralazine interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Hydralazine interactionHydralazine, HydrochlorothiazideApresazide, Apresoline-Esidrix
How Hydralazine, Hydrochlorothiazide interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Hydralazine, Hydrochlorothiazide interactionHydralazine, Hydrochlorothiazide, ReserpineSer-Ap-Es, Unipres, Uniserp
How Hydralazine, Hydrochlorothiazide, Reserpine interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Hydralazine, Hydrochlorothiazide, Reserpine interactionHydralazine, ReserpineSerpasil-Apresoline1, Serpasil-Apresoline2
How Hydralazine, Reserpine interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Hydralazine, Reserpine interactionHydrochlorothiazideAquazide, Aquazide H, Esidrix, HCTZ, Hydro, Hydro-D +3 more
How Hydrochlorothiazide interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Hydrochlorothiazide interactionHydrochlorothiazide, IrbesartanAvalide
How Hydrochlorothiazide, Irbesartan interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Hydrochlorothiazide, Irbesartan interactionHydrochlorothiazide, LabetalolTrandate HCT
How Hydrochlorothiazide, Labetalol interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Hydrochlorothiazide, Labetalol interactionHydrochlorothiazide, LisinoprilPrinzide, Zestoretic
How Hydrochlorothiazide, Lisinopril interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Hydrochlorothiazide, Lisinopril interactionHydrochlorothiazide, Losartan PotassiumHyzaar
How Hydrochlorothiazide, Losartan Potassium interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Hydrochlorothiazide, Losartan Potassium interactionHydrochlorothiazide, MethyldopaAldoril 15, Aldoril 25, Aldoril D30, Methazide
How Hydrochlorothiazide, Methyldopa interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Hydrochlorothiazide, Methyldopa interactionHydrochlorothiazide, MetoprololLopressor HCT
How Hydrochlorothiazide, Metoprolol interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Hydrochlorothiazide, Metoprolol interactionHydrochlorothiazide, MoexiprilUniretic
How Hydrochlorothiazide, Moexipril interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Hydrochlorothiazide, Moexipril interactionHydrochlorothiazide, PindololViskazide
How Hydrochlorothiazide, Pindolol interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Hydrochlorothiazide, Pindolol interactionHydrochlorothiazide, PropranololInderide
How Hydrochlorothiazide, Propranolol interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Hydrochlorothiazide, Propranolol interactionHydrochlorothiazide, QuinaprilAccuretic
How Hydrochlorothiazide, Quinapril interacts with Citrulline Unflavored — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Hydrochlorothiazide, Quinapril interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Citrulline Unflavored with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Citrulline
Antihypertensive Drugs
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.
Phosphodiesterase-5 Inhibitors
Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.
Brand information
Manufacturer and brand details for Citrulline Unflavored, from the product label.
Kaged
See all Kaged products- Name
- Kaged Muscle
- Street Address
- 101 Main Street, Suite 360
- City
- Huntington Beach
- State
- CA
- ZipCode
- 92648
- Phone Number
- (844) 445-2433
- Web Address
- kaged.com
Citrulline Unflavored by Kaged: Common Questions
Does Citrulline Unflavored by Kaged interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this with my blood pressure medication?
What's L-citrulline actually for?
What side effects should I watch for?
Is this safe if I'm pregnant or breastfeeding?
How long does it take to work?
Can I take this with ED medication?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Citrulline Unflavored is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Citrulline Unflavored’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Citrulline Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 8 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
L-citrulline 8 references
- Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
- Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
- Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
- Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
- Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
- Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
- Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
- Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC